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DNA methylation can predict chronological age, and advanced methylation-predicted age beyond chronological age (DNA methylation age acceleration) is associated with ACEs, adverse mental and physical health, and elevated diurnal and baseline salivary cortisol. Childhood adversity is also associated with dysregulation of the hypothalamic-pituitary-adrenal axis, which produces the neuroendocrine hormone cortisol. It remains unknown whether these associations are specific to certain types of adversity. Herein, we investigate the associations of ACEs with DNA methylation age acceleration and plasma cortisol in the Avon Longitudinal Study of Parents and Children (ALSPAC) birth cohort.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this study of the children in ALSPAC, we used multiple linear regression to examine associations of cumulative exposure to ACE, as well as exposure to ten individual types of ACEs, with Horvath-estimated DNA methylation age acceleration and with baseline plasma cortisol. The ten ACEs were those included in the World Health Organization\u2019s ACE International Questionnaire. Data on ACEs were prospectively collected from age 0\u201314\u2009years. DNA methylation age acceleration and plasma cortisol were measured at mean 17.1\u2009years and 15.5\u2009years, respectively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      We included 974 UK children in the present study. Exposure to four or more ACEs compared to zero was associated with DNA methylation age acceleration in girls (\n                      <jats:italic>\u03b2<\/jats:italic>\n                      , 95% CI = 1.65, 0.25 to 3.04\u2009years) but not in boys (\n                      <jats:italic>\u03b2<\/jats:italic>\n                      , 95% CI = \u2212 0.11, \u2212 1.48 to 1.26\u2009years). Also, in girls, emotional abuse and physical abuse were each associated with DNA methylation age acceleration (\n                      <jats:italic>\u03b2<\/jats:italic>\n                      , 95% CI = 1.20, 0.15 to 2.26\u2009years and\n                      <jats:italic>\u03b2<\/jats:italic>\n                      , 95% CI = 1.22, 0.06 to 2.38\u2009years, respectively). No other ACEs were associated with accelerated DNA methylation age in either sex. Associations were also null between ACE and cortisol, and cortisol and DNA methylation age acceleration.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In this prospective population-based study of UK children, cumulative ACE exposure, emotional abuse, and physical abuse between age 0 and 14\u2009years were each associated with Horvath-estimated DNA methylation age acceleration at age 17\u2009years in girls but not in boys.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s13148-020-00844-2","type":"journal-article","created":{"date-parts":[[2020,4,7]],"date-time":"2020-04-07T05:04:33Z","timestamp":1586235873000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":58,"title":["Adverse childhood experiences, DNA methylation age acceleration, and cortisol in UK children: a prospective population-based cohort study"],"prefix":"10.1186","volume":"12","author":[{"given":"Rosalind","family":"Tang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura D.","family":"Howe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew","family":"Suderman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline L.","family":"Relton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew A.","family":"Crawford","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lotte C.","family":"Houtepen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,4,7]]},"reference":[{"key":"844_CR1","doi-asserted-by":"crossref","unstructured":"Conti G, Morris S, Melnychuk M, Pizzo E. 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