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Children of mothers with mental health problems are at higher risk of developmental problems, possibly through epigenetic mechanisms together with other factors such as genetic and environmental. We investigated DNA methylation in cord blood in relation to PND, taking into consideration a history of depression, co-morbidity with anxiety and selective serotonin reuptake inhibitors (SSRI) use, and stratified by sex of the child. Mothers (<jats:italic>N<\/jats:italic>\u2009=\u2009373) prospectively filled out web-based questionnaires regarding mood symptoms and SSRI use throughout pregnancy. Cord blood was collected at birth and DNA methylation was measured using Illumina MethylationEPIC array at 850 000 CpG sites throughout the genome. Differentially methylated regions were identified using\u00a0Kruskal\u2013Wallis test, and Benjamini-Hochberg\u00a0adjusted<jats:italic>p<\/jats:italic>-values\u2009&lt;\u20090.05 were considered significant.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>No differential DNA methylation was associated with PND alone; however, differential DNA methylation was observed in children exposed to comorbid PND with anxiety symptoms compared with healthy controls in<jats:italic>ABCF1<\/jats:italic>(log twofold change \u2212\u20090.2), but not after stratification by sex of the child. DNA methylation in children exposed to PND without SSRI treatment and healthy controls both differed in comparison with SSRI exposed children at several sites and regions, among which hypomethylation was observed in CpGs in the promoter region of<jats:italic>CRBN (<\/jats:italic>log2 fold change \u2212\u20090.57), involved in brain development, and hypermethylation in<jats:italic>MDFIC<\/jats:italic>(log2 fold change 0.45), associated with the glucocorticoid stress response.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Although it is not possible to assess if these methylation differences are due to SSRI treatment itself or to more severe depression, our findings add on to existing knowledge that there might be different biological consequences for the child depending on whether maternal PND was treated with SSRIs or not.<\/jats:p><\/jats:sec>","DOI":"10.1186\/s13148-021-01054-0","type":"journal-article","created":{"date-parts":[[2021,4,12]],"date-time":"2021-04-12T17:03:00Z","timestamp":1618246980000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["DNA methylation in cord blood in association with prenatal depressive symptoms"],"prefix":"10.1186","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2112-8674","authenticated-orcid":false,"given":"Theodora Kunovac","family":"Kallak","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emma","family":"Br\u00e4nn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emma","family":"Fransson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00c5sa","family":"Johansson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susanne","family":"Lager","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erika","family":"Comasco","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Lyle","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alkistis","family":"Skalkidou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,4,12]]},"reference":[{"issue":"9","key":"1054_CR1","doi-asserted-by":"publisher","first-page":"960","DOI":"10.3109\/14767058.2013.845157","volume":"27","author":"K Szegda","year":"2014","unstructured":"Szegda K, Markenson G, Bertone-Johnson ER, Chasan-Taber L. 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