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Differential expression was integrated with loci-specific alterations in DNA-methylation and chromatin marks in MM patients. A CRISPR-based targeted induction of DNA-methylation at the <jats:italic>ITGB7<\/jats:italic> super-enhancer (SE) in MM.1S cells was employed to intersect the impact of cis-regulatory elements on <jats:italic>ITGB7<\/jats:italic> expression.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p><jats:italic>ITGB7<\/jats:italic> was significantly (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05) upregulated in patients with t(14;16) and t(14;20) subgroups in all MGUS, SMM and MM stages, but sporadically upregulated in t(4;14) subgroup at the MM stage. We demonstrate a predetermined enhancer state on <jats:italic>ITGB7<\/jats:italic> in primary-B cells that is maintained under bivalent chromatin, which undergoes a process of chromatin-state alterations and develops into an active enhancer in cases of the t(4;14) subgroup or SE in cases of the t(14;16) subgroup. We also demonstrate that while targeted induction of DNA-methylation at the <jats:italic>ITGB7<\/jats:italic>-SE further upregulated the gene, inhibition of <jats:italic>ITGB7<\/jats:italic>-SE-associated transcription factor bromodomain-4 downregulated expression of the gene.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>Our findings suggest an epigenetic regulation of oncogenic overexpression of <jats:italic>ITGB7<\/jats:italic> in MM cells, which could be critical in MM progression and an attractive therapeutic target.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s13148-023-01433-9","type":"journal-article","created":{"date-parts":[[2023,2,4]],"date-time":"2023-02-04T03:03:04Z","timestamp":1675479784000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Expression of integrin \u03b2-7 is epigenetically enhanced in multiple myeloma subgroups with high-risk cytogenetics"],"prefix":"10.1186","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6555-3031","authenticated-orcid":false,"given":"Samrat","family":"Roy Choudhury","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie D.","family":"Byrum","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Duah","family":"Alkam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cody","family":"Ashby","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fenghuang","family":"Zhan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan J.","family":"Tackett","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frits","family":"Van Rhee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,2,4]]},"reference":[{"key":"1433_CR1","unstructured":"Kazandjian, D. in Seminars in oncology. 676\u2013681 (Elsevier)."},{"key":"1433_CR2","doi-asserted-by":"publisher","first-page":"2020","DOI":"10.1182\/blood-2005-11-013458","volume":"108","author":"F Zhan","year":"2006","unstructured":"Zhan F, et al. 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