{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T12:40:32Z","timestamp":1785328832584,"version":"3.55.0"},"reference-count":58,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,8,14]],"date-time":"2024-08-14T00:00:00Z","timestamp":1723593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2024,8,14]],"date-time":"2024-08-14T00:00:00Z","timestamp":1723593600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"name":"Hunan Engineering Research Center for Glaucoma with Artificial Intelligence in the Diagnosis and Application of New Materials, China","award":["2023TP2225"],"award-info":[{"award-number":["2023TP2225"]}]},{"DOI":"10.13039\/501100004761","name":"Natural Science Foundation of Hunan Province, China","doi-asserted-by":"crossref","award":["2023JJ70014"],"award-info":[{"award-number":["2023JJ70014"]}],"id":[{"id":"10.13039\/501100004761","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Changsha Municipal Natural Science Foundation, China","award":["kq2208495"],"award-info":[{"award-number":["kq2208495"]}]},{"name":"Science and Technology Foundation of Aier Eye Hospital Group, China","award":["AR2206D5"],"award-info":[{"award-number":["AR2206D5"]}]},{"name":"Aier Glaucoma Institute"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Clin Epigenet"],"DOI":"10.1186\/s13148-024-01723-w","type":"journal-article","created":{"date-parts":[[2024,8,14]],"date-time":"2024-08-14T12:03:03Z","timestamp":1723636983000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Mendelian randomization implicates causal association between epigenetic age acceleration and age-related eye diseases or glaucoma endophenotypes"],"prefix":"10.1186","volume":"16","author":[{"given":"Jiawei","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiang-Ling","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyu","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiahao","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyue","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3148-1703","authenticated-orcid":false,"given":"Xuanchu","family":"Duan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,8,14]]},"reference":[{"issue":"1","key":"1723_CR1","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1016\/j.maturitas.2013.01.018","volume":"75","author":"VB Voleti","year":"2013","unstructured":"Voleti VB, Hubschman J-P. Age-related eye disease. Maturitas. 2013;75(1):29\u201333.","journal-title":"Maturitas"},{"issue":"9","key":"1723_CR2","doi-asserted-by":"publisher","first-page":"e888","DOI":"10.1016\/S2214-109X(17)30293-0","volume":"5","author":"RRA Bourne","year":"2017","unstructured":"Bourne RRA, et al. Magnitude, temporal trends, and projections of the global prevalence of blindness and distance and near vision impairment: a systematic review and meta-analysis. Lancet Glob Health. 2017;5(9):e888\u201397.","journal-title":"Lancet Glob Health"},{"issue":"2","key":"1723_CR3","doi-asserted-by":"publisher","first-page":"e144","DOI":"10.1016\/S2214-109X(20)30489-7","volume":"9","author":"JD Steinmetz","year":"2021","unstructured":"Steinmetz JD, et al. Causes of blindness and vision impairment in 2020 and trends over 30 years, and prevalence of avoidable blindness in relation to VISION 2020: the Right to Sight: an analysis for the Global Burden of Disease Study. Lancet Glob Health. 2021;9(2):e144\u201360.","journal-title":"Lancet Glob Health"},{"key":"1723_CR4","doi-asserted-by":"publisher","first-page":"101247","DOI":"10.1016\/j.preteyeres.2024.101247","volume":"100","author":"S Becker","year":"2024","unstructured":"Becker S, et al. Modeling complex age-related eye disease. Prog Retin Eye Res. 2024;100:101247.","journal-title":"Prog Retin Eye Res"},{"key":"1723_CR5","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1016\/j.ebiom.2017.03.046","volume":"21","author":"J Jylh\u00e4v\u00e4","year":"2017","unstructured":"Jylh\u00e4v\u00e4 J, et al. Biological age predictors. EBioMedicine. 2017;21:29\u201336.","journal-title":"EBioMedicine"},{"key":"1723_CR6","doi-asserted-by":"publisher","first-page":"101743","DOI":"10.1016\/j.arr.2022.101743","volume":"81","author":"R Duan","year":"2022","unstructured":"Duan R, et al. Epigenetic clock: a promising biomarker and practical tool in aging. Ageing Res Rev. 2022;81:101743.","journal-title":"Ageing Res Rev"},{"issue":"10","key":"1723_CR7","doi-asserted-by":"publisher","first-page":"R115","DOI":"10.1186\/gb-2013-14-10-r115","volume":"14","author":"S Horvath","year":"2013","unstructured":"Horvath S. DNA methylation age of human tissues and cell types. Genome Biol. 2013;14(10):R115.","journal-title":"Genome Biol"},{"issue":"2","key":"1723_CR8","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1016\/j.molcel.2012.10.016","volume":"49","author":"G Hannum","year":"2013","unstructured":"Hannum G, et al. Genome-wide methylation profiles reveal quantitative views of human aging rates. Mol Cell. 2013;49(2):359\u201367.","journal-title":"Mol Cell"},{"issue":"6","key":"1723_CR9","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1038\/s41576-018-0004-3","volume":"19","author":"S Horvath","year":"2018","unstructured":"Horvath S, Raj K. DNA methylation-based biomarkers and the epigenetic clock theory of ageing. Nat Rev Genet. 2018;19(6):371\u201384.","journal-title":"Nat Rev Genet"},{"issue":"4","key":"1723_CR10","doi-asserted-by":"publisher","first-page":"573","DOI":"10.18632\/aging.101414","volume":"10","author":"ME Levine","year":"2018","unstructured":"Levine ME, et al. An epigenetic biomarker of aging for lifespan and healthspan. Aging (Albany NY). 2018;10(4):573\u201391.","journal-title":"Aging (Albany NY)"},{"issue":"2","key":"1723_CR11","doi-asserted-by":"publisher","first-page":"303","DOI":"10.18632\/aging.101684","volume":"11","author":"AT Lu","year":"2019","unstructured":"Lu AT, et al. DNA methylation GrimAge strongly predicts lifespan and healthspan. Aging (Albany NY). 2019;11(2):303\u201327.","journal-title":"Aging (Albany NY)"},{"issue":"11","key":"1723_CR12","doi-asserted-by":"publisher","first-page":"e1008104","DOI":"10.1371\/journal.pgen.1008104","volume":"15","author":"J Gibson","year":"2019","unstructured":"Gibson J, et al. A meta-analysis of genome-wide association studies of epigenetic age acceleration. PLoS Genet. 2019;15(11):e1008104.","journal-title":"PLoS Genet"},{"key":"1723_CR13","doi-asserted-by":"crossref","unstructured":"Smith GD, Ebrahim S. 'Mendelian randomization': can genetic epidemiology contribute to understanding environmental determinants of disease? Int J Epidemiol. 2003;32(1).","DOI":"10.1093\/ije\/dyg070"},{"issue":"19","key":"1723_CR14","doi-asserted-by":"publisher","first-page":"1925","DOI":"10.1001\/jama.2017.17219","volume":"318","author":"CA Emdin","year":"2017","unstructured":"Emdin CA, et al. Mendelian randomization. JAMA. 2017;318(19):1925\u20136.","journal-title":"JAMA"},{"issue":"1","key":"1723_CR15","doi-asserted-by":"publisher","first-page":"194","DOI":"10.1186\/s13059-021-02398-9","volume":"22","author":"DL Mccartney","year":"2021","unstructured":"Mccartney DL, et al. Genome-wide association studies identify 137 genetic loci for DNA methylation biomarkers of aging. Genome Biol. 2021;22(1):194.","journal-title":"Genome Biol"},{"key":"1723_CR16","doi-asserted-by":"publisher","first-page":"101553","DOI":"10.1016\/j.arr.2021.101553","volume":"74","author":"I Mart\u00ednez-Alberquilla","year":"2022","unstructured":"Mart\u00ednez-Alberquilla I, et al. Neutrophils and neutrophil extracellular trap components: emerging biomarkers and therapeutic targets for age-related eye diseases. Ageing Res Rev. 2022;74:101553.","journal-title":"Ageing Res Rev"},{"issue":"2","key":"1723_CR17","doi-asserted-by":"publisher","first-page":"220","DOI":"10.1001\/archopht.123.2.220","volume":"123","author":"J Dan","year":"2005","unstructured":"Dan J, et al. Plasminogen activator inhibitor-1 in the aqueous humor of patients with and without glaucoma. Arch Ophthalmol. 2005;123(2):220\u20134.","journal-title":"Arch Ophthalmol"},{"issue":"6","key":"1723_CR18","doi-asserted-by":"publisher","first-page":"1021","DOI":"10.1096\/fsb2fj000393com","volume":"15","author":"V Lambert","year":"2001","unstructured":"Lambert V, et al. Influence of plasminogen activator inhibitor type 1 on choroidal neovascularization. FASEB J. 2001;15(6):1021\u20137.","journal-title":"FASEB J"},{"issue":"7944","key":"1723_CR19","doi-asserted-by":"publisher","first-page":"508","DOI":"10.1038\/s41586-022-05473-8","volume":"613","author":"MI Kurki","year":"2023","unstructured":"Kurki MI, et al. FinnGen provides genetic insights from a well-phenotyped isolated population. Nature. 2023;613(7944):508\u201318.","journal-title":"Nature"},{"key":"1723_CR20","doi-asserted-by":"publisher","first-page":"435","DOI":"10.1038\/s42003-019-0634-9","volume":"2","author":"PWM Bonnemaijer","year":"2019","unstructured":"Bonnemaijer PWM, et al. Multi-trait genome-wide association study identifies new loci associated with optic disc parameters. Commun Biol. 2019;2:435.","journal-title":"Commun Biol"},{"issue":"5","key":"1723_CR21","doi-asserted-by":"publisher","first-page":"e1009497","DOI":"10.1371\/journal.pgen.1009497","volume":"17","author":"H Currant","year":"2021","unstructured":"Currant H, et al. Genetic variation affects morphological retinal phenotypes extracted from UK Biobank optical coherence tomography images. PLoS Genet. 2021;17(5):e1009497.","journal-title":"PLoS Genet"},{"issue":"1","key":"1723_CR22","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1186\/s13148-024-01647-5","volume":"16","author":"W Pan","year":"2024","unstructured":"Pan W, et al. Epigenetic age acceleration and risk of aortic valve stenosis: a bidirectional Mendelian randomization study. Clin Epigenetics. 2024;16(1):41.","journal-title":"Clin Epigenetics"},{"issue":"1","key":"1723_CR23","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1186\/s13148-023-01575-w","volume":"15","author":"Z Wang","year":"2023","unstructured":"Wang Z, et al. Effects of iron homeostasis on epigenetic age acceleration: a two-sample Mendelian randomization study. Clin Epigenetics. 2023;15(1):159.","journal-title":"Clin Epigenetics"},{"issue":"3","key":"1723_CR24","doi-asserted-by":"publisher","first-page":"755","DOI":"10.1093\/ije\/dyr036","volume":"40","author":"S Burgess","year":"2011","unstructured":"Burgess S, Thompson SG. Avoiding bias from weak instruments in Mendelian randomization studies. Int J Epidemiol. 2011;40(3):755\u201364.","journal-title":"Int J Epidemiol"},{"issue":"3","key":"1723_CR25","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1177\/0962280210394459","volume":"21","author":"TM Palmer","year":"2012","unstructured":"Palmer TM, et al. Using multiple genetic variants as instrumental variables for modifiable risk factors. Stat Methods Med Res. 2012;21(3):223\u201342.","journal-title":"Stat Methods Med Res"},{"key":"1723_CR26","unstructured":"Codd V, et al. Identification of seven loci affecting mean telomere length and their association with disease. Nat Genet. 2013;45(4)."},{"issue":"11","key":"1723_CR27","doi-asserted-by":"publisher","first-page":"e1007081","DOI":"10.1371\/journal.pgen.1007081","volume":"13","author":"G Hemani","year":"2017","unstructured":"Hemani G, et al. Orienting the causal relationship between imprecisely measured traits using GWAS summary data. PLoS Genet. 2017;13(11):e1007081.","journal-title":"PLoS Genet"},{"key":"1723_CR28","doi-asserted-by":"publisher","first-page":"673451","DOI":"10.3389\/fpubh.2021.673451","volume":"9","author":"M Yoshikawa","year":"2021","unstructured":"Yoshikawa M, Asaba K. Educational attainment decreases the risk of COVID-19 severity in the european population: a two-sample mendelian randomization study. Front Public Health. 2021;9:673451.","journal-title":"Front Public Health"},{"issue":"5","key":"1723_CR29","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1007\/s10654-021-00757-1","volume":"36","author":"AR Carter","year":"2021","unstructured":"Carter AR, et al. Mendelian randomisation for mediation analysis: current methods and challenges for implementation. Eur J Epidemiol. 2021;36(5):465\u201378.","journal-title":"Eur J Epidemiol"},{"issue":"21","key":"1723_CR30","doi-asserted-by":"publisher","first-page":"2926","DOI":"10.1002\/sim.6522","volume":"34","author":"MFD Greco","year":"2015","unstructured":"Greco MFD, et al. Detecting pleiotropy in Mendelian randomisation studies with summary data and a continuous outcome. Stat Med. 2015;34(21):2926\u201340.","journal-title":"Stat Med"},{"key":"1723_CR31","doi-asserted-by":"publisher","first-page":"186","DOI":"10.12688\/wellcomeopenres.15555.1","volume":"4","author":"S Burgess","year":"2019","unstructured":"Burgess S, et al. Guidelines for performing Mendelian randomization investigations: update for summer 2023. Wellcome Open Res. 2019;4:186.","journal-title":"Wellcome Open Res"},{"issue":"3","key":"1723_CR32","doi-asserted-by":"publisher","first-page":"922","DOI":"10.1093\/ije\/dyu005","volume":"43","author":"S Burgess","year":"2014","unstructured":"Burgess S. Sample size and power calculations in Mendelian randomization with a single instrumental variable and a binary outcome. Int J Epidemiol. 2014;43(3):922\u20139.","journal-title":"Int J Epidemiol"},{"key":"1723_CR33","doi-asserted-by":"crossref","unstructured":"Hemani G, et al. The MR-base platform supports systematic causal inference across the human phenome. Elife. 2018;7.","DOI":"10.7554\/eLife.34408"},{"issue":"25","key":"1723_CR34","doi-asserted-by":"publisher","first-page":"5434","DOI":"10.1002\/sim.9133","volume":"40","author":"E Sanderson","year":"2021","unstructured":"Sanderson E, et al. Testing and correcting for weak and pleiotropic instruments in two-sample multivariable Mendelian randomization. Stat Med. 2021;40(25):5434\u201352.","journal-title":"Stat Med"},{"issue":"6","key":"1723_CR35","doi-asserted-by":"publisher","first-page":"1734","DOI":"10.1093\/ije\/dyx034","volume":"46","author":"OO Yavorska","year":"2017","unstructured":"Yavorska OO, Burgess S. MendelianRandomization: an R package for performing Mendelian randomization analyses using summarized data. Int J Epidemiol. 2017;46(6):1734\u20139.","journal-title":"Int J Epidemiol"},{"issue":"10414","key":"1723_CR36","doi-asserted-by":"publisher","first-page":"1788","DOI":"10.1016\/S0140-6736(23)01289-8","volume":"402","author":"H Jayaram","year":"2023","unstructured":"Jayaram H, et al. Glaucoma: now and beyond. Lancet. 2023;402(10414):1788\u2013801.","journal-title":"Lancet"},{"issue":"11","key":"1723_CR37","doi-asserted-by":"publisher","first-page":"2081","DOI":"10.1016\/j.ophtha.2014.05.013","volume":"121","author":"Y-C Tham","year":"2014","unstructured":"Tham Y-C, et al. Global prevalence of glaucoma and projections of glaucoma burden through 2040: a systematic review and meta-analysis. Ophthalmology. 2014;121(11):2081\u201390.","journal-title":"Ophthalmology"},{"issue":"1","key":"1723_CR38","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1136\/bjophthalmol-2014-306102","volume":"100","author":"EWE Chan","year":"2016","unstructured":"Chan EWE, et al. Glaucoma in Asia: regional prevalence variations and future projections. Br J Ophthalmol. 2016;100(1):78\u201385.","journal-title":"Br J Ophthalmol"},{"issue":"2","key":"1723_CR39","doi-asserted-by":"publisher","first-page":"546","DOI":"10.14336\/AD.2023.0630-1","volume":"15","author":"Y Zhang","year":"2024","unstructured":"Zhang Y, et al. Aging, cellular senescence, and glaucoma. Aging Dis. 2024;15(2):546\u201364.","journal-title":"Aging Dis"},{"issue":"6","key":"1723_CR40","doi-asserted-by":"publisher","first-page":"931","DOI":"10.1016\/j.molcel.2015.07.027","volume":"59","author":"D Skowronska-Krawczyk","year":"2015","unstructured":"Skowronska-Krawczyk D, et al. P16INK4a upregulation mediated by SIX6 defines retinal ganglion cell pathogenesis in glaucoma. Mol Cell. 2015;59(6):931\u201340.","journal-title":"Mol Cell"},{"issue":"30","key":"1723_CR41","doi-asserted-by":"publisher","first-page":"11181","DOI":"10.1073\/pnas.1402819111","volume":"111","author":"W Chi","year":"2014","unstructured":"Chi W, et al. Caspase-8 promotes NLRP1\/NLRP3 inflammasome activation and IL-1\u03b2 production in acute glaucoma. Proc Natl Acad Sci USA. 2014;111(30):11181\u20136.","journal-title":"Proc Natl Acad Sci USA"},{"issue":"12","key":"1723_CR42","doi-asserted-by":"publisher","DOI":"10.1111\/acel.13737","volume":"21","author":"Q Xu","year":"2022","unstructured":"Xu Q, et al. Stress induced aging in mouse eye. Aging Cell. 2022;21(12): e13737.","journal-title":"Aging Cell"},{"issue":"18","key":"1723_CR43","doi-asserted-by":"publisher","first-page":"e2311028121","DOI":"10.1073\/pnas.2311028121","volume":"121","author":"Y Liu","year":"2024","unstructured":"Liu Y, et al. Senolytic and senomorphic agent procyanidin C1 alleviates structural and functional decline in the aged retina. Proc Natl Acad Sci USA. 2024;121(18):e2311028121.","journal-title":"Proc Natl Acad Sci USA"},{"issue":"2","key":"1723_CR44","doi-asserted-by":"publisher","first-page":"e13089","DOI":"10.1111\/acel.13089","volume":"19","author":"LR Rocha","year":"2020","unstructured":"Rocha LR, et al. Early removal of senescent cells protects retinal ganglion cells loss in experimental ocular hypertension. Aging Cell. 2020;19(2):e13089.","journal-title":"Aging Cell"},{"issue":"10","key":"1723_CR45","doi-asserted-by":"publisher","first-page":"e834","DOI":"10.1097\/IJG.0000000000000453","volume":"25","author":"FS Mcdonnell","year":"2016","unstructured":"Mcdonnell FS, et al. Increased global DNA methylation and decreased TGF\u03b21 promoter methylation in glaucomatous lamina cribrosa cells. J Glaucoma. 2016;25(10):e834\u201342.","journal-title":"J Glaucoma"},{"issue":"4","key":"1723_CR46","doi-asserted-by":"publisher","first-page":"e0153354","DOI":"10.1371\/journal.pone.0153354","volume":"11","author":"F Mcdonnell","year":"2016","unstructured":"Mcdonnell F, et al. Hypoxia-induced changes in DNA methylation alter RASAL1 and TGF\u03b21 expression in human trabecular meshwork cells. PLoS ONE. 2016;11(4):e0153354.","journal-title":"PLoS ONE"},{"key":"1723_CR47","first-page":"483","volume":"26","author":"J Cai","year":"2020","unstructured":"Cai J, et al. Differential DNA methylation patterns in human Schlemm\u2019s canal endothelial cells with glaucoma. Mol Vis. 2020;26:483\u201393.","journal-title":"Mol Vis"},{"issue":"4","key":"1723_CR48","doi-asserted-by":"publisher","first-page":"1639","DOI":"10.1016\/j.ymthe.2020.12.030","volume":"29","author":"P Wan","year":"2021","unstructured":"Wan P, et al. TET-dependent GDF7 hypomethylation impairs aqueous humor outflow and serves as a potential therapeutic target in glaucoma. Mol Ther. 2021;29(4):1639\u201357.","journal-title":"Mol Ther"},{"issue":"7836","key":"1723_CR49","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1038\/s41586-020-2975-4","volume":"588","author":"Y Lu","year":"2020","unstructured":"Lu Y, et al. Reprogramming to recover youthful epigenetic information and restore vision. Nature. 2020;588(7836):124\u20139.","journal-title":"Nature"},{"issue":"2","key":"1723_CR50","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1007\/s13167-019-00166-1","volume":"10","author":"Q Chen","year":"2019","unstructured":"Chen Q, et al. Associations between the red blood cell distribution width and primary angle-closure glaucoma: a potential for disease prediction. EPMA J. 2019;10(2):185\u201393.","journal-title":"EPMA J"},{"issue":"1","key":"1723_CR51","doi-asserted-by":"publisher","first-page":"300060522114743","DOI":"10.1177\/03000605221147434","volume":"51","author":"H-B Zeng","year":"2023","unstructured":"Zeng H-B, et al. The inflammatory cytokine profiles and ocular biometric characteristics of primary angle-closure glaucoma. J Int Med Res. 2023;51(1):3000605221147434.","journal-title":"J Int Med Res"},{"issue":"5","key":"1723_CR52","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1167\/iovs.65.5.34","volume":"65","author":"M Pan","year":"2024","unstructured":"Pan M, et al. Biomechanical correlations between the cornea and the optic nerve head. Invest Ophthalmol Vis Sci. 2024;65(5):34.","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"2","key":"1723_CR53","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1016\/j.ophtha.2019.09.013","volume":"127","author":"BC Chauhan","year":"2020","unstructured":"Chauhan BC, et al. Differential effects of aging in the macular retinal layers, neuroretinal rim, and peripapillary retinal nerve fiber layer. Ophthalmology. 2020;127(2):177\u201385.","journal-title":"Ophthalmology"},{"issue":"13","key":"1723_CR54","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1167\/iovs.61.13.8","volume":"61","author":"AA Jammal","year":"2020","unstructured":"Jammal AA, et al. The effect of age on increasing susceptibility to retinal nerve fiber layer loss in glaucoma. Invest Ophthalmol Vis Sci. 2020;61(13):8.","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"8","key":"1723_CR55","doi-asserted-by":"publisher","first-page":"5134","DOI":"10.1167\/iovs.14-14303","volume":"55","author":"NB Patel","year":"2014","unstructured":"Patel NB, et al. Age-associated changes in the retinal nerve fiber layer and optic nerve head. Invest Ophthalmol Vis Sci. 2014;55(8):5134\u201343.","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"2","key":"1723_CR56","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1001\/jama.2023.26074","volume":"331","author":"M Fleckenstein","year":"2024","unstructured":"Fleckenstein M, et al. Age-related macular degeneration: a review. JAMA. 2024;331(2):147\u201357.","journal-title":"JAMA"},{"issue":"3","key":"1723_CR57","doi-asserted-by":"publisher","first-page":"379","DOI":"10.1016\/j.preteyeres.2004.11.001","volume":"24","author":"SA Strenk","year":"2005","unstructured":"Strenk SA, et al. The mechanism of presbyopia. Prog Retin Eye Res. 2005;24(3):379\u201393.","journal-title":"Prog Retin Eye Res"},{"issue":"12","key":"1723_CR58","doi-asserted-by":"publisher","first-page":"834","DOI":"10.1038\/s41419-023-06350-6","volume":"14","author":"DE Maidana","year":"2023","unstructured":"Maidana DE, et al. Peripheral monocytes and neutrophils promote photoreceptor cell death in an experimental retinal detachment model. Cell Death Dis. 2023;14(12):834.","journal-title":"Cell Death Dis"}],"container-title":["Clinical Epigenetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13148-024-01723-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s13148-024-01723-w\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13148-024-01723-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,14]],"date-time":"2024-08-14T13:03:31Z","timestamp":1723640611000},"score":1,"resource":{"primary":{"URL":"https:\/\/clinicalepigeneticsjournal.biomedcentral.com\/articles\/10.1186\/s13148-024-01723-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8,14]]},"references-count":58,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["1723"],"URL":"https:\/\/doi.org\/10.1186\/s13148-024-01723-w","relation":{},"ISSN":["1868-7083"],"issn-type":[{"value":"1868-7083","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,8,14]]},"assertion":[{"value":"27 June 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 August 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 August 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"Ethics approval and consent have been obtained in each original study. Since only publicly available data were used, no additional ethics approval or individual consent was required.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}}],"article-number":"106"}}