{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T00:18:10Z","timestamp":1792801090915,"version":"4.5.0"},"reference-count":46,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,8,16]],"date-time":"2024-08-16T00:00:00Z","timestamp":1723766400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2024,8,16]],"date-time":"2024-08-16T00:00:00Z","timestamp":1723766400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"name":"State Key Laboratory for Complex, Severe and Rare Diseases in Peking Union Medical College Hospital, by the Beijing Science and Technology Projects","award":["Z211100002921068"],"award-info":[{"award-number":["Z211100002921068"]}],"id":[{"id":"https:\/\/ror.org\/04jztag35","id-type":"ROR","asserted-by":"crossref"}]},{"name":"the Key Research Project of Beijing Natural Science Foundation","award":["Z220013"],"award-info":[{"award-number":["Z220013"]}]},{"name":"the CAMS Innovation Fund for Medical Sciences","award":["2022-I2M-C&T-B-033"],"award-info":[{"award-number":["2022-I2M-C&T-B-033"]}]},{"name":"the National High Level Hospital Clinical Research Funding","award":["2022-PUMCH-A-117, 2022-PUMCH-B-083, 2022-PUMCH-C-010, 2022-PUMCH-C-022 and 2022-PUMCH-D-003"],"award-info":[{"award-number":["2022-PUMCH-A-117, 2022-PUMCH-B-083, 2022-PUMCH-C-010, 2022-PUMCH-C-022 and 2022-PUMCH-D-003"]}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2022T150066"],"award-info":[{"award-number":["2022T150066"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Clin Epigenet"],"DOI":"10.1186\/s13148-024-01731-w","type":"journal-article","created":{"date-parts":[[2024,8,16]],"date-time":"2024-08-16T08:01:58Z","timestamp":1723795318000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Triage performance of PAX1m\/JAM3m in opportunistic cervical cancer screening of non\u201216\/18 human papillomavirus-positive women: a multicenter prospective study in China"],"prefix":"10.1186","volume":"16","author":[{"given":"Xiaojing","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xitong","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linghua","family":"Kong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuligh","family":"Liou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pei","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhe","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sijun","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bingli","family":"Qi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Fei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangwu","family":"Xiong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuchong","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shikai","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianwei","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huafeng","family":"Shou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,8,16]]},"reference":[{"key":"1731_CR1","doi-asserted-by":"crossref","unstructured":"Tekle, T., et al., Knowledge, Attitude and Practice Towards Cervical Cancer Screening Among Women and Associated Factors in Hospitals of Wolaita Zone, Southern Ethiopia. Cancer Management and Research, 2020. 12.","DOI":"10.2147\/CMAR.S240364"},{"issue":"1","key":"1731_CR2","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1016\/S1470-2045(20)30729-4","volume":"22","author":"M Das","year":"2021","unstructured":"Das M. WHO launches strategy to accelerate elimination of cervical cancer. Lancet Oncol. 2021;22(1):20\u20131.","journal-title":"Lancet Oncol"},{"key":"1731_CR3","doi-asserted-by":"publisher","first-page":"107327482211179","DOI":"10.1177\/10732748221117900","volume":"29","author":"K Ephrem Dibisa","year":"2022","unstructured":"Ephrem Dibisa K, et al. Precancerous lesion of the cervix and associated factors among women of West Wollega, West Ethiopia, 2022. Cancer Control. 2022;29:10732748221117900.","journal-title":"Cancer Control"},{"issue":"1","key":"1731_CR4","doi-asserted-by":"publisher","first-page":"e0191506","DOI":"10.1371\/journal.pone.0191506","volume":"13","author":"H.,","year":"2018","unstructured":"Teame, H., et al. Factors associated with cervical precancerous lesions among women screened for cervical cancer in Addis Ababa, Ethiopia: a case control study. PLoS ONE. 2018;13(1):e0191506.","journal-title":"PLoS ONE"},{"issue":"8","key":"1731_CR5","doi-asserted-by":"publisher","first-page":"965","DOI":"10.1007\/s10147-023-02337-7","volume":"28","author":"M Kusakabe","year":"2023","unstructured":"Kusakabe M, et al. Carcinogenesis and management of human papillomavirus-associated cervical cancer. Int J Clin Oncol. 2023;28(8):965\u201374.","journal-title":"Int J Clin Oncol"},{"key":"1731_CR6","doi-asserted-by":"publisher","first-page":"149","DOI":"10.11604\/pamj.2021.39.149.26467","volume":"39","author":"G Murewanhema","year":"2021","unstructured":"Murewanhema G. The COVID-19 pandemic and its implications for cervical cancer treatment and prevention in Zimbabwe: perspectives and recommendations. Pan Afr Med J. 2021;39:149.","journal-title":"Pan Afr Med J"},{"issue":"2","key":"1731_CR7","doi-asserted-by":"publisher","first-page":"396","DOI":"10.1002\/ijc.33320","volume":"148","author":"J Bonde","year":"2021","unstructured":"Bonde J, et al. Methylation markers FAM19A4 and miR124-2 as triage strategy for primary human papillomavirus screen positive women: a large European multicenter study. Int J Cancer. 2021;148(2):396\u2013405.","journal-title":"Int J Cancer"},{"issue":"1","key":"1731_CR8","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1186\/s12905-024-03186-w","volume":"24","author":"J Song","year":"2024","unstructured":"Song J, et al. The levels of women\u2019s awareness, experience, acceptability and preference for Vaginal Human Papillomavirus (HPV) self-sampling in three provinces of China: a cross-sectional study. BMC Womens Health. 2024;24(1):343.","journal-title":"BMC Womens Health"},{"issue":"4","key":"1731_CR9","doi-asserted-by":"publisher","first-page":"2835","DOI":"10.3390\/curroncol29040231","volume":"29","author":"AS Gheorghe","year":"2022","unstructured":"Gheorghe AS, et al. New targeted therapies and combinations of treatments for cervical, endometrial, and ovarian cancers: a year in review. Curr Oncol. 2022;29(4):2835\u201347.","journal-title":"Curr Oncol"},{"issue":"37","key":"1731_CR10","doi-asserted-by":"publisher","first-page":"62274","DOI":"10.18632\/oncotarget.19459","volume":"8","author":"Y Tian","year":"2017","unstructured":"Tian Y, et al. Utility of gene methylation analysis, cytological examination, and HPV-16\/18 genotyping in triage of high-risk human papilloma virus-positive women. Oncotarget. 2017;8(37):62274\u201385.","journal-title":"Oncotarget"},{"issue":"2","key":"1731_CR11","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1097\/LGT.0000000000000528","volume":"24","author":"LC Cheung","year":"2020","unstructured":"Cheung LC, et al. 2019 ASCCP risk-based management consensus guidelines: methods for risk estimation, recommended management, and validation. J Low Genit Tract Dis. 2020;24(2):90\u2013101.","journal-title":"J Low Genit Tract Dis"},{"issue":"3","key":"1731_CR12","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1097\/LGT.0000000000000480","volume":"23","author":"CK Stockdale","year":"2019","unstructured":"Stockdale CK. ASCCP president 2019\u20132020 vision. J Low Genit Tract Dis. 2019;23(3):187.","journal-title":"J Low Genit Tract Dis"},{"issue":"2","key":"1731_CR13","doi-asserted-by":"publisher","first-page":"630","DOI":"10.1093\/jnci\/dju423","volume":"107","author":"C Bergeron","year":"2015","unstructured":"Bergeron C, et al. Informed cytology for triaging HPV-positive women: substudy nested in the NTCC randomized controlled trial. J Natl Cancer Inst. 2015;107(2):630.","journal-title":"J Natl Cancer Inst"},{"issue":"12","key":"1731_CR14","doi-asserted-by":"publisher","first-page":"2922","DOI":"10.1002\/ijc.30030","volume":"138","author":"R Bhatia","year":"2016","unstructured":"Bhatia R, et al. Use of HPV testing for cervical screening in vaccinated women\u2013Insights from the SHEVa (Scottish HPV Prevalence in Vaccinated Women) study. Int J Cancer. 2016;138(12):2922\u201331.","journal-title":"Int J Cancer"},{"issue":"9","key":"1731_CR15","doi-asserted-by":"publisher","first-page":"923","DOI":"10.1093\/jnci\/djy225","volume":"111","author":"L Hu","year":"2019","unstructured":"Hu L, et al. An observational study of deep learning and automated evaluation of cervical images for cancer screening. J Natl Cancer Inst. 2019;111(9):923\u201332.","journal-title":"J Natl Cancer Inst"},{"issue":"2","key":"1731_CR16","doi-asserted-by":"publisher","first-page":"429","DOI":"10.1016\/j.ygyno.2021.02.011","volume":"161","author":"CL Chang","year":"2021","unstructured":"Chang CL, et al. DNA methylation marker for the triage of hrHPV positive women in cervical cancer screening: real-world evidence in Taiwan. Gynecol Oncol. 2021;161(2):429\u201335.","journal-title":"Gynecol Oncol"},{"issue":"1","key":"1731_CR17","doi-asserted-by":"publisher","first-page":"1182","DOI":"10.1186\/s12885-018-4877-5","volume":"18","author":"Q Bu","year":"2018","unstructured":"Bu Q, et al. The clinical significance of FAM19A4 methylation in high-risk HPV-positive cervical samples for the detection of cervical (pre)cancer in Chinese women. BMC Cancer. 2018;18(1):1182.","journal-title":"BMC Cancer"},{"issue":"2","key":"1731_CR18","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1016\/j.ygyno.2018.09.006","volume":"151","author":"A Leeman","year":"2018","unstructured":"Leeman A, et al. Defining hrHPV genotypes in cervical intraepithelial neoplasia by laser capture microdissection supports reflex triage of self-samples using HPV16\/18 and FAM19A4\/miR124-2 methylation. Gynecol Oncol. 2018;151(2):311\u20138.","journal-title":"Gynecol Oncol"},{"issue":"1","key":"1731_CR19","doi-asserted-by":"publisher","first-page":"125 e1","DOI":"10.1016\/j.cmi.2020.03.018","volume":"27","author":"FJ Vink","year":"2021","unstructured":"Vink FJ, et al. FAM19A4\/miR124\u20132 methylation analysis as a triage test for HPV-positive women: cross-sectional and longitudinal data from a Dutch screening cohort. Clin Microbiol Infect. 2021;27(1):125 e1-125 e6.","journal-title":"Clin Microbiol Infect"},{"issue":"1","key":"1731_CR20","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1186\/s13148-019-0743-9","volume":"11","author":"R Hern\u00e1ndez-L\u00f3pez","year":"2019","unstructured":"Hern\u00e1ndez-L\u00f3pez R, et al. Methylation estimates the risk of precancer in HPV-infected women with discrepant results between cytology and HPV16\/18 genotyping. Clin Epigenetics. 2019;11(1):140.","journal-title":"Clin Epigenetics"},{"issue":"11","key":"1731_CR21","doi-asserted-by":"publisher","first-page":"2745","DOI":"10.1002\/ijc.30008","volume":"138","author":"AT Lorincz","year":"2016","unstructured":"Lorincz AT, et al. Validation of a DNA methylation HPV triage classifier in a screening sample. Int J Cancer. 2016;138(11):2745\u201351.","journal-title":"Int J Cancer"},{"issue":"6","key":"1731_CR22","doi-asserted-by":"publisher","first-page":"1095","DOI":"10.1038\/bjc.2014.392","volume":"111","author":"A Boers","year":"2014","unstructured":"Boers A, et al. DNA methylation analysis in self-sampled brush material as a triage test in hrHPV-positive women. Br J Cancer. 2014;111(6):1095\u2013101.","journal-title":"Br J Cancer"},{"issue":"4","key":"1731_CR23","doi-asserted-by":"publisher","first-page":"746","DOI":"10.1002\/ijc.31897","volume":"144","author":"RW van Leeuwen","year":"2019","unstructured":"van Leeuwen RW, et al. DNA methylation markers as a triage test for identification of cervical lesions in a high risk human papillomavirus positive screening cohort. Int J Cancer. 2019;144(4):746\u201354.","journal-title":"Int J Cancer"},{"key":"1731_CR24","unstructured":"Sivakamasundari, V., et al. A developmental transcriptomic analysis of Pax1 and Pax9 in embryonic intervertebral disc development."},{"key":"1731_CR25","unstructured":"Kan, Y.-Y., et al. PAX1 methylation as a potential biomarker for cervical cancer screening."},{"key":"1731_CR26","unstructured":"Cheng, S.-J., et al. Hypermethylated ZNF582 and PAX1 genes in oral scrapings collected from cancer-adjacent normal oral mucosal sites are associated with aggressive progression and poor prognosis of oral cancer."},{"issue":"6","key":"1731_CR27","doi-asserted-by":"publisher","first-page":"5675","DOI":"10.1007\/s13277-014-1751-1","volume":"35","author":"S Hao","year":"2014","unstructured":"Hao S, et al. JAM-C promotes lymphangiogenesis and nodal metastasis in non-small cell lung cancer. Tumour Biol. 2014;35(6):5675\u201387.","journal-title":"Tumour Biol"},{"issue":"25","key":"1731_CR28","doi-asserted-by":"publisher","first-page":"19139","DOI":"10.1074\/jbc.M003189200","volume":"275","author":"D Palmeri","year":"2000","unstructured":"Palmeri D, et al. Vascular endothelial junction-associated molecule, a novel member of the immunoglobulin superfamily, is localized to intercellular boundaries of endothelial cells. J Biol Chem. 2000;275(25):19139\u201345.","journal-title":"J Biol Chem"},{"issue":"2","key":"1731_CR29","doi-asserted-by":"publisher","first-page":"e14","DOI":"10.3802\/jgo.2016.27.e14","volume":"27","author":"MK Kim","year":"2016","unstructured":"Kim MK, et al. DNA methylation in human papillomavirus-infected cervical cells is elevated in high-grade squamous intraepithelial lesions and cancer. J Gynecol Oncol. 2016;27(2):e14.","journal-title":"J Gynecol Oncol"},{"issue":"7","key":"1731_CR30","doi-asserted-by":"publisher","first-page":"1768","DOI":"10.1002\/ijc.33430","volume":"148","author":"N Li","year":"2021","unstructured":"Li N, et al. DNA methylation markers as triage test for the early identification of cervical lesions in a Chinese population. Int J Cancer. 2021;148(7):1768\u201377.","journal-title":"Int J Cancer"},{"issue":"3","key":"1731_CR31","doi-asserted-by":"publisher","first-page":"131","DOI":"10.2217\/epi-2022-0396","volume":"15","author":"Y Wang","year":"2023","unstructured":"Wang Y, et al. Evaluation of PAX1\/ST6GALNAC5 methylation as a triage test for cervical intraepithelial neoplasia and cervical cancer. Epigenomics. 2023;15(3):131\u201345.","journal-title":"Epigenomics"},{"issue":"23","key":"1731_CR32","doi-asserted-by":"publisher","first-page":"2583","DOI":"10.2217\/fon-2021-1625","volume":"18","author":"Y Su","year":"2022","unstructured":"Su Y, et al. Methylated ZNF582 as a triage marker for occult cervical cancer and advanced cervical intraepithelial neoplasia. Fut Oncol. 2022;18(23):2583\u201392.","journal-title":"Fut Oncol"},{"issue":"5","key":"1731_CR33","doi-asserted-by":"publisher","first-page":"1478","DOI":"10.1128\/JCM.03386-12","volume":"51","author":"A Rao","year":"2013","unstructured":"Rao A, et al. Development and characterization of the cobas human papillomavirus test. J Clin Microbiol. 2013;51(5):1478\u201384.","journal-title":"J Clin Microbiol"},{"issue":"5","key":"1731_CR34","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1002\/cncy.21521","volume":"123","author":"R Nayar","year":"2015","unstructured":"Nayar R, Wilbur DC. The Pap test and Bethesda 2014. Cancer Cytopathol. 2015;123(5):271\u201381.","journal-title":"Cancer Cytopathol"},{"issue":"5","key":"1731_CR35","doi-asserted-by":"publisher","first-page":"321","DOI":"10.3322\/caac.21628","volume":"70","author":"ETH Fontham","year":"2020","unstructured":"Fontham ETH, et al. Cervical cancer screening for individuals at average risk: 2020 guideline update from the American Cancer Society. CA Cancer J Clin. 2020;70(5):321\u201346.","journal-title":"CA Cancer J Clin"},{"issue":"6","key":"1731_CR36","doi-asserted-by":"publisher","first-page":"547","DOI":"10.1001\/jama.2023.13174","volume":"330","author":"RB Perkins","year":"2023","unstructured":"Perkins RB, et al. Cervical cancer screening: a review. JAMA. 2023;330(6):547\u201358.","journal-title":"JAMA"},{"key":"1731_CR37","unstructured":"Chan, P.K.S., et al. Meta-Analysis on Prevalence and Attribution of Human Papillomavirus Types 52 and 58 in Cervical Neoplasia Worldwide."},{"issue":"11","key":"1731_CR38","doi-asserted-by":"publisher","first-page":"6355","DOI":"10.1002\/jmv.27185","volume":"93","author":"X Wang","year":"2021","unstructured":"Wang X, Wu S, Li Y. Risks for cervical abnormalities in women with non-16\/18 high-risk human papillomavirus infections in south Shanghai. China J Med Virol. 2021;93(11):6355\u201361.","journal-title":"China J Med Virol"},{"issue":"28","key":"1731_CR39","doi-asserted-by":"publisher","first-page":"1917","DOI":"10.2217\/fon-2023-0226","volume":"19","author":"L Yang","year":"2023","unstructured":"Yang L, et al. Utilization of PAX1 methylation test for cervical cancer screening of non-HPV16\/18 high-risk HPV infection in women. Fut Oncol. 2023;19(28):1917\u201327.","journal-title":"Fut Oncol"},{"issue":"1","key":"1731_CR40","doi-asserted-by":"publisher","first-page":"125.e1","DOI":"10.1016\/j.cmi.2020.03.018","volume":"27","author":"FJ Vink","year":"2021","unstructured":"Vink FJ, et al. FAM19A4\/miR124-2 methylation analysis as a triage test for HPV-positive women: cross-sectional and longitudinal data from a Dutch screening cohort. Clin Microbiol Infect. 2021;27(1):125.e1-125.e6.","journal-title":"Clin Microbiol Infect"},{"issue":"8","key":"1731_CR41","doi-asserted-by":"publisher","first-page":"2720","DOI":"10.1111\/jog.14869","volume":"47","author":"B Li","year":"2021","unstructured":"Li B, et al. The application of PAX1 methylation detection and HPV E6\/E7 mRNA detection in cervical cancer screening. J Obstet Gynaecol Res. 2021;47(8):2720\u20138.","journal-title":"J Obstet Gynaecol Res"},{"issue":"9","key":"1731_CR42","doi-asserted-by":"publisher","first-page":"1933","DOI":"10.1158\/1055-9965.EPI-14-0347","volume":"23","author":"LM De Strooper","year":"2014","unstructured":"De Strooper LM, et al. Combined CADM1\/MAL methylation and cytology testing for colposcopy triage of high-risk HPV-positive women. Cancer Epidemiol Biomarkers Prev. 2014;23(9):1933\u20137.","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"issue":"3","key":"1731_CR43","doi-asserted-by":"publisher","first-page":"504","DOI":"10.1111\/1471-0528.16395","volume":"128","author":"WW Kremer","year":"2021","unstructured":"Kremer WW, et al. The use of host cell DNA methylation analysis in the detection and management of women with advanced cervical intraepithelial neoplasia: a review. Bjog. 2021;128(3):504\u201314.","journal-title":"Bjog"},{"key":"1731_CR44","doi-asserted-by":"publisher","first-page":"246","DOI":"10.1016\/j.ebiom.2019.10.053","volume":"50","author":"SJ Bowden","year":"2019","unstructured":"Bowden SJ, et al. The use of human papillomavirus DNA methylation in cervical intraepithelial neoplasia: a systematic review and meta-analysis. EBioMedicine. 2019;50:246\u201359.","journal-title":"EBioMedicine"},{"issue":"2","key":"1731_CR45","doi-asserted-by":"publisher","first-page":"463","DOI":"10.1002\/ijc.29706","volume":"138","author":"R van Baars","year":"2016","unstructured":"van Baars R, et al. CADM1 and MAL methylation status in cervical scrapes is representative of the most severe underlying lesion in women with multiple cervical biopsies. Int J Cancer. 2016;138(2):463\u201371.","journal-title":"Int J Cancer"},{"issue":"9","key":"1731_CR46","doi-asserted-by":"crossref","first-page":"632","DOI":"10.3390\/ijms20092262","volume":"20","author":"M Del Pino","year":"2019","unstructured":"Del Pino M, et al. CADM1, MAL, and miR124 promoter methylation as biomarkers of transforming cervical intrapithelial lesions. Int J Mol Sci. 2019;20(9):632.","journal-title":"Int J Mol Sci"}],"container-title":["Clinical Epigenetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13148-024-01731-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s13148-024-01731-w\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13148-024-01731-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,16]],"date-time":"2024-08-16T09:04:26Z","timestamp":1723799066000},"score":1,"resource":{"primary":{"URL":"https:\/\/clinicalepigeneticsjournal.biomedcentral.com\/articles\/10.1186\/s13148-024-01731-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8,16]]},"references-count":46,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["1731"],"URL":"https:\/\/doi.org\/10.1186\/s13148-024-01731-w","relation":{},"ISSN":["1868-7083"],"issn-type":[{"value":"1868-7083","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,8,16]]},"assertion":[{"value":"27 February 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 August 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 August 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The Institutional Review Board of Peking Union Medical College Hospital approved this study (No. JS-2380 and K-S2021211 for METHY3 and METHY4, respectively). The registration numbers are NCT04646954 and NCT05290428 (<i>clinicaltrials.gov<\/i>, registered on November 26, 2020, and March 12, 2022). Informed consent was obtained from the subjects prior to their participation in the study.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"The paper is not under consideration by another journal, and the results presented in this work have not been previously presented or published.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Statement of submission"}},{"value":"Consent for publication has been obtained from all patients.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"108"}}