{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T21:26:03Z","timestamp":1761168363789,"version":"build-2065373602"},"reference-count":55,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T00:00:00Z","timestamp":1761004800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T00:00:00Z","timestamp":1761004800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Clin Epigenet"],"DOI":"10.1186\/s13148-025-01982-1","type":"journal-article","created":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T11:23:33Z","timestamp":1761045813000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["DNA methylation profiles and cancer in children conceived after assisted reproductive technology"],"prefix":"10.1186","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8636-7361","authenticated-orcid":false,"given":"Bastien","family":"Ducreux","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8269-7515","authenticated-orcid":false,"given":"Julie","family":"Firmin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4822-9176","authenticated-orcid":false,"given":"Lucile","family":"Ferreux","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4885-8885","authenticated-orcid":false,"given":"Catherine","family":"Patrat","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3616-7676","authenticated-orcid":false,"given":"Jacqueline","family":"Clavel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2582-6402","authenticated-orcid":false,"given":"Akram","family":"Ghantous","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4109-3154","authenticated-orcid":false,"given":"Zdenko","family":"Herceg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9088-0720","authenticated-orcid":false,"given":"Mary","family":"Callanan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9708-1710","authenticated-orcid":false,"given":"Patricia","family":"Fauque","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,10,21]]},"reference":[{"key":"1982_CR1","doi-asserted-by":"crossref","unstructured":"Zhang S, Luo Q, Meng R, Yan J, Wu Y, Huang H. Long-term health risk of offspring born from assisted reproductive technologies. J Assist Reprod Genet. Springer; 2024. p. 527\u201350.","DOI":"10.1007\/s10815-023-02988-5"},{"key":"1982_CR2","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1093\/humrep\/deaa272","volume":"36","author":"B Luke","year":"2021","unstructured":"Luke B, Brown MB, Wantman E, Forestieri NE, Browne ML, Fisher SC, et al. The risk of birth defects with conception by ART. Hum Reprod. 2021;36:116\u201329.","journal-title":"Hum Reprod"},{"key":"1982_CR3","doi-asserted-by":"publisher","first-page":"E249429","DOI":"10.1001\/jamanetworkopen.2024.9429","volume":"7","author":"P Rios","year":"2024","unstructured":"Rios P, Herlemont P, Fauque P, Lacour B, Jouannet P, Weill A, et al. Medically assisted reproduction and risk of cancer among offspring. JAMA Netw Open. 2024;7:E249429.","journal-title":"JAMA Netw Open"},{"key":"1982_CR4","doi-asserted-by":"crossref","unstructured":"Marshall GM, Carter DR, Cheung BB, Liu T, Mateos MK, Meyerowitz JG, et al. The prenatal origins of cancer. Nat Rev Cancer. Nature Publishing Group; 2014. p. 277\u201389.","DOI":"10.1038\/nrc3679"},{"key":"1982_CR5","doi-asserted-by":"publisher","DOI":"10.1186\/gb-2013-14-9-r105","author":"J Nordlund","year":"2013","unstructured":"Nordlund J, B\u00e4cklin CL, Wahlberg P, Busche S, Berglund EC, Eloranta ML, et al. Genome-wide signatures of differential DNA methylation in pediatric acute lymphoblastic leukemia. Genome Biol. 2013. https:\/\/doi.org\/10.1186\/gb-2013-14-9-r105.","journal-title":"Genome Biol"},{"key":"1982_CR6","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-33677-z","author":"EM Nickels","year":"2022","unstructured":"Nickels EM, Li S, Myint SS, Arroyo K, Feng Q, Siegmund KD, et al. DNA methylation at birth in monozygotic twins discordant for pediatric acute lymphoblastic leukemia. Nat Commun. 2022. https:\/\/doi.org\/10.1038\/s41467-022-33677-z.","journal-title":"Nat Commun"},{"key":"1982_CR7","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmac010","author":"J Barberet","year":"2022","unstructured":"Barberet J, Ducreux B, Guilleman M, Simon E, Bruno C, Fauque P. DNA methylation profiles after ART during human lifespan: a systematic review and meta-analysis. Hum Reprod Update. 2022. https:\/\/doi.org\/10.1093\/humupd\/dmac010.","journal-title":"Hum Reprod Update"},{"key":"1982_CR8","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pcbi.1003118","author":"M Lawrence","year":"2013","unstructured":"Lawrence M, Huber W, Pag\u00e8s H, Aboyoun P, Carlson M, Gentleman R, et al. Software for computing and annotating genomic ranges. PLoS Comput Biol. 2013. https:\/\/doi.org\/10.1371\/journal.pcbi.1003118.","journal-title":"PLoS Comput Biol"},{"key":"1982_CR9","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1200\/PO.17.00011","volume":"1","author":"D Chakravarty","year":"2017","unstructured":"Chakravarty D, Gao J, Phillips S, Kundra R, Zhang H, Wang J, et al. OncoKB: a precision oncology knowledge base. JCO Precis Oncol. 2017;1:1\u201316.","journal-title":"JCO Precis Oncol"},{"key":"1982_CR10","doi-asserted-by":"crossref","unstructured":"Sondka Z, Bamford S, Cole CG, Ward SA, Dunham I, Forbes SA. The COSMIC Cancer Gene Census: describing genetic dysfunction across all human cancers. Nat Rev Cancer. Nature Publishing Group; 2018. p. 696\u2013705.","DOI":"10.1038\/s41568-018-0060-1"},{"key":"1982_CR11","doi-asserted-by":"crossref","unstructured":"Douglas SPM, Lahtinen AK, Koski JR, Leimi L, Ker\u00e4nen MAI, Koskenvuo M, et al. Enrichment of cancer-predisposing germline variants in adult and pediatric patients with acute lymphoblastic leukemia. Sci Rep. 2022;12.","DOI":"10.1038\/s41598-022-14364-x"},{"key":"1982_CR12","doi-asserted-by":"publisher","first-page":"1376","DOI":"10.1038\/s41588-022-01159-z","volume":"54","author":"SW Brady","year":"2022","unstructured":"Brady SW, Roberts KG, Gu Z, Shi L, Pounds S, Pei D, et al. The genomic landscape of pediatric acute lymphoblastic leukemia. Nat Genet. 2022;54:1376\u201389.","journal-title":"Nat Genet"},{"key":"1982_CR13","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1038\/s41588-023-01640-3","volume":"56","author":"M Umeda","year":"2024","unstructured":"Umeda M, Ma J, Westover T, Ni Y, Song G, Maciaszek JL, et al. A new genomic framework to categorize pediatric acute myeloid leukemia. Nat Genet. 2024;56:281\u201393.","journal-title":"Nat Genet"},{"key":"1982_CR14","unstructured":"Khoury JD, Solary E, Abla O, Akkari Y, Alaggio R, Apperley JF, et al. The 5th edition of the World Health Organization Classification of Haematolymphoid Tumours: Myeloid and Histiocytic\/Dendritic\u00a0Neoplasms. Leukemia. Springer Nature; 2022. p. 1703\u201319."},{"key":"1982_CR15","unstructured":"Alaggio R, Amador C, Anagnostopoulos I, Attygalle AD, Araujo IB de O, Berti E, et al. The 5th edition of the world health organization classification of haematolymphoid tumours: lymphoid neoplasms. Leukemia. Springer Nature; 2022. p. 1720\u201348."},{"key":"1982_CR16","doi-asserted-by":"publisher","first-page":"3099","DOI":"10.1172\/JCI66203","volume":"123","author":"ME Figueroa","year":"2013","unstructured":"Figueroa ME, Chen SC, Andersson AK, Phillips LA, Li Y, Sotzen J, et al. Integrated genetic and epigenetic analysis of childhood acute lymphoblastic leukemia. J Clin Invest. 2013;123:3099\u2013111.","journal-title":"J Clin Invest"},{"key":"1982_CR17","doi-asserted-by":"publisher","DOI":"10.1186\/s13148-024-01662-6","author":"A Mosquera Orgueira","year":"2024","unstructured":"Mosquera Orgueira A, Krali O, P\u00e9rez M\u00edguez C, Peleteiro Ra\u00edndo A, D\u00edaz Arias J\u00c1, Gonz\u00e1lez P\u00e9rez MS, et al. Refining risk prediction in pediatric acute lymphoblastic leukemia through DNA methylation profiling. Clin Epigenetics. 2024. https:\/\/doi.org\/10.1186\/s13148-024-01662-6.","journal-title":"Clin Epigenetics"},{"key":"1982_CR18","doi-asserted-by":"publisher","first-page":"3741","DOI":"10.1093\/hmg\/ddac137","volume":"31","author":"K Xu","year":"2022","unstructured":"Xu K, Li S, Pandey P, Kang AY, Morimoto LM, Mancuso N, et al. Investigating DNA methylation as a mediator of genetic risk in childhood acute lymphoblastic leukemia. Hum Mol Genet. 2022;31:3741\u201356.","journal-title":"Hum Mol Genet"},{"key":"1982_CR19","doi-asserted-by":"crossref","unstructured":"Ghantous A, Nussl\u00e9 SG, Nassar FJ, Spitz N, Novoloaca A, Krali O, et al. Epigenome-wide analysis across the development span of pediatric acute lymphoblastic leukemia: backtracking to birth. Mol Cancer. BioMed Central Ltd; 2024.","DOI":"10.1186\/s12943-024-02118-4"},{"key":"1982_CR20","doi-asserted-by":"crossref","unstructured":"Novakovic B, Lewis S, Halliday J, Kennedy J, Burgner DP, Czajko A, et al. Assisted reproductive technologies are associated with limited epigenetic variation at birth that largely resolves by adulthood. Nat Commun [Internet]. 2019;10. Available from: https:\/\/embase.com\/search\/results?subaction=viewrecord&id=L2002709329&from=export","DOI":"10.1038\/s41467-019-11929-9"},{"key":"1982_CR21","doi-asserted-by":"publisher","first-page":"e7","DOI":"10.1016\/j.fertnstert.2019.07.154","volume":"112","author":"E Yeung","year":"2019","unstructured":"Yeung E, Mendola P, Sundaram R, Zeng X, Guan W, Tsai MY, et al. Conception by infertility treatment and newborn DNA methylation. Fertil Steril. 2019;112:e7.","journal-title":"Fertil Steril"},{"key":"1982_CR22","doi-asserted-by":"crossref","unstructured":"Chen W, Peng Y, Ma X, Kong S, Tan S, Wei Y, et al. Integrated multi-omics reveal epigenomic disturbance of assisted reproductive technologies in human offspring. EBioMedicine [Internet]. 2020;61. Available from: https:\/\/embase.com\/search\/results?subaction=viewrecord&id=L2008366009&from=export","DOI":"10.1016\/j.ebiom.2020.103076"},{"key":"1982_CR23","doi-asserted-by":"publisher","first-page":"3769","DOI":"10.1093\/hmg\/ddp319","volume":"18","author":"S Katari","year":"2009","unstructured":"Katari S, Turan N, Bibikova M, Erinle O, Chalian R, Foster M, et al. DNA methylation and gene expression differences in children conceived in vitro or in vivo. Hum Mol Genet. 2009;18:3769\u201378.","journal-title":"Hum Mol Genet"},{"key":"1982_CR24","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1095\/biolreprod.113.108456","volume":"89","author":"C Camprub\u00ed","year":"2013","unstructured":"Camprub\u00ed C, Iglesias-Platas I, Martin-Trujillo A, Salvador-Alarcon C, et al. Stability of genomic imprinting and gestational-age dynamic methylation in complicated pregnancies conceived following assisted reproductive technologies. Biol Reprod. 2013;89:50.","journal-title":"Biol Reprod"},{"key":"1982_CR25","doi-asserted-by":"publisher","first-page":"474","DOI":"10.4161\/15592294.2014.988041","volume":"10","author":"N Melamed","year":"2015","unstructured":"Melamed N, Choufani S, Wilkins-Haug LE, Koren G, Weksberg R. Comparison of genome-wide and gene-specific DNA methylation between ART and naturally conceived pregnancies. Epigenetics. 2015;10:474\u201383.","journal-title":"Epigenetics"},{"key":"1982_CR26","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1186\/s13073-017-0413-5","volume":"9","author":"JE Castillo-Fernandez","year":"2017","unstructured":"Castillo-Fernandez JE, Loke YJ, Bass-Stringer S, Gao F, Xia Y, Wu H, et al. DNA methylation changes at infertility genes in newborn twins conceived by in vitro fertilisation. Genome Med. 2017;9:28.","journal-title":"Genome Med"},{"key":"1982_CR27","doi-asserted-by":"publisher","first-page":"1761","DOI":"10.1093\/humrep\/dex209","volume":"32","author":"N El Hajj","year":"2017","unstructured":"El Hajj N, Haertle L, Dittrich M, Denk S, Lehnen H, Hahn T, et al. DNA methylation signatures in cord blood of ICSI children. Hum Reprod. 2017;32:1761\u20139.","journal-title":"Hum Reprod"},{"key":"1982_CR28","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1186\/s13148-018-0510-3","volume":"10","author":"D Gentilini","year":"2018","unstructured":"Gentilini D, Somigliana E, Pagliardini L, Rabellotti E, Garagnani P, Bernardinelli L, et al. Multifactorial analysis of the stochastic epigenetic variability in cord blood confirmed an impact of common behavioral and environmental factors but not of in vitro conception. Clin Epigenet. 2018;10:77.","journal-title":"Clin Epigenet"},{"key":"1982_CR29","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/deab137","author":"D Caramaschi","year":"2021","unstructured":"Caramaschi D, Jungius J, Page CM, Novakovic B, Saffery R, Halliday J, et al. Association of medically assisted reproduction with offspring cord blood DNA methylation across cohorts. Hum Reprod. 2021. https:\/\/doi.org\/10.1093\/humrep\/deab137.","journal-title":"Hum Reprod"},{"key":"1982_CR30","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-29540-w","author":"SE H\u00e5berg","year":"2022","unstructured":"H\u00e5berg SE, Page CM, Lee Y, Nustad HE, Magnus MC, Haftorn KL, et al. DNA methylation in newborns conceived by assisted reproductive technology. Nat Commun. 2022. https:\/\/doi.org\/10.1038\/s41467-022-29540-w.","journal-title":"Nat Commun"},{"key":"1982_CR31","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1186\/s40246-023-00484-6","volume":"17","author":"J Romanowska","year":"2023","unstructured":"Romanowska J, Nustad HE, Page CM, Denault WRP, Lee Y, Magnus MC, et al. The X-factor in ART: does the use of assisted reproductive technologies influence DNA methylation on the X chromosome? Hum Genom. 2023;17:35. https:\/\/doi.org\/10.1186\/s40246-023-00484-6.","journal-title":"Hum Genom"},{"key":"1982_CR32","first-page":"248","volume":"36","author":"EW Tobi","year":"2021","unstructured":"Tobi EW, Almqvist C, Hedman A, Andolf E, Holte J, Olofsson JI, et al. DNA methylation differences at birth after conception through ART. Hum Reprod. 2021;36:248\u201359.","journal-title":"Hum Reprod"},{"key":"1982_CR33","doi-asserted-by":"publisher","first-page":"629","DOI":"10.1016\/j.fertnstert.2016.05.006","volume":"106","author":"MS Estill","year":"2016","unstructured":"Estill MS, Bolnick JM, Waterland RA, Bolnick AD, Diamond MP, Krawetz SA. Assisted reproductive technology alters deoxyribonucleic acid methylation profiles in bloodspots of newborn infants. Fertil Steril. 2016;106:629-639.e10.","journal-title":"Fertil Steril"},{"key":"1982_CR34","doi-asserted-by":"publisher","first-page":"2035","DOI":"10.1093\/humrep\/deab078","volume":"36","author":"B Penova-Veselinovic","year":"2021","unstructured":"Penova-Veselinovic B, Melton PE, Huang RC, Yovich JL, Burton P, Wijs LA, et al. DNA methylation patterns within whole blood of adolescents born from assisted reproductive technology are not different from adolescents born from natural conception. Hum Reprod. 2021;36:2035\u201349.","journal-title":"Hum Reprod"},{"key":"1982_CR35","doi-asserted-by":"publisher","DOI":"10.3390\/genes12121912","author":"B Ducreux","year":"2021","unstructured":"Ducreux B, Frappier J, Bruno C, Doukani A, Guilleman M, Simon E, et al. Genome-wide analysis of DNA methylation in buccal cells of children conceived through IVF and ICSI. Genes. 2021. https:\/\/doi.org\/10.3390\/genes12121912.","journal-title":"Genes"},{"key":"1982_CR36","doi-asserted-by":"publisher","first-page":"479","DOI":"10.1093\/humrep\/deaa310","volume":"36","author":"J Barberet","year":"2021","unstructured":"Barberet J, Binquet C, Guilleman M, Doukani A, Choux C, Bruno C, et al. Do assisted reproductive technologies and in vitro embryo culture influence the epigenetic control of imprinted genes and transposable elements in children? Hum Reprod. 2021;36:479\u201392.","journal-title":"Hum Reprod"},{"key":"1982_CR37","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s13073-017-0413-5","volume":"9","author":"JE Castillo-Fernandez","year":"2017","unstructured":"Castillo-Fernandez JE, Loke YJ, Bass-Stringer S, Gao F, Xia Y, Wu H, et al. DNA methylation changes at infertility genes in newborn twins conceived by in vitro fertilisation. Genome Med. 2017;9:1\u201315.","journal-title":"Genome Med"},{"key":"1982_CR38","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1016\/j.celrep.2014.12.009","volume":"10","author":"L Brisson","year":"2015","unstructured":"Brisson L, Pouyet L, N\u2019guessan P, Garcia S, Lopes N, Warcollier G, et al. The thymus-specific serine protease TSSP\/PRSS16 is crucial for the antitumoral role of CD4+ T cells. Cell Rep. 2015;10:39\u201346.","journal-title":"Cell Rep"},{"key":"1982_CR39","doi-asserted-by":"crossref","unstructured":"Osterburg C, D\u00f6tsch V. Structural diversity of p63 and p73 isoforms. Cell Death Differ. Springer Nature; 2022. p. 921\u201337.","DOI":"10.1038\/s41418-022-00975-4"},{"key":"1982_CR40","doi-asserted-by":"crossref","unstructured":"Liu M, Taketani T, Li R, Takita J, Taki T, Yang H, et al. Loss of p73 gene expression in lymphoid leukemia cell lines is associated with hypermethylation [Internet]. Leuk Res. 2000. Available from: www.elsevier.com\/locate\/leukres","DOI":"10.1016\/S0145-2126(00)00148-X"},{"key":"1982_CR41","doi-asserted-by":"crossref","unstructured":"Nishiyama A, Nakanishi M. Navigating the DNA methylation landscape of cancer. Trends in Genetics. Elsevier Ltd; 2021. p. 1012\u201327.","DOI":"10.1016\/j.tig.2021.05.002"},{"key":"1982_CR42","doi-asserted-by":"publisher","first-page":"471","DOI":"10.1093\/molehr\/gap038","volume":"15","author":"MV Gomes","year":"2009","unstructured":"Gomes MV, Huber J, Ferriani RA, Amaral Neto AM, Ramos ES. Abnormal methylation at the KvDMR1 imprinting control region in clinically normal children conceived by assisted reproductive technologies. Mol Hum Reprod. 2009;15:471\u20137.","journal-title":"Mol Hum Reprod"},{"key":"1982_CR43","doi-asserted-by":"crossref","unstructured":"Stampone E, Caldarelli I, Zullo A, Bencivenga D, Mancini FP, Della Ragione F, et al. Genetic and epigenetic control of CDKN1C expression: Importance in cell commitment and differentiation, tissue homeostasis and human diseases. Int J Mol Sci. MDPI AG; 2018.","DOI":"10.3390\/ijms19041055"},{"key":"1982_CR44","doi-asserted-by":"publisher","first-page":"668","DOI":"10.1016\/j.rbmo.2016.09.006","volume":"33","author":"YJR Menezo","year":"2016","unstructured":"Menezo YJR, Silvestris E, Dale B, Elder K. Oxidative stress and alterations in DNA methylation: two sides of the same coin in reproduction. Reprod Biomed. 2016;33:668\u201383.","journal-title":"Reprod Biomed"},{"key":"1982_CR45","doi-asserted-by":"crossref","unstructured":"Scutiero G, Iannone P, Bernardi G, Bonaccorsi G, Spadaro S, Volta CA, et al. Oxidative stress and endometriosis: a systematic review of the literature. Oxid Med Cell Longev. Hindawi Limited; 2017.","DOI":"10.1155\/2017\/7265238"},{"key":"1982_CR46","doi-asserted-by":"publisher","DOI":"10.1186\/s13072-018-0224-y","author":"S Wyck","year":"2018","unstructured":"Wyck S, Herrera C, Requena CE, Bittner L, Hajkova P, Bollwein H, et al. Oxidative stress in sperm affects the epigenetic reprogramming in early embryonic development. Epigenetics Chromatin. 2018. https:\/\/doi.org\/10.1186\/s13072-018-0224-y.","journal-title":"Epigenetics Chromatin"},{"key":"1982_CR47","doi-asserted-by":"crossref","unstructured":"Greaves M. In utero origins of childhood leukaemia. Early Hum Dev. Elsevier Ireland Ltd; 2005. p. 123\u20139.","DOI":"10.1016\/j.earlhumdev.2004.10.004"},{"key":"1982_CR48","doi-asserted-by":"crossref","unstructured":"Marcotte EL, Spector LG, Mendes-de-Almeida DP, Nelson HH. The prenatal origin of childhood leukemia: potential applications for epidemiology and newborn screening. Front Pediatr. Frontiers Media S.A.; 2021.","DOI":"10.3389\/fped.2021.639479"},{"key":"1982_CR49","doi-asserted-by":"crossref","unstructured":"Cofre J, Abdelhay E. Cancer is to embryology as mutation is to genetics: hypothesis of the cancer as embryological phenomenon. Sci World J. Hindawi Limited; 2017.","DOI":"10.1155\/2017\/3578090"},{"key":"1982_CR50","doi-asserted-by":"crossref","unstructured":"Kaitsuka T, Hakim F. Response of pluripotent stem cells to environmental stress and its application for directed differentiation. Biology (Basel). MDPI AG; 2021. p. 1\u201316.","DOI":"10.3390\/biology10020084"},{"key":"1982_CR51","doi-asserted-by":"crossref","unstructured":"Timms JA, Relton CL, Rankin J, Strathdee G, McKay JA. DNA methylation as a potential mediator of environmental risks in the development of childhood acute lymphoblastic leukemia. Epigenomics. Future Medicine Ltd.; 2016. p. 519\u201336.","DOI":"10.2217\/epi-2015-0011"},{"key":"1982_CR52","doi-asserted-by":"publisher","first-page":"2933","DOI":"10.1002\/ijc.32203","volume":"145","author":"JA Timms","year":"2019","unstructured":"Timms JA, Relton CL, Sharp GC, Rankin J, Strathdee G, McKay JA. Exploring a potential mechanistic role of DNA methylation in the relationship between in utero and post-natal environmental exposures and risk of childhood acute lymphoblastic leukaemia. Int J Cancer. 2019;145:2933\u201343.","journal-title":"Int J Cancer"},{"key":"1982_CR53","doi-asserted-by":"crossref","unstructured":"Canovas S, Ross PJ, Kelsey G, Coy P. DNA Methylation in Embryo Development: Epigenetic Impact of ART (Assisted Reproductive Technologies). BioEssays [Internet]. 2017;39. Available from: https:\/\/www.embase.com\/search\/results?subaction=viewrecord&id=L618512918&from=export","DOI":"10.1002\/bies.201700106"},{"key":"1982_CR54","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1017\/S2040174415000161","volume":"6","author":"YJ Loke","year":"2015","unstructured":"Loke YJ, Galati JC, Saffery R, Craig JM. Association of in vitro fertilization with global and IGF2\/H19 methylation variation in newborn twins. J Dev Orig Health Dis. 2015;6:115\u201324.","journal-title":"J Dev Orig Health Dis"},{"key":"1982_CR55","doi-asserted-by":"crossref","unstructured":"Scarpato R, Testi S, Colosimo V, Garcia Crespo C, Micheli C, Azzar\u00e0 A, et al. Role of oxidative stress, genome damage and DNA methylation as determinants of pathological conditions in the newborn: an overview from conception to early neonatal stage. Mutat Res Rev Mutat Res. Elsevier B.V.; 2020.","DOI":"10.1016\/j.mrrev.2019.108295"}],"container-title":["Clinical Epigenetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13148-025-01982-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s13148-025-01982-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13148-025-01982-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T00:04:01Z","timestamp":1761091441000},"score":1,"resource":{"primary":{"URL":"https:\/\/clinicalepigeneticsjournal.biomedcentral.com\/articles\/10.1186\/s13148-025-01982-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,21]]},"references-count":55,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["1982"],"URL":"https:\/\/doi.org\/10.1186\/s13148-025-01982-1","relation":{},"ISSN":["1868-7083"],"issn-type":[{"type":"electronic","value":"1868-7083"}],"subject":[],"published":{"date-parts":[[2025,10,21]]},"assertion":[{"value":"19 June 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 September 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 October 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"174"}}