{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T18:15:39Z","timestamp":1790273739044,"version":"4.1.0"},"reference-count":47,"publisher":"Springer Science and Business Media LLC","issue":"1","funder":[{"name":"Nutricia Research"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Alz Res Therapy"],"published-print":{"date-parts":[[2017,12]]},"DOI":"10.1186\/s13195-017-0286-2","type":"journal-article","created":{"date-parts":[[2017,7,26]],"date-time":"2017-07-26T15:53:57Z","timestamp":1501084437000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["The medical food Souvenaid affects brain phospholipid metabolism in mild Alzheimer\u2019s disease: results from a randomized controlled trial"],"prefix":"10.1186","volume":"9","author":[{"given":"Anne","family":"Rijpma","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marinette","family":"van der Graaf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marieke M.","family":"Lansbergen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olga","family":"Meulenbroek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aysun","family":"Cetinyurek-Yavuz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John W.","family":"Sijben","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arend","family":"Heerschap","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcel G. M.","family":"Olde Rikkert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2017,7,26]]},"reference":[{"key":"286_CR1","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1002\/ana.410300410","volume":"30","author":"RD Terry","year":"1991","unstructured":"Terry RD, Masliah E, Salmon DP, Butters N, DeTeresa R, Hill R, et al. Physical basis of cognitive alterations in Alzheimer\u2019s disease: synapse loss is the major correlate of cognitive impairment. Ann Neurol. 1991;30:572\u201380.","journal-title":"Ann Neurol"},{"key":"286_CR2","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1126\/science.1074069","volume":"298","author":"DJ Selkoe","year":"2002","unstructured":"Selkoe DJ. Alzheimer\u2019s disease is a synaptic failure. Science. 2002;298:789\u201391.","journal-title":"Science"},{"key":"286_CR3","doi-asserted-by":"crossref","first-page":"1671","DOI":"10.1073\/pnas.89.5.1671","volume":"89","author":"RM Nitsch","year":"1992","unstructured":"Nitsch RM, Blusztajn JK, Pittas AG, Slack BE, Growdon JH, Wurtman RJ. Evidence for a membrane defect in Alzheimer disease brain. Proc Natl Acad Sci U S A. 1992;89:1671\u20135.","journal-title":"Proc Natl Acad Sci U S A"},{"key":"286_CR4","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1023\/A:1011603916962","volume":"26","author":"JW Pettegrew","year":"2001","unstructured":"Pettegrew JW, Panchalingam K, Hamilton RL, McClure RJ. Brain membrane phospholipid alterations in Alzheimer\u2019s disease. Neurochem Res. 2001;26:771\u201382.","journal-title":"Neurochem Res"},{"key":"286_CR5","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/0163-7827(85)90011-6","volume":"24","author":"PS Sastry","year":"1985","unstructured":"Sastry PS. Lipids of nervous tissue: composition and metabolism. Prog Lipid Res. 1985;24:69\u2013176.","journal-title":"Prog Lipid Res"},{"key":"286_CR6","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/S0021-9258(19)50785-2","volume":"222","author":"EP Kennedy","year":"1956","unstructured":"Kennedy EP, Weiss SB. The function of cytidine coenzymes in the biosynthesis of phospholipides. J Biol Chem. 1956;222:193\u2013214.","journal-title":"J Biol Chem"},{"key":"286_CR7","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1046\/j.1471-4159.1998.70020786.x","volume":"70","author":"BM Ross","year":"1998","unstructured":"Ross BM, Moszczynska A, Erlich J, Kish SJ. Phospholipid-metabolizing enzymes in Alzheimer\u2019s disease: increased lysophospholipid acyltransferase activity and decreased phospholipase A2 activity. J Neurochem. 1998;70:786\u201393.","journal-title":"J Neurochem"},{"key":"286_CR8","doi-asserted-by":"crossref","first-page":"459","DOI":"10.3233\/JAD-130998","volume":"38","author":"N Wijk van","year":"2014","unstructured":"van Wijk N, Broersen LM, de Wilde MC, Hageman RJ, Groenendijk M, Sijben JW, et al. Targeting synaptic dysfunction in Alzheimer\u2019s disease by administering a specific nutrient combination. J Alzheimers Dis. 2014;38:459\u201379.","journal-title":"J Alzheimers Dis"},{"key":"286_CR9","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1146\/annurev-nutr-080508-141059","volume":"29","author":"RJ Wurtman","year":"2009","unstructured":"Wurtman RJ, Cansev M, Sakamoto T, Ulus IH. Use of phosphatide precursors to promote synaptogenesis. Annu Rev Nutr. 2009;29:59\u201387.","journal-title":"Annu Rev Nutr"},{"issue":"1 Suppl 1","key":"286_CR10","doi-asserted-by":"crossref","first-page":"S153","DOI":"10.1016\/j.jalz.2007.10.005","volume":"4","author":"M Cansev","year":"2008","unstructured":"Cansev M, Wurtman RJ, Sakamoto T, Ulus IH. Oral administration of circulating precursors for membrane phosphatides can promote the synthesis of new brain synapses. Alzheimers Dement. 2008;4(1 Suppl 1):S153\u201368.","journal-title":"Alzheimers Dement"},{"key":"286_CR11","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.brainres.2007.08.089","volume":"1182","author":"T Sakamoto","year":"2007","unstructured":"Sakamoto T, Cansev M, Wurtman RJ. Oral supplementation with docosahexaenoic acid and uridine-5\u2032-monophosphate increases dendritic spine density in adult gerbil hippocampus. Brain Res. 2007;1182:50\u20139.","journal-title":"Brain Res"},{"key":"286_CR12","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.brainres.2006.03.019","volume":"1088","author":"RJ Wurtman","year":"2006","unstructured":"Wurtman RJ, Ulus IH, Cansev M, Watkins CJ, Wang L, Marzloff G. Synaptic proteins and phospholipids are increased in gerbil brain by administering uridine plus docosahexaenoic acid orally. Brain Res. 2006;1088:83\u201392.","journal-title":"Brain Res"},{"key":"286_CR13","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1016\/j.jalz.2013.05.1771","volume":"10","author":"S Lopes da Silva","year":"2014","unstructured":"Lopes da Silva S, Vellas B, Elemans S, Luchsinger J, Kamphuis P, Yaffe K, et al. Plasma nutrient status of patients with Alzheimer\u2019s disease: systematic review and meta-analysis. Alzheimers Dement. 2014;10:485\u2013502.","journal-title":"Alzheimers Dement"},{"key":"286_CR14","doi-asserted-by":"crossref","first-page":"261","DOI":"10.3233\/JAD-131892","volume":"41","author":"MG Olde Rikkert","year":"2014","unstructured":"Olde Rikkert MG, Verhey FR, Sijben JW, Bouwman FH, Dautzenberg PL, Lansink M, et al. Differences in nutritional status between very mild Alzheimer\u2019s disease patients and healthy controls. J Alzheimers Dis. 2014;41:261\u201371.","journal-title":"J Alzheimers Dis"},{"key":"286_CR15","doi-asserted-by":"publisher","unstructured":"de Wilde MC, Vellas B, Girault E, Cetinyurek-Yavuz A, Sijben JW. Lower brain and blood nutrient status in Alzheimer\u2019s disease: results from meta-analyses. Alzheimers Dement. doi: 10.1016\/j.trci.2017.06.002 .","DOI":"10.1016\/j.trci.2017.06.002"},{"key":"286_CR16","doi-asserted-by":"crossref","first-page":"e75393","DOI":"10.1371\/journal.pone.0075393","volume":"8","author":"D Jansen","year":"2013","unstructured":"Jansen D, Zerbi V, Arnoldussen IC, Wiesmann M, Rijpma A, Fang XT, et al. Effects of specific multi-nutrient enriched diets on cerebral metabolism, cognition and neuropathology in A\u03b2PPswe-PS1dE9 mice. PLoS One. 2013;8:e75393.","journal-title":"PLoS One"},{"key":"286_CR17","doi-asserted-by":"crossref","first-page":"233","DOI":"10.3233\/JAD-130179","volume":"37","author":"M Wiesmann","year":"2013","unstructured":"Wiesmann M, Jansen D, Zerbi V, Broersen LM, Garthe A, Kiliaan AJ. Improved spatial learning strategy and memory in aged Alzheimer A\u03b2PPswe\/PS1dE9 mice on a multi-nutrient diet. J Alzheimers Dis. 2013;37:233\u201345.","journal-title":"J Alzheimers Dis"},{"key":"286_CR18","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1016\/j.neurobiolaging.2014.07.021","volume":"36","author":"M Cansev","year":"2015","unstructured":"Cansev M, van Wijk N, Turkyilmaz M, Orhan F, Sijben JWC, Broersen LM. Specific multi-nutrient enriched diet enhances hippocampal cholinergic transmission in aged rats. Neurobiol Aging. 2015;36:344\u201351.","journal-title":"Neurobiol Aging"},{"key":"286_CR19","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jalz.2009.10.003","volume":"6","author":"P Scheltens","year":"2010","unstructured":"Scheltens P, Kamphuis PJGH, Verhey FRJ, Rikker MGMO, Wurtman RJ, Wilkinson D, et al. Efficacy of a medical food in mild Alzheimer\u2019s disease: a randomized, controlled trial. Alzheimers Dement. 2010;6:1\u201310.e1.","journal-title":"Alzheimers Dement"},{"key":"286_CR20","doi-asserted-by":"crossref","first-page":"225","DOI":"10.3233\/JAD-2012-121189","volume":"31","author":"P Scheltens","year":"2012","unstructured":"Scheltens P, Twisk JWR, Blesa R, Scarpini E, von Arnim CAF, Bongers A, et al. Efficacy of Souvenaid in mild Alzheimer\u2019s disease: results from a randomized, controlled trial. J Alzheimers Dis. 2012;31:225\u201336.","journal-title":"J Alzheimers Dis"},{"key":"286_CR21","doi-asserted-by":"crossref","first-page":"e86558","DOI":"10.1371\/journal.pone.0086558","volume":"9","author":"H Waal de","year":"2014","unstructured":"de Waal H, Stam CJ, Lansbergen MM, Wieggers RL, Kamphuis PJ, Scheltens P, et al. The effect of Souvenaid on functional brain network organisation in patients with mild Alzheimer\u2019s disease: a randomised controlled study. PLoS One. 2014;9:e86558.","journal-title":"PLoS One"},{"key":"286_CR22","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1007\/s11307-007-0087-2","volume":"9","author":"WRW Martin","year":"2007","unstructured":"Martin WRW. MR spectroscopy in neurodegenerative disease. Mol Imaging Biol. 2007;9:196\u2013203.","journal-title":"Mol Imaging Biol"},{"key":"286_CR23","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1148\/radiol.13130531","volume":"270","author":"G Oz","year":"2014","unstructured":"Oz G, Alger JR, Barker PB, Bartha R, Bizzi A, Boesch C, et al. Clinical proton MR spectroscopy in central nervous system disorders. Radiology. 2014;270:658\u201379.","journal-title":"Radiology"},{"key":"286_CR24","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.jalz.2011.03.005","volume":"7","author":"GM McKhann","year":"2011","unstructured":"McKhann GM, Knopman DS, Chertkow H, Hyman BT, Jack Jr CR, Kawas CH, et al. The diagnosis of dementia due to Alzheimer\u2019s disease: recommendations from the National Institute on Aging-Alzheimer\u2019s Association workgroups on diagnostic guidelines for Alzheimer\u2019s disease. Alzheimers Dement. 2011;7:263\u20139.","journal-title":"Alzheimers Dement"},{"key":"286_CR25","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1111\/j.1399-5618.2010.00884.x","volume":"12","author":"N Agarwal","year":"2010","unstructured":"Agarwal N, Sung YH, Jensen JE, daCunha G, Harper D, Olson D, et al. Short-term administration of uridine increases brain membrane phospholipid precursors in healthy adults: a 31-phosphorus magnetic resonance spectroscopy study at 4T. Bipolar Disord. 2010;12:825\u201333.","journal-title":"Bipolar Disord"},{"key":"286_CR26","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1002\/nbm.1281","volume":"21","author":"MM Silveri","year":"2008","unstructured":"Silveri MM, Dikan J, Ross AJ, Jensen JE, Kamiya T, Kawada Y, et al. Citicoline enhances frontal lobe bioenergetics as measured by phosphorus magnetic resonance spectroscopy. NMR Biomed. 2008;21:1066\u201375.","journal-title":"NMR Biomed"},{"key":"286_CR27","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1186\/s13195-015-0134-1","volume":"7","author":"A Rijpma","year":"2015","unstructured":"Rijpma A, Meulenbroek O, van Hees AM, Sijben JW, Vellas B, Shah RC, et al. Effects of Souvenaid on plasma micronutrient levels and fatty acid profiles in mild and mild-to-moderate Alzheimer\u2019s disease. Alzheimers Res Ther. 2015;7:51.","journal-title":"Alzheimers Res Ther"},{"key":"286_CR28","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1002\/mrm.1110","volume":"45","author":"R Pohmann","year":"2001","unstructured":"Pohmann R, von Kienlin M. Accurate phosphorus metabolite images of the human heart by 3D acquisition-weighted CSI. Magn Reson Med. 2001;45:817\u201326.","journal-title":"Magn Reson Med"},{"key":"286_CR29","doi-asserted-by":"crossref","DOI":"10.1002\/9780470512968","volume-title":"In vivo NMR spectroscopy: principles and techniques","author":"RA Graaf de","year":"2007","unstructured":"de Graaf RA. In vivo NMR spectroscopy: principles and techniques. 2nd ed. Chichester: Wiley; 2007.","edition":"2"},{"key":"286_CR30","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1212\/WNL.35.6.781","volume":"35","author":"OAC Petroff","year":"1985","unstructured":"Petroff OAC, Prichard JW, Behar KL, Alger JR, den Hollander JA, Shulman RG. Cerebral intracellular pH by 31P nuclear magnetic resonance spectroscopy. Neurology. 1985;35:781\u20138.","journal-title":"Neurology"},{"key":"286_CR31","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1002\/mrm.1910300604","volume":"30","author":"SW Provencher","year":"1993","unstructured":"Provencher SW. Estimation of metabolite concentrations from localized in vivo proton NMR spectra. Magn Reson Med. 1993;30:672\u20139.","journal-title":"Magn Reson Med"},{"key":"286_CR32","doi-asserted-by":"crossref","first-page":"489","DOI":"10.3233\/JAD-2010-1242","volume":"19","author":"V Mart\u00edn","year":"2010","unstructured":"Mart\u00edn V, Fabelo N, Santpere G, Puig B, Mar\u00edn R, Ferrer I, et al. Lipid alterations in lipid rafts from Alzheimer\u2019s disease human brain cortex. J Alzheimers Dis. 2010;19:489\u2013502.","journal-title":"J Alzheimers Dis"},{"key":"286_CR33","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1007\/s11745-997-0044-x","volume":"32","author":"BM Ross","year":"1997","unstructured":"Ross BM, Moszczynska A, Blusztajn JK, Sherwin A, Lozano A, Kish SJ. Phospholipid biosynthetic enzymes in human brain. Lipids. 1997;32:351\u20138.","journal-title":"Lipids"},{"key":"286_CR34","doi-asserted-by":"crossref","first-page":"39","DOI":"10.3233\/JAD-2008-13104","volume":"13","author":"M Pomponi","year":"2008","unstructured":"Pomponi M, Bria P, Pomponi M. Is Alzheimer\u2019s disease a synaptic disorder? J Alzheimers Dis. 2008;13:39\u201347.","journal-title":"J Alzheimers Dis"},{"key":"286_CR35","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1111\/j.1749-6632.1989.tb12486.x","volume":"568","author":"JW Pettegrew","year":"1989","unstructured":"Pettegrew JW. Molecular insights into Alzheimer\u2019s disease. Ann N Y Acad Sci. 1989;568:5\u201328.","journal-title":"Ann N Y Acad Sci"},{"key":"286_CR36","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.trci.2016.07.004","volume":"2","author":"NME Scheltens","year":"2016","unstructured":"Scheltens NME, Kuyper IS, Boellaard R, Barkhof F, Teunissen CE, Broersen LM, et al. Design of the NL-ENIGMA study: exploring the effect of Souvenaid on cerebral glucose metabolism in early Alzheimer\u2019s disease. Alzheimers Dement (N Y). 2016;2:233\u201340.","journal-title":"Alzheimers Dement (N Y)"},{"key":"286_CR37","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1002\/ana.410380211","volume":"38","author":"CD Smith","year":"1995","unstructured":"Smith CD, Pettigrew LC, Avison MJ, Kirsch JE, Tinkhtman AJ, Schmitt FA, et al. Frontal lobe phosphorus metabolism and neuropsychological function in aging and in Alzheimer\u2019s disease. Ann Neurol. 1995;38:194\u2013201.","journal-title":"Ann Neurol"},{"key":"286_CR38","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1001\/archneur.1993.00540040046012","volume":"50","author":"GG Brown","year":"1993","unstructured":"Brown GG, Garcia JH, Gdowski JW, Levine SR, Helpern JA. Altered brain energy metabolism in demented patients with multiple subcortical ischemic lesions: working hypotheses. Arch Neurol. 1993;50:384\u20138.","journal-title":"Arch Neurol"},{"key":"286_CR39","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1148\/radiology.183.3.1584923","volume":"183","author":"PA Bottomley","year":"1992","unstructured":"Bottomley PA, Cousins JP, Pendrey DL, Wagle WA, Hardy CJ, Eames FA, et al. Alzheimer dementia: quantification of energy metabolism and mobile phosphoesters with P-31 NMR spectroscopy. Radiology. 1992;183:695\u20139.","journal-title":"Radiology"},{"key":"286_CR40","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/0197-4580(94)90152-X","volume":"15","author":"JW Pettegrew","year":"1994","unstructured":"Pettegrew JW, Panchalingam K, Klunk WE, McClure RJ, Muenz LR. Alterations of cerebral metabolism in probable Alzheimer\u2019s disease: a preliminary study. Neurobiol Aging. 1994;15:117\u201332.","journal-title":"Neurobiol Aging"},{"key":"286_CR41","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1007\/s00213-005-2168-8","volume":"180","author":"OV Forlenza","year":"2005","unstructured":"Forlenza OV, Wacker P, Nunes PV, Yacubian J, Castro CC, Otaduy MCG, et al. Reduced phospholipid breakdown in Alzheimer\u2019s brains: a 31P spectroscopy study. Psychopharmacology (Berl). 2005;180:359\u201365.","journal-title":"Psychopharmacology (Berl)"},{"issue":"Suppl 3","key":"286_CR42","doi-asserted-by":"crossref","first-page":"S75","DOI":"10.3233\/JAD-2012-120166","volume":"31","author":"PK Mandal","year":"2012","unstructured":"Mandal PK, Akolkar H, Tripathi M. Mapping of hippocampal pH and neurochemicals from in vivo multi-voxel 31P study in healthy normal young male\/female, mild cognitive impairment, and Alzheimer\u2019s disease. J Alzheimers Dis. 2012;31 Suppl 3:S75\u201386.","journal-title":"J Alzheimers Dis"},{"key":"286_CR43","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1007\/s00213-002-1045-y","volume":"161","author":"SM Babb","year":"2002","unstructured":"Babb SM, Wald LL, Cohen BM, Villafuerte RA, Gruber SA, Yurgelun-Todd DA, et al. Chronic citicoline increases phosphodiesters in the brains of healthy older subjects: an in vivo phosphorus magnetic resonance spectroscopy study. Psychopharmacology (Berl). 2002;161:248\u201354.","journal-title":"Psychopharmacology (Berl)"},{"key":"286_CR44","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1159\/000064927","volume":"14","author":"MJ Firbank","year":"2002","unstructured":"Firbank MJ, Harrison RM, O\u2019Brien JT. A comprehensive review of proton magnetic resonance spectroscopy studies in dementia and Parkinson\u2019s disease. Dement Geriatr Cogn. 2002;14:64\u201376.","journal-title":"Dement Geriatr Cogn"},{"key":"286_CR45","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.neuroscience.2005.03.050","volume":"134","author":"AM Pooler","year":"2005","unstructured":"Pooler AM, Guez DH, Benedictus R, Wurtman RJ. Uridine enhances neurite outgrowth in nerve growth factor-differentiated PC12. Neuroscience. 2005;134:207\u201314.","journal-title":"Neuroscience"},{"key":"286_CR46","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1111\/j.1471-4159.2004.02520.x","volume":"90","author":"F Calderon","year":"2004","unstructured":"Calderon F, Kim HY. Docosahexaenoic acid promotes neurite growth in hippocampal neurons. J Neurochem. 2004;90:979\u201388. A published erratum appears in J Neurochem. 2004;90:1540.","journal-title":"J Neurochem"},{"key":"286_CR47","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1111\/j.1471-4159.2006.04371.x","volume":"101","author":"AA Farooqui","year":"2007","unstructured":"Farooqui AA, Horrocks LA, Farooqui T. Modulation of inflammation in brain: a matter of fat. J Neurochem. 2007;101:577\u201399.","journal-title":"J Neurochem"}],"container-title":["Alzheimer's Research & Therapy"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s13195-017-0286-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,31]],"date-time":"2022-07-31T14:03:37Z","timestamp":1659276217000},"score":1,"resource":{"primary":{"URL":"http:\/\/alzres.biomedcentral.com\/articles\/10.1186\/s13195-017-0286-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,7,26]]},"references-count":47,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2017,12]]}},"alternative-id":["286"],"URL":"https:\/\/doi.org\/10.1186\/s13195-017-0286-2","relation":{},"ISSN":["1758-9193"],"issn-type":[{"value":"1758-9193","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,7,26]]},"article-number":"51"}}