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(WMHs). Some preclinical evidence also indicates that white matter degeneration may precede or affect the development of AD pathology. This study aimed to clarify the direction of influence between in vivo AD pathologies, particularly beta-amyloid (A\u03b2) and tau deposition, and WMHs through longitudinal approach.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Total 282 older adults including cognitively normal and cognitively impaired individuals were recruited from the Korean Brain Aging Study for the Early Diagnosis and Prediction of Alzheimer\u2019s Disease (KBASE) cohort. The participants underwent comprehensive clinical and neuropsychological assessment, [\n                      <jats:sup>11<\/jats:sup>\n                      C] Pittsburgh Compound B PET for measuring A\u03b2 deposition, [\n                      <jats:sup>18<\/jats:sup>\n                      F] AV-1451 PET for measuring tau deposition, and MRI scans with fluid-attenuated inversion recovery image for measuring WMH volume. The relationships between A\u03b2 or tau deposition and WMH volume were examined using multiple linear regression analysis. In this analysis, baseline A\u03b2 or tau were used as independent variables, and change of WMH volume over 2 years was used as dependent variable to examine the effect of AD pathology on increase of WMH volume. Additionally, we set baseline WMH volume as independent variable and longitudinal change of A\u03b2 or tau deposition for 2 years as dependent variables to investigate whether WMH volume could precede AD pathologies.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Baseline A\u03b2 deposition, but not tau deposition, had significant positive association with longitudinal change of WMH volume over 2 years. Baseline WMH volume was not related with any of longitudinal change of A\u03b2 or tau deposition for 2 years. We also found a significant interaction effect between baseline A\u03b2 deposition and sex on longitudinal change of WMH volume. Subsequent subgroup analyses showed that high baseline A\u03b2 deposition was associated with increase of WMH volume over 2 years in female, but not in male.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our findings suggest that A\u03b2 deposition accelerates cerebral WMHs, particularly in female, whereas white matter degeneration appears not influence on longitudinal A\u03b2 increase. The results also did not support any direction of influence between tau deposition and WMHs.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s13195-024-01417-8","type":"journal-article","created":{"date-parts":[[2024,3,7]],"date-time":"2024-03-07T00:01:28Z","timestamp":1709769688000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Association between brain amyloid deposition and longitudinal changes of white matter hyperintensities"],"prefix":"10.1186","volume":"16","author":[{"given":"Woo-Jin","family":"Cha","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dahyun","family":"Yi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyejin","family":"Ahn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min Soo","family":"Byun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoon Young","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jung-Min","family":"Choi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyungtae","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyeji","family":"Choi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gijung","family":"Jung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koung Mi","family":"Kang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chul-Ho","family":"Sohn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun-Sang","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu Kyeong","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong Young","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,3,7]]},"reference":[{"issue":"5","key":"1417_CR1","doi-asserted-by":"publisher","first-page":"645","DOI":"10.1007\/s00401-015-1522-0","volume":"131","author":"S Love","year":"2016","unstructured":"Love S, Miners JS. 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