{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T17:40:46Z","timestamp":1793814046185,"version":"4.6.1"},"reference-count":63,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,3,14]],"date-time":"2024-03-14T00:00:00Z","timestamp":1710374400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,3,14]],"date-time":"2024-03-14T00:00:00Z","timestamp":1710374400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"the Science and Technology Innovation 2030 Major Projects","award":["2022ZD0211606"],"award-info":[{"award-number":["2022ZD0211606"]}]},{"DOI":"10.13039\/501100001809","name":"the National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["62376150"],"award-info":[{"award-number":["62376150"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Alz Res Therapy"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Functional connectivity (FC) biomarkers play a crucial role in the early diagnosis and mechanistic study of Alzheimer\u2019s disease (AD). However, the identification of effective FC biomarkers remains challenging. In this study, we introduce a novel approach, the spatiotemporal graph convolutional network (ST-GCN) combined with the gradient-based class activation mapping (Grad-CAM) model (STGC-GCAM), to effectively identify FC biomarkers for AD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This multi-center cross-racial retrospective study involved 2,272 participants, including 1,105 cognitively normal (CN) subjects, 790 mild cognitive impairment (MCI) individuals, and 377 AD patients. All participants underwent functional magnetic resonance imaging (fMRI) and T1-weighted MRI scans. In this study, firstly, we optimized the STGC-GCAM model to enhance classification accuracy. Secondly, we identified novel AD-associated biomarkers using the optimized model. Thirdly, we validated the imaging biomarkers using Kaplan\u2013Meier analysis. Lastly, we performed correlation analysis and causal mediation analysis to confirm the physiological significance of the identified biomarkers.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The STGC-GCAM model demonstrated great classification performance (The average area under the curve (AUC) values for different categories were: CN vs MCI\u2009=\u20090.98, CN vs AD\u2009=\u20090.95, MCI vs AD\u2009=\u20090.96, stable MCI vs progressive MCI\u2009=\u20090.79). Notably, the model identified specific brain regions, including the sensorimotor network (SMN), visual network (VN), and default mode network (DMN), as key differentiators between patients and CN individuals. These brain regions exhibited significant associations with the severity of cognitive impairment (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05). Moreover, the topological features of important brain regions demonstrated excellent predictive capability for the conversion from MCI to AD (Hazard ratio\u2009=\u20093.885,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Additionally, our findings revealed that the topological features of these brain regions mediated the impact of amyloid beta (A\u03b2) deposition (bootstrapped average causal mediation effect: \u03b2\u2009=\u2009-0.01 [-0.025, 0.00],\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) and brain glucose metabolism (bootstrapped average causal mediation effect: \u03b2\u2009=\u2009-0.02 [-0.04, -0.001],\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) on cognitive status.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This study presents the STGC-GCAM framework, which identifies FC biomarkers using a large multi-site fMRI dataset.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s13195-024-01425-8","type":"journal-article","created":{"date-parts":[[2024,3,14]],"date-time":"2024-03-14T03:47:29Z","timestamp":1710388049000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["A novel spatiotemporal graph convolutional network framework for functional connectivity biomarkers identification of Alzheimer\u2019s disease"],"prefix":"10.1186","volume":"16","author":[{"given":"Ying","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Le","family":"Xue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuoyan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiacheng","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luyao","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingkai","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiehui","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunxia","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"for the Alzheimer\u2019s Disease Neuroimaging Initiative","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael W.","family":"Weiner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Aisen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronald","family":"Petersen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clifford R.","family":"Jack","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William","family":"Jagust","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John Q.","family":"Trojanowski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arthur W.","family":"Toga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurel","family":"Beckett","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert C.","family":"Green","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew J.","family":"Saykin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Morris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leslie M.","family":"Shaw","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zaven","family":"Khachaturian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Greg","family":"Sorensen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lew","family":"Kuller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcus","family":"Raichle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven","family":"Paul","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Davies","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Howard","family":"Fillit","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franz","family":"Hefti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Holtzman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marek M.","family":"Mesulam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William","family":"Potter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Snyder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam","family":"Schwartz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tom","family":"Montine","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronald G.","family":"Thomas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Donohue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Walter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Devon","family":"Gessert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tamie","family":"Sather","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gus","family":"Jiminez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danielle","family":"Harvey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew","family":"Bernstein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Thompson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norbert","family":"Schuff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bret","family":"Borowski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeff","family":"Gunter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matt","family":"Senjem","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prashanthi","family":"Vemuri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Jones","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kejal","family":"Kantarci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chad","family":"Ward","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert A.","family":"Koeppe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norm","family":"Foster","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric M.","family":"Reiman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kewei","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chet","family":"Mathis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan","family":"Landau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nigel J.","family":"Cairns","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erin","family":"Householder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa","family":"Taylor-Reinwald","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Virginia","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magdalena","family":"Korecka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michal","family":"Figurski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen","family":"Crawford","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott","family":"Neu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatiana M.","family":"Foroud","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven G.","family":"Potkin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelley","family":"Faber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sungeun","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kwangsik","family":"Nho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leon","family":"Thal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neil","family":"Buckholtz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marylyn","family":"Albert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Frank","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Hsiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey","family":"Kaye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph","family":"Quinn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Betty","family":"Lind","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raina","family":"Carter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Dolen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lon S.","family":"Schneider","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonia","family":"Pawluczyk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mauricio","family":"Beccera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liberty","family":"Teodoro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bryan M.","family":"Spann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Brewer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helen","family":"Vanderswag","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam","family":"Fleisher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judith L.","family":"Heidebrink","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanne L.","family":"Lord","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara S.","family":"Mason","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Colleen S.","family":"Albers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Knopman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kris","family":"Johnson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachelle S.","family":"Doody","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javier","family":"Villanueva-Meyer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Munir","family":"Chowdhury","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan","family":"Rountree","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mimi","family":"Dang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaakov","family":"Stern","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lawrence S.","family":"Honig","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen L.","family":"Bell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beau","family":"Ances","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Carroll","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sue","family":"Leon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark A.","family":"Mintun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stacy","family":"Schneider","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"Oliver","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Marson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Randall","family":"Griffith","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Clark","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Geldmacher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Brockington","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erik","family":"Roberson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hillel","family":"Grossman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Effie","family":"Mitsis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leyla","family":"de Toledo-Morrell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raj C.","family":"Shah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ranjan","family":"Duara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Varon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria T.","family":"Greig","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peggy","family":"Roberts","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiadi","family":"Onyike","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"D\u2019Agostino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie","family":"Kielb","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James E.","family":"Galvin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brittany","family":"Cerbone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina A.","family":"Michel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henry","family":"Rusinek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mony J.","family":"de Leon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lidia","family":"Glodzik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan","family":"De Santi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"PMurali","family":"Doraiswamy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey R.","family":"Petrella","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Terence Z.","family":"Wong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven E.","family":"Arnold","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason H.","family":"Karlawish","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Wolk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles D.","family":"Smith","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Greg","family":"Jicha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Hardy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Partha","family":"Sinha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Oates","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gary","family":"Conrad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oscar L.","family":"Lopez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MaryAnn","family":"Oakley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donna M.","family":"Simpson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anton P.","family":"Porsteinsson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bonnie S.","family":"Goldstein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kim","family":"Martin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelly M.","family":"Makino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MSaleem","family":"Ismail","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Connie","family":"Brand","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruth A.","family":"Mulnard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaby","family":"Thai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"McAdams-Ortiz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyle","family":"Womack","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dana","family":"Mathews","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary","family":"Quiceno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramon","family":"Diaz-Arrastia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"King","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Myron","family":"Weiner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristen","family":"Martin-Cook","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"DeVous","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allan I.","family":"Levey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James J.","family":"Lah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janet S.","family":"Cellar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey M.","family":"Burns","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heather S.","family":"Anderson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Russell H.","family":"Swerdlow","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liana","family":"Apostolova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathleen","family":"Tingus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ellen","family":"Woo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel H. S.","family":"Silverman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Po H.","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George","family":"Bartzokis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neill R.","family":"Graff-Radford","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francine","family":"Parfitt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tracy","family":"Kendall","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heather","family":"Johnson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin R.","family":"Farlow","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ann Marie","family":"Hake","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brandy R.","family":"Matthews","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott","family":"Herring","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cynthia","family":"Hunt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher H.","family":"van Dyck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard E.","family":"Carson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martha G.","family":"MacAvoy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Howard","family":"Chertkow","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Howard","family":"Bergman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chris","family":"Hosein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ging-Yuek Robin","family":"Hsiung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Howard","family":"Feldman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benita","family":"Mudge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michele","family":"Assaly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles","family":"Bernick","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donna","family":"Munic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Kertesz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Rogers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dick","family":"Trost","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diana","family":"Kerwin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristine","family":"Lipowski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuang-Kuo","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nancy","family":"Johnson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carl","family":"Sadowsky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Walter","family":"Martinez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teresa","family":"Villena","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raymond Scott","family":"Turner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathleen","family":"Johnson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brigid","family":"Reynolds","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reisa A.","family":"Sperling","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keith A.","family":"Johnson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gad","family":"Marshall","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meghan","family":"Frey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barton","family":"Lane","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allyson","family":"Rosen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jared","family":"Tinklenberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marwan N.","family":"Sabbagh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine M.","family":"Belden","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra A.","family":"Jacobson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sherye A.","family":"Sirrel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neil","family":"Kowall","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronald","family":"Killiany","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew E.","family":"Budson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Norbash","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia Lynn","family":"Johnson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanne","family":"Allard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan","family":"Lerner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paula","family":"Ogrocki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leon","family":"Hudson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evan","family":"Fletcher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Owen","family":"Carmichae","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Olichney","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles","family":"DeCarli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Smita","family":"Kittur","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Borrie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.-Y.","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rob","family":"Bartha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sterling","family":"Johnson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanjay","family":"Asthana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cynthia M.","family":"Carlsson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adrian","family":"Preda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dana","family":"Nguyen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Tariot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie","family":"Reeder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vernice","family":"Bates","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Horacio","family":"Capote","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle","family":"Rainka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Douglas W.","family":"Scharre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Kataki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anahita","family":"Adeli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Earl A.","family":"Zimmerman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dzintra","family":"Celmins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alice D.","family":"Brown","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Godfrey D.","family":"Pearlson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen","family":"Blank","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen","family":"Anderson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert B.","family":"Santulli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tamar J.","family":"Kitzmiller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eben S.","family":"Schwartz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaycee M.","family":"Sink","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeff D.","family":"Williamson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pradeep","family":"Garg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franklin","family":"Watkins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian R.","family":"Ott","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henry","family":"Querfurth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geoffrey","family":"Tremont","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen","family":"Salloway","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Malloy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen","family":"Correia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Howard J.","family":"Rosen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruce L.","family":"Miller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacobo","family":"Mintzer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth","family":"Spicer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Bachman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen","family":"Pasternak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irina","family":"Rachinsky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dick","family":"Drost","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nunzio","family":"Pomara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raymundo","family":"Hernando","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antero","family":"Sarrael","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan K.","family":"Schultz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura L. Boles","family":"Ponto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyungsub","family":"Shim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen Elizabeth","family":"Smith","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norman","family":"Relkin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gloria","family":"Chaing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa","family":"Raudin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda","family":"Smith","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristin","family":"Fargher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Balebail Ashok","family":"Raj","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Neylan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jordan","family":"Grafman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melissa","family":"Davis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosemary","family":"Morrison","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacqueline","family":"Hayes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shannon","family":"Finley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karl","family":"Friedl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Debra","family":"Fleischman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Konstantinos","family":"Arfanakis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olga","family":"James","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dino","family":"Massoglia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JJay","family":"Fruehling","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"Harding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elaine R.","family":"Peskind","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric C.","family":"Petrie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gail","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jerome A.","family":"Yesavage","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joy L.","family":"Taylor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ansgar J.","family":"Furst","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,3,14]]},"reference":[{"issue":"7","key":"1425_CR1","doi-asserted-by":"publisher","first-page":"1245","DOI":"10.1007\/s11548-022-02620-4","volume":"17","author":"S Ghafoori","year":"2022","unstructured":"Ghafoori S, Shalbaf A. Predicting conversion from MCI to AD by integration of rs-fMRI and clinical information using 3D-convolutional neural network. Int J Comput Assist Radiol Surg. 2022;17(7):1245\u201355. https:\/\/doi.org\/10.1007\/s11548-022-02620-4.","journal-title":"Int J Comput Assist Radiol Surg"},{"issue":"14","key":"1425_CR2","doi-asserted-by":"publisher","first-page":"2000675","DOI":"10.1002\/advs.202000675","volume":"7","author":"D Jin","year":"2020","unstructured":"Jin D, Zhou B, Han Y, Ren J, Han T, Liu B, et al. Generalizable, reproducible, and neuroscientifically interpretable imaging biomarkers for Alzheimer\u2019s disease. Adv Sci. 2020;7(14):2000675. https:\/\/doi.org\/10.1002\/advs.202000675.","journal-title":"Adv Sci"},{"key":"1425_CR3","first-page":"535","volume-title":"Biometric Recognition","author":"Z Luo","year":"2014","unstructured":"Luo Z, Zeng L-L, Chen F. Classification of Patients with Alzheimer\u2019s Disease Based on Structural MRI Using Locally Linear Embedding (LLE). In: Sun Z, Shan S, Sang H, Zhou J, Wang Y, Yuan W, editors. Biometric Recognition. Cham: Springer International Publishing; 2014. p. 535\u201340."},{"key":"1425_CR4","doi-asserted-by":"publisher","first-page":"413","DOI":"10.1007\/978-3-319-60964-5_36","volume-title":"Medical Image Understanding and Analysis","author":"A Ortiz","year":"2017","unstructured":"Ortiz A, Munilla J, Mart\u00ednez-Murcia FJ, G\u00f3rriz JM, Ram\u00edrez J. Learning longitudinal MRI patterns by SICE and deep learning: Assessing the Alzheimer\u2019s disease progression. In: Vald\u00e9s Hern\u00e1ndez M, Gonz\u00e1lez-Castro V, editors. Medical Image Understanding and Analysis. Springer International Publishing: Cham; 2017. p. 413\u201324."},{"key":"1425_CR5","doi-asserted-by":"crossref","unstructured":"Li F, Cheng D, Liu M. Alzheimer\u2019s disease classification based on combination of multi-model convolutional networks. In: 2017 IEEE International Conference on Imaging Systems and Techniques (IST). 2017. pp.1\u20135.","DOI":"10.1109\/IST.2017.8261566"},{"key":"1425_CR6","doi-asserted-by":"publisher","first-page":"449","DOI":"10.3389\/fnhum.2015.00449","volume":"9","author":"L Griffanti","year":"2015","unstructured":"Griffanti L, Dipasquale O, Lagan\u00e0 MM, Nemni R, Clerici M, Smith SM, et al. Effective artifact removal in resting state fMRI data improves detection of DMN functional connectivity alteration in Alzheimer\u2019s disease. Front Hum Neurosci. 2015;9:449. https:\/\/doi.org\/10.3389\/fnhum.2015.00449.","journal-title":"Front Hum Neurosci"},{"issue":"12","key":"1425_CR7","doi-asserted-by":"publisher","first-page":"2042","DOI":"10.1007\/s00259-017-3761-x","volume":"44","author":"M Pagani","year":"2017","unstructured":"Pagani M, Nobili F, Morbelli S, Arnaldi D, Giuliani A, \u00d6berg J, et al. Early identification of MCI converting to AD: a FDG PET study. Eur J Nucl Med Mol Imaging. 2017;44(12):2042\u201352. https:\/\/doi.org\/10.1007\/s00259-017-3761-x.","journal-title":"Eur J Nucl Med Mol Imaging"},{"issue":"5","key":"1425_CR8","doi-asserted-by":"publisher","first-page":"827","DOI":"10.1097\/rct.0000000000000435","volume":"40","author":"A Bin Zahid","year":"2016","unstructured":"Bin Zahid A, Mikheev A, Srivatsa N, Babb J, Samadani U, Rusinek H. Accelerated brain atrophy on serial computed tomography: potential marker of the progression of Alzheimer disease. J Comput Assist Tomogr. 2016;40(5):827\u201332. https:\/\/doi.org\/10.1097\/rct.0000000000000435.","journal-title":"J Comput Assist Tomogr"},{"issue":"9","key":"1425_CR9","doi-asserted-by":"publisher","first-page":"545","DOI":"10.1038\/s41582-021-00529-1","volume":"17","author":"M Yu","year":"2021","unstructured":"Yu M, Sporns O, Saykin AJ. The human connectome in Alzheimer disease - relationship to biomarkers and genetics. Nat Rev Neurol. 2021;17(9):545\u201363. https:\/\/doi.org\/10.1038\/s41582-021-00529-1.","journal-title":"Nat Rev Neurol"},{"key":"1425_CR10","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1196\/annals.1440.011","volume":"1124","author":"RL Buckner","year":"2008","unstructured":"Buckner RL, Andrews-Hanna JR, Schacter DL. The brain\u2019s default network: anatomy, function, and relevance to disease. Ann N Y Acad Sci. 2008;1124:1\u201338. https:\/\/doi.org\/10.1196\/annals.1440.011.","journal-title":"Ann N Y Acad Sci"},{"issue":"4","key":"1425_CR11","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1016\/j.jalz.2008.04.006","volume":"4","author":"Y Zhou","year":"2008","unstructured":"Zhou Y, Dougherty JH, Hubner KF, Bai B, Cannon RL, Hutson RK. Abnormal connectivity in the posterior cingulate and hippocampus in early Alzheimer\u2019s disease and mild cognitive impairment. Alzheimers Dement. 2008;4(4):265\u201370. https:\/\/doi.org\/10.1016\/j.jalz.2008.04.006.","journal-title":"Alzheimers Dement"},{"issue":"1","key":"1425_CR12","doi-asserted-by":"publisher","first-page":"276","DOI":"10.1007\/s11682-019-00255-9","volume":"15","author":"B Lei","year":"2021","unstructured":"Lei B, Yu S, Zhao X, Frangi AF, Tan EL, Elazab A, et al. Diagnosis of early Alzheimer\u2019s disease based on dynamic high order networks. Brain Imaging Behav. 2021;15(1):276\u201387. https:\/\/doi.org\/10.1007\/s11682-019-00255-9.","journal-title":"Brain Imaging Behav"},{"key":"1425_CR13","doi-asserted-by":"publisher","first-page":"103977","DOI":"10.1016\/j.ebiom.2022.103977","volume":"78","author":"K Qin","year":"2022","unstructured":"Qin K, Lei D, Pinaya WHL, Pan N, Li W, Zhu Z, et al. Using graph convolutional network to characterize individuals with major depressive disorder across multiple imaging sites. eBioMedicine. 2022;78:103977. https:\/\/doi.org\/10.1016\/j.ebiom.2022.103977.","journal-title":"eBioMedicine."},{"issue":"1","key":"1425_CR14","doi-asserted-by":"publisher","first-page":"244","DOI":"10.1109\/tcbb.2017.2776910","volume":"16","author":"R Ju","year":"2019","unstructured":"Ju R, Hu C, Zhou P, Li Q. Early diagnosis of Alzheimer\u2019s disease based on resting-state brain networks and deep learning. IEEE\/ACM Trans Comput Biol Bioinf. 2019;16(1):244\u201357. https:\/\/doi.org\/10.1109\/tcbb.2017.2776910.","journal-title":"IEEE\/ACM Trans Comput Biol Bioinf"},{"key":"1425_CR15","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1007\/978-3-030-00931-1_29","volume":"11072","author":"W Yan","year":"2018","unstructured":"Yan W, Zhang H, Sui J, Shen D. Deep chronnectome learning via full bidirectional long short-term memory networks for MCI diagnosis. Med Image Comput Comput Assist Interv. 2018;11072:249\u201357. https:\/\/doi.org\/10.1007\/978-3-030-00931-1_29.","journal-title":"Med Image Comput Comput Assist Interv"},{"issue":"4","key":"1425_CR16","doi-asserted-by":"publisher","first-page":"1279","DOI":"10.1109\/tmi.2021.3051604","volume":"40","author":"D Yao","year":"2021","unstructured":"Yao D, Sui J, Wang M, Yang E, Jiaerken Y, Luo N, et al. A mutual multi-scale triplet graph convolutional network for classification of brain disorders using functional or structural connectivity. IEEE Trans Med Imaging. 2021;40(4):1279\u201389. https:\/\/doi.org\/10.1109\/tmi.2021.3051604.","journal-title":"IEEE Trans Med Imaging"},{"key":"1425_CR17","doi-asserted-by":"publisher","unstructured":"Sarraf S, DeSouza DD, Anderson JAE, Tofighi GJb. DeepAD: Alzheimer\u2019s Disease Classification via Deep Convolutional Neural Networks using MRI and fMRI. BioRxiv. 2016:070441. https:\/\/doi.org\/10.1101\/070441.","DOI":"10.1101\/070441"},{"issue":"5","key":"1425_CR18","doi-asserted-by":"publisher","first-page":"5833","DOI":"10.1109\/TPAMI.2022.3209686","volume":"45","author":"A Bessadok","year":"2023","unstructured":"Bessadok A, Mahjoub MA, Rekik I. Graph neural networks in network neuroscience. IEEE Trans Pattern Anal Mach Intell. 2023;45(5):5833\u201348. https:\/\/doi.org\/10.1109\/TPAMI.2022.3209686.","journal-title":"IEEE Trans Pattern Anal Mach Intell"},{"key":"1425_CR19","doi-asserted-by":"publisher","first-page":"14","DOI":"10.3390\/s21144758","volume":"21","author":"D Ahmedt-Aristizabal","year":"2021","unstructured":"Ahmedt-Aristizabal D, Armin MA, Denman S, Fookes C, Petersson L. Graph-based deep learning for medical diagnosis and analysis: past, present and future. Sensors (Basel). 2021;21:14. https:\/\/doi.org\/10.3390\/s21144758.","journal-title":"Sensors (Basel)."},{"key":"1425_CR20","doi-asserted-by":"crossref","unstructured":"Qu G, Hu W, Xiao L, Wang Y-P. A graph deep learning model for the classification of groups with different IQ using resting state fMRI. In: Medical Imaging 2020: Biomedical Applications in Molecular, Structural, and Functional Imaging 2020 p.113170A.","DOI":"10.1117\/12.2549274"},{"key":"1425_CR21","doi-asserted-by":"publisher","first-page":"918969","DOI":"10.3389\/fnhum.2022.918969","volume":"16","author":"F Zhao","year":"2022","unstructured":"Zhao F, Li N, Pan H, Chen X, Li Y, Zhang H, et al. Multi-view feature enhancement based on self-attention mechanism graph convolutional network for autism spectrum disorder diagnosis. Front Hum Neurosci. 2022;16:918969. https:\/\/doi.org\/10.3389\/fnhum.2022.918969.","journal-title":"Front Hum Neurosci"},{"key":"1425_CR22","first-page":"69","volume-title":"Imaging systems for GI endoscopy, and graphs in biomedical image analysis","author":"L Mei","year":"2022","unstructured":"Mei L, Liu M, Bian L, Zhang Y, Shi F, Zhang H, et al. Modular Graph Encoding and Hierarchical Readout for Functional Brain Network Based eMCI Diagnosis. In: Manfredi L, Ahmadi S-A, Bronstein M, Kazi A, Lomanto D, Mathew A, et al., editors. Imaging systems for GI endoscopy, and graphs in biomedical image analysis. Cham: Springer Nature Switzerland; 2022. p. 69\u201378."},{"issue":"11","key":"1425_CR23","doi-asserted-by":"publisher","first-page":"13261","DOI":"10.1007\/s10489-022-04203-x","volume":"53","author":"X Wang","year":"2023","unstructured":"Wang X, Xin J, Wang Z, Chen Q, Wang Z. An evolving graph convolutional network for dynamic functional brain network. Appl Intell. 2023;53(11):13261\u201374. https:\/\/doi.org\/10.1007\/s10489-022-04203-x.","journal-title":"Appl Intell"},{"key":"1425_CR24","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/978-3-030-59861-7_1","volume":"12436","author":"D Yao","year":"2020","unstructured":"Yao D, Sui J, Yang E, Yap PT, Shen D, Liu M. Temporal-adaptive graph convolutional network for automated identification of major depressive disorder using resting-state fMRI. Mach Learn Med Imaging MLMI (Workshop). 2020;12436:1\u201310. https:\/\/doi.org\/10.1007\/978-3-030-59861-7_1.","journal-title":"Mach Learn Med Imaging MLMI (Workshop)"},{"key":"1425_CR25","doi-asserted-by":"publisher","first-page":"639","DOI":"10.1007\/978-3-030-32251-9_70","volume-title":"Medical Image Computing and Computer Assisted Intervention \u2013 MICCAI 2019","author":"X Xing","year":"2019","unstructured":"Xing X, Li Q, Wei H, Zhang M, Zhan Y, Zhou XS, et al. Dynamic spectral graph convolution networks with assistant task training for early MCI diagnosis. In: Shen D, Liu T, Peters TM, Staib LH, Essert C, Zhou S, et al., editors. Medical Image Computing and Computer Assisted Intervention \u2013 MICCAI 2019. Cham: Springer International Publishing; 2019. p. 639\u201346."},{"issue":"17","key":"1425_CR26","doi-asserted-by":"publisher","first-page":"5194","DOI":"10.1002\/hbm.25994","volume":"43","author":"X Shan","year":"2022","unstructured":"Shan X, Cao J, Huo S, Chen L, Sarrigiannis PG, Zhao Y. Spatial-temporal graph convolutional network for Alzheimer classification based on brain functional connectivity imaging of electroencephalogram. Hum Brain Mapp. 2022;43(17):5194\u2013209. https:\/\/doi.org\/10.1002\/hbm.25994.","journal-title":"Hum Brain Mapp"},{"key":"1425_CR27","doi-asserted-by":"publisher","first-page":"102370","DOI":"10.1016\/j.media.2022.102370","volume":"77","author":"SG Huang","year":"2022","unstructured":"Huang SG, Xia J, Xu L, Qiu A. Spatio-temporal directed acyclic graph learning with attention mechanisms on brain functional time series and connectivity. Med Image Anal. 2022;77:102370. https:\/\/doi.org\/10.1016\/j.media.2022.102370.","journal-title":"Med Image Anal"},{"issue":"7","key":"1425_CR28","doi-asserted-by":"publisher","first-page":"2163","DOI":"10.1007\/s00259-022-05687-y","volume":"49","author":"J Jiang","year":"2022","unstructured":"Jiang J, Wang M, Alberts I, Sun X, Li T, Rominger A, et al. Using radiomics-based modelling to predict individual progression from mild cognitive impairment to Alzheimer\u2019s disease. Eur J Nucl Med Mol Imaging. 2022;49(7):2163\u201373. https:\/\/doi.org\/10.1007\/s00259-022-05687-y.","journal-title":"Eur J Nucl Med Mol Imaging"},{"issue":"7","key":"1425_CR29","doi-asserted-by":"publisher","first-page":"e028188","DOI":"10.1136\/bmjopen-2018-028188","volume":"9","author":"X Li","year":"2019","unstructured":"Li X, Wang X, Su L, Hu X, Han Y. Sino Longitudinal Study on Cognitive Decline (SILCODE): protocol for a Chinese longitudinal observational study to develop risk prediction models of conversion to mild cognitive impairment in individuals with subjective cognitive decline. BMJ Open. 2019;9(7):e028188. https:\/\/doi.org\/10.1136\/bmjopen-2018-028188.","journal-title":"BMJ Open"},{"key":"1425_CR30","doi-asserted-by":"publisher","unstructured":"Li T-R, Wu Y, Jiang J-J, Lin H, Han C-L, Jiang J-H, et al. Radiomics analysis of magnetic resonance imaging facilitates the identification of preclinical Alzheimer\u2019s disease: an exploratory study. 2020;8. https:\/\/doi.org\/10.3389\/fcell.2020.605734.","DOI":"10.3389\/fcell.2020.605734"},{"issue":"3","key":"1425_CR31","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1016\/j.jalz.2011.03.005","volume":"7","author":"GM McKhann","year":"2011","unstructured":"McKhann GM, Knopman DS, Chertkow H, Hyman BT, Jack CR Jr, Kawas CH, et al. The diagnosis of dementia due to Alzheimer\u2019s disease: recommendations from the National Institute on Aging-Alzheimer\u2019s Association workgroups on diagnostic guidelines for Alzheimer\u2019s disease. Alzheimer\u2019s Dementia. 2011;7(3):263\u20139. https:\/\/doi.org\/10.1016\/j.jalz.2011.03.005.","journal-title":"Alzheimer\u2019s Dementia"},{"issue":"3","key":"1425_CR32","doi-asserted-by":"publisher","first-page":"1129","DOI":"10.1002\/hbm.26146","volume":"44","author":"R Shi","year":"2023","unstructured":"Shi R, Sheng C, Jin S, Zhang Q, Zhang S, Zhang L, et al. Generative adversarial network constrained multiple loss autoencoder: A deep learning-based individual atrophy detection for Alzheimer\u2019s disease and mild cognitive impairment. Hum Brain Mapp. 2023;44(3):1129\u201346. https:\/\/doi.org\/10.1002\/hbm.26146.","journal-title":"Hum Brain Mapp"},{"issue":"12","key":"1425_CR33","doi-asserted-by":"publisher","first-page":"1985","DOI":"10.1001\/archneur.58.12.1985","volume":"58","author":"RC Petersen","year":"2001","unstructured":"Petersen RC, Doody R, Kurz A, Mohs RC, Morris JC, Rabins PV, et al. Current concepts in mild cognitive impairment. Arch Neurol. 2001;58(12):1985\u201392. https:\/\/doi.org\/10.1001\/archneur.58.12.1985.","journal-title":"Arch Neurol"},{"issue":"6","key":"1425_CR34","doi-asserted-by":"publisher","first-page":"614","DOI":"10.1016\/s1474-4422(14)70090-0","volume":"13","author":"B Dubois","year":"2014","unstructured":"Dubois B, Feldman HH, Jacova C, Hampel H, Molinuevo JL, Blennow K, et al. Advancing research diagnostic criteria for Alzheimer\u2019s disease: the IWG-2 criteria. Lancet Neurol. 2014;13(6):614\u201329. https:\/\/doi.org\/10.1016\/s1474-4422(14)70090-0.","journal-title":"Lancet Neurol"},{"key":"1425_CR35","doi-asserted-by":"publisher","first-page":"13","DOI":"10.3389\/fnsys.2010.00013","volume":"4","author":"Y Chao-Gan","year":"2010","unstructured":"Chao-Gan Y, Yu-Feng Z. DPARSF: A MATLAB toolbox for \u201cPipeline\u201d data analysis of resting-state fMRI. Front Syst Neurosci. 2010;4:13. https:\/\/doi.org\/10.3389\/fnsys.2010.00013.","journal-title":"Front Syst Neurosci"},{"issue":"3","key":"1425_CR36","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1007\/s12021-016-9299-4","volume":"14","author":"C-G Yan","year":"2016","unstructured":"Yan C-G, Wang X-D, Zuo X-N, Zang Y-F. DPABI: data processing & analysis for (Resting-State) brain imaging. Neuroinformatics. 2016;14(3):339\u201351. https:\/\/doi.org\/10.1007\/s12021-016-9299-4.","journal-title":"Neuroinformatics"},{"issue":"1","key":"1425_CR37","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1093\/biostatistics\/kxj037","volume":"8","author":"WE Johnson","year":"2007","unstructured":"Johnson WE, Li C, Rabinovic A. Adjusting batch effects in microarray expression data using empirical Bayes methods. Biostatistics (Oxford, England). 2007;8(1):118\u201327. https:\/\/doi.org\/10.1093\/biostatistics\/kxj037.","journal-title":"Biostatistics (Oxford, England)"},{"issue":"1","key":"1425_CR38","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1006\/nimg.2001.0978","volume":"15","author":"N Tzourio-Mazoyer","year":"2002","unstructured":"Tzourio-Mazoyer N, Landeau B, Papathanassiou D, Crivello F, Etard O, Delcroix N, et al. Automated anatomical labeling of activations in SPM using a macroscopic anatomical parcellation of the MNI MRI single-subject brain. Neuroimage. 2002;15(1):273\u201389. https:\/\/doi.org\/10.1006\/nimg.2001.0978.","journal-title":"Neuroimage"},{"key":"1425_CR39","doi-asserted-by":"publisher","unstructured":"Jiang M, Chen Y, Yan J, Xiao Z, Mao W, Zhao B, et al. Anatomy-Guided Spatio-Temporal Graph Convolutional Networks (AG-STGCNs) for modeling functional connectivity between gyri and sulci across multiple task domains. IEEE Trans Neural Netw Learn Syst. 2022:1\u201311. https:\/\/doi.org\/10.1109\/TNNLS.2022.3194733.","DOI":"10.1109\/TNNLS.2022.3194733"},{"key":"1425_CR40","doi-asserted-by":"publisher","first-page":"528","DOI":"10.1007\/978-3-030-59728-3_52","volume-title":"Medical Image Computing and Computer Assisted Intervention \u2013 MICCAI 2020","author":"S Gadgil","year":"2020","unstructured":"Gadgil S, Zhao Q, Pfefferbaum A, Sullivan EV, Adeli E, Pohl KM, et al. Spatio-temporal graph convolution for resting-state fMRI analysis. In: Martel AL, Abolmaesumi P, Stoyanov D, Mateus D, Zuluaga MA, Zhou SK, et al., editors. Medical Image Computing and Computer Assisted Intervention \u2013 MICCAI 2020. Cham: Springer International Publishing; 2020. p. 528\u201338."},{"key":"1425_CR41","doi-asserted-by":"crossref","unstructured":"Zhou B, Khosla A, Lapedriza A, Oliva A, Torralba A. Learning deep features for discriminative localization. In: 2016 IEEE Conference on Computer Vision and Pattern Recognition (CVPR). 2016. pp. 2921\u20139.","DOI":"10.1109\/CVPR.2016.319"},{"issue":"2","key":"1425_CR42","doi-asserted-by":"publisher","first-page":"336","DOI":"10.1007\/s11263-019-01228-7","volume":"128","author":"RR Selvaraju","year":"2020","unstructured":"Selvaraju RR, Cogswell M, Das A, Vedantam R, Parikh D, Batra D. Grad-CAM: visual explanations from deep networks via gradient-based localization. Int J Comput Vision. 2020;128(2):336\u201359. https:\/\/doi.org\/10.1007\/s11263-019-01228-7.","journal-title":"Int J Comput Vision"},{"key":"1425_CR43","doi-asserted-by":"crossref","unstructured":"Das P and Ortega A. Gradient-weighted class activation mapping for spatio temporal graph convolutional network. In: ICASSP 2022 - 2022 IEEE International Conference on Acoustics, Speech and Signal Processing (ICASSP). 2022, pp.4043\u20137.","DOI":"10.1109\/ICASSP43922.2022.9746621"},{"key":"1425_CR44","first-page":"2579","volume":"9","author":"Lvd Maaten","year":"2008","unstructured":"Maaten Lvd, Hinton GEJ. Visualizing data using t-SNE. J Mach Learn Res. 2008;9:2579\u2013605.","journal-title":"J Mach Learn Res"},{"issue":"7","key":"1425_CR45","doi-asserted-by":"publisher","first-page":"e68910","DOI":"10.1371\/journal.pone.0068910","volume":"8","author":"M Xia","year":"2013","unstructured":"Xia M, Wang J, He Y. BrainNet Viewer: a network visualization tool for human brain connectomics. PLoS ONE. 2013;8(7):e68910. https:\/\/doi.org\/10.1371\/journal.pone.0068910.","journal-title":"PLoS ONE"},{"key":"1425_CR46","doi-asserted-by":"publisher","first-page":"1038","DOI":"10.1016\/j.neuroimage.2016.09.046","volume":"146","author":"J Kawahara","year":"2017","unstructured":"Kawahara J, Brown CJ, Miller SP, Booth BG, Chau V, Grunau RE, et al. BrainNetCNN: Convolutional neural networks for brain networks; towards predicting neurodevelopment. Neuroimage. 2017;146:1038\u201349. https:\/\/doi.org\/10.1016\/j.neuroimage.2016.09.046.","journal-title":"Neuroimage"},{"key":"1425_CR47","doi-asserted-by":"publisher","unstructured":"Kingma DP, Ba JJC. Adam: A Method for Stochastic Optimization. arXiv preprint, arXiv:1412.6980. 2014. https:\/\/doi.org\/10.48550\/arXiv.1412.6980.","DOI":"10.48550\/arXiv.1412.6980"},{"key":"1425_CR48","unstructured":"Paszke A, Gross S, Chintala S, Chanan G, Yang E, De Vito Z, et al. Automatic differentiation in PyTorch. 2017."},{"key":"1425_CR49","doi-asserted-by":"publisher","first-page":"3","DOI":"10.3390\/brainsci12030368","volume":"12","author":"J Wei","year":"2022","unstructured":"Wei J, Wang X, Cui X, Wang B, Xue J, Niu Y, et al. Functional integration and segregation in a multilayer network model of patients with schizophrenia. Brain Sci. 2022;12:3. https:\/\/doi.org\/10.3390\/brainsci12030368.","journal-title":"Brain Sci."},{"issue":"8","key":"1425_CR50","doi-asserted-by":"publisher","first-page":"e774","DOI":"10.1212\/wnl.0000000000008867","volume":"94","author":"VR Mishra","year":"2020","unstructured":"Mishra VR, Sreenivasan KR, Yang Z, Zhuang X, Cordes D, Mari Z, et al. Unique white matter structural connectivity in early-stage drug-naive Parkinson disease. Neurology. 2020;94(8):e774\u201384. https:\/\/doi.org\/10.1212\/wnl.0000000000008867.","journal-title":"Neurology"},{"key":"1425_CR51","volume-title":"Introduction to mediation, moderation, and conditional process analysis: a regression-based approach","author":"AF Hayes","year":"2013","unstructured":"Hayes AF. Introduction to mediation, moderation, and conditional process analysis: a regression-based approach. New York: Guilford Press; 2013."},{"issue":"6","key":"1425_CR52","doi-asserted-by":"publisher","first-page":"e1000100","DOI":"10.1371\/journal.pcbi.1000100","volume":"4","author":"K Supekar","year":"2008","unstructured":"Supekar K, Menon V, Rubin D, Musen M, Greicius MD. Network analysis of intrinsic functional brain connectivity in Alzheimer\u2019s disease. PLoS Comput Biol. 2008;4(6):e1000100. https:\/\/doi.org\/10.1371\/journal.pcbi.1000100.","journal-title":"PLoS Comput Biol"},{"issue":"6","key":"1425_CR53","doi-asserted-by":"publisher","first-page":"511","DOI":"10.1212\/WNL.0b013e31820af94e","volume":"76","author":"JR Petrella","year":"2011","unstructured":"Petrella JR, Sheldon FC, Prince SE, Calhoun VD, Doraiswamy PM. Default mode network connectivity in stable vs progressive mild cognitive impairment. Neurology. 2011;76(6):511\u20137. https:\/\/doi.org\/10.1212\/WNL.0b013e31820af94e.","journal-title":"Neurology"},{"key":"1425_CR54","doi-asserted-by":"publisher","first-page":"471","DOI":"10.1016\/j.dadm.2018.06.002","volume":"10","author":"CA Fredericks","year":"2018","unstructured":"Fredericks CA, Sturm VE, Brown JA, Hua AY, Bilgel M, Wong DF, et al. Early affective changes and increased connectivity in preclinical Alzheimer\u2019s disease. Alzheimer\u2019s & dementia (Amsterdam, Netherlands). 2018;10:471\u20139. https:\/\/doi.org\/10.1016\/j.dadm.2018.06.002.","journal-title":"Alzheimer\u2019s & dementia (Amsterdam, Netherlands)"},{"issue":"10","key":"1425_CR55","doi-asserted-by":"publisher","first-page":"683","DOI":"10.1038\/nrn3801","volume":"15","author":"CJ Stam","year":"2014","unstructured":"Stam CJ. Modern network science of neurological disorders. Nat Rev Neurosci. 2014;15(10):683\u201395. https:\/\/doi.org\/10.1038\/nrn3801.","journal-title":"Nat Rev Neurosci"},{"key":"1425_CR56","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1016\/j.neuroimage.2013.05.011","volume":"81","author":"K Hahn","year":"2013","unstructured":"Hahn K, Myers N, Prigarin S, Rodenacker K, Kurz A, F\u00f6rstl H, et al. Selectively and progressively disrupted structural connectivity of functional brain networks in Alzheimer\u2019s disease - revealed by a novel framework to analyze edge distributions of networks detecting disruptions with strong statistical evidence. Neuroimage. 2013;81:96\u2013109. https:\/\/doi.org\/10.1016\/j.neuroimage.2013.05.011.","journal-title":"Neuroimage"},{"key":"1425_CR57","doi-asserted-by":"publisher","first-page":"106240","DOI":"10.1016\/j.compbiomed.2022.106240","volume":"151 Pt A","author":"A Alorf","year":"2022","unstructured":"Alorf A, Khan MUG. Multi-label classification of Alzheimer\u2019s disease stages from resting-state fMRI-based correlation connectivity data and deep learning. Comput Biol Med. 2022;151 Pt A:106240. https:\/\/doi.org\/10.1016\/j.compbiomed.2022.106240.","journal-title":"Comput Biol Med."},{"key":"1425_CR58","doi-asserted-by":"publisher","first-page":"262","DOI":"10.1016\/j.brainres.2017.10.025","volume":"1678","author":"Q Zhao","year":"2018","unstructured":"Zhao Q, Lu H, Metmer H, Li WXY, Lu J. Evaluating functional connectivity of executive control network and frontoparietal network in Alzheimer\u2019s disease. Brain Res. 2018;1678:262\u201372. https:\/\/doi.org\/10.1016\/j.brainres.2017.10.025.","journal-title":"Brain Res"},{"issue":"3","key":"1425_CR59","doi-asserted-by":"publisher","first-page":"284","DOI":"10.1016\/j.jalz.2011.12.006","volume":"9","author":"JN Browndyke","year":"2013","unstructured":"Browndyke JN, Giovanello K, Petrella J, Hayden K, Chiba-Falek O, Tucker KA, et al. Phenotypic regional functional imaging patterns during memory encoding in mild cognitive impairment and Alzheimer\u2019s disease. Alzheimer\u2019s Dement. 2013;9(3):284\u201394. https:\/\/doi.org\/10.1016\/j.jalz.2011.12.006.","journal-title":"Alzheimer\u2019s Dement"},{"issue":"3","key":"1425_CR60","doi-asserted-by":"publisher","first-page":"1217","DOI":"10.1002\/hbm.22689","volume":"36","author":"HJ Li","year":"2015","unstructured":"Li HJ, Hou XH, Liu HH, Yue CL, He Y, Zuo XN. Toward systems neuroscience in mild cognitive impairment and Alzheimer\u2019s disease: a meta-analysis of 75 fMRI studies. Hum Brain Mapp. 2015;36(3):1217\u201332. https:\/\/doi.org\/10.1002\/hbm.22689.","journal-title":"Hum Brain Mapp"},{"key":"1425_CR61","doi-asserted-by":"publisher","first-page":"1333","DOI":"10.3389\/fnins.2019.01333","volume":"13","author":"Y Yu","year":"2019","unstructured":"Yu Y, Li Z, Lin Y, Yu J, Peng G, Zhang K, et al. Depression affects intrinsic brain activity in patients with mild cognitive impairment. Front Neurosci. 2019;13:1333. https:\/\/doi.org\/10.3389\/fnins.2019.01333.","journal-title":"Front Neurosci"},{"issue":"10284","key":"1425_CR62","doi-asserted-by":"publisher","first-page":"1577","DOI":"10.1016\/s0140-6736(20)32205-4","volume":"397","author":"P Scheltens","year":"2021","unstructured":"Scheltens P, De Strooper B, Kivipelto M, Holstege H, Ch\u00e9telat G, Teunissen CE, et al. Alzheimer\u2019s disease. Lancet (London, England). 2021;397(10284):1577\u201390. https:\/\/doi.org\/10.1016\/s0140-6736(20)32205-4.","journal-title":"Lancet (London, England)"},{"key":"1425_CR63","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1016\/j.neurobiolaging.2020.08.007","volume":"96","author":"PR Millar","year":"2020","unstructured":"Millar PR, Ances BM, Gordon BA, Benzinger TLS, Fagan AM, Morris JC, et al. Evaluating resting-state BOLD variability in relation to biomarkers of preclinical Alzheimer\u2019s disease. Neurobiol Aging. 2020;96:233\u201345. https:\/\/doi.org\/10.1016\/j.neurobiolaging.2020.08.007.","journal-title":"Neurobiol Aging"}],"container-title":["Alzheimer's Research &amp; Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13195-024-01425-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s13195-024-01425-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13195-024-01425-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,17]],"date-time":"2024-03-17T04:02:08Z","timestamp":1710648128000},"score":1,"resource":{"primary":{"URL":"https:\/\/alzres.biomedcentral.com\/articles\/10.1186\/s13195-024-01425-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3,14]]},"references-count":63,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["1425"],"URL":"https:\/\/doi.org\/10.1186\/s13195-024-01425-8","relation":{},"ISSN":["1758-9193"],"issn-type":[{"value":"1758-9193","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,3,14]]},"assertion":[{"value":"20 July 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 March 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 March 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All the procedures involving human subjects were performed following the Helsinki Declaration. All the patients and\/or their legal representatives gave informed written consent and the inclusion in the study was approved by the local Ethics Committee.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interest.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"60"}}