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The effects of AD and DLB on MTL metabolism were evaluated using general linear models (GLMs). Associations between MTL metabolism, cognition, and clinical features were evaluated using GLMs or logistic regression models separately performed for the AD spectrum (NC\u2009+\u2009AD\u2009+\u2009MD), DLB spectrum (NC\u2009+\u2009DLB\u2009+\u2009MD), and disease groups (AD\u2009+\u2009DLB\u2009+\u2009MD). Covariates included age, sex, and education.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>AD was associated with hippocampal\/entorhinal hypometabolism, whereas DLB was associated with relative amygdalar\/hippocampal hypermetabolism. Relative MTL hypermetabolism was associated with lower attention\/visuospatial\/executive scores and severe parkinsonism in both the AD and DLB spectra and disease groups. Left hippocampal\/entorhinal hypometabolism was associated with lower verbal memory scores, whereas right hippocampal hypometabolism was associated with lower visual memory scores in both the AD spectrum and disease groups. Relative MTL hypermetabolism was associated with an increased risk of CF and VH in the disease group, and relative amygdalar hypermetabolism was associated with an increased risk of VH in the DLB spectrum.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>Entorhinal-hippocampal hypometabolism and relative amygdala-hippocampal hypermetabolism could be characteristics of AD- and DLB-related neurodegeneration, respectively.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s13195-024-01429-4","type":"journal-article","created":{"date-parts":[[2024,4,23]],"date-time":"2024-04-23T10:02:24Z","timestamp":1713866544000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Alteration of medial temporal lobe metabolism related to Alzheimer\u2019s disease and dementia with lewy bodies"],"prefix":"10.1186","volume":"16","author":[{"given":"Sungwoo","family":"Kang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seun","family":"Jeon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young-gun","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Byoung Seok","family":"Ye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,4,23]]},"reference":[{"issue":"3","key":"1429_CR1","doi-asserted-by":"publisher","first-page":"378","DOI":"10.1111\/j.1750-3639.2000.tb00269.x","volume":"10","author":"RL Hamilton","year":"2000","unstructured":"Hamilton RL. 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