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This study aimed to test the association of retinal microvascular abnormalities in mid and late life and late life cerebral amyloid.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>Participants from the ARIC\u2010PET (Atherosclerosis Risk in Communities\u2010Positron Emission Tomography) study with a valid retinal measure (<jats:italic>N<\/jats:italic>\u2009=\u2009285) were included. The associations of mid- and late-life retinal signs with late-life amyloid-\u03b2 (A\u03b2) by florbetapir PET were tested. Two different measures of A\u03b2 burden were included: (1) elevated amyloid (SUVR\u2009&gt;\u20091.2) and (2) continuous amyloid SUVR. The retinal measures\u2019 association with A\u03b2 burden was assessed using logistic and robust linear regression models. A newly created retinal score, incorporating multiple markers of retinal abnormalities, was also evaluated in association with greater A\u03b2 burden.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Retinopathy in midlife (<jats:italic>OR<\/jats:italic> (95% CI)\u2009=\u20090.36 (0.08, 1.40)) was not significantly associated with elevated amyloid burden. In late life, retinopathy was associated with increased continuous amyloid standardized value uptake ratio (SUVR) (<jats:italic>\u03b2<\/jats:italic> (95%CI)\u2009=\u20090.16 (0.02, 0.32)) but not elevated amyloid burden (<jats:italic>OR<\/jats:italic> (95%CI)\u2009=\u20092.37 (0.66, 9.88)) when accounting for demographic, genetic and clinical risk factors. A high retinal score in late life, indicating a higher burden of retinal abnormalities, was also significantly associated with increased continuous amyloid SUVR (<jats:italic>\u03b2<\/jats:italic> (95% CI)\u2009=\u20090.16 (0.04, 0.32)) independent of vascular risk factors.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>Retinopathy in late life may be an easily obtainable marker to help evaluate the mechanistic vascular pathway between retinal measures and dementia, perhaps acting via AD pathogenesis. Well-powered future studies with a greater number of retinal features and other microvascular signs are needed to test these findings.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s13195-024-01461-4","type":"journal-article","created":{"date-parts":[[2024,5,6]],"date-time":"2024-05-06T04:01:51Z","timestamp":1714968111000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Association between retinal microvascular abnormalities\u00a0and late-life\u00a0brain amyloid-\u03b2 deposition: the ARIC-PET study"],"prefix":"10.1186","volume":"16","author":[{"given":"Marco","family":"Egle","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer A.","family":"Deal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keenan A.","family":"Walker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dean F.","family":"Wong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. 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The study was performed in accordance with the ethical standards as laid down in the 1964 Declaration of Helsinki and its later amendments or comparable ethical standards. Diversity, equity, and inclusion (DEI) was addressed in the study design, execution, and interpretation. Participants came from multiple study centers across the US characterized by varying economic and racial profiles. When analyzing and interpreting the results, the study accounted for differences in age, sex, and race.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"100"}}