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Prescription medication use may provide insights into early signs and symptoms, which may help facilitate timely diagnosis.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>In a register-based nested case-control study, we examined medication use for everyone diagnosed with YOAD in a Danish memory clinic during 2016\u20132020 compared to cognitively healthy controls. Prescription medication use were grouped into 13 overall categories (<jats:italic>alimentary tract and metabolism, blood and blood forming organs, cardiovascular system, dermatologicals, genitourinary system and sex hormones, systemic hormonal preparations, antiinfectives for systemic use, antineoplastic and immunomodulating agents, musculo-skeletal system, nervous system, antiparasitic products, respiratory system<\/jats:italic>, and <jats:italic>sensory organs<\/jats:italic>). Further stratifications were done for predetermined subcategories with a use-prevalence of at least 5% in the study population. Conditional logistic regression produced odds ratios, which given the use of incidence-density matching is interpretable as incidence rate ratios (IRRs). The association between prescription medication use and subsequent YOAD diagnosis was examined in the entire 10-year study period and in three time-intervals.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>The study included 1745 YOAD cases and 5235 controls. In the main analysis, several overall categories showed significant associations with YOAD in one or more time-intervals, namely <jats:italic>blood and blood forming organs<\/jats:italic> and <jats:italic>nervous system<\/jats:italic>. Prescription medication use in the <jats:italic>nervous system<\/jats:italic> category was increased for YOAD cases compared to controls already 10-&gt;5 years prior to diagnosis (IRR 1.17, 95% CI 1.05\u20131.31), increasing to 1.57 (95% CI 1.39\u20131.78) in the year preceding diagnosis. This was largely driven by antidepressant and antipsychotic use, and especially prominent for first-time users.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>In this study, medication use in several categories was associated with YOAD. Onset of treatment-requiring psychiatric symptoms such as depression or psychosis in mid-life may serve as potential early indicators of YOAD.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s13195-024-01523-7","type":"journal-article","created":{"date-parts":[[2024,7,5]],"date-time":"2024-07-05T06:02:08Z","timestamp":1720159328000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Prescription medication use in the 10 years prior to diagnosis of young onset Alzheimer\u2019s disease: a nationwide nested case-control study"],"prefix":"10.1186","volume":"16","author":[{"given":"Line","family":"Damsgaard","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janet","family":"Janbek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas Munk","family":"Laursen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karsten","family":"Vestergaard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanne","family":"Gottrup","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina","family":"Jensen-Dahm","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gunhild","family":"Waldemar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,7,5]]},"reference":[{"issue":"11","key":"1523_CR1","doi-asserted-by":"publisher","first-page":"1217","DOI":"10.1002\/gps.4430","volume":"31","author":"B Draper","year":"2016","unstructured":"Draper B, Cations M, White F, et al. 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