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We evaluated the feasibility, test-retest reliability, and association with AD-related amyloid-beta (A\u03b2) pathology of speech acoustics measured over multiple assessments in a remote setting.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>Fifty cognitively unimpaired adults (Age 68\u2009\u00b1\u20096.2 years, 58% female, 46% A\u03b2-positive) completed remote, tablet-based speech assessments (i.e., picture description, journal-prompt storytelling, verbal fluency tasks) for five days. The testing paradigm was repeated after 2\u20133 weeks. Acoustic speech features were automatically extracted from the voice recordings, and mean scores were calculated over the 5-day period. We assessed feasibility by adherence rates and usability ratings on the System Usability Scale (SUS) questionnaire. Test-retest reliability was examined with intraclass correlation coefficients (ICCs). We investigated the associations between acoustic features and A\u03b2-pathology, using linear regression models, adjusted for age, sex and education.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>The speech assessment was feasible, indicated by 91.6% adherence and usability scores of 86.0\u2009\u00b1\u20099.9. High reliability (ICC\u2009\u2265\u20090.75) was found across averaged speech samples. A\u03b2-positive individuals displayed a higher pause-to-word ratio in picture description (<jats:italic>B<\/jats:italic> = -0.05, <jats:italic>p<\/jats:italic>\u2009=\u20090.040) and journal-prompt storytelling (<jats:italic>B<\/jats:italic> = -0.07, <jats:italic>p<\/jats:italic>\u2009=\u20090.032) than A\u03b2-negative individuals, although this effect lost significance after correction for multiple testing.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>Our findings support the feasibility and reliability of multi-day remote assessment of speech acoustics in cognitively unimpaired individuals with and without A\u03b2-pathology, which lays the foundation for the use of speech biomarkers in the context of early AD.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s13195-024-01543-3","type":"journal-article","created":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T04:15:42Z","timestamp":1722485742000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Digital remote assessment of speech acoustics in cognitively unimpaired adults: feasibility, reliability and associations with amyloid pathology"],"prefix":"10.1186","volume":"16","author":[{"given":"Rosanne L.","family":"van den Berg","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Casper","family":"de Boer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marissa D.","family":"Zwan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roos J.","family":"Jutten","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariska","family":"van Liere","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie-Christine A.B.J.","family":"van de Glind","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark A.","family":"Dubbelman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa Marie","family":"Schl\u00fcter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Argonde C.","family":"van Harten","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charlotte E.","family":"Teunissen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elsmarieke","family":"van de Giessen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frederik","family":"Barkhof","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lyduine E.","family":"Collij","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica","family":"Robin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William","family":"Simpson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John E","family":"Harrison","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wiesje M.","family":"van der Flier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sietske A.M.","family":"Sikkes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,8,1]]},"reference":[{"key":"1543_CR1","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1186\/s12915-017-0405-3","volume":"15","author":"M Pagel","year":"2017","unstructured":"Pagel M, Q&A. 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The study was reviewed by the Medical Ethics Committee of the VU University Medical Center, Amsterdam UMC (2021.0228). All participants provided written informed consent to participate in the study, and to publish unidentifiable data.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval, consent to participate, and consent to publication"}},{"value":"FB is a member of the steering committee or Data Safety Monitoring Board member for Biogen, Merck, Eisai and Prothena, an advisory board member for Combinostics, Scottish Brain Sciences, a consultant for Roche, Celltrion, Rewind Therapeutics, Merck, Bracco. FB has research agreements with ADDI, Merck, Biogen, GE Healthcare, Roche, and is a co-founder and shareholder of Queen Square Analytics LTD. JR and WS are employees of and share holders in Cambridge Cognition (and previously, Winterlight Labs). JH is an employee and share holder in Scottish Brain Sciences and a paid consultant to Cambridge Cognition, owners of the the Winterlight system.SS is a scientific advisory board member of Prothena Biosciences and Cogstate, provides consultancy services to Aribio Co LTD and Biogen, and receives license fees from Brain Research Center, Green Valley, VtV Therapeutics, Alzheon, Vivoryon and Roche, and the developer of the Amsterdam IADL. All license fees are for the organization.Research programs of WF have been funded by ZonMW, NWO, EU-JPND, EU-IHI, Alzheimer Nederland, Hersenstichting CardioVascular Onderzoek Nederland, Health~Holland, Topsector Life Sciences & Health, stichting Dioraphte, Gieskes-Strijbis fonds, stichting Equilibrio, Edwin Bouw fonds, Pasman stichting, stichting Alzheimer & Neuropsychiatrie Foundation, Philips, Biogen MA Inc, Novartis-NL, Life-MI, AVID, Roche BV, Fujifilm, Eisai, Combinostics. WF holds the Pasman chair. WF is recipient of ABOARD, which is a public-private partnership receiving funding from ZonMW (#73305095007) and Health~Holland, Topsector Life Sciences & Health (PPP-allowance; #LSHM20106). WF is recipient of TAP-dementia (www.tap-dementia.nl), receiving funding from ZonMw (#10510032120003). TAP-dementia receives co-financing from Avid Radiopharmaceuticals and Amprion. All funding is paid to her institution. WF has been an invited speaker at Biogen MA Inc, Danone, Eisai, WebMD Neurology (Medscape), NovoNordisk, Springer Healthcare, European Brain Council. WF is consultant to Oxford Health Policy Forum CIC, Roche, Biogen MA Inc, and Eisai. WF participated in advisory boards of Biogen MA Inc, Roche, and Eli Lilly. WF is member of the steering committee of EVOKE\/EVOKE+ (NovoNordisk). All funding is paid to her institution. WF is member of the steering committee of PAVE, and Think Brain Health. WF was associate editor of Alzheimer, Research & Therapy in 2020\/2021. 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