{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T02:20:54Z","timestamp":1790389254872,"version":"4.1.0"},"reference-count":48,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,8,19]],"date-time":"2024-08-19T00:00:00Z","timestamp":1724025600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2024,8,19]],"date-time":"2024-08-19T00:00:00Z","timestamp":1724025600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"name":"1.3.5 Project of West China Hospital of Sichuan University","award":["2023HXFH043"],"award-info":[{"award-number":["2023HXFH043"]}]},{"name":"the Foundation of Science and Technology Department of Sichuan Province","award":["2023NSFSC1668"],"award-info":[{"award-number":["2023NSFSC1668"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Alz Res Therapy"],"DOI":"10.1186\/s13195-024-01551-3","type":"journal-article","created":{"date-parts":[[2024,8,19]],"date-time":"2024-08-19T09:03:04Z","timestamp":1724058184000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Association of outer retinal and choroidal alterations with neuroimaging and clinical features in posterior cortical atrophy"],"prefix":"10.1186","volume":"16","author":[{"given":"Yuzhu","family":"Gao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruihan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kefan","family":"Mou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yifan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanyue","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yilin","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunxia","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyue","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Bao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qin","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongbo","family":"Yin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,8,19]]},"reference":[{"key":"1551_CR1","doi-asserted-by":"publisher","first-page":"789","DOI":"10.1001\/archneur.1988.00520310107024","volume":"45","author":"DF Benson","year":"1988","unstructured":"Benson DF, Davis RJ, Snyder BD. Posterior cortical atrophy. Arch Neurol. 1988;45:789\u201393. https:\/\/doi.org\/10.1001\/archneur.1988.00520310107024.","journal-title":"Arch Neurol"},{"key":"1551_CR2","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1016\/S1474-4422(11)70289-7","volume":"11","author":"SJ Crutch","year":"2012","unstructured":"Crutch SJ, Lehmann M, Schott JM, et al. Posterior cortical atrophy. Lancet Neurol. 2012;11:170\u20138. https:\/\/doi.org\/10.1016\/S1474-4422(11)70289-7.","journal-title":"Lancet Neurol"},{"key":"1551_CR3","doi-asserted-by":"publisher","first-page":"835","DOI":"10.1016\/s0010-9452(08)70683-x","volume":"43","author":"JS Snowden","year":"2007","unstructured":"Snowden JS, Stopford CL, Julien CL, et al. Cognitive phenotypes in Alzheimer\u2019s disease and genetic risk. Cortex. 2007;43:835\u201345. https:\/\/doi.org\/10.1016\/s0010-9452(08)70683-x.","journal-title":"Cortex"},{"key":"1551_CR4","doi-asserted-by":"publisher","first-page":"1401","DOI":"10.3233\/JAD-2010-1337","volume":"19","author":"EL Koedam","year":"2010","unstructured":"Koedam EL, Lauffer V, van der Vlies AE, et al. Early-versus late-onset Alzheimer\u2019s disease: more than age alone. J Alzheimers Dis. 2010;19:1401\u20138. https:\/\/doi.org\/10.3233\/JAD-2010-1337.","journal-title":"J Alzheimers Dis"},{"key":"1551_CR5","doi-asserted-by":"publisher","first-page":"168","DOI":"10.1016\/S1474-4422(23)00414-3","volume":"23","author":"M Chapleau","year":"2024","unstructured":"Chapleau M, La Joie R, Yong K, et al. Demographic, clinical, biomarker, and neuropathological correlates of posterior cortical atrophy: an international cohort study and individual participant data meta-analysis. Lancet Neurol. 2024;23:168\u201377. https:\/\/doi.org\/10.1016\/S1474-4422(23)00414-3.","journal-title":"Lancet Neurol"},{"key":"1551_CR6","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1016\/S1474-4422(23)00501-X","volume":"23","author":"A Bejanin","year":"2024","unstructured":"Bejanin A, Villain N. Posterior cortical atrophy: new insights into treatments and biomarkers for Alzheimer\u2019s disease. Lancet Neurol. 2024;23:127\u20138. https:\/\/doi.org\/10.1016\/S1474-4422(23)00501-X.","journal-title":"Lancet Neurol"},{"key":"1551_CR7","doi-asserted-by":"publisher","first-page":"870","DOI":"10.1016\/j.jalz.2017.01.014","volume":"13","author":"SJ Crutch","year":"2017","unstructured":"Crutch SJ, Schott JM, Rabinovici GD, et al. Consensus classification of posterior cortical atrophy. Alzheimers Dement. 2017;13:870\u201384. https:\/\/doi.org\/10.1016\/j.jalz.2017.01.014.","journal-title":"Alzheimers Dement"},{"key":"1551_CR8","doi-asserted-by":"publisher","first-page":"526","DOI":"10.1212\/01.wnl.0000228222.17111.2a","volume":"67","author":"WM van der Flier","year":"2006","unstructured":"van der Flier WM, Schoonenboom SN, Pijnenburg YA, et al. The effect of APOE genotype on clinical phenotype in Alzheimer disease. Neurology. 2006;67:526\u20137. https:\/\/doi.org\/10.1212\/01.wnl.0000228222.17111.2a.","journal-title":"Neurology"},{"key":"1551_CR9","doi-asserted-by":"publisher","unstructured":"Liu CC, Zhao N, Fu Y et al.,. ApoE4 Accelerates Early Seeding of Amyloid Pathology. Neuron 2017;96:1024-32 e3https:\/\/doi.org\/10.1016\/j.neuron.2017.11.013.","DOI":"10.1016\/j.neuron.2017.11.013"},{"key":"1551_CR10","doi-asserted-by":"publisher","DOI":"10.1002\/alz.12711","author":"NA Singh","year":"2022","unstructured":"Singh NA, Tosakulwong N, Graff-Radford J, et al. APOE epsilon4 influences medial temporal atrophy and tau deposition in atypical Alzheimer\u2019s disease. Alzheimers Dement. 2022. https:\/\/doi.org\/10.1002\/alz.12711.","journal-title":"Alzheimers Dement"},{"key":"1551_CR11","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1186\/s13195-020-00710-6","volume":"12","author":"MS Baek","year":"2020","unstructured":"Baek MS, Cho H, Lee HS, et al. Effect of APOE epsilon4 genotype on amyloid-beta and tau accumulation in Alzheimer\u2019s disease. Alzheimers Res Ther. 2020;12:140. https:\/\/doi.org\/10.1186\/s13195-020-00710-6.","journal-title":"Alzheimers Res Ther"},{"key":"1551_CR12","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1146\/annurev-pathmechdis-030421-112756","volume":"17","author":"N Koutsodendris","year":"2022","unstructured":"Koutsodendris N, Nelson MR, Rao A, Huang Y, Apolipoprotein E. Alzheimer\u2019s Disease: findings, hypotheses, and potential mechanisms. Annu Rev Pathol. 2022;17:73\u201399. https:\/\/doi.org\/10.1146\/annurev-pathmechdis-030421-112756.","journal-title":"Annu Rev Pathol"},{"key":"1551_CR13","doi-asserted-by":"publisher","first-page":"1455","DOI":"10.1212\/WNL.0000000000000335","volume":"82","author":"MM Carrasquillo","year":"2014","unstructured":"Carrasquillo MM, Khan Q, Murray ME, et al. Late-onset Alzheimer disease genetic variants in posterior cortical atrophy and posterior AD. Neurology. 2014;82:1455\u201362. https:\/\/doi.org\/10.1212\/WNL.0000000000000335.","journal-title":"Neurology"},{"key":"1551_CR14","doi-asserted-by":"publisher","first-page":"862","DOI":"10.1016\/j.jalz.2016.01.010","volume":"12","author":"JM Schott","year":"2016","unstructured":"Schott JM, Crutch SJ, Carrasquillo MM, et al. Genetic risk factors for the posterior cortical atrophy variant of Alzheimer\u2019s disease. Alzheimers Dement. 2016;12:862\u201371. https:\/\/doi.org\/10.1016\/j.jalz.2016.01.010.","journal-title":"Alzheimers Dement"},{"key":"1551_CR15","doi-asserted-by":"publisher","first-page":"3858","DOI":"10.1002\/alz.13059","volume":"19","author":"NA Singh","year":"2023","unstructured":"Singh NA, Martin PR, Graff-Radford J, et al. APOE epsilon4 influences within and between network functional connectivity in posterior cortical atrophy and logopenic progressive aphasia. Alzheimers Dement. 2023;19:3858\u201366. https:\/\/doi.org\/10.1002\/alz.13059.","journal-title":"Alzheimers Dement"},{"key":"1551_CR16","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1186\/s12886-021-02143-7","volume":"22","author":"Y Gao","year":"2022","unstructured":"Gao Y, Kwapong WR, Zhang Y, et al. Retinal microvascular changes in white matter hyperintensities investigated by swept source optical coherence tomography angiography. BMC Ophthalmol. 2022;22:77. https:\/\/doi.org\/10.1186\/s12886-021-02143-7.","journal-title":"BMC Ophthalmol"},{"key":"1551_CR17","doi-asserted-by":"publisher","DOI":"10.1097\/WNO.0000000000001970","author":"Y Gao","year":"2023","unstructured":"Gao Y, Liu Y, Zhang Y, et al. Assessment of Outer Retina and Choroid using swept source optical coherence tomography and angiography in patients with multiple sclerosis. J Neuroophthalmol. 2023. https:\/\/doi.org\/10.1097\/WNO.0000000000001970.","journal-title":"J Neuroophthalmol"},{"key":"1551_CR18","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1002\/alz.12179","volume":"17","author":"PJ Snyder","year":"2021","unstructured":"Snyder PJ, Alber J, Alt C, et al. Retinal imaging in Alzheimer\u2019s and neurodegenerative diseases. Alzheimers Dement. 2021;17:103\u201311. https:\/\/doi.org\/10.1002\/alz.12179.","journal-title":"Alzheimers Dement"},{"key":"1551_CR19","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1186\/s13195-022-01054-z","volume":"14","author":"Y Zhang","year":"2022","unstructured":"Zhang Y, Yang L, Gao Y, et al. Choroid and choriocapillaris changes in early-stage Parkinson\u2019s disease: a swept-source optical coherence tomography angiography-based cross-sectional study. Alzheimers Res Ther. 2022;14:116. https:\/\/doi.org\/10.1186\/s13195-022-01054-z.","journal-title":"Alzheimers Res Ther"},{"key":"1551_CR20","doi-asserted-by":"publisher","first-page":"100899","DOI":"10.1016\/j.preteyeres.2020.100899","volume":"82","author":"VB Gupta","year":"2021","unstructured":"Gupta VB, Chitranshi N, den Haan J, et al. Retinal changes in Alzheimer\u2019s disease- integrated prospects of imaging, functional and molecular advances. Prog Retin Eye Res. 2021;82:100899. https:\/\/doi.org\/10.1016\/j.preteyeres.2020.100899.","journal-title":"Prog Retin Eye Res"},{"key":"1551_CR21","doi-asserted-by":"publisher","first-page":"409","DOI":"10.1007\/s00401-023-02548-2","volume":"145","author":"Y Koronyo","year":"2023","unstructured":"Koronyo Y, Rentsendorj A, Mirzaei N, et al. Retinal pathological features and proteome signatures of Alzheimer\u2019s disease. Acta Neuropathol. 2023;145:409\u201338. https:\/\/doi.org\/10.1007\/s00401-023-02548-2.","journal-title":"Acta Neuropathol"},{"key":"1551_CR22","doi-asserted-by":"publisher","first-page":"59","DOI":"10.3233\/JAD-2009-1045","volume":"17","author":"N Origlia","year":"2009","unstructured":"Origlia N, Capsoni S, Cattaneo A, et al. Abeta-dependent inhibition of LTP in different intracortical circuits of the visual cortex: the role of RAGE. J Alzheimers Dis. 2009;17:59\u201368. https:\/\/doi.org\/10.3233\/JAD-2009-1045.","journal-title":"J Alzheimers Dis"},{"key":"1551_CR23","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1186\/s13195-024-01431-w","volume":"16","author":"Y Sun","year":"2024","unstructured":"Sun Y, Zhang L, Ye H, et al. Potential ocular indicators to distinguish posterior cortical atrophy and typical Alzheimer\u2019s disease: a cross-section study using optical coherence tomography angiography. Alzheimers Res Ther. 2024;16:64. https:\/\/doi.org\/10.1186\/s13195-024-01431-w.","journal-title":"Alzheimers Res Ther"},{"key":"1551_CR24","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1186\/s13195-019-0516-x","volume":"11","author":"J den Haan","year":"2019","unstructured":"den Haan J, Csinscik L, Parker T, et al. Retinal thickness as potential biomarker in posterior cortical atrophy and typical Alzheimer\u2019s disease. Alzheimers Res Ther. 2019;11:62. https:\/\/doi.org\/10.1186\/s13195-019-0516-x.","journal-title":"Alzheimers Res Ther"},{"key":"1551_CR25","doi-asserted-by":"publisher","first-page":"e0250440","DOI":"10.1371\/journal.pone.0250440","volume":"16","author":"LY Wen","year":"2021","unstructured":"Wen LY, Wan L, Lai JN, et al. Increased risk of Alzheimer\u2019s disease among patients with age-related macular degeneration: a nationwide population-based study. PLoS ONE. 2021;16:e0250440. https:\/\/doi.org\/10.1371\/journal.pone.0250440.","journal-title":"PLoS ONE"},{"key":"1551_CR26","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1001\/jamaophthalmol.2023.6014","volume":"142","author":"SS Sutton","year":"2024","unstructured":"Sutton SS, Magagnoli J, Cummings TH, et al. Alzheimer Disease Treatment with acetylcholinesterase inhibitors and Incident Age-Related Macular Degeneration. JAMA Ophthalmol. 2024;142:108\u201314. https:\/\/doi.org\/10.1001\/jamaophthalmol.2023.6014.","journal-title":"JAMA Ophthalmol"},{"key":"1551_CR27","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1016\/j.preteyeres.2018.12.003","volume":"70","author":"AA Bergen","year":"2019","unstructured":"Bergen AA, Arya S, Koster C, et al. On the origin of proteins in human drusen: the meet, greet and stick hypothesis. Prog Retin Eye Res. 2019;70:55\u201384. https:\/\/doi.org\/10.1016\/j.preteyeres.2018.12.003.","journal-title":"Prog Retin Eye Res"},{"key":"1551_CR28","doi-asserted-by":"publisher","first-page":"705","DOI":"10.1016\/s1350-9462(01)00010-6","volume":"20","author":"GS Hageman","year":"2001","unstructured":"Hageman GS, Luthert PJ, Victor Chong NH, et al. An integrated hypothesis that considers drusen as biomarkers of immune-mediated processes at the RPE-Bruch\u2019s membrane interface in aging and age-related macular degeneration. Prog Retin Eye Res. 2001;20:705\u201332. https:\/\/doi.org\/10.1016\/s1350-9462(01)00010-6.","journal-title":"Prog Retin Eye Res"},{"key":"1551_CR29","doi-asserted-by":"publisher","first-page":"182","DOI":"10.1159\/000487053","volume":"59","author":"L Csincsik","year":"2018","unstructured":"Csincsik L, MacGillivray TJ, Flynn E, et al. Peripheral retinal imaging biomarkers for Alzheimer\u2019s Disease: a pilot study. Ophthalmic Res. 2018;59:182\u201392. https:\/\/doi.org\/10.1159\/000487053.","journal-title":"Ophthalmic Res"},{"key":"1551_CR30","doi-asserted-by":"publisher","first-page":"e12232","DOI":"10.1002\/dad2.12232","volume":"13","author":"L Csincsik","year":"2021","unstructured":"Csincsik L, Quinn N, Yong KXX, et al. Retinal phenotyping of variants of Alzheimer\u2019s disease using ultra-widefield retinal images. Alzheimers Dement (Amst). 2021;13:e12232. https:\/\/doi.org\/10.1002\/dad2.12232.","journal-title":"Alzheimers Dement (Amst)"},{"key":"1551_CR31","doi-asserted-by":"publisher","first-page":"2123","DOI":"10.1148\/rg.2018180160","volume":"38","author":"TF Lundeen","year":"2018","unstructured":"Lundeen TF, Seibyl JP, Covington MF, et al. Signs and artifacts in amyloid PET. Radiographics. 2018;38:2123\u201333. https:\/\/doi.org\/10.1148\/rg.2018180160.","journal-title":"Radiographics"},{"key":"1551_CR32","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1016\/j.ajo.2024.03.021","volume":"265","author":"D Fang","year":"2024","unstructured":"Fang D, Liang J, Diao Y, et al. Morphologic and functional Assessment of photoreceptors in Laser-Induced Retinopathy using adaptive Optics scanning laser Ophthalmoscopy and Microperimetry. Am J Ophthalmol. 2024;265:61\u201372. https:\/\/doi.org\/10.1016\/j.ajo.2024.03.021.","journal-title":"Am J Ophthalmol"},{"key":"1551_CR33","doi-asserted-by":"publisher","unstructured":"Koronyo Y, Biggs D, Barron E, et al. Retinal amyloid pathology and proof-of-concept imaging trial in Alzheimer\u2019s disease. JCI Insight. 2017;2. https:\/\/doi.org\/10.1172\/jci.insight.93621.","DOI":"10.1172\/jci.insight.93621"},{"key":"1551_CR34","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1007\/s00401-022-02525-1","volume":"145","author":"FJ Hart de Ruyter","year":"2023","unstructured":"Hart de Ruyter FJ, Morrema THJ, den Haan J, et al. Phosphorylated tau in the retina correlates with tau pathology in the brain in Alzheimer\u2019s disease and primary tauopathies. Acta Neuropathol. 2023;145:197\u2013218. https:\/\/doi.org\/10.1007\/s00401-022-02525-1.","journal-title":"Acta Neuropathol"},{"key":"1551_CR35","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1186\/s40478-018-0650-x","volume":"6","author":"J den Haan","year":"2018","unstructured":"den Haan J, Morrema THJ, Verbraak FD, et al. Amyloid-beta and phosphorylated tau in post-mortem Alzheimer\u2019s disease retinas. Acta Neuropathol Commun. 2018;6:147. https:\/\/doi.org\/10.1186\/s40478-018-0650-x.","journal-title":"Acta Neuropathol Commun"},{"key":"1551_CR36","doi-asserted-by":"publisher","first-page":"2018","DOI":"10.1194\/jlr.R001131","volume":"51","author":"NG Bazan","year":"2010","unstructured":"Bazan NG, Calandria JM, Serhan CN. Rescue and repair during photoreceptor cell renewal mediated by docosahexaenoic acid-derived neuroprotectin D1. J Lipid Res. 2010;51:2018\u201331. https:\/\/doi.org\/10.1194\/jlr.R001131.","journal-title":"J Lipid Res"},{"key":"1551_CR37","doi-asserted-by":"publisher","first-page":"132","DOI":"10.1016\/j.survophthal.2015.11.004","volume":"61","author":"MP Simunovic","year":"2016","unstructured":"Simunovic MP. Acquired color vision deficiency. Surv Ophthalmol. 2016;61:132\u201355. https:\/\/doi.org\/10.1016\/j.survophthal.2015.11.004.","journal-title":"Surv Ophthalmol"},{"key":"1551_CR38","doi-asserted-by":"publisher","unstructured":"Sheriff S, Shen T, Saks D, et al. The Association of APOE epsilon4 allele with retinal layer thickness and microvasculature in older adults: Optic nerve decline and cognitive change study. J Clin Med. 2023;12. https:\/\/doi.org\/10.3390\/jcm12196219.","DOI":"10.3390\/jcm12196219"},{"key":"1551_CR39","doi-asserted-by":"publisher","first-page":"1847","DOI":"10.1038\/s41598-020-80892-z","volume":"11","author":"JY Shin","year":"2021","unstructured":"Shin JY, Choi EY, Kim M, et al. Changes in retinal microvasculature and retinal layer thickness in association with apolipoprotein E genotype in Alzheimer\u2019s disease. Sci Rep. 2021;11:1847. https:\/\/doi.org\/10.1038\/s41598-020-80892-z.","journal-title":"Sci Rep"},{"key":"1551_CR40","doi-asserted-by":"publisher","first-page":"1466","DOI":"10.1016\/j.neurobiolaging.2009.08.017","volume":"32","author":"M Lehmann","year":"2011","unstructured":"Lehmann M, Crutch SJ, Ridgway GR, et al. Cortical thickness and voxel-based morphometry in posterior cortical atrophy and typical Alzheimer\u2019s disease. Neurobiol Aging. 2011;32:1466\u201376. https:\/\/doi.org\/10.1016\/j.neurobiolaging.2009.08.017.","journal-title":"Neurobiol Aging"},{"key":"1551_CR41","doi-asserted-by":"publisher","first-page":"296","DOI":"10.1016\/j.survophthal.2017.09.010","volume":"63","author":"M Lawlor","year":"2018","unstructured":"Lawlor M, Danesh-Meyer H, Levin LA, et al. Glaucoma and the brain: trans-synaptic degeneration, structural change, and implications for neuroprotection. Surv Ophthalmol. 2018;63:296\u2013306. https:\/\/doi.org\/10.1016\/j.survophthal.2017.09.010.","journal-title":"Surv Ophthalmol"},{"key":"1551_CR42","doi-asserted-by":"publisher","first-page":"1714","DOI":"10.1167\/iovs.18-26086","volume":"60","author":"J Ye","year":"2019","unstructured":"Ye J, Shen M, Huang S, et al. Visual acuity in pathological myopia is correlated with the photoreceptor myoid and Ellipsoid Zone Thickness and affected by Choroid Thickness. Invest Ophthalmol Vis Sci. 2019;60:1714\u201323. https:\/\/doi.org\/10.1167\/iovs.18-26086.","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"1551_CR43","doi-asserted-by":"publisher","first-page":"6743","DOI":"10.1167\/iovs.10-6723","volume":"52","author":"RR Pappuru","year":"2011","unstructured":"Pappuru RR, Ouyang Y, Nittala MG, et al. Relationship between outer retinal thickness substructures and visual acuity in eyes with dry age-related macular degeneration. Invest Ophthalmol Vis Sci. 2011;52:6743\u20138. https:\/\/doi.org\/10.1167\/iovs.10-6723.","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"1551_CR44","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1167\/iovs.65.5.16","volume":"65","author":"C Owsley","year":"2024","unstructured":"Owsley C, McGwin G Jr., Swain TA, et al. Outer retinal thickness is Associated with cognitive function in normal aging to Intermediate Age-Related Macular Degeneration. Invest Ophthalmol Vis Sci. 2024;65:16. https:\/\/doi.org\/10.1167\/iovs.65.5.16.","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"1551_CR45","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1136\/bjo.2010.183756","volume":"95","author":"SS Choi","year":"2011","unstructured":"Choi SS, Zawadzki RJ, Lim MC, et al. Evidence of outer retinal changes in glaucoma patients as revealed by ultrahigh-resolution in vivo retinal imaging. Br J Ophthalmol. 2011;95:131\u201341. https:\/\/doi.org\/10.1136\/bjo.2010.183756.","journal-title":"Br J Ophthalmol"},{"key":"1551_CR46","doi-asserted-by":"publisher","first-page":"507","DOI":"10.3233\/JPD-223481","volume":"14","author":"A Chrysou","year":"2024","unstructured":"Chrysou A, Heikka T, van der Zee S, et al. Reduced thickness of the retina in de novo Parkinson\u2019s Disease shows a distinct pattern, different from Glaucoma. J Parkinsons Dis. 2024;14:507\u201319. https:\/\/doi.org\/10.3233\/JPD-223481.","journal-title":"J Parkinsons Dis"},{"key":"1551_CR47","doi-asserted-by":"publisher","unstructured":"Zheng G, Li J, Zhou Y et al. Outer retina and choroid as potential imaging markers for evaluation of neural impairment in early type 2 diabetic patients. Eur J Ophthalmol 202411206721241258637. https:\/\/doi.org\/10.1177\/11206721241258637","DOI":"10.1177\/11206721241258637"},{"key":"1551_CR48","doi-asserted-by":"publisher","first-page":"e422","DOI":"10.1016\/S2666-7568(24)00066-7","volume":"5","author":"M Regy","year":"2024","unstructured":"Regy M, Dugravot A, Sabia S, et al. The role of dementia in the association between APOE4 and all-cause mortality: pooled analyses of two population-based cohort studies. Lancet Healthy Longev. 2024;5:e422\u201330. https:\/\/doi.org\/10.1016\/S2666-7568(24)00066-7.","journal-title":"Lancet Healthy Longev"}],"container-title":["Alzheimer's Research & Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13195-024-01551-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s13195-024-01551-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13195-024-01551-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,19]],"date-time":"2024-08-19T09:04:32Z","timestamp":1724058272000},"score":1,"resource":{"primary":{"URL":"https:\/\/alzres.biomedcentral.com\/articles\/10.1186\/s13195-024-01551-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8,19]]},"references-count":48,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["1551"],"URL":"https:\/\/doi.org\/10.1186\/s13195-024-01551-3","relation":{},"ISSN":["1758-9193"],"issn-type":[{"value":"1758-9193","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,8,19]]},"assertion":[{"value":"22 May 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 August 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 August 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This study was audited and approved by Ethics Committee on Biomedical Research, West China Hospital of Sichuan University. All participants signed an informed consent form before the examination according to the Declaration of Helsinki.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"187"}}