{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T03:41:47Z","timestamp":1775792507008,"version":"3.50.1"},"reference-count":68,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,8,19]],"date-time":"2024-08-19T00:00:00Z","timestamp":1724025600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2024,8,19]],"date-time":"2024-08-19T00:00:00Z","timestamp":1724025600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81971032"],"award-info":[{"award-number":["81971032"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82201587"],"award-info":[{"award-number":["82201587"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Alz Res Therapy"],"DOI":"10.1186\/s13195-024-01554-0","type":"journal-article","created":{"date-parts":[[2024,8,19]],"date-time":"2024-08-19T09:03:04Z","timestamp":1724058184000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Risk factors for cognitive decline in non-demented elders with amyloid-beta positivity"],"prefix":"10.1186","volume":"16","author":[{"given":"An-Yi","family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"He-Ying","family":"Hu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liang-Yu","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chu-Yun","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiong-Yao","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lan","family":"Tan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hao","family":"Hu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,8,19]]},"reference":[{"issue":"2","key":"1554_CR1","doi-asserted-by":"publisher","first-page":"e105","DOI":"10.1016\/S2468-2667(21)00249-8","volume":"7","author":"Estimation of the global prevalence of dementia","year":"2022","unstructured":"Estimation of the global prevalence of dementia. In 2019 and forecasted prevalence in 2050: an analysis for the global burden of Disease Study 2019. Lancet Public Health. 2022;7(2):e105\u201325.","journal-title":"Lancet Public Health"},{"issue":"1","key":"1554_CR2","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1111\/ene.13439","volume":"25","author":"CA Lane","year":"2018","unstructured":"Lane CA, Hardy J, Schott JM. Alzheimer\u2019s disease. Eur J Neurol. 2018;25(1):59\u201370.","journal-title":"Eur J Neurol"},{"issue":"1","key":"1554_CR3","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1016\/S1474-4422(19)30290-X","volume":"19","author":"L Jia","year":"2020","unstructured":"Jia L, Quan M, Fu Y, Zhao T, Li Y, Wei C, et al. Dementia in China: epidemiology, clinical management, and research advances. Lancet Neurol. 2020;19(1):81\u201392.","journal-title":"Lancet Neurol"},{"issue":"5","key":"1554_CR4","doi-asserted-by":"publisher","first-page":"459","DOI":"10.1016\/S1474-4422(18)30499-X","volume":"18","author":"regional Global","year":"2019","unstructured":"Global regional, national burden of neurological disorders. 1990\u20132016: a systematic analysis for the global burden of Disease Study 2016. Lancet Neurol. 2019;18(5):459\u201380.","journal-title":"Lancet Neurol"},{"issue":"1","key":"1554_CR5","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s00401-011-0910-3","volume":"123","author":"TJ Montine","year":"2012","unstructured":"Montine TJ, Phelps CH, Beach TG, Bigio EH, Cairns NJ, Dickson DW, et al. National Institute on Aging-Alzheimer\u2019s Association guidelines for the neuropathologic assessment of Alzheimer\u2019s disease: a practical approach. Acta Neuropathol. 2012;123(1):1\u201311.","journal-title":"Acta Neuropathol"},{"issue":"2","key":"1554_CR6","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1007\/s00401-014-1375-y","volume":"129","author":"DR Thal","year":"2015","unstructured":"Thal DR, Walter J, Saido TC, F\u00e4ndrich M. Neuropathology and biochemistry of A\u03b2 and its aggregates in Alzheimer\u2019s disease. Acta Neuropathol. 2015;129(2):167\u201382.","journal-title":"Acta Neuropathol"},{"issue":"10284","key":"1554_CR7","doi-asserted-by":"publisher","first-page":"1577","DOI":"10.1016\/S0140-6736(20)32205-4","volume":"397","author":"P Scheltens","year":"2021","unstructured":"Scheltens P, De Strooper B, Kivipelto M, Holstege H, Ch\u00e9telat G, Teunissen CE, et al. Alzheimer\u2019s disease. Lancet. 2021;397(10284):1577\u201390.","journal-title":"Lancet"},{"issue":"1","key":"1554_CR8","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1186\/s13195-017-0283-5","volume":"9","author":"PS Aisen","year":"2017","unstructured":"Aisen PS, Cummings J, Jack CR Jr., Morris JC, Sperling R, Fr\u00f6lich L, et al. On the path to 2025: understanding the Alzheimer\u2019s disease continuum. Alzheimers Res Ther. 2017;9(1):60.","journal-title":"Alzheimers Res Ther"},{"key":"1554_CR9","doi-asserted-by":"crossref","unstructured":"Nabers A, Perna L, Lange J, Mons U, Schartner J, G\u00fcldenhaupt J et al. Amyloid blood biomarker detects Alzheimer\u2019s disease. EMBO Mol Med. 2018;10(5).","DOI":"10.15252\/emmm.201708763"},{"issue":"4","key":"1554_CR10","doi-asserted-by":"publisher","first-page":"535","DOI":"10.1016\/j.jalz.2018.02.018","volume":"14","author":"CR Jack Jr","year":"2018","unstructured":"Jack CR Jr., Bennett DA, Blennow K, Carrillo MC, Dunn B, Haeberlein SB, et al. NIA-AA Research Framework: toward a biological definition of Alzheimer\u2019s disease. Alzheimers Dement. 2018;14(4):535\u201362.","journal-title":"Alzheimers Dement"},{"issue":"19","key":"1554_CR11","doi-asserted-by":"publisher","first-page":"1784","DOI":"10.1212\/WNL.0b013e3182918ca6","volume":"80","author":"CM Roe","year":"2013","unstructured":"Roe CM, Fagan AM, Grant EA, Hassenstab J, Moulder KL, Maue Dreyfus D, et al. Amyloid imaging and CSF biomarkers in predicting cognitive impairment up to 7.5 years later. Neurology. 2013;80(19):1784\u201391.","journal-title":"Neurology"},{"issue":"6","key":"1554_CR12","doi-asserted-by":"publisher","first-page":"698","DOI":"10.1001\/jamaneurol.2016.0194","volume":"73","author":"A Soldan","year":"2016","unstructured":"Soldan A, Pettigrew C, Cai Q, Wang MC, Moghekar AR, O\u2019Brien RJ, et al. Hypothetical preclinical Alzheimer Disease groups and Longitudinal Cognitive Change. JAMA Neurol. 2016;73(6):698\u2013705.","journal-title":"JAMA Neurol"},{"key":"1554_CR13","doi-asserted-by":"crossref","unstructured":"Dominguez LJ, Veronese N, Vernuccio L, Catanese G, Inzerillo F, Salemi G et al. Nutrition, Physical Activity, and other Lifestyle factors in the Prevention of Cognitive decline and Dementia. Nutrients. 2021;13(11).","DOI":"10.3390\/nu13114080"},{"issue":"4","key":"1554_CR14","doi-asserted-by":"publisher","first-page":"873","DOI":"10.1016\/j.cger.2013.07.009","volume":"29","author":"NL Campbell","year":"2013","unstructured":"Campbell NL, Unverzagt F, LaMantia MA, Khan BA, Boustani MA. Risk factors for the progression of mild cognitive impairment to dementia. Clin Geriatr Med. 2013;29(4):873\u201393.","journal-title":"Clin Geriatr Med"},{"issue":"1","key":"1554_CR15","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1186\/s13195-017-0297-z","volume":"9","author":"M Crous-Bou","year":"2017","unstructured":"Crous-Bou M, Minguill\u00f3n C, Gramunt N, Molinuevo JL. Alzheimer\u2019s disease prevention: from risk factors to early intervention. Alzheimers Res Ther. 2017;9(1):71.","journal-title":"Alzheimers Res Ther"},{"issue":"12","key":"1554_CR16","first-page":"1299","volume":"86","author":"W Xu","year":"2015","unstructured":"Xu W, Tan L, Wang HF, Jiang T, Tan MS, Tan L, et al. Meta-analysis of modifiable risk factors for Alzheimer\u2019s disease. J Neurol Neurosurg Psychiatry. 2015;86(12):1299\u2013306.","journal-title":"J Neurol Neurosurg Psychiatry"},{"issue":"18","key":"1554_CR17","doi-asserted-by":"publisher","first-page":"e1605","DOI":"10.1212\/WNL.0000000000005415","volume":"90","author":"T Ge","year":"2018","unstructured":"Ge T, Sabuncu MR, Smoller JW, Sperling RA, Mormino EC. Dissociable influences of APOE \u03b54 and polygenic risk of AD dementia on amyloid and cognition. Neurology. 2018;90(18):e1605\u201312.","journal-title":"Neurology"},{"key":"1554_CR18","doi-asserted-by":"publisher","first-page":"109120","DOI":"10.1016\/j.abb.2022.109120","volume":"717","author":"E Chau","year":"2022","unstructured":"Chau E, Kim JR. \u03b1-synuclein-assisted oligomerization of \u03b2-amyloid (1\u201342). Arch Biochem Biophys. 2022;717:109120.","journal-title":"Arch Biochem Biophys"},{"issue":"3","key":"1554_CR19","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1016\/j.jalz.2010.03.006","volume":"6","author":"PS Aisen","year":"2010","unstructured":"Aisen PS, Petersen RC, Donohue MC, Gamst A, Raman R, Thomas RG, et al. Clinical core of the Alzheimer\u2019s Disease Neuroimaging Initiative: progress and plans. Alzheimers Dement. 2010;6(3):239\u201346.","journal-title":"Alzheimers Dement"},{"issue":"4","key":"1554_CR20","doi-asserted-by":"publisher","first-page":"403","DOI":"10.1002\/ana.21610","volume":"65","author":"LM Shaw","year":"2009","unstructured":"Shaw LM, Vanderstichele H, Knapik-Czajka M, Clark CM, Aisen PS, Petersen RC, et al. Cerebrospinal fluid biomarker signature in Alzheimer\u2019s disease neuroimaging initiative subjects. Ann Neurol. 2009;65(4):403\u201313.","journal-title":"Ann Neurol"},{"issue":"9","key":"1554_CR21","doi-asserted-by":"publisher","first-page":"819","DOI":"10.1016\/j.biopsych.2019.12.021","volume":"87","author":"JA Elman","year":"2020","unstructured":"Elman JA, Panizzon MS, Gustavson DE, Franz CE, Sanderson-Cimino ME, Lyons MJ, et al. Amyloid-\u03b2 positivity predicts cognitive decline but Cognition predicts progression to Amyloid-\u03b2 positivity. Biol Psychiatry. 2020;87(9):819\u201328.","journal-title":"Biol Psychiatry"},{"issue":"1","key":"1554_CR22","doi-asserted-by":"publisher","first-page":"70","DOI":"10.2967\/jnumed.112.109009","volume":"54","author":"SM Landau","year":"2013","unstructured":"Landau SM, Breault C, Joshi AD, Pontecorvo M, Mathis CA, Jagust WJ, et al. Amyloid-\u03b2 imaging with Pittsburgh compound B and florbetapir: comparing radiotracers and quantification methods. J Nucl Med. 2013;54(1):70\u20137.","journal-title":"J Nucl Med"},{"issue":"11","key":"1554_CR23","doi-asserted-by":"publisher","first-page":"2913","DOI":"10.1016\/j.neurobiolaging.2015.08.007","volume":"36","author":"M Araque Caballero","year":"2015","unstructured":"Araque Caballero M, Brendel M, Delker A, Ren J, Rominger A, Bartenstein P, et al. Mapping 3-year changes in gray matter and metabolism in A\u03b2-positive nondemented subjects. Neurobiol Aging. 2015;36(11):2913\u201324.","journal-title":"Neurobiol Aging"},{"issue":"1","key":"1554_CR24","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1186\/s12929-019-0524-y","volume":"26","author":"MVF Silva","year":"2019","unstructured":"Silva MVF, Loures CMG, Alves LCV, de Souza LC, Borges KBG, Carvalho MDG. Alzheimer\u2019s disease: risk factors and potentially protective measures. J Biomed Sci. 2019;26(1):33.","journal-title":"J Biomed Sci"},{"issue":"4","key":"1554_CR25","doi-asserted-by":"publisher","first-page":"508","DOI":"10.1001\/jamaneurol.2019.4749","volume":"77","author":"PF Meyer","year":"2020","unstructured":"Meyer PF, Pichet Binette A, Gonneaud J, Breitner JCS, Villeneuve S. Characterization of Alzheimer Disease Biomarker discrepancies using Cerebrospinal Fluid Phosphorylated Tau and AV1451 Positron Emission Tomography. JAMA Neurol. 2020;77(4):508\u201316.","journal-title":"JAMA Neurol"},{"issue":"6","key":"1554_CR26","doi-asserted-by":"publisher","first-page":"690","DOI":"10.1016\/j.jalz.2014.04.513","volume":"10","author":"HH Dodge","year":"2014","unstructured":"Dodge HH, Zhu J, Harvey D, Saito N, Silbert LC, Kaye JA, et al. Biomarker progressions explain higher variability in stage-specific cognitive decline than baseline values in Alzheimer disease. Alzheimers Dement. 2014;10(6):690\u2013703.","journal-title":"Alzheimers Dement"},{"issue":"4","key":"1554_CR27","doi-asserted-by":"publisher","first-page":"517","DOI":"10.1007\/s11682-012-9176-1","volume":"6","author":"LE Gibbons","year":"2012","unstructured":"Gibbons LE, Carle AC, Mackin RS, Harvey D, Mukherjee S, Insel P, et al. A composite score for executive functioning, validated in Alzheimer\u2019s Disease Neuroimaging Initiative (ADNI) participants with baseline mild cognitive impairment. Brain Imaging Behav. 2012;6(4):517\u201327.","journal-title":"Brain Imaging Behav"},{"issue":"4","key":"1554_CR28","doi-asserted-by":"publisher","first-page":"502","DOI":"10.1007\/s11682-012-9186-z","volume":"6","author":"PK Crane","year":"2012","unstructured":"Crane PK, Carle A, Gibbons LE, Insel P, Mackin RS, Gross A, et al. Development and assessment of a composite score for memory in the Alzheimer\u2019s Disease Neuroimaging Initiative (ADNI). Brain Imaging Behav. 2012;6(4):502\u201316.","journal-title":"Brain Imaging Behav"},{"issue":"3","key":"1554_CR29","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1159\/000110111","volume":"6","author":"CA Molgaard","year":"1987","unstructured":"Molgaard CA. Multivariate analysis of Hachinski\u2019s scale for discriminating senile dementia of the Alzheimer\u2019s type from multiinfarct dementia. Neuroepidemiology. 1987;6(3):153\u201360.","journal-title":"Neuroepidemiology"},{"issue":"8","key":"1554_CR30","doi-asserted-by":"publisher","first-page":"930","DOI":"10.1136\/jnnp-2013-307110","volume":"85","author":"A Lebedeva","year":"2014","unstructured":"Lebedeva A, Westman E, Lebedev AV, Li X, Winblad B, Simmons A, et al. Structural brain changes associated with depressive symptoms in the elderly with Alzheimer\u2019s disease. J Neurol Neurosurg Psychiatry. 2014;85(8):930\u20135.","journal-title":"J Neurol Neurosurg Psychiatry"},{"issue":"1","key":"1554_CR31","doi-asserted-by":"publisher","first-page":"576","DOI":"10.1038\/s41398-021-01711-1","volume":"11","author":"C Wen","year":"2021","unstructured":"Wen C, Hu H, Ou YN, Bi YL, Ma YH, Tan L, et al. Risk factors for subjective cognitive decline: the CABLE study. Transl Psychiatry. 2021;11(1):576.","journal-title":"Transl Psychiatry"},{"issue":"1","key":"1554_CR32","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1016\/S0304-3940(99)00845-9","volume":"277","author":"K B\u00fcrger n\u00e9e Buch","year":"1999","unstructured":"B\u00fcrger n\u00e9e Buch K, Padberg F, Nolde T, Teipel SJ, St\u00fcbner S, Haslinger A, et al. Cerebrospinal fluid tau protein shows a better discrimination in young old (<\u200970 years) than in old old patients with Alzheimer\u2019s disease compared with controls. Neurosci Lett. 1999;277(1):21\u20134.","journal-title":"Neurosci Lett"},{"issue":"5054","key":"1554_CR33","doi-asserted-by":"publisher","first-page":"184","DOI":"10.1126\/science.1566067","volume":"256","author":"JA Hardy","year":"1992","unstructured":"Hardy JA, Higgins GA. Alzheimer\u2019s disease: the amyloid cascade hypothesis. Science. 1992;256(5054):184\u20135.","journal-title":"Science"},{"issue":"2","key":"1554_CR34","doi-asserted-by":"publisher","first-page":"553","DOI":"10.1007\/s40120-022-00338-8","volume":"11","author":"AA Tahami Monfared","year":"2022","unstructured":"Tahami Monfared AA, Byrnes MJ, White LA, Zhang Q. Alzheimer\u2019s Disease: Epidemiology and Clinical Progression. Neurol Ther. 2022;11(2):553\u201369.","journal-title":"Neurol Ther"},{"issue":"7","key":"1554_CR35","doi-asserted-by":"publisher","first-page":"1370","DOI":"10.1002\/alz.12480","volume":"18","author":"D Tosun","year":"2022","unstructured":"Tosun D, Demir Z, Veitch DP, Weintraub D, Aisen P, Jack CR Jr., et al. Contribution of Alzheimer\u2019s biomarkers and risk factors to cognitive impairment and decline across the Alzheimer\u2019s disease continuum. Alzheimers Dement. 2022;18(7):1370\u201382.","journal-title":"Alzheimers Dement"},{"issue":"4","key":"1554_CR36","doi-asserted-by":"publisher","first-page":"488","DOI":"10.1001\/jamaneurol.2017.4325","volume":"75","author":"YY Lim","year":"2018","unstructured":"Lim YY, Kalinowski P, Pietrzak RH, Laws SM, Burnham SC, Ames D, et al. Association of \u03b2-Amyloid and apolipoprotein E \u03b54 with memory decline in preclinical Alzheimer Disease. JAMA Neurol. 2018;75(4):488\u201394.","journal-title":"JAMA Neurol"},{"issue":"15","key":"1554_CR37","doi-asserted-by":"publisher","first-page":"e009578","DOI":"10.1161\/JAHA.118.009578","volume":"7","author":"Y Yano","year":"2018","unstructured":"Yano Y, Griswold M, Wang W, Greenland P, Lloyd-Jones DM, Heiss G, et al. Long-term blood pressure level and variability from midlife to later life and subsequent cognitive change: the ARIC Neurocognitive Study. J Am Heart Assoc. 2018;7(15):e009578.","journal-title":"J Am Heart Assoc"},{"key":"1554_CR38","doi-asserted-by":"publisher","first-page":"153331752311722","DOI":"10.1177\/15333175231172283","volume":"38","author":"A Mathew","year":"2023","unstructured":"Mathew A, Mesa RA, Nahodyl L, Tremblay J, Rundek T, Zeki Al Hazzouri A, et al. Diastolic blood pressure and cognitive functioning: differences by systolic blood pressure among US adults. Am J Alzheimers Dis Other Demen. 2023;38:15333175231172283.","journal-title":"Am J Alzheimers Dis Other Demen"},{"issue":"6","key":"1554_CR39","doi-asserted-by":"publisher","first-page":"892","DOI":"10.1212\/01.wnl.0000176061.33817.90","volume":"65","author":"AS Buchman","year":"2005","unstructured":"Buchman AS, Wilson RS, Bienias JL, Shah RC, Evans DA, Bennett DA. Change in body mass index and risk of incident Alzheimer disease. Neurology. 2005;65(6):892\u20137.","journal-title":"Neurology"},{"issue":"23","key":"1554_CR40","doi-asserted-by":"publisher","first-page":"10939","DOI":"10.18632\/aging.102496","volume":"11","author":"LZ Ma","year":"2019","unstructured":"Ma LZ, Huang YY, Wang ZT, Li JQ, Hou XH, Shen XN, et al. Metabolically healthy obesity reduces the risk of Alzheimer\u2019s disease in elders: a longitudinal study. Aging. 2019;11(23):10939\u201351.","journal-title":"Aging"},{"key":"1554_CR41","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1016\/j.exger.2017.10.013","volume":"100","author":"J Mathys","year":"2017","unstructured":"Mathys J, Gholamrezaee M, Henry H, von Gunten A, Popp J. Decreasing body mass index is associated with cerebrospinal fluid markers of Alzheimer\u2019s pathology in MCI and mild dementia. Exp Gerontol. 2017;100:45\u201353.","journal-title":"Exp Gerontol"},{"issue":"11","key":"1554_CR42","doi-asserted-by":"publisher","first-page":"1747","DOI":"10.1093\/gerona\/glz009","volume":"74","author":"M Maltais","year":"2019","unstructured":"Maltais M, De Souto Barreto P, Hooper C, Payoux P, Rolland Y, Vellas B. Association between Brain \u03b2-Amyloid and Frailty in older adults. J Gerontol Biol Sci Med Sci. 2019;74(11):1747\u201352.","journal-title":"J Gerontol Biol Sci Med Sci"},{"key":"1554_CR43","doi-asserted-by":"publisher","first-page":"178","DOI":"10.1016\/j.bbi.2021.03.015","volume":"95","author":"LE Oberlin","year":"2021","unstructured":"Oberlin LE, Erickson KI, Mackey R, Klunk WE, Aizenstein H, Lopresti BJ, et al. Peripheral inflammatory biomarkers predict the deposition and progression of amyloid-\u03b2 in cognitively unimpaired older adults. Brain Behav Immun. 2021;95:178\u201389.","journal-title":"Brain Behav Immun"},{"key":"1554_CR44","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1111\/j.1749-6632.2011.06274.x","volume":"1243","author":"EB Lee","year":"2011","unstructured":"Lee EB. Obesity, leptin, and Alzheimer\u2019s disease. Ann N Y Acad Sci. 2011;1243:15\u201329.","journal-title":"Ann N Y Acad Sci"},{"key":"1554_CR45","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1016\/j.neubiorev.2020.05.012","volume":"115","author":"Y Qu","year":"2020","unstructured":"Qu Y, Hu HY, Ou YN, Shen XN, Xu W, Wang ZT, et al. Association of body mass index with risk of cognitive impairment and dementia: a systematic review and meta-analysis of prospective studies. Neurosci Biobehav Rev. 2020;115:189\u201398.","journal-title":"Neurosci Biobehav Rev"},{"key":"1554_CR46","doi-asserted-by":"crossref","unstructured":"Fu C, Li Z, Mao Z. Association between Social activities and cognitive function among the Elderly in China: a cross-sectional study. Int J Environ Res Public Health. 2018;15(2).","DOI":"10.3390\/ijerph15020231"},{"issue":"1","key":"1554_CR47","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1159\/000117405","volume":"37","author":"MP Grassi","year":"1997","unstructured":"Grassi MP, Perin C, Clerici F, Zocchetti C, Borella M, Cargnel A, et al. Effects of HIV seropositivity and drug abuse on cognitive function. Eur Neurol. 1997;37(1):48\u201352.","journal-title":"Eur Neurol"},{"issue":"5","key":"1554_CR48","doi-asserted-by":"publisher","first-page":"362","DOI":"10.1176\/appi.ajp.2021.21060664","volume":"179","author":"MH Meier","year":"2022","unstructured":"Meier MH, Caspi A, A RK, Hall W, Ambler A, Harrington H, et al. Long-term Cannabis Use and Cognitive reserves and hippocampal volume in midlife. Am J Psychiatry. 2022;179(5):362\u201374.","journal-title":"Am J Psychiatry"},{"issue":"11","key":"1554_CR49","doi-asserted-by":"publisher","first-page":"2115","DOI":"10.1093\/pm\/pnx210","volume":"19","author":"H Taipale","year":"2018","unstructured":"Taipale H, Hamina A, Lampela P, Tanskanen A, Tiihonen J, Karttunen N, et al. Is Alzheimer\u2019s Disease Associated with previous opioid use? Pain Med. 2018;19(11):2115\u201321.","journal-title":"Pain Med"},{"issue":"25","key":"1554_CR50","doi-asserted-by":"publisher","first-page":"4112","DOI":"10.2174\/13816128113199990620","volume":"20","author":"L Karila","year":"2014","unstructured":"Karila L, Roux P, Rolland B, Benyamina A, Reynaud M, Aubin HJ, et al. Acute and long-term effects of cannabis use: a review. Curr Pharm Des. 2014;20(25):4112\u20138.","journal-title":"Curr Pharm Des"},{"key":"1554_CR51","doi-asserted-by":"crossref","unstructured":"Kodidela S, Gerth K, Haque S, Gong Y, Ismael S, Singh A et al. Extracellular Vesicles: A Possible Link between HIV and Alzheimer\u2019s Disease-Like Pathology in HIV Subjects? Cells. 2019;8(9).","DOI":"10.3390\/cells8090968"},{"key":"1554_CR52","doi-asserted-by":"crossref","unstructured":"Umoh IO, Dos Reis HJ, de Oliveira ACP. Molecular Mechanisms Linking Osteoarthritis and Alzheimer\u2019s Disease: Shared Pathways, Mechanisms and Breakthrough Prospects. Int J Mol Sci. 2024;25(5).","DOI":"10.3390\/ijms25053044"},{"issue":"4","key":"1554_CR53","doi-asserted-by":"publisher","first-page":"264","DOI":"10.22365\/jpsych.2016.274.264","volume":"27","author":"EC Stamouli","year":"2016","unstructured":"Stamouli EC, Politis AM. [Pro-inflammatory cytokines in Alzheimer\u2019s disease]. Psychiatriki. 2016;27(4):264\u201375.","journal-title":"Psychiatriki"},{"issue":"6","key":"1554_CR54","doi-asserted-by":"publisher","first-page":"1571","DOI":"10.1152\/jn.00503.2020","volume":"124","author":"CM Dungan","year":"2020","unstructured":"Dungan CM, Valentino T, Vechetti IJ Jr., Zdunek CJ, Murphy MP, Lin AL, et al. Exercise-mediated alteration of hippocampal dicer mRNA and miRNAs is associated with lower BACE1 gene expression and A\u03b2(1\u201342) in female 3xTg-AD mice. J Neurophysiol. 2020;124(6):1571\u20137.","journal-title":"J Neurophysiol"},{"issue":"9","key":"1554_CR55","doi-asserted-by":"publisher","first-page":"5343","DOI":"10.1007\/s12035-023-03420-w","volume":"60","author":"HL Sun","year":"2023","unstructured":"Sun HL, Yao XQ, Lei L, Jin WS, Bai YD, Zeng GH, et al. Associations of blood and cerebrospinal fluid A\u03b2 and tau levels with renal function. Mol Neurobiol. 2023;60(9):5343\u201351.","journal-title":"Mol Neurobiol"},{"issue":"10","key":"1554_CR56","doi-asserted-by":"publisher","first-page":"6074","DOI":"10.1038\/s41380-021-01073-6","volume":"26","author":"DY Tian","year":"2021","unstructured":"Tian DY, Cheng Y, Zhuang ZQ, He CY, Pan QG, Tang MZ, et al. Physiological clearance of amyloid-beta by the kidney and its therapeutic potential for Alzheimer\u2019s disease. Mol Psychiatry. 2021;26(10):6074\u201382.","journal-title":"Mol Psychiatry"},{"issue":"12","key":"1554_CR57","doi-asserted-by":"publisher","first-page":"1628","DOI":"10.1001\/archneurol.2012.764","volume":"69","author":"V Kotagal","year":"2012","unstructured":"Kotagal V, Bohnen NI, M\u00fcller ML, Koeppe RA, Frey KA, Albin RL. Cerebral amyloid deposition and serotoninergic innervation in Parkinson disease. Arch Neurol. 2012;69(12):1628\u201331.","journal-title":"Arch Neurol"},{"issue":"4","key":"1554_CR58","doi-asserted-by":"publisher","first-page":"417","DOI":"10.1007\/s00401-007-0336-0","volume":"115","author":"T Lashley","year":"2008","unstructured":"Lashley T, Holton JL, Gray E, Kirkham K, O\u2019Sullivan SS, Hilbig A, et al. Cortical alpha-synuclein load is associated with amyloid-beta plaque burden in a subset of Parkinson\u2019s disease patients. Acta Neuropathol. 2008;115(4):417\u201325.","journal-title":"Acta Neuropathol"},{"issue":"Pt 5","key":"1554_CR59","doi-asserted-by":"publisher","first-page":"1493","DOI":"10.1093\/brain\/awr031","volume":"134","author":"Y Compta","year":"2011","unstructured":"Compta Y, Parkkinen L, O\u2019Sullivan SS, Vandrovcova J, Holton JL, Collins C, et al. Lewy- and Alzheimer-type pathologies in Parkinson\u2019s disease dementia: which is more important? Brain. 2011;134(Pt 5):1493\u2013505.","journal-title":"Brain"},{"issue":"7","key":"1554_CR60","doi-asserted-by":"publisher","first-page":"928","DOI":"10.1002\/mds.26191","volume":"30","author":"M Petrou","year":"2015","unstructured":"Petrou M, Dwamena BA, Foerster BR, MacEachern MP, Bohnen NI, M\u00fcller ML, et al. Amyloid deposition in Parkinson\u2019s disease and cognitive impairment: a systematic review. Mov Disord. 2015;30(7):928\u201335.","journal-title":"Mov Disord"},{"issue":"5","key":"1554_CR61","doi-asserted-by":"publisher","first-page":"716","DOI":"10.1007\/s00259-014-2975-4","volume":"42","author":"M Brendel","year":"2015","unstructured":"Brendel M, Pogarell O, Xiong G, Delker A, Bartenstein P, Rominger A. Depressive symptoms accelerate cognitive decline in amyloid-positive MCI patients. Eur J Nucl Med Mol Imaging. 2015;42(5):716\u201324.","journal-title":"Eur J Nucl Med Mol Imaging"},{"issue":"7","key":"1554_CR62","doi-asserted-by":"publisher","first-page":"1603","DOI":"10.1016\/j.pnpbp.2011.05.013","volume":"35","author":"YS Moon","year":"2011","unstructured":"Moon YS, Kang SH, No HJ, Won MH, Ki SB, Lee SK, et al. The correlation of plasma A\u03b242 levels, depressive symptoms, and cognitive function in the Korean elderly. Prog Neuropsychopharmacol Biol Psychiatry. 2011;35(7):1603\u20136.","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"issue":"11","key":"1554_CR63","doi-asserted-by":"publisher","first-page":"1339","DOI":"10.1586\/ern.12.127","volume":"12","author":"AP Hermida","year":"2012","unstructured":"Hermida AP, McDonald WM, Steenland K, Levey A. The association between late-life depression, mild cognitive impairment and dementia: is inflammation the missing link? Expert Rev Neurother. 2012;12(11):1339\u201350.","journal-title":"Expert Rev Neurother"},{"key":"1554_CR64","doi-asserted-by":"publisher","first-page":"148423","DOI":"10.1016\/j.brainres.2023.148423","volume":"1813","author":"SMN Hasan","year":"2023","unstructured":"Hasan SMN, Clarke C, Strand T, Bambico FR. Putative pathological mechanisms of late-life depression and Alzheimer\u2019s disease. Brain Res. 2023;1813:148423.","journal-title":"Brain Res"},{"issue":"6","key":"1554_CR65","doi-asserted-by":"publisher","first-page":"743","DOI":"10.1016\/j.jalz.2013.11.005","volume":"10","author":"YY Lim","year":"2014","unstructured":"Lim YY, Maruff P, Pietrzak RH, Ellis KA, Darby D, Ames D, et al. A\u03b2 and cognitive change: examining the preclinical and prodromal stages of Alzheimer\u2019s disease. Alzheimers Dement. 2014;10(6):743\u2013e511.","journal-title":"Alzheimers Dement"},{"issue":"1","key":"1554_CR66","doi-asserted-by":"publisher","first-page":"12861","DOI":"10.1038\/s41598-017-13168-8","volume":"7","author":"S Policicchio","year":"2017","unstructured":"Policicchio S, Ahmad AN, Powell JF, Proitsi P. Rheumatoid arthritis and risk for Alzheimer\u2019s disease: a systematic review and meta-analysis and a mendelian randomization study. Sci Rep. 2017;7(1):12861.","journal-title":"Sci Rep"},{"issue":"1","key":"1554_CR67","doi-asserted-by":"publisher","first-page":"e0186475","DOI":"10.1371\/journal.pone.0186475","volume":"13","author":"TM Lin","year":"2018","unstructured":"Lin TM, Chen WS, Sheu JJ, Chen YH, Chen JH, Chang CC. Autoimmune rheumatic diseases increase dementia risk in middle-aged patients: a nationwide cohort study. PLoS ONE. 2018;13(1):e0186475.","journal-title":"PLoS ONE"},{"issue":"15","key":"1554_CR68","doi-asserted-by":"publisher","first-page":"5709","DOI":"10.1523\/JNEUROSCI.20-15-05709.2000","volume":"20","author":"GP Lim","year":"2000","unstructured":"Lim GP, Yang F, Chu T, Chen P, Beech W, Teter B, et al. Ibuprofen suppresses plaque pathology and inflammation in a mouse model for Alzheimer\u2019s disease. J Neurosci. 2000;20(15):5709\u201314.","journal-title":"J Neurosci"}],"container-title":["Alzheimer's Research &amp; Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13195-024-01554-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s13195-024-01554-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13195-024-01554-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,19]],"date-time":"2024-08-19T10:07:32Z","timestamp":1724062052000},"score":1,"resource":{"primary":{"URL":"https:\/\/alzres.biomedcentral.com\/articles\/10.1186\/s13195-024-01554-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8,19]]},"references-count":68,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["1554"],"URL":"https:\/\/doi.org\/10.1186\/s13195-024-01554-0","relation":{},"ISSN":["1758-9193"],"issn-type":[{"value":"1758-9193","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,8,19]]},"assertion":[{"value":"11 January 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 August 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 August 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The study procedures were approved by the institutional review boards of all participating centres (), and written informed consent was obtained from all participants or their authorised representatives according to the Declaration of Helsinki (consent for research). Ethics approval was obtained from the institutional review boards of each institution involved: Oregon Health and Science University; University of Southern California; University of California\u2014San Diego; University of Michigan; Mayo Clinic, Rochester; Baylor College of Medicine; Columbia University Medical Center; Washington University, St. Louis; University of Alabama at Birmingham; Mount Sinai School of Medicine; Rush University Medical Center; Wien Center; Johns Hopkins University; New York University; Duke University Medical Center; University of Pennsylvania; University of Kentucky; University of Pittsburgh; University of Rochester Medical Center; University of California, Irvine; University of Texas Southwestern Medical School; Emory University; University of Kansas, Medical Center; University of California, Los Angeles; Mayo Clinic, Jacksonville; Indiana University; Yale University School of Medicine; McGill University, Montreal-Jewish General Hospital; Sunnybrook Health Sciences, Ontario; U.B.C. Clinic for AD & Related Disorders; Cognitive Neurology\u2014St. Joseph\u2019s, Ontario; Cleveland Clinic Lou Ruvo Center for Brain Health; Northwestern University; Premiere Research Inst (Palm Beach Neurology); Georgetown University Medical Center; Brigham and Women\u2019s Hospital; Stanford University; Banner Sun Health Research Institute; Boston University; Howard University; Case Western Reserve University; University of California, Davis\u2014Sacramento; Neurological Care of CNY; Parkwood Hospital; University of Wisconsin; University of California, Irvine\u2014BIC; Banner Alzheimer\u2019s Institute; Dent Neurologic Institute; Ohio State University; Albany Medical College; Hartford Hospital, Olin Neuropsychiatry Research Center; Dartmouth-Hitchcock Medical Center; Wake Forest University Health Sciences; Rhode Island Hospital; Butler Hospital; UC San Francisco; Medical University South Carolina; St. Joseph\u2019s Health Care Nathan Kline Institute; University of Iowa College of Medicine; Cornell University and University of South Florida: USF Health Byrd Alzheimer\u2019s Institute. The investigators within the ADNI contributed to the design and implementation of the ADNI and\/or provided data but did not participate in analysis or writing of this report. A complete listing of ADNI investigators can be found online ().","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"189"}}