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The investigators performed all aspects of this study in accordance with the ethical principles that have their origin in the Declaration of Helsinki, the study protocol, and all national, state, and local laws or regulations. The original study protocol and protocol amendments were approved by appropriate institutional review boards and ethics committees at the following sites: Advarra (Columbia, MD, USA), The Alfred Hospital (Melbourne, Australia), Medical Research Ethics Committee of the Foundation BEBO (Assen, Netherlands), Skipton House (London, UK). For animal studies, all experimental procedures were conducted according to the approved protocols from the relevant institutions: 4-week GLP study, Covance Laboratories, Inc #8372868; DRF study, Covance Laboratories, Inc #8372866; non-GLP interval study, Charles River Laboratories, Inc. # 2946-001. All procedures complied with the Animal Welfare Act, the Guide for the Care and Use of Laboratory Animals, and the Office of Laboratory Animal Welfare.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"H.L., A.S., A.M., Br.B., T.N., Ba.B., An.R., and Ar.R. are employees of Alector, LLC and may have an equity interest in Alector, Inc. D.M., H.R., I.T., M.W., T.S., and R.P. were employees of Alector at the time of manuscript conception and may have an equity interest in Alector, Inc.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"235"}}