{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T06:35:08Z","timestamp":1793946908147,"version":"4.8.0"},"reference-count":62,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,10,22]],"date-time":"2024-10-22T00:00:00Z","timestamp":1729555200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2024,10,22]],"date-time":"2024-10-22T00:00:00Z","timestamp":1729555200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"name":"Spanish Ministry of Economy and Competitiveness","award":["RTI2018-095753-B-I00 and PID2021-125364OB-I00"],"award-info":[{"award-number":["RTI2018-095753-B-I00 and PID2021-125364OB-I00"]}]},{"name":"European Union project","award":["H2020-MSCA-ITN-2017 number 766124"],"award-info":[{"award-number":["H2020-MSCA-ITN-2017 number 766124"]}]},{"name":"UCM-Santander Central Hispano Bank","award":["PR41\/17-21014"],"award-info":[{"award-number":["PR41\/17-21014"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Alz Res Therapy"],"DOI":"10.1186\/s13195-024-01600-x","type":"journal-article","created":{"date-parts":[[2024,10,22]],"date-time":"2024-10-22T08:03:22Z","timestamp":1729584202000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Blockade of brain alkaline phosphatase efficiently reduces amyloid-\u03b2 plaque burden and associated cognitive impairment"],"prefix":"10.1186","volume":"16","author":[{"given":"Lucia","family":"Soria-Tobar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Rom\u00e1n-Valero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c1lvaro","family":"Sebasti\u00e1n-Serrano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paloma","family":"Aivar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beatriz","family":"\u00c1lvarez-Castelao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel","family":"D\u00edaz-Hern\u00e1ndez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,10,22]]},"reference":[{"key":"1600_CR1","doi-asserted-by":"publisher","first-page":"1121","DOI":"10.1146\/annurev.neuro.24.1.1121","volume":"24","author":"VM Lee","year":"2001","unstructured":"Lee VM, Goedert M, Trojanowski JQ. Neurodegenerative tauopathies. Annu Rev Neurosci. 2001;24:1121\u201359.","journal-title":"Annu Rev Neurosci"},{"issue":"2","key":"1600_CR2","doi-asserted-by":"publisher","first-page":"741","DOI":"10.1152\/physrev.2001.81.2.741","volume":"81","author":"DJ Selkoe","year":"2001","unstructured":"Selkoe DJ. Alzheimer\u2019s disease: genes, proteins, and therapy. Physiol Rev. 2001;81(2):741\u201366.","journal-title":"Physiol Rev"},{"issue":"11","key":"1600_CR3","doi-asserted-by":"publisher","first-page":"1505","DOI":"10.1016\/S1357-2725(03)00133-X","volume":"35","author":"Y Ling","year":"2003","unstructured":"Ling Y, Morgan K, Kalsheker N. Amyloid precursor protein (APP) and the biology of proteolytic processing: relevance to Alzheimer\u2019s disease. Int J Biochem Cell Biol. 2003;35(11):1505\u201335.","journal-title":"Int J Biochem Cell Biol"},{"key":"1600_CR4","doi-asserted-by":"publisher","first-page":"479","DOI":"10.1146\/annurev.neuro.21.1.479","volume":"21","author":"DL Price","year":"1998","unstructured":"Price DL, Sisodia SS. Mutant genes in familial Alzheimer\u2019s disease and transgenic models. Annu Rev Neurosci. 1998;21:479\u2013505.","journal-title":"Annu Rev Neurosci"},{"issue":"1","key":"1600_CR5","doi-asserted-by":"publisher","first-page":"1214","DOI":"10.1038\/s41467-017-01150-x","volume":"8","author":"S Palmqvist","year":"2017","unstructured":"Palmqvist S, Scholl M, Strandberg O, Mattsson N, Stomrud E, Zetterberg H, et al. Earliest accumulation of beta-amyloid occurs within the default-mode network and concurrently affects brain connectivity. Nat Commun. 2017;8(1):1214.","journal-title":"Nat Commun"},{"issue":"3","key":"1600_CR6","doi-asserted-by":"publisher","first-page":"608","DOI":"10.1016\/j.neuron.2014.10.038","volume":"84","author":"R Sperling","year":"2014","unstructured":"Sperling R, Mormino E, Johnson K. The evolution of preclinical Alzheimer\u2019s disease: implications for prevention trials. Neuron. 2014;84(3):608\u201322.","journal-title":"Neuron"},{"key":"1600_CR7","doi-asserted-by":"crossref","unstructured":"Maia MA, Sousa E. BACE-1 and gamma-Secretase as Therapeutic Targets for Alzheimer\u2019s Disease. Pharmaceuticals (Basel). 2019;12(1).","DOI":"10.3390\/ph12010041"},{"issue":"10","key":"1600_CR8","doi-asserted-by":"publisher","first-page":"1002","DOI":"10.1021\/acsmedchemlett.7b00178","volume":"8","author":"Z Zhao","year":"2017","unstructured":"Zhao Z, Pissarnitski DA, Huang X, Palani A, Zhu Z, Greenlee WJ, et al. Discovery of a Tetrahydrobenzisoxazole Series of gamma-secretase modulators. ACS Med Chem Lett. 2017;8(10):1002\u20136.","journal-title":"ACS Med Chem Lett"},{"issue":"2","key":"1600_CR9","doi-asserted-by":"publisher","first-page":"401","DOI":"10.3233\/JAD-160965","volume":"58","author":"MS Rafii","year":"2017","unstructured":"Rafii MS, Skotko BG, McDonough ME, Pulsifer M, Evans C, Doran E, et al. A Randomized, Double-Blind, Placebo-Controlled, phase II study of oral ELND005 (scyllo-Inositol) in young adults with Down Syndrome without Dementia. J Alzheimers Dis. 2017;58(2):401\u201311.","journal-title":"J Alzheimers Dis"},{"issue":"1","key":"1600_CR10","doi-asserted-by":"publisher","first-page":"160","DOI":"10.1186\/s13195-022-01106-4","volume":"14","author":"AA Tsiknia","year":"2022","unstructured":"Tsiknia AA, Sundermann EE, Reas ET, Edland SD, Brewer JB, Galasko D, et al. Sex differences in Alzheimer\u2019s disease: plasma MMP-9 and markers of disease severity. Alzheimers Res Ther. 2022;14(1):160.","journal-title":"Alzheimers Res Ther"},{"issue":"1","key":"1600_CR11","doi-asserted-by":"publisher","first-page":"4414","DOI":"10.1038\/s41598-019-40736-x","volume":"9","author":"H Seok","year":"2019","unstructured":"Seok H, Lee M, Shin E, Yun MR, Lee YH, Moon JH, et al. Low-dose pioglitazone can ameliorate learning and memory impairment in a mouse model of dementia by increasing LRP1 expression in the hippocampus. Sci Rep. 2019;9(1):4414.","journal-title":"Sci Rep"},{"key":"1600_CR12","doi-asserted-by":"publisher","first-page":"173554","DOI":"10.1016\/j.ejphar.2020.173554","volume":"887","author":"M Vaz","year":"2020","unstructured":"Vaz M, Silvestre S. Alzheimer\u2019s disease: recent treatment strategies. Eur J Pharmacol. 2020;887:173554.","journal-title":"Eur J Pharmacol"},{"issue":"9","key":"1600_CR13","doi-asserted-by":"publisher","first-page":"2187","DOI":"10.1038\/s41591-023-02505-2","volume":"29","author":"WK Self","year":"2023","unstructured":"Self WK, Holtzman DM. Emerging diagnostics and therapeutics for Alzheimer disease. Nat Med. 2023;29(9):2187\u201399.","journal-title":"Nat Med"},{"key":"1600_CR14","doi-asserted-by":"crossref","unstructured":"Kang C. Donanemab: First Approval. Drugs. 2024.","DOI":"10.1007\/s40265-024-02087-4"},{"issue":"7618","key":"1600_CR15","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1038\/nature19323","volume":"537","author":"J Sevigny","year":"2016","unstructured":"Sevigny J, Chiao P, Bussiere T, Weinreb PH, Williams L, Maier M, et al. The antibody aducanumab reduces Abeta plaques in Alzheimer\u2019s disease. Nature. 2016;537(7618):50\u20136.","journal-title":"Nature"},{"issue":"1","key":"1600_CR16","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1056\/NEJMoa2212948","volume":"388","author":"CH van Dyck","year":"2023","unstructured":"van Dyck CH, Swanson CJ, Aisen P, Bateman RJ, Chen C, Gee M, et al. Lecanemab in Early Alzheimer\u2019s Disease. N Engl J Med. 2023;388(1):9\u201321.","journal-title":"N Engl J Med"},{"issue":"3","key":"1600_CR17","first-page":"362","volume":"10","author":"J Cummings","year":"2023","unstructured":"Cummings J, Apostolova L, Rabinovici GD, Atri A, Aisen P, Greenberg S, et al. Lecanemab: appropriate use recommendations. J Prev Alzheimers Dis. 2023;10(3):362\u201377.","journal-title":"J Prev Alzheimers Dis"},{"key":"1600_CR18","doi-asserted-by":"publisher","first-page":"797","DOI":"10.2147\/CIA.S325026","volume":"17","author":"M Vaz","year":"2022","unstructured":"Vaz M, Silva V, Monteiro C, Silvestre S. Role of Aducanumab in the treatment of Alzheimer\u2019s Disease: challenges and opportunities. Clin Interv Aging. 2022;17:797\u2013810.","journal-title":"Clin Interv Aging"},{"issue":"1","key":"1600_CR19","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1159\/000329722","volume":"9","author":"ER Vardy","year":"2012","unstructured":"Vardy ER, Kellett KA, Cocklin SL, Hooper NM. Alkaline phosphatase is increased in both brain and plasma in Alzheimer\u2019s disease. Neurodegener Dis. 2012;9(1):31\u20137.","journal-title":"Neurodegener Dis"},{"key":"1600_CR20","doi-asserted-by":"publisher","first-page":"105632","DOI":"10.1016\/j.nbd.2022.105632","volume":"165","author":"A Sebastian-Serrano","year":"2022","unstructured":"Sebastian-Serrano A, Merchan-Rubira J, Di Lauro C, Bianchi C, Soria-Tobar L, Narisawa S, et al. TNAP upregulation is a critical factor in Tauopathies and its blockade ameliorates neurotoxicity and increases life-expectancy. Neurobiol Dis. 2022;165:105632.","journal-title":"Neurobiol Dis"},{"key":"1600_CR21","doi-asserted-by":"crossref","unstructured":"Aivar P, Bianchi C, Di Lauro C, Soria-Tobar L, Alvarez-Castelao B, Calero M et al. TNAP and P2X7R: New Plasma Biomarkers for Alzheimer\u2019s Disease. Int J Mol Sci. 2023;24(13).","DOI":"10.3390\/ijms241310897"},{"issue":"42","key":"1600_CR22","doi-asserted-by":"publisher","first-page":"32539","DOI":"10.1074\/jbc.M110.145003","volume":"285","author":"M Diaz-Hernandez","year":"2010","unstructured":"Diaz-Hernandez M, Gomez-Ramos A, Rubio A, Gomez-Villafuertes R, Naranjo JR, Miras-Portugal MT, et al. Tissue-nonspecific alkaline phosphatase promotes the neurotoxicity effect of extracellular tau. J Biol Chem. 2010;285(42):32539\u201348.","journal-title":"J Biol Chem"},{"issue":"7","key":"1600_CR23","doi-asserted-by":"publisher","first-page":"1587","DOI":"10.1002\/jbmr.1901","volume":"28","author":"S Narisawa","year":"2013","unstructured":"Narisawa S, Yadav MC, Millan JL. In vivo overexpression of tissue-nonspecific alkaline phosphatase increases skeletal mineralization and affects the phosphorylation status of osteopontin. J Bone Min Res. 2013;28(7):1587\u201398.","journal-title":"J Bone Min Res"},{"key":"1600_CR24","doi-asserted-by":"crossref","unstructured":"Lalwani RC, Volmar CH, Wahlestedt C, Webster KA, Shehadeh LA. Contextualizing the Role of Osteopontin in the Inflammatory Responses of Alzheimer\u2019s Disease. Biomedicines. 2023;11(12).","DOI":"10.3390\/biomedicines11123232"},{"issue":"7","key":"1600_CR25","doi-asserted-by":"publisher","first-page":"1014","DOI":"10.1091\/mbc.e10-09-0740","volume":"22","author":"M Diez-Zaera","year":"2011","unstructured":"Diez-Zaera M, Diaz-Hernandez JI, Hernandez-Alvarez E, Zimmermann H, Diaz-Hernandez M, Miras-Portugal MT. Tissue-nonspecific alkaline phosphatase promotes axonal growth of hippocampal neurons. Mol Biol Cell. 2011;22(7):1014\u201324.","journal-title":"Mol Biol Cell"},{"issue":"8","key":"1600_CR26","doi-asserted-by":"publisher","first-page":"1816","DOI":"10.1016\/j.neurobiolaging.2011.09.040","volume":"33","author":"JI Diaz-Hernandez","year":"2012","unstructured":"Diaz-Hernandez JI, Gomez-Villafuertes R, Leon-Otegui M, Hontecillas-Prieto L, Del Puerto A, Trejo JL, et al. In vivo P2X7 inhibition reduces amyloid plaques in Alzheimer\u2019s disease through GSK3beta and secretases. Neurobiol Aging. 2012;33(8):1816\u201328.","journal-title":"Neurobiol Aging"},{"key":"1600_CR27","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1016\/j.neuroscience.2014.08.036","volume":"279","author":"X Chen","year":"2014","unstructured":"Chen X, Hu J, Jiang L, Xu S, Zheng B, Wang C, et al. Brilliant blue G improves cognition in an animal model of Alzheimer\u2019s disease and inhibits amyloid-beta-induced loss of filopodia and dendrite spines in hippocampal neurons. Neuroscience. 2014;279:94\u2013101.","journal-title":"Neuroscience"},{"issue":"1","key":"1600_CR28","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1038\/s41380-018-0108-3","volume":"24","author":"E Martin","year":"2019","unstructured":"Martin E, Amar M, Dalle C, Youssef I, Boucher C, Le Duigou C, et al. New role of P2X7 receptor in an Alzheimer\u2019s disease mouse model. Mol Psychiatry. 2019;24(1):108\u201325.","journal-title":"Mol Psychiatry"},{"issue":"6","key":"1600_CR29","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1016\/S1389-0344(01)00067-3","volume":"17","author":"JL Jankowsky","year":"2001","unstructured":"Jankowsky JL, Slunt HH, Ratovitski T, Jenkins NA, Copeland NG, Borchelt DR. Co-expression of multiple transgenes in mouse CNS: a comparison of strategies. Biomol Eng. 2001;17(6):157\u201365.","journal-title":"Biomol Eng"},{"issue":"3","key":"1600_CR30","doi-asserted-by":"publisher","first-page":"432","DOI":"10.1002\/(SICI)1097-0177(199703)208:3<432::AID-AJA13>3.0.CO;2-1","volume":"208","author":"S Narisawa","year":"1997","unstructured":"Narisawa S, Frohlander N, Millan JL. Inactivation of two mouse alkaline phosphatase genes and establishment of a model of infantile hypophosphatasia. Dev Dyn. 1997;208(3):432\u201346.","journal-title":"Dev Dyn"},{"issue":"5","key":"1600_CR31","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1080\/00480169.1998.36084","volume":"46","author":"M Fernandez","year":"1998","unstructured":"Fernandez M, Garcia JJ, Sierra M, Diez MJ, Teran MT. Bioavailability of levamisole after intramuscular and oral administration in sheep. N Z Vet J. 1998;46(5):173\u20136.","journal-title":"N Z Vet J"},{"issue":"11","key":"1600_CR32","doi-asserted-by":"publisher","first-page":"e80355","DOI":"10.1371\/journal.pone.0080355","volume":"8","author":"A Attar","year":"2013","unstructured":"Attar A, Liu T, Chan WT, Hayes J, Nejad M, Lei K, et al. A shortened Barnes maze protocol reveals memory deficits at 4-months of age in the triple-transgenic mouse model of Alzheimer\u2019s disease. PLoS ONE. 2013;8(11):e80355.","journal-title":"PLoS ONE"},{"key":"1600_CR33","unstructured":"Paxinos G KF, editor. Mouse brain in stereotaxic coordinates, Compact. New York Academic; 2008."},{"key":"1600_CR34","doi-asserted-by":"publisher","first-page":"143","DOI":"10.3389\/fncel.2019.00143","volume":"13","author":"C Martinez-Frailes","year":"2019","unstructured":"Martinez-Frailes C, Di Lauro C, Bianchi C, de Diego-Garcia L, Sebastian-Serrano A, Bosca L, et al. Amyloid Peptide Induced Neuroinflammation Increases the P2X7 Receptor Expression in Microglial Cells, Impacting on Its Functionality. Front Cell Neurosci. 2019;13:143.","journal-title":"Front Cell Neurosci"},{"key":"1600_CR35","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1016\/j.bbi.2017.08.019","volume":"67","author":"A Rentsendorj","year":"2018","unstructured":"Rentsendorj A, Sheyn J, Fuchs DT, Daley D, Salumbides BC, Schubloom HE, et al. A novel role for osteopontin in macrophage-mediated amyloid-beta clearance in Alzheimer\u2019s models. Brain Behav Immun. 2018;67:163\u201380.","journal-title":"Brain Behav Immun"},{"key":"1600_CR36","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1016\/j.neurobiolaging.2021.12.009","volume":"113","author":"LA Hulshof","year":"2022","unstructured":"Hulshof LA, Frajmund LA, van Nuijs D, van der Heijden DCN, Middeldorp J, Hol EM. Both male and female APPswe\/PSEN1dE9 mice are impaired in spatial memory and cognitive flexibility at 9 months of age. Neurobiol Aging. 2022;113:28\u201338.","journal-title":"Neurobiol Aging"},{"issue":"1","key":"1600_CR37","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1111\/j.1601-183X.2006.00221.x","volume":"6","author":"RS Reiserer","year":"2007","unstructured":"Reiserer RS, Harrison FE, Syverud DC, McDonald MP. Impaired spatial learning in the APPSwe\u2009+\u2009PSEN1DeltaE9 bigenic mouse model of Alzheimer\u2019s disease. Genes Brain Behav. 2007;6(1):54\u201365.","journal-title":"Genes Brain Behav"},{"issue":"2","key":"1600_CR38","doi-asserted-by":"publisher","first-page":"342","DOI":"10.1016\/j.bbr.2011.03.072","volume":"222","author":"W Zhang","year":"2011","unstructured":"Zhang W, Hao J, Liu R, Zhang Z, Lei G, Su C, et al. Soluble abeta levels correlate with cognitive deficits in the 12-month-old APPswe\/PS1dE9 mouse model of Alzheimer\u2019s disease. Behav Brain Res. 2011;222(2):342\u201350.","journal-title":"Behav Brain Res"},{"key":"1600_CR39","doi-asserted-by":"publisher","first-page":"113192","DOI":"10.1016\/j.bbr.2021.113192","volume":"404","author":"A Locci","year":"2021","unstructured":"Locci A, Orellana H, Rodriguez G, Gottliebson M, McClarty B, Dominguez S, et al. Comparison of memory, affective behavior, and neuropathology in APP(NLGF) knock-in mice to 5xFAD and APP\/PS1 mice. Behav Brain Res. 2021;404:113192.","journal-title":"Behav Brain Res"},{"issue":"10","key":"1600_CR40","doi-asserted-by":"publisher","first-page":"1227","DOI":"10.1038\/nn.2923","volume":"14","author":"M Prinz","year":"2011","unstructured":"Prinz M, Priller J, Sisodia SS, Ransohoff RM. Heterogeneity of CNS myeloid cells and their roles in neurodegeneration. Nat Neurosci. 2011;14(10):1227\u201335.","journal-title":"Nat Neurosci"},{"key":"1600_CR41","doi-asserted-by":"publisher","first-page":"757","DOI":"10.1016\/j.expneurol.2014.08.015","volume":"261","author":"JL Chan","year":"2014","unstructured":"Chan JL, Reeves TM, Phillips LL. Osteopontin expression in acute immune response mediates hippocampal synaptogenesis and adaptive outcome following cortical brain injury. Exp Neurol. 2014;261:757\u201371.","journal-title":"Exp Neurol"},{"issue":"36","key":"1600_CR42","doi-asserted-by":"publisher","first-page":"22736","DOI":"10.1074\/jbc.272.36.22736","volume":"272","author":"MT Kaartinen","year":"1997","unstructured":"Kaartinen MT, Pirhonen A, Linnala-Kankkunen A, Maenpaa PH. Transglutaminase-catalyzed cross-linking of osteopontin is inhibited by osteocalcin. J Biol Chem. 1997;272(36):22736\u201341.","journal-title":"J Biol Chem"},{"issue":"11","key":"1600_CR43","doi-asserted-by":"publisher","first-page":"2302","DOI":"10.1161\/ATVBAHA.107.144824","volume":"27","author":"M Scatena","year":"2007","unstructured":"Scatena M, Liaw L, Giachelli CM. Osteopontin: a multifunctional molecule regulating chronic inflammation and vascular disease. Arterioscler Thromb Vasc Biol. 2007;27(11):2302\u20139.","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"12","key":"1600_CR44","doi-asserted-by":"publisher","first-page":"1489","DOI":"10.1172\/JCI10498","volume":"106","author":"M Shibata","year":"2000","unstructured":"Shibata M, Yamada S, Kumar SR, Calero M, Bading J, Frangione B, et al. Clearance of Alzheimer\u2019s amyloid-ss(1\u201340) peptide from brain by LDL receptor-related protein-1 at the blood-brain barrier. J Clin Invest. 2000;106(12):1489\u201399.","journal-title":"J Clin Invest"},{"issue":"7","key":"1600_CR45","doi-asserted-by":"publisher","first-page":"1267","DOI":"10.1194\/jlr.R075796","volume":"58","author":"M Shinohara","year":"2017","unstructured":"Shinohara M, Tachibana M, Kanekiyo T, Bu G. Role of LRP1 in the pathogenesis of Alzheimer\u2019s disease: evidence from clinical and preclinical studies. J Lipid Res. 2017;58(7):1267\u201381.","journal-title":"J Lipid Res"},{"issue":"9","key":"1600_CR46","doi-asserted-by":"publisher","first-page":"3727","DOI":"10.1007\/s12035-020-01982-7","volume":"57","author":"Y He","year":"2020","unstructured":"He Y, Ruganzu JB, Zheng Q, Wu X, Jin H, Peng X, et al. Silencing of LRP1 exacerbates Inflammatory Response Via TLR4\/NF-kappaB\/MAPKs signaling pathways in APP\/PS1 transgenic mice. Mol Neurobiol. 2020;57(9):3727\u201343.","journal-title":"Mol Neurobiol"},{"issue":"3","key":"1600_CR47","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1016\/j.neuron.2004.07.017","volume":"43","author":"R Deane","year":"2004","unstructured":"Deane R, Wu Z, Sagare A, Davis J, Du Yan S, Hamm K, et al. LRP\/amyloid beta-peptide interaction mediates differential brain efflux of Abeta isoforms. Neuron. 2004;43(3):333\u201344.","journal-title":"Neuron"},{"issue":"34","key":"1600_CR48","doi-asserted-by":"publisher","first-page":"24566","DOI":"10.1074\/jbc.M602440200","volume":"281","author":"P Yan","year":"2006","unstructured":"Yan P, Hu X, Song H, Yin K, Bateman RJ, Cirrito JR, et al. Matrix metalloproteinase-9 degrades amyloid-beta fibrils in vitro and compact plaques in situ. J Biol Chem. 2006;281(34):24566\u201374.","journal-title":"J Biol Chem"},{"issue":"2","key":"1600_CR49","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1007\/s00441-008-0681-x","volume":"334","author":"D Langer","year":"2008","unstructured":"Langer D, Hammer K, Koszalka P, Schrader J, Robson S, Zimmermann H. Distribution of ectonucleotidases in the rodent brain revisited. Cell Tissue Res. 2008;334(2):199\u2013217.","journal-title":"Cell Tissue Res"},{"issue":"4","key":"1600_CR50","doi-asserted-by":"publisher","first-page":"e0175936","DOI":"10.1371\/journal.pone.0175936","volume":"12","author":"M Pettengill","year":"2017","unstructured":"Pettengill M, Matute JD, Tresenriter M, Hibbert J, Burgner D, Richmond P, et al. Human alkaline phosphatase dephosphorylates microbial products and is elevated in preterm neonates with a history of late-onset sepsis. PLoS ONE. 2017;12(4):e0175936.","journal-title":"PLoS ONE"},{"key":"1600_CR51","doi-asserted-by":"publisher","first-page":"115262","DOI":"10.1016\/j.bone.2020.115262","volume":"133","author":"L Bessueille","year":"2020","unstructured":"Bessueille L, Briolay A, Como J, Mebarek S, Mansouri C, Gleizes M, et al. Tissue-nonspecific alkaline phosphatase is an anti-inflammatory nucleotidase. Bone. 2020;133:115262.","journal-title":"Bone"},{"key":"1600_CR52","doi-asserted-by":"publisher","first-page":"10555","DOI":"10.1038\/ncomms10555","volume":"7","author":"M Karmakar","year":"2016","unstructured":"Karmakar M, Katsnelson MA, Dubyak GR, Pearlman E. Neutrophil P2X7 receptors mediate NLRP3 inflammasome-dependent IL-1beta secretion in response to ATP. Nat Commun. 2016;7:10555.","journal-title":"Nat Commun"},{"issue":"3","key":"1600_CR53","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1007\/s00296-008-0710-9","volume":"29","author":"C Beck","year":"2009","unstructured":"Beck C, Morbach H, Richl P, Stenzel M, Girschick HJ. How can calcium pyrophosphate crystals induce inflammation in hypophosphatasia or chronic inflammatory joint diseases? Rheumatol Int. 2009;29(3):229\u201338.","journal-title":"Rheumatol Int"},{"issue":"7081","key":"1600_CR54","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1038\/nature04516","volume":"440","author":"F Martinon","year":"2006","unstructured":"Martinon F, Petrilli V, Mayor A, Tardivel A, Tschopp J. Gout-associated uric acid crystals activate the NALP3 inflammasome. Nature. 2006;440(7081):237\u201341.","journal-title":"Nature"},{"issue":"4","key":"1600_CR55","doi-asserted-by":"publisher","first-page":"1199","DOI":"10.1016\/S0002-9440(10)63208-7","volume":"164","author":"D Harmey","year":"2004","unstructured":"Harmey D, Hessle L, Narisawa S, Johnson KA, Terkeltaub R, Millan JL. Concerted regulation of inorganic pyrophosphate and osteopontin by akp2, enpp1, and ank: an integrated model of the pathogenesis of mineralization disorders. Am J Pathol. 2004;164(4):1199\u2013209.","journal-title":"Am J Pathol"},{"issue":"3","key":"1600_CR56","doi-asserted-by":"publisher","first-page":"288","DOI":"10.2478\/s13380-012-0028-7","volume":"3","author":"A Brown","year":"2012","unstructured":"Brown A, Osteopontin. A key link between immunity, inflammation and the Central Nervous System. Transl Neurosci. 2012;3(3):288\u201393.","journal-title":"Transl Neurosci"},{"issue":"9","key":"1600_CR57","doi-asserted-by":"publisher","first-page":"1377","DOI":"10.1359\/jbmr.060619","volume":"21","author":"D Harmey","year":"2006","unstructured":"Harmey D, Johnson KA, Zelken J, Camacho NP, Hoylaerts MF, Noda M, et al. Elevated skeletal osteopontin levels contribute to the hypophosphatasia phenotype in Akp2(-\/-) mice. J Bone Min Res. 2006;21(9):1377\u201386.","journal-title":"J Bone Min Res"},{"issue":"4","key":"1600_CR58","doi-asserted-by":"publisher","first-page":"752","DOI":"10.1189\/jlb.72.4.752","volume":"72","author":"GF Weber","year":"2002","unstructured":"Weber GF, Zawaideh S, Hikita S, Kumar VA, Cantor H, Ashkar S. Phosphorylation-dependent interaction of osteopontin with its receptors regulates macrophage migration and activation. J Leukoc Biol. 2002;72(4):752\u201361.","journal-title":"J Leukoc Biol"},{"key":"1600_CR59","doi-asserted-by":"publisher","first-page":"147170","DOI":"10.1016\/j.brainres.2020.147170","volume":"1751","author":"X Zhang","year":"2021","unstructured":"Zhang X, Shu Q, Liu Z, Gao C, Wang Z, Xing Z, et al. Recombinant osteopontin provides protection for cerebral infarction by inhibiting the NLRP3 inflammasome in microglia. Brain Res. 2021;1751:147170.","journal-title":"Brain Res"},{"issue":"7434","key":"1600_CR60","doi-asserted-by":"publisher","first-page":"674","DOI":"10.1038\/nature11729","volume":"493","author":"MT Heneka","year":"2013","unstructured":"Heneka MT, Kummer MP, Stutz A, Delekate A, Schwartz S, Vieira-Saecker A, et al. NLRP3 is activated in Alzheimer\u2019s disease and contributes to pathology in APP\/PS1 mice. Nature. 2013;493(7434):674\u20138.","journal-title":"Nature"},{"issue":"46","key":"1600_CR61","doi-asserted-by":"publisher","first-page":"16458","DOI":"10.1523\/JNEUROSCI.3987-12.2012","volume":"32","author":"T Kanekiyo","year":"2012","unstructured":"Kanekiyo T, Liu CC, Shinohara M, Li J, Bu G. LRP1 in brain vascular smooth muscle cells mediates local clearance of Alzheimer\u2019s amyloid-beta. J Neurosci. 2012;32(46):16458\u201365.","journal-title":"J Neurosci"},{"key":"1600_CR62","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1007\/978-94-017-7197-9_12","volume":"76","author":"LG Nowak","year":"2015","unstructured":"Nowak LG, Rosay B, Czege D, Fonta C. Tetramisole and Levamisole suppress neuronal activity independently from their inhibitory action on tissue non-specific alkaline phosphatase in mouse cortex. Subcell Biochem. 2015;76:239\u201381.","journal-title":"Subcell Biochem"}],"container-title":["Alzheimer's Research &amp; Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13195-024-01600-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s13195-024-01600-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13195-024-01600-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,22]],"date-time":"2024-10-22T09:09:27Z","timestamp":1729588167000},"score":1,"resource":{"primary":{"URL":"https:\/\/alzres.biomedcentral.com\/articles\/10.1186\/s13195-024-01600-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,22]]},"references-count":62,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["1600"],"URL":"https:\/\/doi.org\/10.1186\/s13195-024-01600-x","relation":{},"ISSN":["1758-9193"],"issn-type":[{"value":"1758-9193","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,10,22]]},"assertion":[{"value":"24 July 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 October 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 October 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"For human samples. A written informed consent for brain removal after death for diagnostic and research purposes was obtained from the brain donors and\/or next of kin. Procedures, information, and consent forms were approved by the Bioethics Subcommittee of Fundaci\u00f3n Cien Madrid, Spain (S19001).All animal procedures were carried out at the Universidad Complutense de Madrid (UCM) in compliance with National and European regulations (RD1201\/2005; 86\/609\/CEE) and following the International Council for the Laboratory Animal Science guidelines. The protocol for animal experiments was approved by the Committee of Animal Experiments at the UCM and the Environmental Counselling of the Comunidad de Madrid, Spain (PROEX 137.8\/22).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"233"}}