{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T13:13:48Z","timestamp":1776777228544,"version":"3.51.2"},"reference-count":9,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,12,19]],"date-time":"2024-12-19T00:00:00Z","timestamp":1734566400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,12,19]],"date-time":"2024-12-19T00:00:00Z","timestamp":1734566400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/100014013","name":"UK Research and Innovation","doi-asserted-by":"publisher","award":["MR\/W011581\/1"],"award-info":[{"award-number":["MR\/W011581\/1"]}],"id":[{"id":"10.13039\/100014013","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Alz Res Therapy"],"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A recent paper concluded that cholesteryl ester transfer protein (CETP) inhibition may be a viable target to treat dementia, based on human genetic evidence of a protective effect of target inhibition on risk of Lewy body and Parkinson\u2019s dementia. Alzheimer\u2019s disease, which is by far the most prevalent cause of dementia (around 80% of all dementia cases) was not included as an outcome. Evidence shows CETP inhibition is unlikely to affect Alzheimer\u2019s risk and may even potentially modestly increase risk. There is also little evidence to support an effect of CETP inhibition on all-cause or vascular dementia. Thus, CETP inhibition is unlikely to be a viable target to treat the most prevalent causes of dementia.<\/jats:p>","DOI":"10.1186\/s13195-024-01631-4","type":"journal-article","created":{"date-parts":[[2024,12,19]],"date-time":"2024-12-19T14:50:16Z","timestamp":1734619816000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Response to Schmidt et al.: Lower activity of cholesteryl ester transfer protein (CETP) and the risk of dementia: a Mendelian randomization analysis"],"prefix":"10.1186","volume":"16","author":[{"given":"Emma L","family":"Anderson","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,12,19]]},"reference":[{"key":"1631_CR1","doi-asserted-by":"crossref","unstructured":"Schmidt, A. F., Davidson, M. H., Ditmarsch, M., Kastelein, J. J. & Finan, C. Lower activity of cholesteryl ester transfer protein (CETP) and the risk of dementia: a Mendelian randomization analysis. Alzheimers Res Ther. 2024;16:228. http:\/\/doi.org\/10.1186\/s13195-024-01594-6","DOI":"10.1186\/s13195-024-01594-6"},{"key":"1631_CR2","doi-asserted-by":"crossref","unstructured":"Neuropathology Group. Medical Research Council Cognitive, F. & Aging, S. Pathological correlates of late-onset dementia in a multicentre, community-based population in England and Wales. Neuropathology Group of the Medical Research Council Cognitive Function and Ageing Study (MRC CFAS). Lancet. 2001;357:169\u2013175. http:\/\/doi.org\/10.1016\/s0140-6736(00)03589-3","DOI":"10.1016\/S0140-6736(00)03589-3"},{"key":"1631_CR3","doi-asserted-by":"crossref","unstructured":"Vann Jones, S. A. & O\u2019Brien, J. T. The prevalence and incidence of dementia with Lewy bodies: a systematic review of population and clinical studies. Psychol Med. 2014;44:673\u2013683. http:\/\/doi.org\/10.1017\/S0033291713000494","DOI":"10.1017\/S0033291713000494"},{"key":"1631_CR4","doi-asserted-by":"crossref","unstructured":"Bellenguez, C. et al. New insights on the genetic etiology of Alzheimer\u2019s and related dementia. medRxiv. 2020;2010:2001.20200659. http:\/\/doi.org\/10.1101\/2020.10.01.20200659","DOI":"10.1101\/2020.10.01.20200659"},{"key":"1631_CR5","doi-asserted-by":"crossref","unstructured":"Schmidt, A. F. et al. Cholesteryl ester transfer protein (CETP) as a drug target for cardiovascular disease. Nat Commun. 2021;12:5640. http:\/\/doi.org\/10.1038\/s41467-021-25703-3","DOI":"10.1038\/s41467-021-25703-3"},{"key":"1631_CR6","doi-asserted-by":"crossref","unstructured":"Lambert, J. C. et al. Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer\u2019s disease. Nat Genet. 2013;45:1452\u20131458. http:\/\/doi.org\/10.1038\/ng.2802","DOI":"10.1038\/ng.2802"},{"key":"1631_CR7","doi-asserted-by":"crossref","unstructured":"Kunkle, B. W. et al. Genetic meta-analysis of diagnosed Alzheimer\u2019s disease identifies new risk loci and implicates A\u03b2, tau, immunity and lipid processing. Nat Genet. 2019;51:414\u2013430. http:\/\/doi.org\/10.1038\/s41588-019-0358-2","DOI":"10.1038\/s41588-019-0358-2"},{"key":"1631_CR8","doi-asserted-by":"crossref","unstructured":"Jansen, I. E. et al. Genome-wide meta-analysis identifies new loci and functional pathways influencing Alzheimer\u2019s disease risk. Nat Genet. 2019;51:404\u2013413. http:\/\/doi.org\/10.1038\/s41588-018-0311-9","DOI":"10.1038\/s41588-018-0311-9"},{"key":"1631_CR9","doi-asserted-by":"crossref","unstructured":"consortium., T. M. V. C. I. a. D. M. A genome-wide association meta-analysis of all-cause and vascular dementia. Alzheimer\u2019s & Dementia. 2014;20:5973\u20135995. http:\/\/doi.org\/10.1002\/alz.14115","DOI":"10.1002\/alz.14115"}],"container-title":["Alzheimer's Research &amp; Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13195-024-01631-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s13195-024-01631-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13195-024-01631-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,19]],"date-time":"2024-12-19T15:09:50Z","timestamp":1734620990000},"score":1,"resource":{"primary":{"URL":"https:\/\/alzres.biomedcentral.com\/articles\/10.1186\/s13195-024-01631-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,19]]},"references-count":9,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["1631"],"URL":"https:\/\/doi.org\/10.1186\/s13195-024-01631-4","relation":{},"ISSN":["1758-9193"],"issn-type":[{"value":"1758-9193","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,12,19]]},"assertion":[{"value":"18 November 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 November 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 December 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"No ethics approval is required for this study as all data are publicly available genome-wide association study summary level data, with no identifiable information.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"No consent for publication is required for this study as all data are publicly available genome-wide association study summary level data, with no identifiable information.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"264"}}