{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T07:30:58Z","timestamp":1782977458453,"version":"3.54.5"},"reference-count":71,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,12,20]],"date-time":"2024-12-20T00:00:00Z","timestamp":1734652800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2024,12,20]],"date-time":"2024-12-20T00:00:00Z","timestamp":1734652800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Alz Res Therapy"],"DOI":"10.1186\/s13195-024-01635-0","type":"journal-article","created":{"date-parts":[[2024,12,20]],"date-time":"2024-12-20T06:16:11Z","timestamp":1734675371000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Association of critically short telomeres with brain and blood markers of ageing and Alzheimer\u2019s disease in older adults"],"prefix":"10.1186","volume":"16","author":[{"given":"Asrar","family":"Lehodey","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Perla","family":"Kaliman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cassandre","family":"Palix","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robin","family":"de Flor\u00e8s","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edelweiss","family":"Touron","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne-Laure","family":"Turpin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00e9verine","family":"Fauvel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florence","family":"M\u00e9zenge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brigitte","family":"Landeau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Chocat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agathe","family":"Vrillon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claire","family":"Paquet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denis","family":"Vivien","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent","family":"de La Sayette","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ga\u00ebl","family":"Ch\u00e9telat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00e9raldine","family":"Poisnel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"the Medit-Ageing Research Group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claire","family":"Andr\u00e9","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eider M.","family":"Arenaza-Urquijo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Champetier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabienne","family":"Colette","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robin","family":"De Flores","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marion","family":"Delarue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Felisatti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Egantine Ferrand","family":"Devouge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antoine","family":"Garnier-Crussard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie","family":"Gonneaud","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Heidmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank","family":"Jessen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olga","family":"Klimecki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Kuhn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gwendoline","family":"Le Du","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Val\u00e9rie","family":"Lefranc","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antoine","family":"Lutz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalie","family":"Marchant","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florence","family":"Mezenge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"In\u00e8s","family":"Moulinet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentin","family":"Ourry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L\u00e9o","family":"Paly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"Poletti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Quillard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00e9raldine","family":"Rauchs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"St\u00e9phane","family":"Rehel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Salmon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siya","family":"Sherif","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthieu","family":"Vanhoutte","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrik","family":"Vuilleumier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caitliin","family":"Ware","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miranka","family":"Wirth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,12,20]]},"reference":[{"key":"1635_CR1","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1038\/s41556-022-00842-x","volume":"24","author":"F Rossiello","year":"2022","unstructured":"Rossiello F, Jurk D, Passos JF, et al. Telomere dysfunction in ageing and age-related diseases. Nat Cell Biol. 2022;24:135\u201347.","journal-title":"Nat Cell Biol"},{"key":"1635_CR2","doi-asserted-by":"publisher","first-page":"532","DOI":"10.1038\/sj.onc.1205080","volume":"21","author":"T de Lange","year":"2002","unstructured":"de Lange T. Protection of mammalian telomeres. Oncogene. 2002;21:532\u201340.","journal-title":"Oncogene"},{"key":"1635_CR3","doi-asserted-by":"publisher","first-page":"5753","DOI":"10.1128\/MCB.21.17.5753-5766.2001","volume":"21","author":"R Ohki","year":"2001","unstructured":"Ohki R, Tsurimoto T, Ishikawa F. In Vitro Reconstitution of the End Replication Problem. Mol Cell Biol. 2001;21:5753\u201366.","journal-title":"Mol Cell Biol"},{"key":"1635_CR4","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1016\/j.diff.2017.12.002","volume":"99","author":"W Ahmed","year":"2018","unstructured":"Ahmed W, Lingner J. Impact of oxidative stress on telomere biology. Differentiation. 2018;99:21\u20137.","journal-title":"Differentiation"},{"key":"1635_CR5","doi-asserted-by":"publisher","first-page":"4172","DOI":"10.1038\/ncomms5172","volume":"5","author":"D Jurk","year":"2014","unstructured":"Jurk D, Wilson C, Passos JF, et al. Chronic inflammation induces telomere dysfunction and accelerates ageing in mice. Nat Commun. 2014;5:4172.","journal-title":"Nat Commun"},{"key":"1635_CR6","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1134\/S2079057017020102","volume":"7","author":"VN Maximov","year":"2017","unstructured":"Maximov VN, Malyutina SK, Orlov PS, et al. Leukocyte telomere length as an aging marker and risk factor for human age-related diseases. Adv Gerontol. 2017;7:101\u20136.","journal-title":"Adv Gerontol"},{"key":"1635_CR7","doi-asserted-by":"publisher","first-page":"210","DOI":"10.1016\/j.psyneuen.2019.03.002","volume":"104","author":"SE Mayer","year":"2019","unstructured":"Mayer SE, Prather AA, Puterman E, et al. Cumulative lifetime stress exposure and leukocyte telomere length attrition: The unique role of stressor duration and exposure timing. Psychoneuroendocrinology. 2019;104:210\u20138.","journal-title":"Psychoneuroendocrinology"},{"key":"1635_CR8","doi-asserted-by":"publisher","first-page":"e19687","DOI":"10.1371\/journal.pone.0019687","volume":"6","author":"A O\u2019Donovan","year":"2011","unstructured":"O\u2019Donovan A, Pantell MS, Puterman E, et al. Cumulative inflammatory load is associated with short leukocyte telomere length in the health, aging and body composition study. PLoS ONE. 2011;6:e19687.","journal-title":"PLoS ONE"},{"key":"1635_CR9","doi-asserted-by":"publisher","first-page":"640","DOI":"10.1038\/nchembio.2007.38","volume":"3","author":"MA Blasco","year":"2007","unstructured":"Blasco MA. Telomere length, stem cells and aging. Nat Chem Biol. 2007;3:640\u20139.","journal-title":"Nat Chem Biol"},{"key":"1635_CR10","doi-asserted-by":"publisher","first-page":"732","DOI":"10.1016\/j.celrep.2012.08.023","volume":"2","author":"E Vera","year":"2012","unstructured":"Vera E, Bernardes de Jesus B, Foronda M, et al. The Rate of Increase of Short Telomeres Predicts Longevity in Mammals. Cell Rep. 2012;2:732\u20137.","journal-title":"Cell Rep"},{"key":"1635_CR11","doi-asserted-by":"publisher","first-page":"693","DOI":"10.1038\/nrg3246","volume":"13","author":"M Armanios","year":"2012","unstructured":"Armanios M, Blackburn EH. The telomere syndromes. Nat Rev Genet. 2012;13:693\u2013704.","journal-title":"Nat Rev Genet"},{"key":"1635_CR12","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1111\/j.1474-9726.2010.00568.x","volume":"9","author":"L Bendix","year":"2010","unstructured":"Bendix L, Horn PB, Jensen UB, et al. The load of short telomeres, estimated by a new method, Universal S\u2121A, correlates with number of senescent cells. Aging Cell. 2010;9:383\u201397.","journal-title":"Aging Cell"},{"key":"1635_CR13","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1016\/S0092-8674(01)00504-9","volume":"107","author":"MT Hemann","year":"2001","unstructured":"Hemann MT, Strong MA, Hao L-Y, et al. The shortest telomere, not average telomere length, is critical for cell viability and chromosome stability. Cell. 2001;107:67\u201377.","journal-title":"Cell"},{"key":"1635_CR14","doi-asserted-by":"publisher","first-page":"2467","DOI":"10.1016\/j.jacc.2016.03.530","volume":"67","author":"JM Fern\u00e1ndez-Alvira","year":"2016","unstructured":"Fern\u00e1ndez-Alvira JM, Fuster V, Dorado B, et al. Short telomere load, telomere length, and subclinical atherosclerosis. J Am Coll Cardiol. 2016;67:2467\u201376.","journal-title":"J Am Coll Cardiol"},{"key":"1635_CR15","doi-asserted-by":"publisher","first-page":"455","DOI":"10.1016\/S1474-4422(16)00062-4","volume":"15","author":"B Winblad","year":"2016","unstructured":"Winblad B, Amouyel P, Andrieu S, et al. Defeating Alzheimer\u2019s disease and other dementias: a priority for European science and society. Lancet Neurol. 2016;15:455\u2013532.","journal-title":"Lancet Neurol"},{"key":"1635_CR16","doi-asserted-by":"publisher","first-page":"1069","DOI":"10.1093\/gerona\/glw053","volume":"71","author":"DA Forero","year":"2016","unstructured":"Forero DA, Gonz\u00e1lez-Giraldo Y, L\u00f3pez-Quintero C, et al. Meta-analysis of telomere length in Alzheimer\u2019s disease. J Gerontol Ser A. 2016;71:1069\u201373.","journal-title":"J Gerontol Ser A"},{"key":"1635_CR17","doi-asserted-by":"publisher","first-page":"1286","DOI":"10.3390\/biology12101286","volume":"12","author":"P Crocco","year":"2023","unstructured":"Crocco P, De Rango F, Dato S, et al. The shortening of leukocyte telomere length contributes to Alzheimer\u2019s disease: further evidence from late-onset familial and sporadic cases. Biology. 2023;12:1286.","journal-title":"Biology"},{"key":"1635_CR18","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1007\/s10654-019-00563-w","volume":"35","author":"A Scheller Madrid","year":"2020","unstructured":"Scheller Madrid A, Rasmussen KL, Rode L, et al. Observational and genetic studies of short telomeres and Alzheimer\u2019s disease in 67,000 and 152,000 individuals: a Mendelian randomization study. Eur J Epidemiol. 2020;35:147\u201356.","journal-title":"Eur J Epidemiol"},{"key":"1635_CR19","doi-asserted-by":"publisher","first-page":"101679","DOI":"10.1016\/j.arr.2022.101679","volume":"80","author":"P Gampawar","year":"2022","unstructured":"Gampawar P, Schmidt R, Schmidt H. Telomere length and brain aging: A systematic review and meta-analysis. Ageing Res Rev. 2022;80:101679.","journal-title":"Ageing Res Rev"},{"key":"1635_CR20","doi-asserted-by":"publisher","first-page":"714","DOI":"10.1016\/j.trci.2018.10.011","volume":"4","author":"G Poisnel","year":"2018","unstructured":"Poisnel G, Arenaza-Urquijo E, Collette F, et al. The age-well randomized controlled trial of the Medit-Ageing European project: Effect of meditation or foreign language training on brain and mental health in older adults. Alzheimers Dement Transl Res Clin Interv. 2018;4:714\u201323.","journal-title":"Alzheimers Dement Transl Res Clin Interv"},{"key":"1635_CR21","doi-asserted-by":"publisher","first-page":"5300","DOI":"10.1073\/pnas.0609367104","volume":"104","author":"A Canela","year":"2007","unstructured":"Canela A, Vera E, Klatt P, et al. High-throughput telomere length quantification by FISH and its application to human population studies. Proc Natl Acad Sci U S A. 2007;104:5300\u20135.","journal-title":"Proc Natl Acad Sci U S A"},{"key":"1635_CR22","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1016\/j.jad.2011.08.006","volume":"135","author":"T Elvs\u00e5shagen","year":"2011","unstructured":"Elvs\u00e5shagen T, Vera E, B\u00f8en E, et al. The load of short telomeres is increased and associated with lifetime number of depressive episodes in bipolar II disorder. J Affect Disord. 2011;135:43\u201350.","journal-title":"J Affect Disord"},{"key":"1635_CR23","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1016\/j.nicl.2013.08.007","volume":"3","author":"R La Joie","year":"2013","unstructured":"La Joie R, Perrotin A, de La Sayette V, et al. Hippocampal subfield volumetry in mild cognitive impairment, Alzheimer\u2019s disease and semantic dementia. NeuroImage Clin. 2013;3:155\u201362.","journal-title":"NeuroImage Clin"},{"key":"1635_CR24","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1016\/j.neurobiolaging.2022.06.004","volume":"118","author":"C Palix","year":"2022","unstructured":"Palix C, Felisatti F, Gonneaud J, et al. Relationships between diabetes-related vascular risk factors and neurodegeneration biomarkers in healthy aging and Alzheimer\u2019s disease. Neurobiol Aging. 2022;118:25\u201333.","journal-title":"Neurobiol Aging"},{"key":"1635_CR25","doi-asserted-by":"publisher","first-page":"10402","DOI":"10.1523\/JNEUROSCI.0150-15.2015","volume":"35","author":"FL Besson","year":"2015","unstructured":"Besson FL, La Joie R, Doeuvre L, et al. Cognitive and brain profiles associated with current neuroimaging biomarkers of preclinical Alzheimer\u2019s disease. J Neurosci. 2015;35:10402\u201311.","journal-title":"J Neurosci"},{"key":"1635_CR26","doi-asserted-by":"publisher","first-page":"258","DOI":"10.1002\/hbm.22627","volume":"36","author":"PA Yushkevich","year":"2015","unstructured":"Yushkevich PA, Pluta JB, Wang H, et al. Automated volumetry and regional thickness analysis of hippocampal subfields and medial temporal cortical structures in mild cognitive impairment. Hum Brain Mapp. 2015;36:258\u201387.","journal-title":"Hum Brain Mapp"},{"key":"1635_CR27","doi-asserted-by":"publisher","first-page":"e370","DOI":"10.1212\/WNL.0000000000207421","volume":"101","author":"C Andr\u00e9","year":"2023","unstructured":"Andr\u00e9 C, Kuhn E, Rehel S, et al. Association of sleep-disordered breathing and medial temporal lobe atrophy in cognitively unimpaired amyloid-positive older adults. Neurology. 2023;101:e370\u201385.","journal-title":"Neurology"},{"key":"1635_CR28","doi-asserted-by":"publisher","first-page":"106127","DOI":"10.1016\/j.nbd.2023.106127","volume":"181","author":"R de Flores","year":"2023","unstructured":"de Flores R, Demeilliez-Servouin S, Kuhn E, et al. Respective influence of beta-amyloid and APOE \u03b54 genotype on medial temporal lobe subregions in cognitively unimpaired older adults. Neurobiol Dis. 2023;181:106127.","journal-title":"Neurobiol Dis"},{"key":"1635_CR29","doi-asserted-by":"publisher","first-page":"3431","DOI":"10.1002\/hbm.24607","volume":"40","author":"L Xie","year":"2019","unstructured":"Xie L, Wisse LEM, Pluta J, et al. Automated segmentation of medial temporal lobe subregions on in vivo T1-weighted MRI in early stages of Alzheimer\u2019s disease. Hum Brain Mapp. 2019;40:3431\u201351.","journal-title":"Hum Brain Mapp"},{"key":"1635_CR30","unstructured":"Hepatic and renal function impact concentrations of plasma biomarkers of neuropathology - Berry - 2022 - Alzheimer\u2019s & Dementia: Diagnosis, Assessment & Disease Monitoring - Wiley Online Library."},{"key":"1635_CR31","doi-asserted-by":"publisher","unstructured":"Sch\u00f6ll M, Verberk IMW, Campo M del et al. Challenges in the practical implementation of blood biomarkers for Alzheimer\u2019s disease. Lancet Healthy Longev 2024;5, https:\/\/doi.org\/10.1016\/j.lanhl.2024.07.013.","DOI":"10.1016\/j.lanhl.2024.07.013"},{"key":"1635_CR32","doi-asserted-by":"publisher","first-page":"2203","DOI":"10.1016\/j.neurobiolaging.2014.03.011","volume":"35","author":"N-J Gong","year":"2014","unstructured":"Gong N-J, Wong C-S, Chan C-C, et al. Aging in deep gray matter and white matter revealed by diffusional kurtosis imaging. Neurobiol Aging. 2014;35:2203\u201316.","journal-title":"Neurobiol Aging"},{"issue":"14","key":"1635_CR33","first-page":"721","volume":"2004","author":"DH Salat","year":"1991","unstructured":"Salat DH, Buckner RL, Snyder AZ, et al. Thinning of the cerebral cortex in aging. Cereb Cortex N Y N. 1991;2004(14):721\u201330.","journal-title":"Cereb Cortex N Y N"},{"key":"1635_CR34","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1016\/j.neurobiolaging.2018.04.021","volume":"69","author":"AM Staffaroni","year":"2018","unstructured":"Staffaroni AM, Tosun D, Lin J, et al. Telomere attrition is associated with declines in medial temporal lobe volume and white matter microstructure in functionally independent older adults. Neurobiol Aging. 2018;69:68\u201375.","journal-title":"Neurobiol Aging"},{"key":"1635_CR35","doi-asserted-by":"publisher","first-page":"e0282363","DOI":"10.1371\/journal.pone.0282363","volume":"18","author":"A Topiwala","year":"2023","unstructured":"Topiwala A, Nichols TE, Williams LZJ, et al. Telomere length and brain imaging phenotypes in UK Biobank. PLoS ONE. 2023;18:e0282363.","journal-title":"PLoS ONE"},{"key":"1635_CR36","doi-asserted-by":"publisher","first-page":"812","DOI":"10.1038\/s41467-020-14612-6","volume":"11","author":"M Khalil","year":"2020","unstructured":"Khalil M, Pirpamer L, Hofer E, et al. Serum neurofilament light levels in normal aging and their association with morphologic brain changes. Nat Commun. 2020;11:812.","journal-title":"Nat Commun"},{"key":"1635_CR37","doi-asserted-by":"publisher","first-page":"2781","DOI":"10.1016\/j.neuron.2023.05.017","volume":"111","author":"H Hampel","year":"2023","unstructured":"Hampel H, Hu Y, Cummings J, et al. Blood-based biomarkers for Alzheimer\u2019s disease: Current state and future use in a transformed global healthcare landscape. Neuron. 2023;111:2781\u201399.","journal-title":"Neuron"},{"key":"1635_CR38","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1186\/s13195-022-01101-9","volume":"14","author":"B Rodr\u00edguez-Fern\u00e1ndez","year":"2022","unstructured":"Rodr\u00edguez-Fern\u00e1ndez B, Vilor-Tejedor N, Arenaza-Urquijo EM, et al. Genetically predicted telomere length and Alzheimer\u2019s disease endophenotypes: a Mendelian randomization study. Alzheimers Res Ther. 2022;14:167.","journal-title":"Alzheimers Res Ther"},{"key":"1635_CR39","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1016\/j.neurobiolaging.2018.06.023","volume":"70","author":"EE Moore","year":"2018","unstructured":"Moore EE, Hohman TJ, Badami FS, et al. Neurofilament relates to white matter microstructure in older adults. Neurobiol Aging. 2018;70:233\u201341.","journal-title":"Neurobiol Aging"},{"key":"1635_CR40","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1111\/j.1474-9726.2006.00224.x","volume":"5","author":"S Demissie","year":"2006","unstructured":"Demissie S, Levy D, Benjamin EJ, et al. Insulin resistance, oxidative stress, hypertension, and leukocyte telomere length in men from the Framingham Heart Study. Aging Cell. 2006;5:325\u201330.","journal-title":"Aging Cell"},{"key":"1635_CR41","doi-asserted-by":"publisher","first-page":"948","DOI":"10.1016\/j.neurobiolaging.2014.11.004","volume":"36","author":"BM Bettcher","year":"2015","unstructured":"Bettcher BM, Yaffe K, Boudreau RM, et al. Declines in inflammation predict greater white matter microstructure in older adults. Neurobiol Aging. 2015;36:948\u201354.","journal-title":"Neurobiol Aging"},{"key":"1635_CR42","doi-asserted-by":"publisher","first-page":"e106521","DOI":"10.1371\/journal.pone.0106521","volume":"9","author":"BM Bettcher","year":"2014","unstructured":"Bettcher BM, Watson CL, Walsh CM, et al. Interleukin-6, Age, and Corpus Callosum Integrity. PLoS ONE. 2014;9:e106521.","journal-title":"PLoS ONE"},{"key":"1635_CR43","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1016\/j.exger.2016.05.010","volume":"82","author":"N Malaquin","year":"2016","unstructured":"Malaquin N, Martinez A, Rodier F. Keeping the senescence secretome under control: Molecular reins on the senescence-associated secretory phenotype. Exp Gerontol. 2016;82:39\u201349.","journal-title":"Exp Gerontol"},{"key":"1635_CR44","doi-asserted-by":"publisher","first-page":"1465006","DOI":"10.3389\/fimmu.2024.1465006","volume":"15","author":"L Huang","year":"2024","unstructured":"Huang L, Zhang M, Bai D, et al. Deciphering the impact of TERT\/telomerase on immunosenescence and T cell revitalization. Front Immunol. 2024;15:1465006.","journal-title":"Front Immunol"},{"key":"1635_CR45","doi-asserted-by":"publisher","unstructured":"Rodriguez IJ, Lalinde Ruiz N, Llano Le\u00f3n M et al. Immunosenescence study of T cells: a systematic review. Front Immunol 2021;11. https:\/\/doi.org\/10.3389\/fimmu.2020.604591.","DOI":"10.3389\/fimmu.2020.604591"},{"key":"1635_CR46","doi-asserted-by":"publisher","unstructured":"Deleidi M, J\u00e4ggle M, Rubino G. Immune aging, dysmetabolism, and inflammation in neurological diseases. Front Neurosci 2015;9. https:\/\/doi.org\/10.3389\/fnins.2015.00172.","DOI":"10.3389\/fnins.2015.00172"},{"key":"1635_CR47","doi-asserted-by":"publisher","first-page":"114","DOI":"10.1016\/j.neubiorev.2017.01.044","volume":"75","author":"S Di Benedetto","year":"2017","unstructured":"Di Benedetto S, M\u00fcller L, Wenger E, et al. Contribution of neuroinflammation and immunity to brain aging and the mitigating effects of physical and cognitive interventions. Neurosci Biobehav Rev. 2017;75:114\u201328.","journal-title":"Neurosci Biobehav Rev"},{"key":"1635_CR48","doi-asserted-by":"publisher","first-page":"1099","DOI":"10.1111\/j.1471-4159.2009.06537.x","volume":"112","author":"R von Bernhardi","year":"2010","unstructured":"von Bernhardi R, Tichauer JE, Eugen\u00edn J. Aging-dependent changes of microglial cells and their relevance for neurodegenerative disorders. J Neurochem. 2010;112:1099\u2013114.","journal-title":"J Neurochem"},{"key":"1635_CR49","doi-asserted-by":"publisher","first-page":"689","DOI":"10.1038\/s41582-021-00549-x","volume":"17","author":"BM Bettcher","year":"2021","unstructured":"Bettcher BM, Tansey MG, Doroth\u00e9e G, et al. Peripheral and central immune system crosstalk in Alzheimer disease \u2014 a research prospectus. Nat Rev Neurol. 2021;17:689\u2013701.","journal-title":"Nat Rev Neurol"},{"key":"1635_CR50","doi-asserted-by":"publisher","first-page":"872134","DOI":"10.3389\/fnagi.2022.872134","volume":"14","author":"X Zang","year":"2022","unstructured":"Zang X, Chen S, Zhu J, et al. The emerging role of central and peripheral immune systems in neurodegenerative diseases. Front Aging Neurosci. 2022;14:872134.","journal-title":"Front Aging Neurosci"},{"key":"1635_CR51","doi-asserted-by":"publisher","first-page":"eaaz6876","DOI":"10.1126\/science.aaz6876","volume":"369","author":"K Demanelis","year":"2020","unstructured":"Demanelis K, Jasmine F, Chen LS, et al. Determinants of telomere length across human tissues. Science. 2020;369:eaaz6876.","journal-title":"Science"},{"key":"1635_CR52","doi-asserted-by":"publisher","first-page":"944","DOI":"10.1016\/j.exger.2007.05.003","volume":"42","author":"K-I Nakamura","year":"2007","unstructured":"Nakamura K-I, Takubo K, Izumiyama-Shimomura N, et al. Telomeric DNA length in cerebral gray and white matter is associated with longevity in individuals aged 70 years or older. Exp Gerontol. 2007;42:944\u201350.","journal-title":"Exp Gerontol"},{"key":"1635_CR53","doi-asserted-by":"publisher","first-page":"1507","DOI":"10.1111\/ggi.13500","volume":"18","author":"K Tomita","year":"2018","unstructured":"Tomita K, Aida J, Izumiyama-Shimomura N, et al. Changes in telomere length with aging in human neurons and glial cells revealed by quantitative fluorescence in situ hybridization analysis. Geriatr Gerontol Int. 2018;18:1507\u201312.","journal-title":"Geriatr Gerontol Int"},{"key":"1635_CR54","doi-asserted-by":"publisher","first-page":"e101120","DOI":"10.1136\/gpsych-2023-101120","volume":"36","author":"Z Cao","year":"2023","unstructured":"Cao Z, Hou Y, Xu C. Leucocyte telomere length, brain volume and risk of dementia: a prospective cohort study. Gen Psychiatry. 2023;36:e101120.","journal-title":"Gen Psychiatry"},{"key":"1635_CR55","doi-asserted-by":"publisher","first-page":"e0277344","DOI":"10.1371\/journal.pone.0277344","volume":"17","author":"A Salih","year":"2022","unstructured":"Salih A, Galazzo IB, Petersen SE, et al. Telomere length is causally connected to brain MRI image derived phenotypes: a mendelian randomization study. PLoS ONE. 2022;17:e0277344.","journal-title":"PLoS ONE"},{"key":"1635_CR56","doi-asserted-by":"publisher","first-page":"1247","DOI":"10.1001\/jamaneurol.2014.1926","volume":"71","author":"KS King","year":"2014","unstructured":"King KS, Kozlitina J, Rosenberg RN, et al. Effect of leukocyte telomere length on total and regional brain volumes in a large population-based cohort. JAMA Neurol. 2014;71:1247\u201354.","journal-title":"JAMA Neurol"},{"key":"1635_CR57","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1016\/j.neuroscience.2015.08.033","volume":"309","author":"R de Flores","year":"2015","unstructured":"de Flores R, La Joie R, Ch\u00e9telat G. Structural imaging of hippocampal subfields in healthy aging and Alzheimer\u2019s disease. Neuroscience. 2015;309:29\u201350.","journal-title":"Neuroscience"},{"key":"1635_CR58","doi-asserted-by":"publisher","first-page":"e34292","DOI":"10.1371\/journal.pone.0034292","volume":"7","author":"M Wikgren","year":"2012","unstructured":"Wikgren M, Karlsson T, Lind J, et al. Longer leukocyte telomere length is associated with smaller hippocampal volume among non-demented APOE \u03b53\/\u03b53 subjects. PLoS ONE. 2012;7:e34292.","journal-title":"PLoS ONE"},{"key":"1635_CR59","doi-asserted-by":"publisher","first-page":"118966","DOI":"10.1016\/j.neuroimage.2022.118966","volume":"250","author":"M R\u00e9gy","year":"2022","unstructured":"R\u00e9gy M, Dugravot A, Sabia S, et al. Association of APOE \u03b54 with cerebral gray matter volumes in non-demented older adults: The MEMENTO cohort study. Neuroimage. 2022;250:118966.","journal-title":"Neuroimage"},{"key":"1635_CR60","doi-asserted-by":"publisher","first-page":"1020","DOI":"10.1038\/s41593-022-01127-0","volume":"25","author":"C-C Liu","year":"2022","unstructured":"Liu C-C, Zhao J, Fu Y, et al. Peripheral apoE4 enhances Alzheimer\u2019s pathology and impairs cognition by compromising cerebrovascular function. Nat Neurosci. 2022;25:1020\u201333.","journal-title":"Nat Neurosci"},{"key":"1635_CR61","doi-asserted-by":"publisher","first-page":"1351","DOI":"10.1177\/0271678X20952012","volume":"41","author":"W-J Moon","year":"2021","unstructured":"Moon W-J, Lim C, Ha IH, et al. Hippocampal blood\u2013brain barrier permeability is related to the APOE4 mutation status of elderly individuals without dementia. J Cereb Blood Flow Metab. 2021;41:1351\u201361.","journal-title":"J Cereb Blood Flow Metab"},{"key":"1635_CR62","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1038\/s41586-020-2247-3","volume":"581","author":"A Montagne","year":"2020","unstructured":"Montagne A, Nation DA, Sagare AP, et al. APOE4 leads to blood\u2013brain barrier dysfunction predicting cognitive decline. Nature. 2020;581:71\u20136.","journal-title":"Nature"},{"key":"1635_CR63","doi-asserted-by":"publisher","first-page":"1471","DOI":"10.1001\/jamaneurol.2021.3671","volume":"78","author":"AL Benedet","year":"2021","unstructured":"Benedet AL, Mil\u00e0-Alom\u00e0 M, Vrillon A, et al. Differences between plasma and cerebrospinal fluid glial fibrillary acidic protein levels across the Alzheimer disease continuum. JAMA Neurol. 2021;78:1471\u201383.","journal-title":"JAMA Neurol"},{"key":"1635_CR64","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1186\/s13195-023-01277-8","volume":"15","author":"H Stocker","year":"2023","unstructured":"Stocker H, Trares K, Beyer L, et al. Alzheimer\u2019s polygenic risk scores, APOE, Alzheimer\u2019s disease risk, and dementia-related blood biomarker levels in a population-based cohort study followed over 17 years. Alzheimers Res Ther. 2023;15:129.","journal-title":"Alzheimers Res Ther"},{"key":"1635_CR65","doi-asserted-by":"publisher","first-page":"106175","DOI":"10.1016\/j.nbd.2023.106175","volume":"183","author":"A Snellman","year":"2023","unstructured":"Snellman A, Ekblad LL, Ashton NJ, et al. Head-to-head comparison of plasma p-tau181, p-tau231 and glial fibrillary acidic protein in clinically unimpaired elderly with three levels of APOE4-related risk for Alzheimer\u2019s disease. Neurobiol Dis. 2023;183:106175.","journal-title":"Neurobiol Dis"},{"key":"1635_CR66","doi-asserted-by":"publisher","unstructured":"Erd\u0151 F, Denes L, de Lange E. Age-associated physiological and pathological changes at the blood-brain barrier: A review. J Cereb Blood Flow Metab Off J Int Soc Cereb Blood Flow Metab 2017;37. https:\/\/doi.org\/10.1177\/0271678X16679420.","DOI":"10.1177\/0271678X16679420"},{"key":"1635_CR67","doi-asserted-by":"publisher","unstructured":"Sun Y, Koyama Y, Shimada S. Inflammation From Peripheral Organs to the Brain: How Does Systemic Inflammation Cause Neuroinflammation? Front Aging Neurosci 2022;14. https:\/\/doi.org\/10.3389\/fnagi.2022.903455.","DOI":"10.3389\/fnagi.2022.903455"},{"key":"1635_CR68","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.arr.2015.04.003","volume":"22","author":"V Boccardi","year":"2015","unstructured":"Boccardi V, Pelini L, Ercolani S, et al. From cellular senescence to Alzheimer\u2019s disease: The role of telomere shortening. Ageing Res Rev. 2015;22:1\u20138.","journal-title":"Ageing Res Rev"},{"key":"1635_CR69","doi-asserted-by":"publisher","first-page":"2044","DOI":"10.1093\/brain\/awr133","volume":"134","author":"H Rolyan","year":"2011","unstructured":"Rolyan H, Scheffold A, Heinrich A, et al. Telomere shortening reduces Alzheimer\u2019s disease amyloid pathology in mice. Brain J Neurol. 2011;134:2044\u201356.","journal-title":"Brain J Neurol"},{"key":"1635_CR70","doi-asserted-by":"publisher","first-page":"20160451","DOI":"10.1098\/rstb.2016.0451","volume":"373","author":"T-P Lai","year":"2018","unstructured":"Lai T-P, Wright WE, Shay JW. Comparison of telomere length measurement methods. Philos Trans R Soc B Biol Sci. 2018;373:20160451.","journal-title":"Philos Trans R Soc B Biol Sci"},{"key":"1635_CR71","doi-asserted-by":"publisher","first-page":"1165","DOI":"10.1001\/jamaneurol.2022.3185","volume":"79","author":"G Ch\u00e9telat","year":"2022","unstructured":"Ch\u00e9telat G, Lutz A, Klimecki O, et al. Effect of an 18-month meditation training on regional brain volume and perfusion in older adults: the age-well randomized clinical trial. JAMA Neurol. 2022;79:1165\u201374.","journal-title":"JAMA Neurol"}],"container-title":["Alzheimer's Research & Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13195-024-01635-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s13195-024-01635-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13195-024-01635-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,20]],"date-time":"2024-12-20T08:05:10Z","timestamp":1734681910000},"score":1,"resource":{"primary":{"URL":"https:\/\/alzres.biomedcentral.com\/articles\/10.1186\/s13195-024-01635-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,20]]},"references-count":71,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["1635"],"URL":"https:\/\/doi.org\/10.1186\/s13195-024-01635-0","relation":{},"ISSN":["1758-9193"],"issn-type":[{"value":"1758-9193","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,12,20]]},"assertion":[{"value":"11 September 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 December 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 December 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All participants gave their written informed consent to participate in the study. The Age-Well RCT, sponsored by Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (INSERM), was approved by the ethics committee (CPP Nord-Ouest III, Caen).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Dr Ch\u00e9telat reported receiving grants, personal fees, and nonfinancial support from the Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (INSERM), as well as grants from the European Union's Horizon 2020 Research and Innovation Program (grant 667696) during the conduct of the study and grants and personal fees from Fondation Entrepreneurs MMA and Fondation Alzheimer and grants from MMA and R\u00e9gion Normandie outside the submitted work. Dr Poisnel reported grants and nonfinancial support from INSERM grants from European Union's Horizon 2020 Research and Innovation Program [grant 667696] during the conduct of the study and grants from R\u00e9gion Normandie, Ministry of Higher Education and Research and INSERM outside the submitted work; and has participated in the data safety monitoring board of the Age-Well trial and to the executive committee of Medit-Ageing. No other disclosures were reported.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"269"}}