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We hypothesized that the Everyday Cognition Scale (ECog), a subjective change measure, predicts longitudinal change in cognition in the Brain Health Registry (BHR), an online registry for neuroscience research.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>This study included BHR participants aged 55\u2009+\u2009who completed both the baseline ECog and repeated administrations of the CANTAB<jats:sup>\u00ae<\/jats:sup> Paired Associates Learning (PAL) visual learning and memory test. Both self-reported ECog (Self-ECog) and study partner-reported ECog (SP-ECog), and two PAL scores (first attempt memory score [FAMS] and total errors adjusted [TEA]) were assessed. We estimated associations between multiple ECog scoring outputs (ECog positive [same or above cut-off score], ECog consistent [report of consistent decline in any item], and total score) and longitudinal change in PAL. Additionally we assessed the ability of ECog to identify \u2018decliners\u2019, who exhibited the worst PAL progression slopes corresponding to the fifth percentile and below.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Participants (<jats:italic>n<\/jats:italic>\u2009=\u200916,683) had an average age of 69.07\u2009\u00b1\u20097.34, 72.04% were female, and had an average of 16.66\u2009\u00b1\u20092.26 years of education. They were followed for an average of 2.52\u2009\u00b1\u20091.63 visits over a period of 11.49\u2009\u00b1\u200911.53 months. Both Self-ECog positive (estimate = -0.01, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001, R\u00b2m\u2009=\u20090.56) and Self-ECog consistent (estimate=-0.01, <jats:italic>p<\/jats:italic>\u2009=\u20090.002, R\u00b2m\u2009=\u20090.56) were associated with longitudinal change in PAL FAMS after adjusting demographics and clinical confounders. Those who were Self-ECog total (Odds ratio [95% confidence interval]\u2009=\u20091.390 [1.121\u20131.708]) and SP-ECog consistent (2.417 [1.591\u20133.655]) had higher probability of being decliners based on PAL FAMS.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>In the BHR\u2019s unsupervised online setting, baseline subjective change was feasible in predicting longitudinal decline in neuropsychological tests. Online, self-administered measures of subjective cognitive change might have a potential to predict objective subjective change and identify individuals with cognitive impairments.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s13195-024-01641-2","type":"journal-article","created":{"date-parts":[[2025,1,7]],"date-time":"2025-01-07T08:46:28Z","timestamp":1736239588000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Subjective cognitive decline predicts longitudinal neuropsychological test performance in an unsupervised online setting in the Brain Health Registry"],"prefix":"10.1186","volume":"17","author":[{"given":"Jae Myeong","family":"Kang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manchumad","family":"Manjavong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengshi","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam","family":"Diaz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miriam T.","family":"Ashford","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph","family":"Eichenbaum","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily","family":"Thorp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Wragg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenton H.","family":"Zavitz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Cormack","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Aaronson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. 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All participants provided online informed consent, and the research was conducted in accordance with the Declaration of Helsinki.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"Manchumad Manjavong, Chengshi Jin, Adam Diaz, Miriam T. Ashford, Joseph Eichenbaum, Emily Thorp, Elizabeth Wragg, Kenton H. Zavitz, Francesca Cormack, Anna Aaronson, R. Scott Mackin, Rachana Tank, Bernard Landavazo, Erika Cavallone, Diana Truran, and Sarah Tomaszewski Farias have nothing to disclose. Jae Myeong Kang reports grants from Gachon University, during the conduct of the study. Rachel L. Nosheny reports grants from NIA, during the conduct of the study. Michael W. Weiner serves on Editorial Boards for Alzheimer\u2019s & Dementia, and the Journal for Prevention of Alzheimer\u2019s Disease (JPAD); He has served on Advisory Boards for Acumen Pharmaceutical, Alzheon, Inc., Amsterdam UMC; MIRIADE, Cerecin, Merck Sharp & Dohme Corp., NC Registry for Brain Health, and REGEnLIFE. He also serves on the USC ACTC grant which receives funding from Eisai; He has provided consulting to Boxer Capital, LLC, Cerecin, Inc., Clario, Dementia Society of Japan, Dolby Family Ventures, Eisai, Guidepoint, Health and Wellness Partners, Indiana University, LCN Consulting, MEDA Corp., Merck Sharp & Dohme Corp., NC Registry for Brain Health, Prova Education, T3D Therapeutics, University of Southern California (USC), and WebMD; He has acted as a speaker\/lecturer for China Association for Alzheimer\u2019s Disease (CAAD) and Taipei Medical University, as well as a speaker\/lecturer with academic travel funding provided by: AD\/PD Congress, Amsterdam UMC, Cleveland Clinic, CTAD Congress, Foundation of Learning; Health Society (Japan), Kenes, U. Penn, U. Toulouse, Japan Society for Dementia Research, Korean Dementia Society, Merck Sharp & Dohme Corp., National Center for Geriatrics and Gerontology (NCGG; Japan), University of Southern California (USC); He holds stock options with Alzeca, Alzheon, Inc., ALZPath, Inc., and Anven; He received support for his research from the following funding sources: National Institutes of Health (NIH)\/NINDS\/National Institute on Aging (NIA), Department of Defense (DOD), California Department of Public Health (CDPH), University of Michigan, Siemens, Biogen, Hillblom Foundation, Alzheimer\u2019s Association, Johnson & Johnson, Kevin and Connie Shanahan, GE, VUmc, Australian Catholic University (HBI-BHR), The Stroke Foundation, and the Veterans Administration.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"10"}}