{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T21:56:59Z","timestamp":1773093419197,"version":"3.50.1"},"reference-count":65,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,1,6]],"date-time":"2025-01-06T00:00:00Z","timestamp":1736121600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,1,6]],"date-time":"2025-01-06T00:00:00Z","timestamp":1736121600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Alz Res Therapy"],"DOI":"10.1186\/s13195-024-01654-x","type":"journal-article","created":{"date-parts":[[2025,1,6]],"date-time":"2025-01-06T09:19:16Z","timestamp":1736155156000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Effects of Alzheimer\u2019s disease plasma marker levels on multilayer centrality in healthy individuals"],"prefix":"10.1186","volume":"17","author":[{"given":"Alejandra","family":"Garc\u00eda-Colomo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"L\u00f3pez-Sanz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ignacio","family":"Taguas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mart\u00edn","family":"Carrasco-G\u00f3mez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos","family":"Spuch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda","family":"Comis-Tuche","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fernando","family":"Maest\u00fa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,1,6]]},"reference":[{"key":"1654_CR1","doi-asserted-by":"publisher","unstructured":"2023 Alzheimer's disease facts and figures. Alzheimers Dement. 2023;19(4):1598\u2013695. https:\/\/doi.org\/10.1002\/alz.13016.","DOI":"10.1002\/alz.13016"},{"issue":"22","key":"1654_CR2","doi-asserted-by":"publisher","first-page":"8740","DOI":"10.1073\/pnas.1206171109","volume":"109","author":"MA Busche","year":"2012","unstructured":"Busche MA, Chen X, Henning HA, Reichwald J, Staufenbiel M, Sakmann B, et al. Critical role of soluble amyloid-\u03b2 for early hippocampal hyperactivity in a mouse model of Alzheimer\u2019s disease. Proc Natl Acad Sci. 2012;109(22):8740\u20135.","journal-title":"Proc Natl Acad Sci"},{"issue":"3","key":"1654_CR3","doi-asserted-by":"publisher","first-page":"292","DOI":"10.1016\/j.jalz.2016.02.002","volume":"12","author":"B Dubois","year":"2016","unstructured":"Dubois B, Hampel H, Feldman HH, Scheltens P, Aisen P, Andrieu S, et al. Preclinical Alzheimer\u2019s disease: definition, natural history, and diagnostic criteria. Alzheimers Dement. 2016;12(3):292\u2013323.","journal-title":"Alzheimers Dement"},{"key":"1654_CR4","doi-asserted-by":"crossref","unstructured":"L\u00f3pez-Sanz D, Bru\u00f1a R, Garc\u00e9s P, Mart\u00edn-Buro MC, Walter S, Delgado ML, et al. Functional connectivity disruption in subjective cognitive decline and mild cognitive impairment: a common pattern of alterations. Front Aging Neurosci. 2017;9. Available from: https:\/\/www.frontiersin.org\/articles\/10.3389\/fnagi.2017.00109. Cited 2023 Jan 25.","DOI":"10.3389\/fnagi.2017.00109"},{"issue":"1","key":"1654_CR5","doi-asserted-by":"publisher","first-page":"6517","DOI":"10.1038\/s41598-017-06876-8","volume":"7","author":"A Nakamura","year":"2017","unstructured":"Nakamura A, Cuesta P, Kato T, Arahata Y, Iwata K, Yamagishi M, et al. Early functional network alterations in asymptomatic elders at risk for Alzheimer\u2019s disease. Sci Rep. 2017;7(1):6517.","journal-title":"Sci Rep"},{"issue":"12","key":"1654_CR6","doi-asserted-by":"publisher","first-page":"3936","DOI":"10.1093\/brain\/awz320","volume":"142","author":"S Pusil","year":"2019","unstructured":"Pusil S, L\u00f3pez ME, Cuesta P, Bru\u00f1a R, Pereda E, Maest\u00fa F. Hypersynchronization in mild cognitive impairment: the \u2018X\u2019 model. Brain. 2019;142(12):3936\u201350.","journal-title":"Brain"},{"issue":"2","key":"1654_CR7","doi-asserted-by":"publisher","first-page":"1201","DOI":"10.1093\/cercor\/bhaa286","volume":"31","author":"F Ram\u00edrez-Tora\u00f1o","year":"2021","unstructured":"Ram\u00edrez-Tora\u00f1o F, Bru\u00f1a R, de Frutos-Lucas J, Rodr\u00edguez-Rojo IC, de Marcos Pedro S, Delgado-Losada ML, et al. Functional connectivity hypersynchronization in relatives of alzheimer\u2019s disease patients: an early E\/I balance Dysfunction? Cereb Cortex. 2021;31(2):1201\u201310.","journal-title":"Cereb Cortex."},{"key":"1654_CR8","doi-asserted-by":"crossref","unstructured":"Kudo K, Ranasinghe KG, Morise H, Syed F, Sekihara K, Rankin KP, et al. Neurophysiological trajectories in Alzheimer\u2019s disease progression. 2024. Available from: https:\/\/elifesciences.org\/reviewed-preprints\/91044v2. Cited 2024 Mar 27.","DOI":"10.7554\/eLife.91044.2"},{"issue":"1","key":"1654_CR9","doi-asserted-by":"publisher","first-page":"1214","DOI":"10.1038\/s41467-017-01150-x","volume":"8","author":"S Palmqvist","year":"2017","unstructured":"Palmqvist S, Sch\u00f6ll M, Strandberg O, Mattsson N, Stomrud E, Zetterberg H, et al. Earliest accumulation of \u03b2-amyloid occurs within the default-mode network and concurrently affects brain connectivity. Nat Commun. 2017;8(1):1214.","journal-title":"Nat Commun"},{"key":"1654_CR10","doi-asserted-by":"crossref","unstructured":"Quevenco FC, van Bergen JM, Treyer V, Studer ST, Kagerer SM, Meyer R, et al. Functional Brain Network Connectivity Patterns Associated With Normal Cognition at Old-Age, Local \u03b2-amyloid, Tau, and APOE4. Front Aging Neurosci. 2020;12. Available from: https:\/\/www.frontiersin.org\/articles\/10.3389\/fnagi.2020.00046. Cited 2023 Jan 25.","DOI":"10.3389\/fnagi.2020.00046"},{"issue":"11","key":"1654_CR11","doi-asserted-by":"publisher","first-page":"1261","DOI":"10.1016\/j.jalz.2017.02.011","volume":"13","author":"J Sepulcre","year":"2017","unstructured":"Sepulcre J, Sabuncu MR, Li Q, El Fakhri G, Sperling R, Johnson KA. Tau and amyloid \u03b2 proteins distinctively associate to functional network changes in the aging brain. Alzheimers Dement. 2017;13(11):1261\u20139.","journal-title":"Alzheimers Dement"},{"issue":"7628","key":"1654_CR12","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1038\/nature20412","volume":"539","author":"RG Canter","year":"2016","unstructured":"Canter RG, Penney J, Tsai LH. The road to restoring neural circuits for the treatment of Alzheimer\u2019s disease. Nature. 2016;539(7628):187\u201396.","journal-title":"Nature"},{"issue":"16","key":"1654_CR13","doi-asserted-by":"publisher","first-page":"4323","DOI":"10.1523\/JNEUROSCI.3263-16.2017","volume":"37","author":"AP Schultz","year":"2017","unstructured":"Schultz AP, Chhatwal JP, Hedden T, Mormino EC, Hanseeuw BJ, Sepulcre J, et al. Phases of hyperconnectivity and hypoconnectivity in the default mode and salience networks track with amyloid and tau in clinically normal individuals. J Neurosci. 2017;37(16):4323\u201331.","journal-title":"J Neurosci"},{"issue":"3","key":"1654_CR14","doi-asserted-by":"publisher","first-page":"fcad088","DOI":"10.1093\/braincomms\/fcad088","volume":"5","author":"L Lorenzini","year":"2023","unstructured":"Lorenzini L, Ingala S, Collij LE, Wottschel V, Haller S, Blennow K, et al. Eigenvector centrality dynamics are related to Alzheimer\u2019s disease pathological changes in non-demented individuals. Brain Commun. 2023;5(3):fcad088.","journal-title":"Brain Commun."},{"issue":"3","key":"1654_CR15","doi-asserted-by":"publisher","first-page":"1059","DOI":"10.1016\/j.neuroimage.2009.10.003","volume":"52","author":"M Rubinov","year":"2010","unstructured":"Rubinov M, Sporns O. Complex network measures of brain connectivity: uses and interpretations. Neuroimage. 2010;52(3):1059\u201369.","journal-title":"Neuroimage"},{"issue":"5","key":"1654_CR16","doi-asserted-by":"publisher","first-page":"2383","DOI":"10.1002\/hbm.22335","volume":"35","author":"MAA Binnewijzend","year":"2014","unstructured":"Binnewijzend MAA, Adriaanse SM, Van Der Flier WM, Teunissen CE, De Munck JC, Stam CJ, et al. Brain network alterations in Alzheimer\u2019s disease measured by Eigenvector centrality in fMRI are related to cognition and CSF biomarkers. Hum Brain Mapp. 2014;35(5):2383\u201393.","journal-title":"Hum Brain Mapp"},{"issue":"1","key":"1654_CR17","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1186\/s12883-015-0400-7","volume":"15","author":"MM Engels","year":"2015","unstructured":"Engels MM, Stam CJ, Van Der Flier WM, Scheltens P, De Waal H, Van Straaten EC. Declining functional connectivity and changing hub locations in Alzheimer\u2019s disease: an EEG study. BMC Neurol. 2015;15(1):145.","journal-title":"BMC Neurol"},{"issue":"10","key":"1654_CR18","doi-asserted-by":"publisher","first-page":"683","DOI":"10.1038\/nrn3801","volume":"15","author":"CJ Stam","year":"2014","unstructured":"Stam CJ. Modern network science of neurological disorders. Nat Rev Neurosci. 2014;15(10):683\u201395.","journal-title":"Nat Rev Neurosci"},{"key":"1654_CR19","doi-asserted-by":"publisher","first-page":"150","DOI":"10.1016\/j.neurobiolaging.2016.03.018","volume":"42","author":"M Yu","year":"2016","unstructured":"Yu M, Gouw AA, Hillebrand A, Tijms BM, Stam CJ, Van Straaten ECW, et al. Different functional connectivity and network topology in behavioral variant of frontotemporal dementia and Alzheimer\u2019s disease: an EEG study. Neurobiol Aging. 2016;42:150\u201362.","journal-title":"Neurobiol Aging"},{"issue":"5","key":"1654_CR20","doi-asserted-by":"publisher","first-page":"1466","DOI":"10.1093\/brain\/awx050","volume":"140","author":"M Yu","year":"2017","unstructured":"Yu M, Engels MMA, Hillebrand A, Van Straaten ECW, Gouw AA, Teunissen C, et al. Selective impairment of hippocampus and posterior hub areas in Alzheimer\u2019s disease: an MEG-based multiplex network study. Brain. 2017;140(5):1466\u201385.","journal-title":"Brain"},{"issue":"13","key":"1654_CR21","doi-asserted-by":"publisher","first-page":"26","DOI":"10.3389\/fninf.2019.00026","volume":"24","author":"Z Wang","year":"2019","unstructured":"Wang Z, Qiao K, Chen G, Sui D, Dong HM, Wang YS, et al. Functional connectivity changes across the spectrum of subjective cognitive decline, amnestic mild cognitive impairment and alzheimer\u2019s disease. Front Neuroinformatics. 2019;24(13):26.","journal-title":"Front Neuroinformatics"},{"issue":"8","key":"1654_CR22","doi-asserted-by":"publisher","first-page":"1862","DOI":"10.1093\/cercor\/bhr269","volume":"22","author":"XN Zuo","year":"2012","unstructured":"Zuo XN, Ehmke R, Mennes M, Imperati D, Castellanos FX, Sporns O, et al. Network Centrality in the Human Functional Connectome. Cereb Cortex. 2012;22(8):1862\u201375.","journal-title":"Cereb Cortex"},{"issue":"11","key":"1654_CR23","doi-asserted-by":"publisher","first-page":"118","DOI":"10.3389\/fnagi.2019.00118","volume":"20","author":"Y Xie","year":"2019","unstructured":"Xie Y, Liu T, Ai J, Chen D, Zhuo Y, Zhao G, et al. Changes in centrality frequency of the default mode network in individuals with subjective cognitive decline. Front Aging Neurosci. 2019;20(11):118.","journal-title":"Front Aging Neurosci"},{"issue":"4","key":"1654_CR24","doi-asserted-by":"publisher","first-page":"fcab201","DOI":"10.1093\/braincomms\/fcab201","volume":"3","author":"S Ingala","year":"2021","unstructured":"Ingala S, Tomassen J, Collij LE, Prent N, Van \u2018T Ent D, Ten Kate M, et al. Amyloid-driven disruption of default mode network connectivity in cognitively healthy individuals. Brain Commun. 2021;3(4):fcab201.","journal-title":"Brain Commun."},{"issue":"10","key":"1654_CR25","doi-asserted-by":"publisher","first-page":"2164","DOI":"10.1109\/TNSRE.2020.3014951","volume":"28","author":"F Duan","year":"2020","unstructured":"Duan F, Huang Z, Sun Z, Zhang Y, Zhao Q, Cichocki A, et al. Topological network analysis of early alzheimer\u2019s disease based on resting-state EEG. IEEE Trans Neural Syst Rehabil Eng. 2020;28(10):2164\u201372.","journal-title":"IEEE Trans Neural Syst Rehabil Eng"},{"issue":"1","key":"1654_CR26","doi-asserted-by":"publisher","first-page":"216","DOI":"10.1186\/s13195-024-01576-8","volume":"16","author":"I Taguas","year":"2024","unstructured":"Taguas I, Doval S, Maest\u00fa F, L\u00f3pez-Sanz D. Toward a more comprehensive understanding of network centrality disruption in amnestic mild cognitive impairment: a MEG multilayer approach. Alzheimers Res Ther. 2024;16(1):216. https:\/\/doi.org\/10.1186\/s13195-024-01576-8. PMID:39385281;PMCID:PMC11462918.","journal-title":"Alzheimers Res Ther"},{"issue":"17","key":"1654_CR27","doi-asserted-by":"publisher","first-page":"6904","DOI":"10.18632\/aging.102220","volume":"11","author":"H Hu","year":"2019","unstructured":"Alzheimer\u2019s Disease Neuroimaging Initiative, Hu H, Chen KL, Ou YN, Cao XP, Chen SD, et al. Neurofilament light chain plasma concentration predicts neurodegeneration and clinical progression in nondemented elderly adults. Aging. 2019;11(17):6904\u201314.","journal-title":"Aging."},{"key":"1654_CR28","doi-asserted-by":"crossref","unstructured":"Jack Jr CR, Andrews JS, Beach TG, Buracchio T, Dunn B, Graf A, Carrillo MC. Revised criteria for diagnosis and staging of Alzheimer's disease: Alzheimer's Association Workgroup.\u00a0Alzheimers Dement. 2024;20(8):5143\u201369.","DOI":"10.1002\/alz.13859"},{"issue":"5","key":"1654_CR29","doi-asserted-by":"publisher","first-page":"709","DOI":"10.1007\/s00401-021-02275-6","volume":"141","author":"NJ Ashton","year":"2021","unstructured":"Ashton NJ, Pascoal TA, Karikari TK, Benedet AL, Lantero-Rodriguez J, Brinkmalm G, et al. Plasma p-tau231: a new biomarker for incipient Alzheimer\u2019s disease pathology. Acta Neuropathol (Berl). 2021;141(5):709\u201324.","journal-title":"Acta Neuropathol (Berl)"},{"key":"1654_CR30","doi-asserted-by":"publisher","first-page":"103836","DOI":"10.1016\/j.ebiom.2022.103836","volume":"76","author":"NJ Ashton","year":"2022","unstructured":"Ashton NJ, Benedet AL, Pascoal TA, Karikari TK, Lantero-Rodriguez J, Brum WS, et al. Cerebrospinal fluid p-tau231 as an early indicator of emerging pathology in Alzheimer\u2019s disease. eBioMedicine. 2022;76:103836.","journal-title":"eBioMedicine."},{"key":"1654_CR31","doi-asserted-by":"crossref","unstructured":"Mil\u00e0-Alom\u00e0 M, Ashton NJ, Shekari M, Salvad\u00f3 G, Ortiz-Romero P, Montoliu-Gaya L, et al. Plasma p-tau231 and p-tau217 as state markers of amyloid-\u03b2 pathology in preclinical Alzheimer\u2019s disease. Nat Med. 2022. Available from: https:\/\/www.nature.com\/articles\/s41591-022-01925-w. Cited 2024 Mar 26.","DOI":"10.1038\/s41591-022-01925-w"},{"issue":"12","key":"1654_CR32","doi-asserted-by":"publisher","first-page":"e12921","DOI":"10.15252\/emmm.202012921","volume":"12","author":"M Su\u00e1rez-Calvet","year":"2020","unstructured":"Su\u00e1rez-Calvet M, Karikari TK, Ashton NJ, Lantero Rodr\u00edguez J, Mil\u00e0-Alom\u00e0 M, Gispert JD, et al. Novel tau biomarkers phosphorylated at T181, T217 or T231 rise in the initial stages of the preclinical Alzheimer\u2019s continuum when only subtle changes in A\u03b2 pathology are detected. EMBO Mol Med. 2020;12(12):e12921.","journal-title":"EMBO Mol Med"},{"key":"1654_CR33","doi-asserted-by":"publisher","first-page":"103837","DOI":"10.1016\/j.ebiom.2022.103837","volume":"76","author":"C Tissot","year":"2022","unstructured":"Tissot C, Therriault J, Kunach P, Benedet AL, Pascoal TA, Ashton NJ, et al. Comparing tau status determined via plasma pTau181, pTau231 and [18F]MK6240 tau-PET. eBioMedicine. 2022;76:103837.","journal-title":"eBioMedicine."},{"key":"1654_CR34","doi-asserted-by":"crossref","unstructured":"Nasreddine ZS, Phillips NA, B\u00e9dirian V, Charbonneau S, Whitehead V, Collin I, ... Chertkow H. The Montreal Cognitive Assessment, MoCA: a brief screening tool for mild cognitive impairment. J Am Geriatr Soc. 2005;53(4):695\u2013699.","DOI":"10.1111\/j.1532-5415.2005.53221.x"},{"key":"1654_CR35","doi-asserted-by":"publisher","first-page":"271","DOI":"10.2466\/pms.1958.8.3.271","volume":"8","author":"R Reitan","year":"1958","unstructured":"Reitan R. Validity of the Trail Making test as an indicator of organic brain damage. Percept Mot Skills. 1958;8:271\u20136.","journal-title":"Percept Mot Skills"},{"key":"1654_CR36","volume-title":"WMS-III. Wechsler Memory Scale","author":"D Wechsler","year":"1997","unstructured":"Wechsler D. WMS-III. Wechsler Memory Scale. 3rd ed. San Antonio, TX: Psychological Corporation; 1997.","edition":"3"},{"key":"1654_CR37","unstructured":"Osterreith P, Rey A. Le test de copie d\u2019une figure complexe. Arch Psychol. 1944;30:205\u201320."},{"issue":"7","key":"1654_CR38","doi-asserted-by":"publisher","first-page":"1759","DOI":"10.1088\/0031-9155\/51\/7\/008","volume":"51","author":"S Taulu","year":"2006","unstructured":"Taulu S, Simola J. Spatiotemporal signal space separation method for rejecting nearby interference in MEG measurements. Phys Med Biol. 2006;51(7):1759\u201368.","journal-title":"Phys Med Biol"},{"issue":"1","key":"1654_CR39","first-page":"156869","volume":"2011","author":"R Oostenveld","year":"2011","unstructured":"Oostenveld R, Fries P, Maris E, Schoffelen JM. FieldTrip: open source software for advanced analysis of MEG, EEG, and invasive electrophysiological data. Comput Intell Neurosci. 2011;2011(1):156869.","journal-title":"Comput Intell Neurosci"},{"issue":"12","key":"1654_CR40","doi-asserted-by":"publisher","first-page":"2926","DOI":"10.3390\/s17122926","volume":"17","author":"P Garc\u00e9s","year":"2017","unstructured":"Garc\u00e9s P, L\u00f3pez-Sanz D, Maest\u00fa F, Pereda E. Choice of Magnetometers and Gradiometers after Signal Space Separation. Sensors. 2017;17(12):2926.","journal-title":"Sensors"},{"key":"1654_CR41","doi-asserted-by":"publisher","first-page":"116189","DOI":"10.1016\/j.neuroimage.2019.116189","volume":"206","author":"ET Rolls","year":"2020","unstructured":"Rolls ET, Huang CC, Lin CP, Feng J, Joliot M. Automated anatomical labelling atlas 3. Neuroimage. 2020;206:116189.","journal-title":"Neuroimage"},{"key":"1654_CR42","volume-title":"Statistical parametric mapping: the analysis of functional brain images","author":"KJ Friston","year":"2007","unstructured":"Friston KJ. Statistical parametric mapping: the analysis of functional brain images. 1st ed. Amsterdam Boston: Elsevier \/ Academic Press; 2007.","edition":"1"},{"issue":"40","key":"1654_CR43","doi-asserted-by":"publisher","first-page":"16783","DOI":"10.1073\/pnas.1112685108","volume":"108","author":"MJ Brookes","year":"2011","unstructured":"Brookes MJ, Woolrich M, Luckhoo H, Price D, Hale JR, Stephenson MC, et al. Investigating the electrophysiological basis of resting state networks using magnetoencephalography. Proc Natl Acad Sci. 2011;108(40):16783\u20138.","journal-title":"Proc Natl Acad Sci"},{"key":"1654_CR44","doi-asserted-by":"crossref","unstructured":"Jensen O, Mazaheri A. Shaping Functional Architecture by Oscillatory Alpha Activity: Gating by Inhibition. Front Hum Neurosci. 2010;4. Available from: http:\/\/journal.frontiersin.org\/article\/10.3389\/fnhum.2010.00186\/abstract. Cited 2023 Nov 14.","DOI":"10.3389\/fnhum.2010.00186"},{"issue":"10","key":"1654_CR45","doi-asserted-by":"publisher","first-page":"e13701","DOI":"10.1371\/journal.pone.0013701","volume":"5","author":"BCM Van Wijk","year":"2010","unstructured":"Van Wijk BCM, Stam CJ, Daffertshofer A. Comparing brain networks of different size and connectivity density using graph theory. Sporns O, editor. PLoS One. 2010;5(10):e13701.","journal-title":"PLoS One."},{"issue":"07","key":"1654_CR46","doi-asserted-by":"publisher","first-page":"2303","DOI":"10.1142\/S0218127407018403","volume":"17","author":"U Brandes","year":"2007","unstructured":"Brandes U, Pich C. Centrality estimation in large networks. Int J Bifurc Chaos. 2007;17(07):2303\u201318.","journal-title":"Int J Bifurc Chaos"},{"issue":"1","key":"1654_CR47","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1016\/j.jneumeth.2007.03.024","volume":"164","author":"E Maris","year":"2007","unstructured":"Maris E, Oostenveld R. Nonparametric statistical testing of EEG- and MEG-data. J Neurosci Methods. 2007;164(1):177\u201390.","journal-title":"J Neurosci Methods"},{"issue":"3","key":"1654_CR48","doi-asserted-by":"publisher","first-page":"591","DOI":"10.2307\/1910133","volume":"28","author":"GC Chow","year":"1960","unstructured":"Chow GC. Tests of equality between sets of coefficients in two linear regressions. Econometrica. 1960;28(3):591.","journal-title":"Econometrica"},{"issue":"4","key":"1654_CR49","doi-asserted-by":"publisher","first-page":"533","DOI":"10.1016\/S0197-4580(00)00153-6","volume":"21","author":"V Jelic","year":"2000","unstructured":"Jelic V, Johansson SE, Almkvist O, Shigeta M, Julin P, Nordberg A, et al. Quantitative electroencephalography in mild cognitive impairment: longitudinal changes and possible prediction of Alzheimer\u2019s disease. Neurobiol Aging. 2000;21(4):533\u201340.","journal-title":"Neurobiol Aging"},{"issue":"7","key":"1654_CR50","doi-asserted-by":"publisher","first-page":"1490","DOI":"10.1016\/j.clinph.2004.01.001","volume":"115","author":"J Jeong","year":"2004","unstructured":"Jeong J. EEG dynamics in patients with Alzheimer\u2019s disease. Clin Neurophysiol. 2004;115(7):1490\u2013505.","journal-title":"Clin Neurophysiol"},{"issue":"1","key":"1654_CR51","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1186\/s13195-020-00632-3","volume":"12","author":"CT Briels","year":"2020","unstructured":"Briels CT, Schoonhoven DN, Stam CJ, De Waal H, Scheltens P, Gouw AA. Reproducibility of EEG functional connectivity in Alzheimer\u2019s disease. Alzheimers Res Ther. 2020;12(1):68.","journal-title":"Alzheimers Res Ther"},{"issue":"1","key":"1654_CR52","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1186\/s13195-015-0163-9","volume":"7","author":"F Hatz","year":"2015","unstructured":"Hatz F, Hardmeier M, Benz N, Ehrensperger M, Gschwandtner U, R\u00fcegg S, et al. Microstate connectivity alterations in patients with early Alzheimer\u2019s disease. Alzheimers Res Ther. 2015;7(1):78.","journal-title":"Alzheimers Res Ther"},{"issue":"6","key":"1654_CR53","doi-asserted-by":"publisher","first-page":"066019","DOI":"10.1088\/1741-2552\/ab4024","volume":"16","author":"SJ Ruiz-G\u00f3mez","year":"2019","unstructured":"Ruiz-G\u00f3mez SJ, Hornero R, Poza J, Maturana-Candelas A, Pinto N, G\u00f3mez C. Computational modeling of the effects of EEG volume conduction on functional connectivity metrics Application to Alzheimer\u2019s disease continuum. J Neural Eng. 2019;16(6):066019.","journal-title":"J Neural Eng."},{"key":"1654_CR54","doi-asserted-by":"publisher","first-page":"101777","DOI":"10.1016\/j.nicl.2019.101777","volume":"22","author":"S Skouras","year":"2019","unstructured":"Skouras S, Falcon C, Tucholka A, Rami L, Sanchez-Valle R, Llad\u00f3 A, et al. Mechanisms of functional compensation, delineated by eigenvector centrality mapping, across the pathophysiological continuum of Alzheimer\u2019s disease. NeuroImage Clin. 2019;22:101777.","journal-title":"NeuroImage Clin"},{"issue":"4","key":"1654_CR55","doi-asserted-by":"publisher","first-page":"829","DOI":"10.1007\/s11571-022-09873-4","volume":"17","author":"B G\u00fcntekin","year":"2023","unstructured":"G\u00fcntekin B, Erdal F, B\u00f6l\u00fckba\u015f B, Hano\u011flu L, Yener G, Duygun R. Alterations of resting-state Gamma frequency characteristics in aging and Alzheimer\u2019s disease. Cogn Neurodyn. 2023;17(4):829\u201344.","journal-title":"Cogn Neurodyn"},{"issue":"12","key":"1654_CR56","doi-asserted-by":"publisher","first-page":"e0168800","DOI":"10.1371\/journal.pone.0168800","volume":"11","author":"C Perez","year":"2016","unstructured":"Perez C, Ziburkus J, Ullah G. Analyzing and modeling the dysfunction of inhibitory neurons in alzheimer\u2019s disease. Cymbalyuk G, editor. PLoS One. 2016;11(12):e0168800.","journal-title":"PLoS One."},{"issue":"3","key":"1654_CR57","doi-asserted-by":"publisher","first-page":"708","DOI":"10.1016\/j.cell.2012.02.046","volume":"149","author":"L Verret","year":"2012","unstructured":"Verret L, Mann EO, Hang GB, Barth AMI, Cobos I, Ho K, et al. Inhibitory interneuron deficit links altered network activity and cognitive dysfunction in Alzheimer model. Cell. 2012;149(3):708\u201321.","journal-title":"Cell"},{"issue":"2","key":"1654_CR58","doi-asserted-by":"publisher","first-page":"fcac012","DOI":"10.1093\/braincomms\/fcac012","volume":"4","author":"P Cuesta","year":"2022","unstructured":"Cuesta P, Ochoa-Urrea M, Funke M, Hasan O, Zhu P, Marcos A, et al. Gamma band functional connectivity reduction in patients with amnestic mild cognitive impairment and epileptiform activity. Brain Commun. 2022;4(2):fcac012.","journal-title":"Brain Commun."},{"issue":"4","key":"1654_CR59","doi-asserted-by":"publisher","first-page":"1014","DOI":"10.1016\/j.brs.2020.03.016","volume":"13","author":"MS Bobola","year":"2020","unstructured":"Bobola MS, Chen L, Ezeokeke CK, Olmstead TA, Nguyen C, Sahota A, et al. Transcranial focused ultrasound, pulsed at 40 Hz, activates microglia acutely and reduces A\u03b2 load chronically, as demonstrated in vivo. Brain Stimulat. 2020;13(4):1014\u201323.","journal-title":"Brain Stimulat"},{"issue":"2","key":"1654_CR60","doi-asserted-by":"publisher","first-page":"256","DOI":"10.1016\/j.cell.2019.02.014","volume":"177","author":"AJ Martorell","year":"2019","unstructured":"Martorell AJ, Paulson AL, Suk HJ, Abdurrob F, Drummond GT, Guan W, et al. Multi-sensory gamma stimulation ameliorates alzheimer\u2019s-associated pathology and improves cognition. Cell. 2019;177(2):256\u2013271.e22.","journal-title":"Cell"},{"issue":"5","key":"1654_CR61","doi-asserted-by":"publisher","first-page":"557","DOI":"10.1001\/jamaneurol.2016.6117","volume":"74","author":"N Mattsson","year":"2017","unstructured":"Mattsson N, Andreasson U, Zetterberg H, Blennow K, for the Alzheimer\u2019s Disease Neuroimaging Initiative. Association of plasma neurofilament light with neurodegeneration in patients with Alzheimer disease. JAMA Neurol. 2017;74(5):557.","journal-title":"JAMA Neurol."},{"key":"1654_CR62","doi-asserted-by":"crossref","unstructured":"Nyberg L, Lundquist A, Nordin Adolfsson A, Andersson M, Zetterberg H, Blennow K, et al. Elevated plasma neurofilament light in aging reflects brain white\u2010matter alterations but does not predict cognitive decline or Alzheimer\u2019s disease. Alzheimers Dement Diagn Assess Dis Monit. 2020;12(1). Available from: https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/dad2.12050. Cited 2023 Nov 9.","DOI":"10.1002\/dad2.12050"},{"issue":"6","key":"1654_CR63","doi-asserted-by":"publisher","first-page":"1860","DOI":"10.1523\/JNEUROSCI.5062-08.2009","volume":"29","author":"RL Buckner","year":"2009","unstructured":"Buckner RL, Sepulcre J, Talukdar T, Krienen FM, Liu H, Hedden T, et al. Cortical hubs revealed by intrinsic functional connectivity: mapping, assessment of stability, and relation to Alzheimer\u2019s disease. J Neurosci. 2009;29(6):1860\u201373.","journal-title":"J Neurosci"},{"issue":"8","key":"1654_CR64","doi-asserted-by":"publisher","first-page":"e1002582","DOI":"10.1371\/journal.pcbi.1002582","volume":"8","author":"W De Haan","year":"2012","unstructured":"De Haan W, Mott K, Van Straaten ECW, Scheltens P, Stam CJ. Activity dependent degeneration explains hub vulnerability in Alzheimer\u2019s disease. Sporns O, editor. PLoS Comput Biol. 2012;8(8):e1002582.","journal-title":"PLoS Comput Biol."},{"key":"1654_CR65","doi-asserted-by":"publisher","first-page":"565","DOI":"10.1016\/j.neuroimage.2016.11.064","volume":"155","author":"L Liuzzi","year":"2017","unstructured":"Liuzzi L, Gascoyne LE, Tewarie PK, Barratt EL, Boto E, Brookes MJ. Optimising experimental design for MEG resting state functional connectivity measurement. Neuroimage. 2017;155:565\u201376.","journal-title":"Neuroimage"}],"container-title":["Alzheimer's Research & Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13195-024-01654-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s13195-024-01654-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13195-024-01654-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,6]],"date-time":"2025-01-06T22:02:53Z","timestamp":1736200973000},"score":1,"resource":{"primary":{"URL":"https:\/\/alzres.biomedcentral.com\/articles\/10.1186\/s13195-024-01654-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,6]]},"references-count":65,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["1654"],"URL":"https:\/\/doi.org\/10.1186\/s13195-024-01654-x","relation":{},"ISSN":["1758-9193"],"issn-type":[{"value":"1758-9193","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1,6]]},"assertion":[{"value":"19 June 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 December 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 January 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The \u201cHospital Cl\u00ednico San Carlos\u201d Ethics Committee approved this study, and the procedure was performed following internationally accepted guidelines and regulations, which included informed consent from all participants.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"8"}}