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Written informed consent was given by study participants or their next of kin.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"C.F. has received travel grants or attended conferences upon invitation from Biogen, Sanofi, Novartis and Alexion and has received speaking honoraria from Novartis, Sanofi and AstraZeneca. The other authors have no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"85"}}