{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T06:02:58Z","timestamp":1787724178284,"version":"build-2784847793"},"reference-count":34,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2021,7,22]],"date-time":"2021-07-22T00:00:00Z","timestamp":1626912000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2021,7,22]],"date-time":"2021-07-22T00:00:00Z","timestamp":1626912000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Allergy Asthma Clin Immunol"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      CD8\n                      <jats:sup>+<\/jats:sup>\n                      CD25\n                      <jats:sup>+<\/jats:sup>\n                      fork-head box transcription factor (Foxp3)\n                      <jats:sup>+<\/jats:sup>\n                      regulatory T cells (CD8\n                      <jats:sup>+<\/jats:sup>\n                      Tregs) play a role in immune tolerance. However, the role of these cells in allergic rhinitis (AR) has not been elucidated. The study aimed to evaluate influences of CD8\n                      <jats:sup>+<\/jats:sup>\n                      Tregs on inflammatory conditions in a murine model of AR.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      A murine model of AR was established. CD8\n                      <jats:sup>+<\/jats:sup>\n                      Tregs were isolated from mice nasal mucosa and cultured in vitro. We examined interleukin (IL)-10 and transforming growth factor (TGF)-\u03b2 in cell cultures. Then, we administered CD8\n                      <jats:sup>+<\/jats:sup>\n                      Tregs into mice nasal mucosal cultures, and examined eosinophil cation protein (ECP), IL-4, IL-5 and IL-13 in these cultures. Finally, we adoptively transferred CD8\n                      <jats:sup>+<\/jats:sup>\n                      Tregs into mice models, and evaluated percentages of CD8\n                      <jats:sup>+<\/jats:sup>\n                      Tregs, numbers of sneezing and nasal rubbing, and counts of eosinophils and contents of ECP, IL-4, IL-5, IL-13, IL-10 and TGF-\u03b2 in nasal lavage fluid (NLF) in mice.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The percentage of CD8\n                      <jats:sup>+<\/jats:sup>\n                      Tregs from AR mice was reduced. IL-10 and TGF-\u03b2 were increased in cell cultures from AR mice. ECP, IL-4, IL-5 and IL-13 were decreased after the AR mice CD8\n                      <jats:sup>+<\/jats:sup>\n                      Tregs administration in mucosal cultures. However, their contents were not changed after normal CD8\n                      <jats:sup>+<\/jats:sup>\n                      Tregs treatment. Additionally, the adoptive transfer of AR CD8\n                      <jats:sup>+<\/jats:sup>\n                      Tregs enhanced the percentage of CD8\n                      <jats:sup>+<\/jats:sup>\n                      Tregs and levels of IL-10 and TGF-\u03b2 in NLF, reduced numbers of sneezing and nasal rubbing, and counts of eosinophils and concentrations of ECP, IL-4, IL-5 and IL-13 in NLF. However, normal CD8\n                      <jats:sup>+<\/jats:sup>\n                      Tregs could not change above parameters.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      These findings show that CD8\n                      <jats:sup>+<\/jats:sup>\n                      Tregs may inhibit inflammatory responses in the AR condition.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s13223-021-00577-8","type":"journal-article","created":{"date-parts":[[2021,7,22]],"date-time":"2021-07-22T06:03:00Z","timestamp":1626933780000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["CD8+ Tregs ameliorate inflammatory reactions in a murine model of allergic rhinitis"],"prefix":"10.1186","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3089-4741","authenticated-orcid":false,"given":"Lin","family":"Lin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Dai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinjin","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zheng","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,7,22]]},"reference":[{"issue":"4","key":"577_CR1","doi-asserted-by":"publisher","first-page":"393","DOI":"10.2500\/aap.2007.28.3013","volume":"28","author":"MS Blaiss","year":"2007","unstructured":"Blaiss MS. 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