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We aimed to explore this in the Correlated Expression and Disease Association Research (CEDAR) patient cohort.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>Differential expression analysis of ileal, transverse colon, and rectal biopsies were supplemented by a comparison of transcriptomes from platelets and leukocytes subsets, including CD4+, CD8+, CD14+, CD15+, and CD19+\u00a0cells. Asthma patients (n\u2009=\u200915) and controls (n\u2009=\u200915) had similar age (<jats:italic>p<\/jats:italic>\u2009=\u20090.967), body mass index (<jats:italic>p<\/jats:italic>\u2009=\u20090.870), similar numbers of females (80%) and smoking rates (13.3%).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Significant differential expression was found in the ileum alone, and not in any other cell\/tissue types. More genes were found to be overexpressed (1,150) than under-expressed (380). The most overexpressed genes included Fc Fragment of IgG Binding Protein (<jats:italic>FCGBP<\/jats:italic>, logFC\u2009=\u20093.01, pFDR\u2009=\u20090.015), Mucin 2 (<jats:italic>MUC2<\/jats:italic>, logFC\u2009=\u20092.78, pFDR\u2009=\u20090.015), and Alpha 1B Defensin (<jats:italic>DEFA1B<\/jats:italic>, logFC\u2009=\u20092.73, pFDR\u2009=\u20090.024). Gene ontology implicated the immune system, including interleukins 4 and 13, as well as antimicrobial peptides in this overexpression. There was concordance of gene over- (<jats:italic>STAT1<\/jats:italic>, <jats:italic>XBP1<\/jats:italic>) and underexpression (<jats:italic>NELF<\/jats:italic>, <jats:italic>RARA<\/jats:italic>) in asthma and Crohn\u2019s disease ileum when our results were compared to another dataset (p\u2009=\u20093.66\u2009\u00d7\u200910<jats:sup>\u20137<\/jats:sup>).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>Ileal mucosa in asthma exhibits a specific transcriptomic profile, which includes the overexpression of innate immune genes, mostly characteristic of Paneth and goblet cells, in addition to other changes that may resemble Crohn\u2019s disease.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s13223-021-00584-9","type":"journal-article","created":{"date-parts":[[2021,7,31]],"date-time":"2021-07-31T13:02:53Z","timestamp":1627736573000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Expression profiling of ileal mucosa in asthma reveals upregulation of innate immunity and genes characteristic of Paneth and goblet cells"],"prefix":"10.1186","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0953-2188","authenticated-orcid":false,"given":"Jan K.","family":"Nowak","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marzena","family":"Dworacka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nazgul","family":"Gubaj","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arystan","family":"Dossimov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhumabek","family":"Dossimov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaros\u0142aw","family":"Walkowiak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,7,31]]},"reference":[{"key":"584_CR1","doi-asserted-by":"publisher","first-page":"15025","DOI":"10.1038\/nrdp.2015.25","volume":"1","author":"ST Holgate","year":"2015","unstructured":"Holgate ST, Wenzel S, Postma DS, Weiss ST, Renz H, Sly PD. 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