{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T04:28:07Z","timestamp":1772166487837,"version":"3.50.1"},"reference-count":21,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2022,4,5]],"date-time":"2022-04-05T00:00:00Z","timestamp":1649116800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2022,4,5]],"date-time":"2022-04-05T00:00:00Z","timestamp":1649116800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Allergy Asthma Clin Immunol"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Common variable immunodeficiency (CVID) is a primary immunodeficiency disorder associated with a broad symptom presentation that is still being characterized. We report a rare case of recurrent mycoplasma skin abscesses in a patient with a history of autoimmune disorders and prolonged mycoplasma pneumonia who was diagnosed with CVID.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case presentation<\/jats:title>\n                    <jats:p>\n                      A 34-year-old woman presented with a history of recurrent abscesses previously confirmed positive for\n                      <jats:italic>Mycoplasma pneumoniae<\/jats:italic>\n                      . Her past medical history of recurrent mycoplasma abscesses, prolonged mycoplasma pneumonia, and autoimmune disorders (mixed connective tissue disease and immune thrombocytopenia) raised suspicion of CVID. Workup included negative anti-mycoplasma antibody titers, hypogammaglobulinemia, and negative anti-pneumococcal antibody titers despite prior vaccination, solidifying the diagnosis of CVID. The patient was discharged on antibiotic and intravenous immunoglobulin therapy and now follows allergy and immunology long-term for treatment.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      Her diagnostic history underscores the importance of considering the various criteria of CVID for diagnosis, and her unique presentation of\n                      <jats:italic>M. pneumoniae<\/jats:italic>\n                      skin abscesses highlights the broad sequelae patients with CVID can manifest.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s13223-022-00673-3","type":"journal-article","created":{"date-parts":[[2022,4,5]],"date-time":"2022-04-05T09:10:45Z","timestamp":1649149845000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Turning walking pneumonia into recurrent abscesses: a curious case of CVID and review of the literature"],"prefix":"10.1186","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1314-8800","authenticated-orcid":false,"given":"David X.","family":"Gao","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Habiba","family":"Hussain","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brianna","family":"Bobber","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Phan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2022,4,5]]},"reference":[{"key":"673_CR1","doi-asserted-by":"publisher","first-page":"2545","DOI":"10.3389\/fimmu.2018.02545","volume":"9","author":"PA van Schouwenburg","year":"2018","unstructured":"van Schouwenburg PA, Ispeert H, Pico-Knijnenburg I, et al. Identification of CVID patients with defects in immune repertoire formation or specification. Front Immunol. 2018;9:2545. https:\/\/doi.org\/10.3389\/fimmu.2018.02545.","journal-title":"Front Immunol."},{"issue":"40","key":"673_CR2","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000005081","volume":"95","author":"C Shi","year":"2016","unstructured":"Shi C, Wang F, Tong A, et al. NFKB2 mutation in common variable immunodeficiency and isolated adrenocorticotropic hormone deficiency: a case report and review of literature. Medicine (Baltimore). 2016;95(40): e5081. https:\/\/doi.org\/10.1097\/MD.0000000000005081.","journal-title":"Medicine (Baltimore)"},{"key":"673_CR3","first-page":"369","volume":"25","author":"G Gualdi","year":"2015","unstructured":"Gualdi G, Lougaris V, Baronio M, et al. Burden of skin disease in selective IgA deficiency and common variable immunodeficiency. 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