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Immunoglobulin E (IgE)-mediated reactions to foods are associated with a broad range of signs and symptoms that may involve any of the following body systems: the skin, gastrointestinal tract, respiratory tract, and cardiovascular system. IgE-mediated food allergy is a leading cause of anaphylaxis. Therefore, timely and appropriate diagnosis and treatment are imperative. A diagnosis of food allergy entails a careful history and diagnostic tests, which may include skin prick tests, serum-specific IgE, and oral food challenge. The goal of food allergy care is to empower patients and caregivers to manage the risk of food-allergic reactions, reduce food allergy-related anxiety, and achieve a sense of control over their condition. This can be achieved in different ways for different patients and across different life stages. This article provides an overview of the epidemiology, pathophysiology, diagnosis, and management of IgE-mediated food allergy.<\/jats:p>","DOI":"10.1186\/s13223-024-00930-7","type":"journal-article","created":{"date-parts":[[2024,12,30]],"date-time":"2024-12-30T04:14:37Z","timestamp":1735532077000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Immunoglobulin E (IgE)-mediated food allergy"],"prefix":"10.1186","volume":"20","author":[{"given":"Philippe","family":"B\u00e9gin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan","family":"Waserman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer L. 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He is also a clinical trial investigator with DBV Technologies (Viaskin Patch), Regeneron, Novartis, ALK, and Sanofi. He is on the Board of Directors of the CSACI, AAIQ and CAAIF and medical advisor to Food Allergy Canada. Dr. Susan Waserman has received consulting fees and honoraria from AstraZeneca, GlaxoSmithKline, Novartis, ALK, Bausch Health, Mylan, Meda, CSL Behring, Takeda, Pfizer, Sanofi, Medexus Pharma, and Miravo. She is a clinical trial investigator for Aimmune. She is the President of CAAIF, on the Board of Directors of Asthma Canada, and medical advisor to Food Allergy Canada. Dr. Jennifer Protudjer is Section Head for Allied Health, and Co-Lead, Research Pullar, for the Canadian Society of Allergy and Clinical Immunology; sits on the steering committee for Canada\u2019s National Food Allergy Action Plan, and reports consultancy for Nutricia, Novartis, Ajinomoto Cambrooke and ALK-Abell\u00f3. 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