{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T14:11:46Z","timestamp":1790691106106,"version":"4.1.0"},"reference-count":22,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T00:00:00Z","timestamp":1769990400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T00:00:00Z","timestamp":1772496000000},"content-version":"vor","delay-in-days":29,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Allergy Asthma Clin Immunol"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>observing the clinical effects of dust mite sublingual immunotherapy (SLIT) on children with asthma, changes of Th17 \/ Treg cells and related cytokines in order to investigate the possible pathological mechanism of immune tolerance induced by SLIT.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Sixty children with asthma allergic to dust mites were included, divided into SLIT group (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200930) and non-SLIT group (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200930). Clinical symptoms of asthma in each group had been scored before, 1 year and 2 years after treatment. Meanwhile we also evaluated the proportion of Th17 and CD4\n                      <jats:sup>+<\/jats:sup>\n                      CD25\n                      <jats:sup>+<\/jats:sup>\n                      Treg cells in peripheral blood using flow cytometry. Besides, cell culture supernatant was collected to detect the changes of IL-6, IL-10 and IL-17 levels.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      We found that in SLIT group, asthma symptom and drug use score, Th17 cell percentages, IL-6 and IL-17 levels have significantly decreased throughout the study period (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05), while FEV1%, Treg cell percentages and IL-10 level have prominently increased throughout the study period (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05). By contrast, in non-SLIT group, asthma symptom score, lung function, Th17 cell percentages, IL-6 and IL-17 levels have all significantly improved, but on the whole lower than SLIT group (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05). However, we have observed no statistical differences in drug use score, Treg cell percentages, IL-10 level for non-SLIT group throughout the study period.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>SLIT of Dust mite drops could change T immune cell profiles whereas improve asthma symptoms. SLIT might reverse the functional imbalance of Th 17 \/ Treg cells and induce immune tolerance by upregulating Treg cell function and downregulating Th17 cell function.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s13223-026-01010-8","type":"journal-article","created":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T08:57:24Z","timestamp":1770022644000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Effects of sublingual immunotherapy for dust mite on Th 17 \/ Treg cells in children with asthma"],"prefix":"10.1186","volume":"22","author":[{"given":"Fang","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Yin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao","family":"Chu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kun","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,2,2]]},"reference":[{"issue":"3","key":"1010_CR1","doi-asserted-by":"publisher","first-page":"791","DOI":"10.1016\/j.jaci.2022.01.016","volume":"149","author":"MH Shamji","year":"2022","unstructured":"Shamji MH, Sharif H, Layhadi JA, Zhu R, Kishore U, Renz H. 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