{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T23:17:39Z","timestamp":1792279059935,"version":"4.4.0"},"reference-count":44,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,3,7]],"date-time":"2025-03-07T00:00:00Z","timestamp":1741305600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,3,7]],"date-time":"2025-03-07T00:00:00Z","timestamp":1741305600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["PJT-162412"],"award-info":[{"award-number":["PJT-162412"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["PJT-162412"],"award-info":[{"award-number":["PJT-162412"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["PJT-162412"],"award-info":[{"award-number":["PJT-162412"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["PJT-162412"],"award-info":[{"award-number":["PJT-162412"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["PJT-162412"],"award-info":[{"award-number":["PJT-162412"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["PJT-162412"],"award-info":[{"award-number":["PJT-162412"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["PJT-162412"],"award-info":[{"award-number":["PJT-162412"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["PJT-162412"],"award-info":[{"award-number":["PJT-162412"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["PJT-162412"],"award-info":[{"award-number":["PJT-162412"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["PJT-162412"],"award-info":[{"award-number":["PJT-162412"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["PJT-162412"],"award-info":[{"award-number":["PJT-162412"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Molecular Autism"],"DOI":"10.1186\/s13229-025-00648-2","type":"journal-article","created":{"date-parts":[[2025,3,7]],"date-time":"2025-03-07T10:19:07Z","timestamp":1741342747000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Postnatal downregulation of Fmr1 in microglia promotes microglial reactivity and causes behavioural alterations in female mice"],"prefix":"10.1186","volume":"16","author":[{"given":"Mehdi","family":"Hooshmandi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Ho-Tieng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin C.","family":"Lister","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weihua","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Calvin","family":"Wong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole","family":"Brown","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Volodya","family":"Hovhannisyan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonali","family":"Uttam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masha","family":"Prager-Khoutorsky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nahum","family":"Sonenberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christos G.","family":"Gkogkas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arkady","family":"Khoutorsky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,3,7]]},"reference":[{"issue":"7","key":"648_CR1","doi-asserted-by":"publisher","first-page":"1648","DOI":"10.1002\/ajmg.a.36511","volume":"164A","author":"J Hunter","year":"2014","unstructured":"Hunter J, Rivero-Arias O, Angelov A, Kim E, Fotheringham I, Leal J. Epidemiology of fragile X syndrome: a systematic review and meta-analysis. Am J Med Genet A. 2014;164A(7):1648\u201358.","journal-title":"Am J Med Genet A"},{"issue":"1","key":"648_CR2","first-page":"1","volume":"3","author":"RJ Hagerman","year":"2017","unstructured":"Hagerman RJ, Berry-Kravis E, Hazlett HC, Bailey DB, Moine H, Kooy RF, et al. Fragile X syndrome. Nat Reviews Disease Primers. 2017;3(1):1\u201319.","journal-title":"Nat Reviews Disease Primers"},{"key":"648_CR3","doi-asserted-by":"publisher","first-page":"1016","DOI":"10.1007\/s11064-013-1229-3","volume":"39","author":"F Sethna","year":"2014","unstructured":"Sethna F, Moon C, Wang H. From FMRP function to potential therapies for fragile X syndrome. Neurochem Res. 2014;39:1016\u201331.","journal-title":"Neurochem Res"},{"issue":"6","key":"648_CR4","doi-asserted-by":"publisher","first-page":"674","DOI":"10.1038\/nm.4335","volume":"23","author":"I Gantois","year":"2017","unstructured":"Gantois I, Khoutorsky A, Popic J, Aguilar-Valles A, Freemantle E, Cao R, et al. Metformin ameliorates core deficits in a mouse model of fragile X syndrome. Nat Med. 2017;23(6):674\u20137.","journal-title":"Nat Med"},{"issue":"19","key":"648_CR5","doi-asserted-by":"publisher","first-page":"3028","DOI":"10.1016\/j.neuron.2023.06.017","volume":"111","author":"M Hooshmandi","year":"2023","unstructured":"Hooshmandi M, Sharma V, Perez CT, Sood R, Krimbacher K, Wong C, et al. Excitatory neuron-specific suppression of the integrated stress response contributes to autism-related phenotypes in fragile X syndrome. Neuron. 2023;111(19):3028\u201340. e6.","journal-title":"Neuron"},{"key":"648_CR6","doi-asserted-by":"publisher","first-page":"105577","DOI":"10.1016\/j.nbd.2021.105577","volume":"162","author":"M Rais","year":"2022","unstructured":"Rais M, Lovelace JW, Shuai XS, Woodard W, Bishay S, Estrada L, et al. Functional consequences of postnatal interventions in a mouse model of Fragile X syndrome. Neurobiol Dis. 2022;162:105577.","journal-title":"Neurobiol Dis"},{"issue":"3","key":"648_CR7","doi-asserted-by":"publisher","first-page":"969","DOI":"10.1093\/cercor\/bhz141","volume":"30","author":"JW Lovelace","year":"2020","unstructured":"Lovelace JW, Rais M, Palacios AR, Shuai XS, Bishay S, Popa O, et al. Deletion of Fmr1 from forebrain excitatory neurons triggers abnormal cellular, EEG, and behavioral phenotypes in the auditory cortex of a mouse model of fragile X syndrome. Cereb Cortex. 2020;30(3):969\u201388.","journal-title":"Cereb Cortex"},{"issue":"49","key":"648_CR8","doi-asserted-by":"publisher","first-page":"9852","DOI":"10.1523\/JNEUROSCI.0886-19.2019","volume":"39","author":"D Gonzalez","year":"2019","unstructured":"Gonzalez D, Tomasek M, Hays S, Sridhar V, Ammanuel S, Chang C-w, et al. Audiogenic seizures in the Fmr1 knock-out mouse are induced by Fmr1 deletion in subcortical, VGlut2-expressing excitatory neurons and require deletion in the inferior colliculus. J Neurosci. 2019;39(49):9852\u201363.","journal-title":"J Neurosci"},{"issue":"1","key":"648_CR9","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1186\/s13229-022-00509-2","volume":"13","author":"M Kalinowska","year":"2022","unstructured":"Kalinowska M, van der Lei MB, Kitiashvili M, Mamcarz M, Oliveira MM, Longo F, et al. Deletion of Fmr1 in parvalbumin-expressing neurons results in dysregulated translation and selective behavioral deficits associated with fragile X syndrome. Mol Autism. 2022;13(1):29.","journal-title":"Mol Autism"},{"issue":"3","key":"648_CR10","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1016\/j.neuron.2005.07.005","volume":"47","author":"S Koekkoek","year":"2005","unstructured":"Koekkoek S, Yamaguchi K, Milojkovic B, Dortland B, Ruigrok T, Maex R, et al. Deletion of FMR1 in Purkinje cells enhances parallel fiber LTD, enlarges spines, and attenuates cerebellar eyelid conditioning in Fragile X syndrome. Neuron. 2005;47(3):339\u201352.","journal-title":"Neuron"},{"issue":"15","key":"648_CR11","doi-asserted-by":"publisher","first-page":"1601","DOI":"10.1002\/glia.20573","volume":"55","author":"LK Pacey","year":"2007","unstructured":"Pacey LK, Doering LC. Developmental expression of FMRP in the astrocyte lineage: implications for fragile X syndrome. Glia. 2007;55(15):1601\u20139.","journal-title":"Glia"},{"key":"648_CR12","doi-asserted-by":"publisher","first-page":"105731","DOI":"10.1016\/j.neubiorev.2024.105731","volume":"162","author":"S D\u2019Antoni","year":"2024","unstructured":"D\u2019Antoni S, Spatuzza M, Bonaccorso CM, Catania MV. Role of fragile X messenger ribonucleoprotein 1 in the pathophysiology of brain disorders: a glia perspective. Neurosci Biobehav Rev. 2024;162:105731.","journal-title":"Neurosci Biobehav Rev"},{"key":"648_CR13","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1016\/j.brainres.2014.11.023","volume":"1596","author":"S Gholizadeh","year":"2015","unstructured":"Gholizadeh S, Halder SK, Hampson DR. Expression of fragile X mental retardation protein in neurons and glia of the developing and adult mouse brain. Brain Res. 2015;1596:22\u201330.","journal-title":"Brain Res"},{"issue":"27","key":"648_CR14","doi-asserted-by":"publisher","first-page":"7079","DOI":"10.1523\/JNEUROSCI.1069-16.2016","volume":"36","author":"H Higashimori","year":"2016","unstructured":"Higashimori H, Schin CS, Chiang MSR, Morel L, Shoneye TA, Nelson DL, et al. Selective deletion of astroglial FMRP dysregulates glutamate transporter GLT1 and contributes to fragile X syndrome phenotypes in vivo. J Neurosci. 2016;36(27):7079\u201394.","journal-title":"J Neurosci"},{"key":"648_CR15","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1146\/annurev-genet-112618-043515","volume":"53","author":"CJ Bohlen","year":"2019","unstructured":"Bohlen CJ, Friedman BA, Dejanovic B, Sheng M. Microglia in brain development, homeostasis, and neurodegeneration. Annu Rev Genet. 2019;53:263\u201388.","journal-title":"Annu Rev Genet"},{"issue":"3","key":"648_CR16","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1016\/0165-0173(94)00015-H","volume":"20","author":"J Gehrmann","year":"1995","unstructured":"Gehrmann J, Matsumoto Y, Kreutzberg GW. Microglia: intrinsic immuneffector cell of the brain. Brain Res Rev. 1995;20(3):269\u201387.","journal-title":"Brain Res Rev"},{"issue":"9","key":"648_CR17","doi-asserted-by":"publisher","first-page":"1018","DOI":"10.1038\/nm.4397","volume":"23","author":"MW Salter","year":"2017","unstructured":"Salter MW, Stevens B. Microglia emerge as central players in brain disease. Nat Med. 2017;23(9):1018\u201327.","journal-title":"Nat Med"},{"issue":"6","key":"648_CR18","doi-asserted-by":"publisher","first-page":"485","DOI":"10.1080\/02646830500381930","volume":"17","author":"CA Pardo","year":"2005","unstructured":"Pardo CA, Vargas DL, Zimmerman AW. Immunity, neuroglia and neuroinflammation in autism. Int Rev Psychiatry. 2005;17(6):485\u201395.","journal-title":"Int Rev Psychiatry"},{"issue":"11","key":"648_CR19","doi-asserted-by":"publisher","first-page":"103293","DOI":"10.1016\/j.isci.2021.103293","volume":"24","author":"J Parrott","year":"2021","unstructured":"Parrott J, Oster T, Lee H. Altered inflammatory response in FMRP-deficient microglia. iScience. 2021;24(11):103293.","journal-title":"iScience"},{"issue":"7589","key":"648_CR20","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1038\/nature16549","volume":"530","author":"A Sekar","year":"2016","unstructured":"Sekar A, Bialas AR, De Rivera H, Davis A, Hammond TR, Kamitaki N, et al. Schizophrenia risk from complex variation of complement component 4. Nature. 2016;530(7589):177\u201383.","journal-title":"Nature"},{"issue":"7392","key":"648_CR21","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1038\/nature10907","volume":"484","author":"NC Derecki","year":"2012","unstructured":"Derecki NC, Cronk JC, Lu Z, Xu E, Abbott SB, Guyenet PG, et al. Wild-type microglia arrest pathology in a mouse model of Rett syndrome. Nature. 2012;484(7392):105\u20139.","journal-title":"Nature"},{"issue":"1","key":"648_CR22","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1002\/ana.20315","volume":"57","author":"DL Vargas","year":"2005","unstructured":"Vargas DL, Nascimbene C, Krishnan C, Zimmerman AW, Pardo CA. Neuroglial activation and neuroinflammation in the brain of patients with autism. Annals Neurology: Official J Am Neurol Association Child Neurol Soc. 2005;57(1):67\u201381.","journal-title":"Annals Neurology: Official J Am Neurol Association Child Neurol Soc"},{"issue":"3","key":"648_CR23","doi-asserted-by":"publisher","first-page":"549","DOI":"10.1016\/j.nbd.2005.08.019","volume":"21","author":"E Mientjes","year":"2006","unstructured":"Mientjes E, Nieuwenhuizen I, Kirkpatrick L, Zu T, Hoogeveen-Westerveld M, Severijnen L-a, et al. The generation of a conditional Fmr1 knock out mouse model to study Fmrp function in vivo. Neurobiol Dis. 2006;21(3):549\u201355.","journal-title":"Neurobiol Dis"},{"key":"648_CR24","doi-asserted-by":"crossref","unstructured":"Kaiser T, Feng G. Tmem119-EGFP and Tmem119-CreERT2 transgenic mice for labeling and manipulating microglia. Eneuro. 2019;6(4).","DOI":"10.1101\/624825"},{"issue":"21","key":"648_CR25","doi-asserted-by":"publisher","first-page":"3458","DOI":"10.1016\/j.neuron.2022.10.020","volume":"110","author":"RC Paolicelli","year":"2022","unstructured":"Paolicelli RC, Sierra A, Stevens B, Tremblay M-E, Aguzzi A, Ajami B, et al. Microglia states and nomenclature: a field at its crossroads. Neuron. 2022;110(21):3458\u201383.","journal-title":"Neuron"},{"issue":"2","key":"648_CR26","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1111\/jnc.15689","volume":"163","author":"JR Guedes","year":"2022","unstructured":"Guedes JR, Ferreira PA, Costa JM, Cardoso AL, Pe\u00e7a J. Microglia-dependent remodeling of neuronal circuits. J Neurochem. 2022;163(2):74\u201393.","journal-title":"J Neurochem"},{"issue":"4","key":"648_CR27","doi-asserted-by":"publisher","first-page":"691","DOI":"10.1016\/j.neuron.2012.03.026","volume":"74","author":"DP Schafer","year":"2012","unstructured":"Schafer DP, Lehrman EK, Kautzman AG, Koyama R, Mardinly AR, Yamasaki R, et al. Microglia sculpt postnatal neural circuits in an activity and complement-dependent manner. Neuron. 2012;74(4):691\u2013705.","journal-title":"Neuron"},{"key":"648_CR28","doi-asserted-by":"publisher","unstructured":"Dziabis JE, Bilbo SD. Microglia and sensitive periods in brain development. Curr Top Behav Neurosci. 2022;53:55\u201378. PMID: 34463934 https:\/\/doi.org\/10.1007\/7854_2021_242","DOI":"10.1007\/7854_2021_242"},{"issue":"5","key":"648_CR29","doi-asserted-by":"publisher","first-page":"358","DOI":"10.1016\/j.it.2024.03.009","volume":"45","author":"CC Escoubas","year":"2024","unstructured":"Escoubas CC, Molofsky AV. Microglia as integrators of brain-associated molecular patterns. Trends Immunol. 2024;45(5):358\u201370.","journal-title":"Trends Immunol"},{"issue":"4","key":"648_CR30","doi-asserted-by":"publisher","first-page":"789","DOI":"10.1002\/glia.23284","volume":"66","author":"S Jawaid","year":"2018","unstructured":"Jawaid S, Kidd GJ, Wang J, Swetlik C, Dutta R, Trapp BD. Alterations in CA1 hippocampal synapses in a mouse model of fragile X syndrome. Glia. 2018;66(4):789\u2013800.","journal-title":"Glia"},{"key":"648_CR31","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s13041-019-0478-8","volume":"12","author":"FH Lee","year":"2019","unstructured":"Lee FH, Lai TK, Su P, Liu F. Altered cortical cytoarchitecture in the Fmr1 knockout mouse. Mol Brain. 2019;12:1\u201312.","journal-title":"Mol Brain"},{"issue":"1","key":"648_CR32","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1001\/jamapsychiatry.2013.272","volume":"70","author":"K Suzuki","year":"2013","unstructured":"Suzuki K, Sugihara G, Ouchi Y, Nakamura K, Futatsubashi M, Takebayashi K, et al. Microglial activation in young adults with autism spectrum disorder. JAMA Psychiatry. 2013;70(1):49\u201358.","journal-title":"JAMA Psychiatry"},{"issue":"7351","key":"648_CR33","doi-asserted-by":"publisher","first-page":"380","DOI":"10.1038\/nature10110","volume":"474","author":"I Voineagu","year":"2011","unstructured":"Voineagu I, Wang X, Johnston P, Lowe JK, Tian Y, Horvath S, et al. Transcriptomic analysis of autistic brain reveals convergent molecular pathology. Nature. 2011;474(7351):380\u20134.","journal-title":"Nature"},{"issue":"3","key":"648_CR34","doi-asserted-by":"publisher","first-page":"400","DOI":"10.1038\/nn.3641","volume":"17","author":"Y Zhan","year":"2014","unstructured":"Zhan Y, Paolicelli RC, Sforazzini F, Weinhard L, Bolasco G, Pagani F, et al. Deficient neuron-microglia signaling results in impaired functional brain connectivity and social behavior. Nat Neurosci. 2014;17(3):400\u20136.","journal-title":"Nat Neurosci"},{"issue":"6301","key":"648_CR35","doi-asserted-by":"publisher","first-page":"772","DOI":"10.1126\/science.aag3194","volume":"353","author":"ML Estes","year":"2016","unstructured":"Estes ML, McAllister AK. Maternal immune activation: implications for neuropsychiatric disorders. Science. 2016;353(6301):772\u20137.","journal-title":"Science"},{"key":"648_CR36","doi-asserted-by":"publisher","first-page":"1006612","DOI":"10.3389\/fpsyt.2022.1006612","volume":"13","author":"A Erbescu","year":"2022","unstructured":"Erbescu A, Papuc SM, Budisteanu M, Arghir A, Neagu M. Re-emerging concepts of immune dysregulation in autism spectrum disorders. Front Psychiatry. 2022;13:1006612.","journal-title":"Front Psychiatry"},{"issue":"1","key":"648_CR37","doi-asserted-by":"publisher","first-page":"1797","DOI":"10.1038\/s41467-020-15530-3","volume":"11","author":"Z-X Xu","year":"2020","unstructured":"Xu Z-X, Kim GH, Tan J-W, Riso AE, Sun Y, Xu EY, et al. Elevated protein synthesis in microglia causes autism-like synaptic and behavioral aberrations. Nat Commun. 2020;11(1):1797.","journal-title":"Nat Commun"},{"key":"648_CR38","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1016\/j.bbi.2024.03.035","volume":"119","author":"B Ugursu","year":"2024","unstructured":"Ugursu B, Sah A, Sartori S, Popp O, Mertins P, Dunay IR, et al. Microglial sex differences in innate high anxiety and modulatory effects of minocycline. Brain Behav Immun. 2024;119:465\u201381.","journal-title":"Brain Behav Immun"},{"key":"648_CR39","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12974-021-02124-z","volume":"18","author":"J Han","year":"2021","unstructured":"Han J, Fan Y, Zhou K, Blomgren K, Harris RA. Uncovering sex differences of rodent microglia. J Neuroinflamm. 2021;18:1\u201311.","journal-title":"J Neuroinflamm"},{"key":"648_CR40","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/j.neubiorev.2016.02.019","volume":"67","author":"E Romano","year":"2016","unstructured":"Romano E, Cosentino L, Laviola G, De Filippis B. Genes and sex hormones interaction in neurodevelopmental disorders. Neurosci Biobehav Rev. 2016;67:9\u201324.","journal-title":"Neurosci Biobehav Rev"},{"issue":"2","key":"648_CR41","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1016\/j.brainresrev.2004.12.018","volume":"48","author":"D Garcia-Ovejero","year":"2005","unstructured":"Garcia-Ovejero D, Azcoitia I, Doncarlos LL, Melcangi RC, Garcia-Segura LM. Glia-neuron crosstalk in the neuroprotective mechanisms of sex steroid hormones. Brain Res Brain Res Rev. 2005;48(2):273\u201386.","journal-title":"Brain Res Brain Res Rev"},{"issue":"1","key":"648_CR42","doi-asserted-by":"publisher","first-page":"113660","DOI":"10.1016\/j.celrep.2023.113660","volume":"43","author":"AM Bedolla","year":"2024","unstructured":"Bedolla AM, McKinsey GL, Ware K, Santander N, Arnold TD, Luo Y. A comparative evaluation of the strengths and potential caveats of the microglial inducible CreER mouse models. Cell Rep. 2024;43(1):113660.","journal-title":"Cell Rep"},{"issue":"5","key":"648_CR43","doi-asserted-by":"publisher","first-page":"e12803","DOI":"10.1111\/gbb.12803","volume":"21","author":"JL Silverman","year":"2022","unstructured":"Silverman JL, Thurm A, Ethridge SB, Soller MM, Petkova SP, Abel T, et al. Reconsidering animal models used to study autism spectrum disorder: current state and optimizing future. Genes Brain Behav. 2022;21(5):e12803.","journal-title":"Genes Brain Behav"},{"key":"648_CR44","doi-asserted-by":"publisher","first-page":"105053","DOI":"10.1016\/j.neubiorev.2023.105053","volume":"146","author":"JN Crawley","year":"2023","unstructured":"Crawley JN. Twenty years of discoveries emerging from mouse models of autism. Neurosci Biobehav Rev. 2023;146:105053.","journal-title":"Neurosci Biobehav Rev"}],"container-title":["Molecular Autism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13229-025-00648-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s13229-025-00648-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13229-025-00648-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,7]],"date-time":"2025-03-07T10:56:49Z","timestamp":1741345009000},"score":1,"resource":{"primary":{"URL":"https:\/\/molecularautism.biomedcentral.com\/articles\/10.1186\/s13229-025-00648-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,7]]},"references-count":44,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["648"],"URL":"https:\/\/doi.org\/10.1186\/s13229-025-00648-2","relation":{},"ISSN":["2040-2392"],"issn-type":[{"value":"2040-2392","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,3,7]]},"assertion":[{"value":"21 June 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 February 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 March 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All procedures were compliant with the Canadian Council on Animal Care guidelines and approved by McGill University\u2019s Animal Care Committee.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"17"}}