{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T13:36:51Z","timestamp":1784036211515,"version":"3.55.0"},"reference-count":29,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2020,5,19]],"date-time":"2020-05-19T00:00:00Z","timestamp":1589846400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2020,5,19]],"date-time":"2020-05-19T00:00:00Z","timestamp":1589846400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Insights Imaging"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Adenocarcinoma in situ, minimally invasive adenocarcinoma, lepidic predominant adenocarcinoma and invasive mucinous adenocarcinoma are relatively new classification entities which replace the now retired term, bronchoalveolar carcinoma (BAC). The radiographic appearance of these lesions ranges from pure, ground glass nodules to large, solid masses. A thorough understanding of the new classification is essential to radiologists who work with MDT colleagues to provide accurate staging and treatment. A 2-year review was performed of all surgically resected cases of adenocarcinoma in situ, minimally invasive adenocarcinoma and lepidic predominant adenocarcinoma in our institution. Cases are broken down by age, gender, tumour type and tumour location. A pictorial review is presented to illustrate the radiologic and pathologic features of each entity.<\/jats:p>","DOI":"10.1186\/s13244-020-00875-6","type":"journal-article","created":{"date-parts":[[2020,5,19]],"date-time":"2020-05-19T20:15:06Z","timestamp":1589919306000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":45,"title":["Adenocarcinoma of the lung: from BAC to the future"],"prefix":"10.1186","volume":"11","author":[{"given":"Gerard","family":"Lambe","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Durand","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Buckley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siobhan","family":"Nicholson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronan","family":"McDermott","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,5,19]]},"reference":[{"issue":"14","key":"875_CR1","doi-asserted-by":"publisher","first-page":"3279","DOI":"10.1200\/JCO.2005.15.776","volume":"23","author":"WD Travis","year":"2005","unstructured":"Travis WD, Garg K, Franklin WA et al (2005) Evolving concepts in the pathology and computed tomography imaging of lung adenocarcinoma and bronchioloalveolar carcinoma. J Clin Oncol 23(14):3279\u20133287 https:\/\/doi.org\/10.1200\/JCO.2005.15.776","journal-title":"J Clin Oncol"},{"issue":"1 Suppl","key":"875_CR2","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1002\/1097-0142(19950101)75:1+<191::AID-CNCR2820751307>3.0.CO;2-Y","volume":"75","author":"WD Travis","year":"1995","unstructured":"Travis WD, Travis LB, Devesa SS (1995) Lung cancer. Cancer 75(1 Suppl):191\u2013202","journal-title":"Cancer"},{"key":"875_CR3","unstructured":"Malassez L (1876) Examen histologique d\u2019un cas de cancer encephaloide du poumon (epithelioma). Arch Physiol Norm Pathol 1876;3:353-72 [Google Scholar]."},{"key":"875_CR4","unstructured":"Musser JH (1903) Primary cancer of the lung. U Penn Med Bull 1903:16:289-96 [Google Scholar]."},{"key":"875_CR5","unstructured":"Sweany HC (1935) A so-called alveolar cell cancer of the lung. Arch Pathol 1935;19:203-7 [Google Scholar]."},{"key":"875_CR6","unstructured":"Wood DA, Pierson PH (1945) Pulmonary alveolar adenomatosis in man. Is this the same disease as jaagsiekte in sheep? Am Rev Tuberc 1945;51:205-24 [Google Scholar]."},{"issue":"6","key":"875_CR7","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1016\/S0096-5588(20)31697-4","volume":"19","author":"KE Osserman","year":"1950","unstructured":"Osserman KE, Neuhof H (1950) Mucocellular papillary adenocarcinoma of the lung, lobectomy, five-year follow-up. J Thorac Surg 19(6):875\u2013876","journal-title":"J Thorac Surg"},{"issue":"9","key":"875_CR8","doi-asserted-by":"publisher","first-page":"S20","DOI":"10.1016\/S1556-0864(15)30005-8","volume":"1","author":"David R. Gandara","year":"2006","unstructured":"Gandara DR, Aberle D, Lau D et al (2006) Radiographic imaging of bronchioloalveolar carcinoma: screening, patterns of presentation and response assessment. J Thorac Oncol 1(9):S20\u2013S26 https:\/\/doi.org\/10.1016\/S1556-0864(15)30005-8","journal-title":"Journal of Thoracic Oncology"},{"key":"875_CR9","first-page":"329","volume":"10","author":"AA Liebow","year":"1960","unstructured":"Liebow AA (1960) Bronchiolo-alveolar carcinoma. Adv Intern Med 10:329\u2013358","journal-title":"Adv Intern Med"},{"key":"875_CR10","unstructured":"Weissferdt A, Moran CA (2014) Reclassification of early stage pulmonary adenocarcinoma and its consequences. J Thorac Dis 6(5):S581-S588\u2013S588."},{"issue":"5","key":"875_CR11","doi-asserted-by":"publisher","first-page":"1728","DOI":"10.1016\/j.athoracsur.2004.05.017","volume":"78","author":"H Sakurai","year":"2004","unstructured":"Sakurai H, Dobashi Y, Mizutani E et al (2004) Bronchioloalveolar carcinoma of the lung 3 centimeters or less in diameter: a prognostic assessment. Ann Thorac Surg 78(5):1728\u20131733 https:\/\/doi.org\/10.1016\/j.athoracsur.2004.05.017","journal-title":"Ann Thorac Surg"},{"issue":"3","key":"875_CR12","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1016\/j.lungcan.2013.06.012","volume":"81","author":"K Tsuta","year":"2013","unstructured":"Tsuta K, Kawago M, Inoue E et al (2013) The utility of the proposed IASLC\/ATS\/ERS lung adenocarcinoma subtypes for disease prognosis and correlation of driver gene alterations. Lung Cancer 81(3):371\u2013376 https:\/\/doi.org\/10.1016\/j.lungcan.2013.06.012","journal-title":"Lung Cancer"},{"issue":"2","key":"875_CR13","doi-asserted-by":"publisher","first-page":"413","DOI":"10.1016\/j.athoracsur.2005.07.058","volume":"81","author":"K Suzuki","year":"2006","unstructured":"Suzuki K, Kusumoto M, Watanabe S, Tsuchiya R, Asamura H (2006) Radiologic classification of small adenocarcinoma of the lung: radiologic-pathologic correlation and its prognostic impact. Ann Thorac Surg 81(2):413\u2013419 https:\/\/doi.org\/10.1016\/j.athoracsur.2005.07.058","journal-title":"Ann Thorac Surg"},{"issue":"4","key":"875_CR14","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.1016\/S0003-4975(03)00835-X","volume":"76","author":"H Asamura","year":"2003","unstructured":"Asamura H, Suzuki K, Watanabe S, Matsuno Y, Maeshima A, Tsuchiya R (2003) A clinicopathological study of resected subcentimeter lung cancers: a favorable prognosis for ground glass opacity lesions. Ann Thorac Surg 76(4):1016\u20131022","journal-title":"Ann Thorac Surg"},{"issue":"1","key":"875_CR15","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1148\/radiol.2451061682","volume":"245","author":"HY Kim","year":"2007","unstructured":"Kim HY, Shim YM, Lee KS, Han J, Yi CA, Kim YK (2007) Persistent pulmonary nodular ground-glass opacity at thin-section CT: histopathologic comparisons. Radiology 245(1):267\u2013275 https:\/\/doi.org\/10.1148\/radiol.2451061682","journal-title":"Radiology"},{"issue":"11","key":"875_CR16","doi-asserted-by":"publisher","first-page":"2889","DOI":"10.1002\/cncr.26584","volume":"118","author":"LM Solis","year":"2012","unstructured":"Solis LM, Behrens C, Raso MG et al (2012) Histologic patterns and molecular characteristics of lung adenocarcinoma associated with clinical outcome. Cancer 118(11):2889\u20132899 https:\/\/doi.org\/10.1002\/cncr.26584","journal-title":"Cancer"},{"issue":"6","key":"875_CR17","doi-asserted-by":"publisher","first-page":"677","DOI":"10.1111\/j.1365-2559.2005.02126.x","volume":"46","author":"Y Makimoto","year":"2005","unstructured":"Makimoto Y, Nabeshima K, Iwasaki H et al (2005) Micropapillary pattern: a distinct pathological marker to subclassify tumours with a significantly poor prognosis within small peripheral lung adenocarcinoma (<\/=20\u2009mm) with mixed bronchioloalveolar and invasive subtypes (Noguchi\u2019s type C tumours). Histopathology 46(6):677\u2013684 https:\/\/doi.org\/10.1111\/j.1365-2559.2005.02126.x","journal-title":"Histopathology"},{"issue":"6","key":"875_CR18","doi-asserted-by":"crossref","first-page":"1868","DOI":"10.1378\/chest.123.6.1868","volume":"123","author":"M Wislez","year":"2003","unstructured":"Wislez M, Massiani M-A, Milleron B et al (2003) Clinical characteristics of pneumonic-type adenocarcinoma of the lung. Chest 123(6):1868\u20131877","journal-title":"Chest"},{"issue":"12","key":"875_CR19","doi-asserted-by":"publisher","first-page":"4146","DOI":"10.1016\/j.ejrad.2012.08.023","volume":"81","author":"Anand Gaikwad","year":"2012","unstructured":"Gaikwad A, Gupta A, Hare S et al (2012) Primary adenocarcinoma of lung: a pictorial review of recent updates. Eur J Radiol 81(12):4146\u20134155 https:\/\/doi.org\/10.1016\/j.ejrad.2012.08.023","journal-title":"European Journal of Radiology"},{"issue":"1","key":"875_CR20","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1016\/s0169-5002(01)00185-4","volume":"33","author":"K Kodama","year":"2001","unstructured":"Kodama K, Higashiyama M, Yokouchi H et al (2001) Prognostic value of ground-glass opacity found in small lung adenocarcinoma on high-resolution CT scanning. Lung Cancer 33(1):17\u201325 https:\/\/doi.org\/10.1016\/s0169-5002(01)00185-4","journal-title":"Lung Cancer"},{"issue":"1","key":"875_CR21","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1097\/RCT.0b013e3181633509","volume":"33","author":"H Saito","year":"2009","unstructured":"Saito H, Yamada K, Hamanaka N et al (2009) Initial findings and progression of lung adenocarcinoma on serial computed tomography scans. J Comput Assist Tomogr 33(1):42\u201348 https:\/\/doi.org\/10.1097\/RCT.0b013e3181633509","journal-title":"J Comput Assist Tomogr"},{"issue":"6","key":"875_CR22","first-page":"343","volume":"18","author":"H Yabuuchi","year":"2000","unstructured":"Yabuuchi H, Murayama S, Murakami J et al (2000) High-resolution CT characteristics of poorly differentiated adenocarcinoma of the peripheral lung: comparison with well differentiated adenocarcinoma. Radiat Med 18(6):343\u2013347","journal-title":"Radiat Med"},{"issue":"3","key":"875_CR23","doi-asserted-by":"publisher","first-page":"803","DOI":"10.1148\/radiol.2203001701","volume":"220","author":"T Aoki","year":"2001","unstructured":"Aoki T, Tomoda Y, Watanabe H et al (2001) Peripheral lung adenocarcinoma: correlation of thin-section CT findings with histologic prognostic factors and survival. Radiology 220(3):803\u2013809 https:\/\/doi.org\/10.1148\/radiol.2203001701","journal-title":"Radiology"},{"issue":"1","key":"875_CR24","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1016\/j.ejrad.2010.09.026","volume":"81","author":"M Ikehara","year":"2012","unstructured":"Ikehara M, Saito H, Kondo T et al (2012) Comparison of thin-section CT and pathological findings in small solid-density type pulmonary adenocarcinoma: prognostic factors from CT findings. Eur J Radiol 81(1):189\u2013194 https:\/\/doi.org\/10.1016\/j.ejrad.2010.09.026","journal-title":"Eur J Radiol"},{"issue":"10","key":"875_CR25","doi-asserted-by":"publisher","first-page":"1090","DOI":"10.1164\/ajrccm.178.10.1090","volume":"178","author":"JHM Austin","year":"2008","unstructured":"Austin JHM, Mujoomdar A, Powell CA, Pearson GDN, Raftopoulos H (2008) Carcinoma of the lung and metastatic disease of the central nervous system. Am J Respir Crit Care Med 178(10):1090\u20131090 https:\/\/doi.org\/10.1164\/ajrccm.178.10.1090","journal-title":"Am J Respir Crit Care Med"},{"issue":"4","key":"875_CR26","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1016\/j.ejrad.2014.12.031","volume":"84","author":"JG Cohen","year":"2015","unstructured":"Cohen JG, Reymond E, Lederlin M et al (2015) Differentiating pre- and minimally invasive from invasive adenocarcinoma using CT-features in persistent pulmonary part-solid nodules in Caucasian patients. Eur J Radiol 84(4):738\u2013744","journal-title":"Eur J Radiol"},{"issue":"1","key":"875_CR27","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1097\/JTO.0000000000000019","volume":"9","author":"KH Lee","year":"2014","unstructured":"Lee KH, Goo JM, Park SJ et al (2014) Correlation between the size of the solid component on thin-section CT and the invasive component on pathology in small lung adenocarcinomas manifesting as ground-glass nodules. J Thorac Oncol 9(1):74\u201382 https:\/\/doi.org\/10.1097\/JTO.0000000000000019","journal-title":"J Thorac Oncol"},{"issue":"1","key":"875_CR28","doi-asserted-by":"crossref","first-page":"e21","DOI":"10.1016\/j.crad.2012.09.002","volume":"68","author":"T. Honda","year":"2013","unstructured":"Honda T, Kondo T, Murakami S et al (2013) Radiographic and pathological analysis of small lung adenocarcinoma using the new IASLC classification. Clin Radiol 68:e21\u2014e26.","journal-title":"Clinical Radiology"},{"issue":"3","key":"875_CR29","doi-asserted-by":"publisher","first-page":"451","DOI":"10.1097\/JTO.0b013e31820517a3","volume":"6","author":"N Rekhtman","year":"2011","unstructured":"Rekhtman N, Brandt SM, Sigel CS et al (2011) Suitability of thoracic cytology for new therapeutic paradigms in non-small cell lung carcinoma: high accuracy of tumor subtyping and feasibility of EGFR and KRAS molecular testing. J Thorac Oncol 6(3):451\u2013458 https:\/\/doi.org\/10.1097\/JTO.0b013e31820517a3","journal-title":"J Thorac Oncol"}],"container-title":["Insights into Imaging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13244-020-00875-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s13244-020-00875-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13244-020-00875-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,5,18]],"date-time":"2021-05-18T23:13:11Z","timestamp":1621379591000},"score":1,"resource":{"primary":{"URL":"https:\/\/insightsimaging.springeropen.com\/articles\/10.1186\/s13244-020-00875-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,5,19]]},"references-count":29,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2020,12]]}},"alternative-id":["875"],"URL":"https:\/\/doi.org\/10.1186\/s13244-020-00875-6","relation":{},"ISSN":["1869-4101"],"issn-type":[{"value":"1869-4101","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,5,19]]},"assertion":[{"value":"11 March 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 April 2020","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 May 2020","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Not applicable","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"69"}}