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We explored the diagnostic value of color Doppler ultrasound in detecting synovitis in boys with bleeding disorders.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Sixty boys with hemophilia and 3 boys with type 3 von Willebrand disease aged 5 to 18\u00a0years (median 12.3\u00a0years) were imaged by gray-scale and color Doppler ultrasound (US) in three centers (Beijing, China [<jats:italic>n<\/jats:italic>\u2009=\u200922], Guangzhou, China [<jats:italic>n<\/jats:italic>\u2009=\u200912] and Toronto, Canada [<jats:italic>n<\/jats:italic>\u2009=\u200929])) in this observational study. Images were independently reviewed by two radiologists blinded to clinical data using a subjective semi-quantitative scoring system and objective measurements of synovial thickness and vascularity. Inter-reader reliability for using subjective versus objective color Doppler US methods for assessing synovial vascularity was excellent for the subjective method and moderate\/lower range of substantial for the objective method. Agreement between degree of vascularity on color Doppler and extent of synovial hypertrophy on gray-scale US was overall poor for Canada data and moderate for China data. Correlations between degree of vascularity on color Doppler and synovial hypertrophy on gray-scale US, and clinical constructs (total and itemized HJHS scores and total Pettersson X-ray scores) for assessment of blood-induced arthropathy were all poor.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>Color Doppler US is a valuable scoring method for evaluating reactive synovitis in joints of subjects with inherited bleeding disorders and holds potential for assessing post-bleed reactive synovitis once further information on its association with timing of the joint bleed becomes available in the literature.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s13244-021-01043-0","type":"journal-article","created":{"date-parts":[[2021,9,25]],"date-time":"2021-09-25T17:02:47Z","timestamp":1632589367000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["A semiquantitative color Doppler ultrasound scoring system for evaluation of synovitis in joints of patients with blood-induced arthropathy"],"prefix":"10.1186","volume":"12","author":[{"given":"Ningning","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheng","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne-Fleur","family":"Zwagemaker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aihua","family":"Huo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying-Jia","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pamela","family":"Hilliard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"Squire","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vanessa","family":"Bouskill","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arun","family":"Mohanta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alex","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose","family":"Jarrin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Runhui","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian","family":"Luke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rahim","family":"Moineddin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victor S.","family":"Blanchette","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3202-0447","authenticated-orcid":false,"given":"Andrea S.","family":"Doria\u00a0","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,9,25]]},"reference":[{"issue":"1","key":"1043_CR1","doi-asserted-by":"publisher","first-page":"e1","DOI":"10.1111\/j.1365-2516.2012.02909.x","volume":"19","author":"A Srivastava","year":"2013","unstructured":"Srivastava A, Brewer A, Mauser-Bunschoten E et al (2013) Guidelines for the management of hemophilia. 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Informed consent or assent was obtained from all parents and\/or patients who participated in the original prospective studies conducted in Canada and China.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Available upon request.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"ASD: Research support by Bayer Healthcare Inc (Research Grant), Novo Nordisk Healthcare Inc (Research Grant), Terry Fox Foundation (Research Grant), Physician\u2019s Services Incorporation (Research Grant). Advisory Committee: International Prophylaxis Study Group (not for profit). OMERACT SIG in MRI in JIA (not for profit), Canadian Committee of Point-of-Care Ultrasound (not for profit). Consultant: Baxter Healthcare Inc, Pfizer Healthcare Inc. PH: Patent on HJHS v2.1 (Hemophilia Joint Health Score) used under license by the Hospital for Sick Children. VB: Chair of the International Prophylaxis Study Group (IPSG), a co-operative study group that is funded by Education grants from Bayer Healthcare, Bioverativ\/Sanofi, Novo Nordisk, Pfizer, Shire\/Takeda and Spark Therapeutics to the Hospital for Sick Children (\u201cSickKids\u201d) Foundation. Received personal fees from Amgen, Bayer, Novo Nordisk, Pfizer, Roche, Shire\/Takeda, Octapharma, and Research support Grants from Novo Nordisk, Bioverativ\/Sanofi and Shire\/Takeda. RW: Receives research support from Bayer-China. BL: Received honoraria from Takeda China and Bayer China. NZ, AFZ, AM, SY, AZ, JJ, AH, YL, FZ, SS, JS, VB, YP and RM: no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"132"}}