{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T18:31:32Z","timestamp":1778697092765,"version":"3.51.4"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2021,11,6]],"date-time":"2021-11-06T00:00:00Z","timestamp":1636156800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2021,11,6]],"date-time":"2021-11-06T00:00:00Z","timestamp":1636156800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Insights Imaging"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>We investigated the radiodensity of epicardial (EAT), subcutaneous (SAT), and visceral adipose tissue (VAT) before and after treatment with anthracyclines in a population of breast cancer (BC) patients, and in controls not treated with anthracyclines, to detect a potential role of EAT density as a biomarker of changes related to chemotherapy cardiotoxicity.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>We reviewed BC patients treated with anthracyclines who underwent CT before (CT-t<jats:sub>0<\/jats:sub>) and after (CT-t<jats:sub>1<\/jats:sub>) chemotherapy, and age- and sex-matched controls who underwent two CT examinations at comparable intervals. On non-contrast scans, EAT was segmented contouring the pericardium and thresholding between -190 and -30 Hounsfield units (HU), and SAT and VAT were segmented\u00a0with two 15-mm diameter\u00a0regions of interest  thresholded between -195 and -45 HU.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Thirty-two female patients and 32 controls were included. There were no differences in age (<jats:italic>p<\/jats:italic>\u2009=\u20090.439) and follow-up duration (<jats:italic>p<\/jats:italic>\u2009=\u20090.162) between patients and controls. Between CT-t<jats:sub>0<\/jats:sub> and CT-t<jats:sub>1<\/jats:sub>, EAT density decreased in BC patients (-66 HU, interquartile range [IQR] -71 to -63 HU, to -71 HU, IQR -75 to -66 HU,<jats:italic> p<\/jats:italic>\u2009=\u20090.003), while it did not vary in controls (<jats:italic>p<\/jats:italic>\u2009=\u20090.955). SAT density increased from CT-t<jats:sub>0<\/jats:sub> to CT-t<jats:sub>1<\/jats:sub> in BC patients (-107 HU, IQR -111 to -105 HU, to -105 HU, IQR -110 to -100 HU,<jats:italic> p<\/jats:italic>\u2009=\u20090.014), whereas it did not change in controls (<jats:italic>p<\/jats:italic>\u2009=\u20090.477). VAT density did not vary in either BC patients (<jats:italic>p<\/jats:italic>\u2009=\u20090.911) or controls (<jats:italic>p<\/jats:italic>\u2009=\u20090.627).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>EAT density appears to be influenced by anthracycline treatment for BC, well known for its cardiotoxicity, shifting towards lower values indicative of a less active metabolism.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s13244-021-01069-4","type":"journal-article","created":{"date-parts":[[2021,11,6]],"date-time":"2021-11-06T11:02:22Z","timestamp":1636196542000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Potential role of epicardial adipose tissue as a biomarker of anthracycline cardiotoxicity"],"prefix":"10.1186","volume":"12","author":[{"given":"Caterina Beatrice","family":"Monti","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simone","family":"Schiaffino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Del Mar","family":"Galimberti Ortiz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7978-4730","authenticated-orcid":false,"given":"Davide","family":"Capra","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Moreno","family":"Zanardo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elena","family":"De Benedictis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alberto Gianluigi","family":"Luporini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pietro","family":"Spagnolo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesco","family":"Secchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesco","family":"Sardanelli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,11,6]]},"reference":[{"key":"1069_CR1","unstructured":"European Cancer Information System (ECIS) (2019) Breast cancer burden in EU-27. https:\/\/ecis.jrc.ec.europa.eu\/pdf\/Breast_cancer_factsheet-Oct_2020.pdf. 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Simone Schiaffino has received travel support from Bracco Imaging and is a member of the speakers\u2019 bureau for General Electric Healthcare. Moreno Zanardo is member of the Insights into Imaging Editorial Board. He has not taken part in the review or selection process of this article. All other authors have no conflicts of interest to declare.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"161"}}