{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T04:34:47Z","timestamp":1780547687092,"version":"3.54.1"},"reference-count":20,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2023,5,25]],"date-time":"2023-05-25T00:00:00Z","timestamp":1684972800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2023,5,25]],"date-time":"2023-05-25T00:00:00Z","timestamp":1684972800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82202235"],"award-info":[{"award-number":["82202235"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","award":["ZR2022MH165"],"award-info":[{"award-number":["ZR2022MH165"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100015507","name":"Shandong First Medical University","doi-asserted-by":"publisher","award":["2019LJ005"],"award-info":[{"award-number":["2019LJ005"]}],"id":[{"id":"10.13039\/501100015507","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Insights Imaging"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>Respiratory motion during PET acquisition may result in image blurring and resolution loss, reduced measurement of radiotracer uptake, and consequently, inaccurate lesion quantification and description. With the introduction of the total-body PET system, short-time PET acquisition is feasible due to its high sensitivity and spatial resolution. The purpose of this study was to evaluate the additional value of 20-s breath-hold (BH) lung PET in patients with stage IA pulmonary adenocarcinoma.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>Forty-seven patients with confirmed stage IA pulmonary adenocarcinoma were enrolled in this retrospective study. All patients underwent a 300-s FB whole-body PET, followed by a BH lung PET. The SUV<jats:sub>max<\/jats:sub>, TBR of the lesions and the percentage difference in nodule SUV<jats:sub>max<\/jats:sub> (%\u0394SUV<jats:sub>max<\/jats:sub>) and TBR (%\u0394TBR) between the two acquisitions was also calculated. The lesions were further divided by distance from pleura for subgroup analysis. The lesion detectability on PET images was the percentage of FDG-positive lesions.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Among 47 patients, the BH lung PET images identified all lung nodules, and there was a significant difference in overall nodule SUV<jats:sub>max<\/jats:sub> and TBR between BH PET and FB PET (both <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01). The %\u0394SUV<jats:sub>max<\/jats:sub> and %\u0394TBR were significantly higher in nodules adjacent to pleura (\u2264\u200910\u00a0mm in distance) than those away from pleura (both <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). The lesion detectability of BH lung PET was significantly higher than that of FB PET (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>BH PET acquisition is a practical way to minimize motion artifacts in PET which has the potential to improve lesion detection for stage IA pulmonary adenocarcinoma.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Critical relevance statement<\/jats:title>\n                <jats:p>BH PET acquisition is a practical way to minimize motion artifacts in PET which has the potential to improve lesion detection for stage IA pulmonary adenocarcinoma.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Graphical Abstract<\/jats:title>\n                \n              <\/jats:sec>","DOI":"10.1186\/s13244-023-01446-1","type":"journal-article","created":{"date-parts":[[2023,5,25]],"date-time":"2023-05-25T15:02:27Z","timestamp":1685026947000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Role of breath-hold lung PET in stage IA pulmonary adenocarcinoma"],"prefix":"10.1186","volume":"14","author":[{"given":"Zhaoping","family":"Cheng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ximing","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minjie","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keyu","family":"Zan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao","family":"Cui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leiying","family":"Chai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Ge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kun","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2906-9039","authenticated-orcid":false,"given":"Yanhua","family":"Duan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,5,25]]},"reference":[{"issue":"7","key":"1446_CR1","doi-asserted-by":"publisher","first-page":"914","DOI":"10.1001\/jama.285.7.914","volume":"285","author":"MK Gould","year":"2001","unstructured":"Gould MK, Maclean CC, Kuschner WG, Rydzak CE, Owens DK (2001) Accuracy of positron emission tomography for diagnosis of pulmonary nodules and mass lesions: a meta-analysis. JAMA 285(7):914\u2013924","journal-title":"JAMA"},{"issue":"7","key":"1446_CR2","doi-asserted-by":"publisher","first-page":"2134","DOI":"10.1148\/rg.2018180060","volume":"38","author":"A Kandathil","year":"2018","unstructured":"Kandathil A, Kay FU, Butt YM, Wachsmann JW, Subramaniam RM (2018) Role of FDG PET\/CT in the eighth edition of TNM staging of non-small cell lung cancer. Radiographics 38(7):2134\u20132149","journal-title":"Radiographics"},{"issue":"3","key":"1446_CR3","doi-asserted-by":"publisher","first-page":"328","DOI":"10.1007\/s12149-020-01574-4","volume":"35","author":"SY Kang","year":"2021","unstructured":"Kang SY, Moon BS, Kim HO, Yoon HJ, Kim BS (2021) The impact of data-driven respiratory gating in clinical F-18 FDG PET\/CT: comparison of free breathing and deep-expiration breath-hold CT protocol. Ann Nucl Med 35(3):328\u2013337","journal-title":"Ann Nucl Med"},{"issue":"24","key":"1446_CR4","doi-asserted-by":"publisher","first-page":"7345","DOI":"10.1088\/0031-9155\/54\/24\/007","volume":"54","author":"C Liu","year":"2009","unstructured":"Liu C, Pierce LA 2nd, Alessio AM, Kinahan PE (2009) The impact of respiratory motion on tumor quantification and delineation in static PET\/CT imaging. Phys Med Biol 54(24):7345\u20137362","journal-title":"Phys Med Biol"},{"issue":"3","key":"1446_CR5","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1016\/j.radonc.2010.07.014","volume":"96","author":"V Bettinardi","year":"2010","unstructured":"Bettinardi V, Picchio M, Di Muzio N, Gianolli L, Gilardi MC, Messa C (2010) Detection and compensation of organ\/lesion motion using 4D-PET\/CT respiratory gated acquisition techniques. Radiother Oncol 96(3):311\u2013316","journal-title":"Radiother Oncol"},{"issue":"12","key":"1446_CR6","doi-asserted-by":"publisher","first-page":"7390","DOI":"10.1118\/1.4766876","volume":"39","author":"BK Teo","year":"2012","unstructured":"Teo BK, Saboury B, Munbodh R et al (2012) The effect of breathing irregularities on quantitative accuracy of respiratory gated PET\u2215CT. Med Phys 39(12):7390\u20137397","journal-title":"Med Phys"},{"issue":"7","key":"1446_CR7","doi-asserted-by":"publisher","first-page":"3205","DOI":"10.1002\/mp.12987","volume":"45","author":"F B\u00fcther","year":"2018","unstructured":"B\u00fcther F, Ernst I, Frohwein LJ, Pouw J, Sch\u00e4fers KP, Stegger L (2018) Data-driven gating in PET: Influence of respiratory signal noise on motion resolution. Med Phys 45(7):3205\u20133213","journal-title":"Med Phys"},{"issue":"16","key":"1446_CR8","doi-asserted-by":"publisher","DOI":"10.1088\/1361-6560\/ab9660","volume":"65","author":"K Kim","year":"2020","unstructured":"Kim K, Wang M, Guo N, Schaefferkoetter J, Li Q (2020) Data-driven respiratory gating based on localized diaphragm sensing in TOF PET. Phys Med Biol 65(16):165007","journal-title":"Phys Med Biol"},{"issue":"1","key":"1446_CR9","doi-asserted-by":"publisher","first-page":"260","DOI":"10.1148\/radiol.2017160534","volume":"286","author":"N Balamoutoff","year":"2018","unstructured":"Balamoutoff N, Serrano B, Hugonnet F, Garnier N, Paulmier B, Faraggi M (2018) Added value of a single fast 20-second deep-inspiration breath-hold acquisition in FDG PET\/CT in the assessment of lung nodules. Radiology 286(1):260\u2013270","journal-title":"Radiology"},{"issue":"9","key":"1446_CR10","doi-asserted-by":"publisher","first-page":"1287","DOI":"10.1016\/j.jvir.2011.06.015","volume":"22","author":"PB Shyn","year":"2011","unstructured":"Shyn PB, Tatli S, Sainani NI et al (2011) Minimizing image misregistration during PET\/CT-guided percutaneous interventions with monitored breath-hold PET and CT acquisitions. J Vasc Interv Radiol 22(9):1287\u20131292","journal-title":"J Vasc Interv Radiol"},{"issue":"2","key":"1446_CR11","doi-asserted-by":"publisher","first-page":"325","DOI":"10.2214\/AJR.19.22705","volume":"215","author":"H Tan","year":"2020","unstructured":"Tan H, Gu Y, Yu H et al (2020) Total-Body PET\/CT: Current Applications and Future Perspectives. AJR Am J Roentgenol 215(2):325\u2013337","journal-title":"AJR Am J Roentgenol"},{"issue":"1","key":"1446_CR12","doi-asserted-by":"publisher","first-page":"3","DOI":"10.2967\/jnumed.116.184028","volume":"59","author":"SR Cherry","year":"2018","unstructured":"Cherry SR, Jones T, Karp JS, Qi J, Moses WW, Badawi RD (2018) Total-Body PET: maximizing sensitivity to create new opportunities for clinical research and patient care. J Nucl Med 59(1):3\u201312","journal-title":"J Nucl Med"},{"issue":"11","key":"1446_CR13","doi-asserted-by":"publisher","first-page":"3378","DOI":"10.1007\/s00259-021-05304-4","volume":"48","author":"YM Zhao","year":"2021","unstructured":"Zhao YM, Li YH, Chen T et al (2021) Image quality and lesion detectability in low-dose pediatric 18F-FDG scans using total-body PET\/CT. Eur J Nucl Med Mol Imaging 48(11):3378\u20133385","journal-title":"Eur J Nucl Med Mol Imaging"},{"issue":"8","key":"1446_CR14","doi-asserted-by":"publisher","first-page":"2384","DOI":"10.1007\/s00259-021-05357-5","volume":"48","author":"P Hu","year":"2021","unstructured":"Hu P, Zhang Y, Yu H et al (2021) Total-body 18F-FDG PET\/CT scan in oncology patients: How fast could it be? Eur J Nucl Med Mol Imaging 48(8):2384\u20132394","journal-title":"Eur J Nucl Med Mol Imaging"},{"issue":"2","key":"1446_CR15","doi-asserted-by":"publisher","first-page":"576","DOI":"10.1007\/s00330-015-3832-y","volume":"26","author":"EJ Teoh","year":"2016","unstructured":"Teoh EJ, McGowan DR, Bradley KM, Belcher E, Black E, Gleeson FV (2016) Novel penalised likelihood reconstruction of PET in the assessment of histologically verified small pulmonary nodules. Eur Radiol 26(2):576\u2013584","journal-title":"Eur Radiol"},{"issue":"10","key":"1446_CR16","doi-asserted-by":"publisher","first-page":"3483","DOI":"10.1007\/s00330-015-4200-7","volume":"26","author":"A Moreland","year":"2016","unstructured":"Moreland A, Novogrodsky E, Brody L et al (2016) Pneumothorax with prolonged chest tube requirement after CT-guided percutaneous lung biopsy: incidence and risk factors. Eur Radiol 26(10):3483\u20133491","journal-title":"Eur Radiol"},{"issue":"9","key":"1446_CR17","doi-asserted-by":"publisher","first-page":"1123","DOI":"10.1016\/j.acra.2016.04.007","volume":"23","author":"RR Flavell","year":"2016","unstructured":"Flavell RR, Behr SC, Mabray MC, Hernandez-Pampaloni M, Naeger DM (2016) Detecting pulmonary nodules in lung cancer patients using whole body FDG PET\/CT, high-resolution lung reformat of FDG PET\/CT, or diagnostic breath hold chest CT. Acad Radiol 23(9):1123\u20131129","journal-title":"Acad Radiol"},{"issue":"8","key":"1446_CR18","doi-asserted-by":"publisher","first-page":"1223","DOI":"10.2967\/jnumed.107.049296","volume":"49","author":"T Kawano","year":"2008","unstructured":"Kawano T, Ohtake E, Inoue T (2008) Deep-inspiration breath-hold PET\/CT of lung cancer: maximum standardized uptake value analysis of 108 patients. J Nucl Med 49(8):1223\u20131231","journal-title":"J Nucl Med"},{"issue":"2","key":"1446_CR19","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1007\/s12149-008-0225-1","volume":"23","author":"A Lupi","year":"2009","unstructured":"Lupi A, Zaroccolo M, Salgarello M, Malfatti V, Zanco P (2009) The effect of 18F-FDG-PET\/CT respiratory gating on detected metabolic activity in lung lesions. Ann Nucl Med 23(2):191\u2013196","journal-title":"Ann Nucl Med"},{"issue":"11","key":"1446_CR20","doi-asserted-by":"publisher","first-page":"1678","DOI":"10.2967\/jnumed.120.242248","volume":"61","author":"MD Walker","year":"2020","unstructured":"Walker MD, Morgan AJ, Bradley KM, McGowan DR (2020) Data-driven respiratory gating outperforms device-based gating for clinical 18F-FDG PET\/CT. J Nucl Med 61(11):1678\u20131683","journal-title":"J Nucl Med"}],"container-title":["Insights into Imaging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13244-023-01446-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s13244-023-01446-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s13244-023-01446-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,25]],"date-time":"2023-05-25T15:02:31Z","timestamp":1685026951000},"score":1,"resource":{"primary":{"URL":"https:\/\/insightsimaging.springeropen.com\/articles\/10.1186\/s13244-023-01446-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5,25]]},"references-count":20,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2023,12]]}},"alternative-id":["1446"],"URL":"https:\/\/doi.org\/10.1186\/s13244-023-01446-1","relation":{},"ISSN":["1869-4101"],"issn-type":[{"value":"1869-4101","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,5,25]]},"assertion":[{"value":"22 February 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 April 2023","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 May 2023","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This retrospective study was approved by the institutional review board of The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital. All the enrolled patients have signed the informed consent prior to the examination.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Patients signed informed consent regarding publishing their data and photographs for scientific use.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"YW is a full-time employee of United Imaging Healthcare, China. All the other authors declare that they have no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"100"}}