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Ultrasound-based fat fraction examinations were performed using two different platforms (ultrasound-derived fat fraction [UDFF] and quantitative ultrasound-derived estimated fat fraction [USFF]) on the same day. The correlation between UDFF and USFF was assessed using Pearson correlation coefficient. Intraclass correlation coefficient (ICC), Bland\u2013Altman analysis with 95% limits of agreement (LOAs), and the coefficient of variation (CV) were used to assess inter-platform reproducibility.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 41 patients (21 men and 20 women; mean age, 53.9\u2009\u00b1\u200912.6\u00a0years) were analyzed. Moderate correlation was observed between UDFF and USFF (Pearson\u2019s\n                      <jats:italic>r<\/jats:italic>\n                      \u2009=\u20090.748; 95% confidence interval [CI]: 0.572\u20130.858). On Bland\u2013Altman analysis, the mean difference between UDFF and USFF values was 1.3% with 95% LOAs ranging from\u2009-8.0 to 10.6%. The ICC between UDFF and USFF was 0.842 (95% CI: 0.703\u20130.916), with a CV of 29.9%.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Substantial inter-platform variability was observed among different ultrasound-based fat fraction examinations. Therefore, it is not appropriate to use ultrasound-based fat fraction values obtained from different vendors interchangeably.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Critical relevance statement<\/jats:title>\n                    <jats:p>Considering the substantial inter-platform variability in ultrasound-based fat fraction assessments, caution is imperative when interpreting and comparing fat fraction values obtained from different ultrasound platforms in clinical practice.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Key points<\/jats:title>\n                    <jats:p>\u2022 Inter-platform reproducibility of ultrasound-based fat fraction examinations is important for its clinical application.<\/jats:p>\n                    <jats:p>\u2022 Significant variability across different ultrasound-based fat fraction examinations was observed.<\/jats:p>\n                    <jats:p>\u2022 Using ultrasound-based fat fraction values from different vendors interchangeably is not advisable.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Graphical Abstract<\/jats:title>\n                  <\/jats:sec>","DOI":"10.1186\/s13244-024-01611-0","type":"journal-article","created":{"date-parts":[[2024,2,14]],"date-time":"2024-02-14T00:02:26Z","timestamp":1707868946000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Inter-platform reproducibility of ultrasound-based fat fraction for evaluating hepatic steatosis in nonalcoholic fatty liver disease"],"prefix":"10.1186","volume":"15","author":[{"given":"Sun Kyung","family":"Jeon","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeong Min","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,2,14]]},"reference":[{"key":"1611_CR1","doi-asserted-by":"publisher","first-page":"1313","DOI":"10.1002\/hep.20701","volume":"41","author":"DE Kleiner","year":"2005","unstructured":"Kleiner DE, Brunt EM, Van Natta M et al (2005) Design and validation of a histological scoring system for nonalcoholic fatty liver disease. 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