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This study explored the influence of different spin-locking frequencies on T1\u03c1 values under a 3.0-T MR system.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>Fifty-seven healthy subjects were prospectively and consecutively included in this study, and T1\u03c1 mapping was performed on them in 3 short-axis slices with three spin-lock frequencies at the amplitude of 300\u2009Hz, 400\u2009Hz, and 500\u2009Hz, then nine T1\u03c1 images were acquired per subject. Four T1\u03c1-weighted images were acquired using a spin-lock preparation pulse with varying durations (0 msec, 13.3 msec, 26.6 msec, 40 msec). T1\u03c1 relaxation times were quantified for each slice and each myocardial segment. The results were analyzed using Student\u2019s t-test and one-way analysis of variance (ANOVA) methods.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Mean T1\u03c1 relaxation times were 43.5\u2009\u00b1\u20092.8 msec at 300\u2009Hz, 44.9\u2009\u00b1\u20093.6 msec at 400\u2009Hz, and 46.2\u2009\u00b1\u20093.1 msec at 500 Hz, showing a significant progressive increase from low to high spin-lock frequency (300\u2009Hz vs. 400\u2009Hz, <jats:italic>p<\/jats:italic>\u2009=\u20090.046; 300\u2009Hz vs. 500\u2009Hz, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001; 400\u2009Hz vs. 500\u2009Hz, <jats:italic>p<\/jats:italic>\u2009=\u20090.043). In addition, The T1\u03c1 values of females were significantly higher than those of males (300\u2009Hz, <jats:italic>p<\/jats:italic>\u2009=\u20090.049; 400\u2009Hz, <jats:italic>p<\/jats:italic>\u2009=\u20090.01; 500\u2009Hz, <jats:italic>p<\/jats:italic>\u2009=\u20090.002).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>In this prospective study, myocardial T1\u03c1 values for the specific CMR setting are provided, and we found that gender and spin-lock frequency can affect the T1\u03c1 values.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Critical relevance statement<\/jats:title>\n                <jats:p>T1\u03c1 mapping could supersede late gadolinium enhancement for detection of myocardial fibrosis. Establishing reference mean values that take key technical elements into account will facilitate interpretation of data in disease states.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Key Points<\/jats:title>\n                <jats:p><jats:list list-type=\"bullet\">\n                  <jats:list-item>\n                    <jats:p>This study established myocardial T1\u03c1 reference values for different spin-lock frequencies.<\/jats:p>\n                  <\/jats:list-item>\n                  <jats:list-item>\n                    <jats:p>T1\u03c1 values increased with spin-lock frequency, but numerical differences were minimal.<\/jats:p>\n                  <\/jats:list-item>\n                  <jats:list-item>\n                    <jats:p>Females had higher T1\u03c1 values than males at all frequencies.<\/jats:p>\n                  <\/jats:list-item>\n                <\/jats:list><\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Graphical Abstract<\/jats:title>\n                \n              <\/jats:sec>","DOI":"10.1186\/s13244-024-01762-0","type":"journal-article","created":{"date-parts":[[2024,7,11]],"date-time":"2024-07-11T23:02:21Z","timestamp":1720738941000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Effect of spin-lock frequency on quantitative myocardial T1\u03c1 mapping"],"prefix":"10.1186","volume":"15","author":[{"given":"Caiyun","family":"Han","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huimin","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui","family":"Gao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Deng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiuzheng","family":"Yue","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhigang","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yongqiang","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ren","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuchi","family":"Han","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9084-1254","authenticated-orcid":false,"given":"Xiaohu","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,7,12]]},"reference":[{"key":"1762_CR1","doi-asserted-by":"publisher","first-page":"479","DOI":"10.1038\/s41569-020-00504-1","volume":"18","author":"B L\u00f3pez","year":"2021","unstructured":"L\u00f3pez B, Ravassa S, Moreno MU et al (2021) Diffuse myocardial fibrosis: mechanisms, diagnosis and therapeutic approaches. 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