{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T19:53:57Z","timestamp":1780084437895,"version":"3.54.0"},"reference-count":17,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,9,23]],"date-time":"2024-09-23T00:00:00Z","timestamp":1727049600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,9,23]],"date-time":"2024-09-23T00:00:00Z","timestamp":1727049600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/http:\/\/dx.doi.org\/10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81971640"],"award-info":[{"award-number":["81971640"]}],"id":[{"id":"10.13039\/http:\/\/dx.doi.org\/10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"National High-Level Hospital Clinical Research Funding","award":["2022-PUMCH-C-018"],"award-info":[{"award-number":["2022-PUMCH-C-018"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Insights Imaging"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Objectives<\/jats:title>\n                <jats:p>Creeping fat (CF) is associated with stricture formation in Crohn\u2019s disease (CD). This study evaluated the feasibility of intestinal ultrasound (IUS) for semiquantitative analysis of CF and compared the agreement between IUS and computed tomography enterography (CTE).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>In this retrospective study, we recruited consecutive CD patients who underwent IUS and CTE. CF wrapping angle was analyzed on the most affected bowel segment and was independently evaluated by IUS and CTE. We evaluated the wrapping angle of CF in the cross- and vertical sections of the diseased bowel. CF wrapping angle was divided into &lt;\u2009180\u00b0 and \u2265\u2009180\u00b0. IUS performance was assessed using CTE as a reference standard, and IUS interobserver consistency was evaluated.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>We enrolled 96 patients. CTE showed that CF wrapping angle was &lt;\u2009180\u00b0 in 35 patients and \u2265\u2009180\u00b0 in 61 patients. We excluded three cases in which the observation positions were inconsistent between the IUS and CTE. Excellent agreement was shown between US and CTE (82\/93, 88.2%). The eleven remaining cases showed inconsistencies mostly in the terminal ileum (<jats:italic>n<\/jats:italic>\u2009=\u20095) and small intestine (<jats:italic>n<\/jats:italic>\u2009=\u20094). Total agreement between IUS observers was 89.6% (86\/96, \u03ba\u2009=\u20090.839, <jats:italic>p<\/jats:italic>\u2009=\u20090.000), with perfect agreement for the ileocecal and colonic segments (35\/37, 94.6% and 20\/21, 95.2%, respectively) and moderate agreement for small intestinal segments (16\/21, 76.2%).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>IUS could be of value and complementary to CTE for assessing CF, particularly in patients with affected terminal ileum and colon. IUS is a non-invasive technique for monitoring CD patients.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Critical relevance statement<\/jats:title>\n                <jats:p>In our study, excellent agreement was shown between intestinal US observers as well as between US and CT enterography (CTE) for assessing creeping fat (CF), which showed that ultrasound could be of value and complementary to CTE.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Key Points<\/jats:title>\n                <jats:p><jats:list list-type=\"bullet\">\n                  <jats:list-item>\n                    <jats:p>Creeping fat (CF) is a potential therapeutic target in Crohn\u2019s disease.<\/jats:p>\n                  <\/jats:list-item>\n                  <jats:list-item>\n                    <jats:p>Excellent agreement was shown between US and CT Enterography (CTE) for assessing CF.<\/jats:p>\n                  <\/jats:list-item>\n                  <jats:list-item>\n                    <jats:p>Ultrasound could be complementary to CTE for assessing CF.<\/jats:p>\n                  <\/jats:list-item>\n                <\/jats:list><\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Graphical Abstract<\/jats:title>\n                \n              <\/jats:sec>","DOI":"10.1186\/s13244-024-01807-4","type":"journal-article","created":{"date-parts":[[2024,9,24]],"date-time":"2024-09-24T09:24:32Z","timestamp":1727169872000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Detecting and characterizing creeping fat in Crohn\u2019s disease: agreement between intestinal ultrasound and computed tomography enterography"],"prefix":"10.1186","volume":"15","author":[{"given":"Mengyuan","family":"Zhou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zihan","family":"Niu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenbo","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengsu","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yudi","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Qin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuxin","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0618-2381","authenticated-orcid":false,"given":"Qingli","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,9,23]]},"reference":[{"key":"1807_CR1","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1093\/ibd\/izy331","volume":"25","author":"R Mao","year":"2019","unstructured":"Mao R, Kurada S, Gordon IO et al (2019) The mesenteric fat and intestinal muscle interface: creeping fat influencing stricture formation in Crohn\u2019s disease. 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