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Accurate differential diagnosis of diseases associated with LIBD is crucial for formulating appropriate treatment strategies and improving patient prognosis. This review provides a comprehensive overview of the definitions, etiologies, clinical symptoms, and key imaging features of common diseases associated with LIBD. Furthermore, it proposes a structured approach for differential diagnosis. By integrating imaging findings with clinical and laboratory data, this approach aims to improve diagnostic accuracy and assist radiologists in making optimal clinical decisions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Key Points<\/jats:title>\n                    <jats:p>\n                      <jats:bold>\n                        <jats:italic>Question<\/jats:italic>\n                      <\/jats:bold>\n                      LIBD has diverse etiologies and overlapping imaging patterns, but a practical, standardized radiological framework for differential diagnosis remains lacking.\n                    <\/jats:p>\n                    <jats:p>\n                      <jats:bold>\n                        <jats:italic>Findings<\/jats:italic>\n                      <\/jats:bold>\n                      This pictorial review summarizes characteristic CT\/MRI findings of common LIBD-associated diseases and establishes a stepwise diagnostic approach integrating obstruction points, morphology, and clinical information.\n                    <\/jats:p>\n                    <jats:p>\n                      <jats:bold>\n                        <jats:italic>Critical Relevance Statement<\/jats:italic>\n                      <\/jats:bold>\n                      By combining specific imaging patterns with clinical context, this review provides a practical differential diagnostic framework that may improve diagnostic confidence, guide further evaluation, and facilitate earlier detection of malignant transformation in LIBD.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s13244-026-02419-w","type":"journal-article","created":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T11:57:27Z","timestamp":1791547047000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Imaging in localized intrahepatic bile duct dilatation: a pictorial review of diagnostic and differential approaches"],"prefix":"10.1186","volume":"17","author":[{"given":"Yongyi","family":"Cen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoqi","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mimi","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanjin","family":"Qin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenyu","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jifei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanji","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongyan","family":"Dai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhibing","family":"Ruan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenpeng","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0869-7290","authenticated-orcid":false,"given":"Shi-Ting","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,10,9]]},"reference":[{"key":"2419_CR1","doi-asserted-by":"publisher","first-page":"1083","DOI":"10.1016\/j.jhep.2022.06.002","volume":"77","author":"JPH Drenth","year":"2022","unstructured":"Drenth JPH, Barten TRM, B\u00f6ttler T et al (2022) EASL clinical practice guidelines on the management of cystic liver diseases. 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