{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T03:11:55Z","timestamp":1771297915313,"version":"3.50.1"},"reference-count":39,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2015,6,13]],"date-time":"2015-06-13T00:00:00Z","timestamp":1434153600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Med Case Reports"],"published-print":{"date-parts":[[2015,12]]},"DOI":"10.1186\/s13256-015-0621-9","type":"journal-article","created":{"date-parts":[[2015,6,12]],"date-time":"2015-06-12T08:50:39Z","timestamp":1434099039000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Chemotherapeutic treatment of colorectal cancer in pregnancy: case report"],"prefix":"10.1186","volume":"9","author":[{"given":"Ziyad","family":"Makoshi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claire","family":"Perrott","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Khadija","family":"Al-Khatani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fadia","family":"Al-Mohaisen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2015,6,13]]},"reference":[{"issue":"7","key":"621_CR1","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.ogrm.2011.04.005","volume":"21","author":"Z Saeed","year":"2011","unstructured":"Saeed Z, Shafi M. Cancer in pregnancy. Obstet Gynaecol Reprod Med. 2011;21(7):183\u20139.","journal-title":"Obstet Gynaecol Reprod Med"},{"issue":"Suppl 5","key":"621_CR2","doi-asserted-by":"crossref","first-page":"v266","DOI":"10.1093\/annonc\/mdq198","volume":"21","author":"G Pentheroudakis","year":"2010","unstructured":"Pentheroudakis G, Orecchia R, Hoekstra JH, Pavlidis N, ESMO Guidelines Working Group. Cancer, fertility and pregnancy: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Ann Oncol. 2010;21 Suppl 5:v266\u201373.","journal-title":"Ann Oncol"},{"issue":"2","key":"621_CR3","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1007\/s00280-008-0731-9","volume":"63","author":"M Gensheimer","year":"2009","unstructured":"Gensheimer M, Jones CA, Graves CR, Merchant NB, Lockhart AC. Administration of oxaliplatin to a pregnant woman with rectal cancer. Cancer Chemother Pharmacol. 2009;63(2):371\u20133.","journal-title":"Cancer Chemother Pharmacol"},{"issue":"1","key":"621_CR4","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1177\/1078155208094101","volume":"15","author":"AS Kanate","year":"2009","unstructured":"Kanate AS, Auber ML, Higa GM. Priorities and uncertainties of administering chemotherapy in a pregnant woman with newly diagnosed colorectal cancer. J Oncol Pharm Pract. 2009;15(1):5\u20138.","journal-title":"J Oncol Pharm Pract"},{"issue":"4","key":"621_CR5","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1016\/j.clcc.2011.06.003","volume":"10","author":"JB Jeppesen","year":"2011","unstructured":"Jeppesen JB, \u00d8sterlind K. Successful twin pregnancy outcome after in utero exposure to FOLFOX for metastatic colon cancer: a case report and review of the literature. Clin Colorectal Cancer. 2011;10(4):348\u201352.","journal-title":"Clin Colorectal Cancer"},{"issue":"6","key":"621_CR6","doi-asserted-by":"crossref","first-page":"155e","DOI":"10.1177\/030089161209800627","volume":"98","author":"M Cirillo","year":"2012","unstructured":"Cirillo M, Musola M, Cassandrini PA, Lunardi G, Venturini M. Irinotecan during pregnancy in metastatic colon cancer. Tumori. 2012;98(6):155e\u20137e.","journal-title":"Tumori"},{"issue":"3","key":"621_CR7","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1097\/COC.0b013e3181a44ca9","volume":"33","author":"E Cardonick","year":"2010","unstructured":"Cardonick E, Usmani A, Ghaffar S. Perinatal outcomes of a pregnancy complicated by cancer, including neonatal follow-up after in utero exposure to chemotherapy: results of an international registry. Am J Clin Oncol. 2010;33(3):221\u20138.","journal-title":"Am J Clin Oncol"},{"issue":"2","key":"621_CR8","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1007\/BF02051174","volume":"36","author":"MA Bernstein","year":"1993","unstructured":"Bernstein MA, Madoff RD, Caushaj PF. Colon and rectal cancer in pregnancy. Dis Colon Rectum. 1993;36(2):172\u20138.","journal-title":"Dis Colon Rectum"},{"issue":"2","key":"621_CR9","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1055\/s-2007-994680","volume":"9","author":"JB Woods","year":"1992","unstructured":"Woods JB, Martin Jr JN, Ingram FH, Odom CD, Scott-Conner CE, Rhodes RS. Pregnancy complicated by carcinoma of the colon above the rectum. Am J Perinatol. 1992;9(2):102\u201310.","journal-title":"Am J Perinatol"},{"issue":"1","key":"621_CR10","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/S0301-2115(02)00052-0","volume":"104","author":"N Vitoratos","year":"2002","unstructured":"Vitoratos N, Salamalekis E, Makrakis E, Creatsas G. Sigmoid colon cancer during pregnancy. Eur J Obstet Gynecol Reprod Biol. 2002;104(1):70\u20132.","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"issue":"4","key":"621_CR11","first-page":"575","volume":"63","author":"R Lamerz","year":"1976","unstructured":"Lamerz R, Ruider H. Significance of CEA determinations in patients with cancer of the colon-rectum and the mammary gland in comparison to physiological states in connection with pregnancy. Bull Cancer. 1976;63(4):575\u201386.","journal-title":"Bull Cancer"},{"issue":"3","key":"621_CR12","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1007\/s00411-008-0171-2","volume":"47","author":"R Schulze-Rath","year":"2008","unstructured":"Schulze-Rath R, Hammer GP, Blettner M. Are pre- or postnatal diagnostic X-rays a risk factor for childhood cancer? A systematic review. Radiat Environ Biophys. 2008;47(3):301\u201312.","journal-title":"Radiat Environ Biophys"},{"issue":"7","key":"621_CR13","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1038\/sj.bjc.6604284","volume":"98","author":"K St\u00e5lberg","year":"2008","unstructured":"St\u00e5lberg K, Haglund B, Axelsson O, Cnattingius S, Pfeifer S, Kieler H. Prenatal ultrasound and the risk of childhood brain tumour and its subtypes. Br J Cancer. 2008;98(7):1285\u20137.","journal-title":"Br J Cancer"},{"issue":"12","key":"621_CR14","doi-asserted-by":"crossref","first-page":"2353","DOI":"10.1007\/BF02100127","volume":"41","author":"MS Cappell","year":"1996","unstructured":"Cappell MS, Colon VJ, Sidhom OA. A study at 10 medical centers of the safety and efficacy of 48 flexible sigmoidoscopies and 8 colonoscopies during pregnancy with follow-up of fetal outcome and with comparison to control groups. Dig Dis Sci. 1996;41(12):2353\u201361.","journal-title":"Dig Dis Sci"},{"issue":"6","key":"621_CR15","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1016\/j.mri.2004.01.047","volume":"22","author":"RD Kok","year":"2004","unstructured":"Kok RD, de Vries MM, Heerschap A, van den Berg PP. Absence of harmful effects of magnetic resonance exposure at 1.5 T in utero during the third trimester of pregnancy: a follow-up study. Magn Reson Imaging. 2004;22(6):851\u20134.","journal-title":"Magn Reson Imaging"},{"issue":"1","key":"621_CR16","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1148\/radiol.2491071665","volume":"249","author":"E Angel","year":"2008","unstructured":"Angel E, Wellnitz CV, Goodsitt MM, Yaghmai N, DeMarco JJ, Cagnon CH, et al. Radiation dose to the fetus for pregnant patients undergoing multidetector CT imaging: Monte Carlo simulations estimating fetal dose for a range of gestational age and patient size. Radiology. 2008;249(1):220\u20137. A published erratum appears in Radiology. 2010;255(2):664.","journal-title":"Radiology"},{"issue":"3","key":"621_CR17","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1002\/bdrc.20099","volume":"81","author":"M Santis De","year":"2007","unstructured":"De Santis M, Cesari E, Nobili E, Straface G, Cavaliere AF, Caruso A. Radiation effects on development. Birth Defects Res C Embryo Today. 2007;81(3):177\u201382.","journal-title":"Birth Defects Res C Embryo Today"},{"key":"621_CR18","volume-title":"Radiation protection 100: guidance for protection of unborn children and infants irradiated due to parental medical exposures","author":"European Commission","year":"1998","unstructured":"European Commission. Radiation protection 100: guidance for protection of unborn children and infants irradiated due to parental medical exposures. Brussels: Publications Office of the European Union; 1998. http:\/\/ec.europa.eu\/energy\/sites\/ener\/files\/documents\/100_en.pdf. Accessed 1 June 2015."},{"issue":"6","key":"621_CR19","first-page":"633","volume":"27","author":"JF Greskovich Jr","year":"2000","unstructured":"Greskovich Jr JF, Macklis RM. Radiation therapy in pregnancy: risk calculation and risk minimization. Semin Oncol. 2000;27(6):633\u201345.","journal-title":"Semin Oncol"},{"issue":"4","key":"621_CR20","doi-asserted-by":"crossref","first-page":"e175","DOI":"10.1016\/j.suronc.2011.06.002","volume":"20","author":"E Voulgaris","year":"2011","unstructured":"Voulgaris E, Pentheroudakis G, Pavlidis N. Cancer and pregnancy: a comprehensive review. Surg Oncol. 2011;20(4):e175\u201385.","journal-title":"Surg Oncol"},{"issue":"1","key":"621_CR21","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1007\/s00404-011-2058-8","volume":"285","author":"F Hoellen","year":"2012","unstructured":"Hoellen F, Reibke R, Hornemann K, Thill M, Luedders DW, Kelling K, et al. Cancer in pregnancy. Part I: basic diagnostic and therapeutic principles and treatment of gynecological malignancies. Arch Gynecol Obstet. 2012;285(1):195\u2013205.","journal-title":"Arch Gynecol Obstet."},{"issue":"11","key":"621_CR22","first-page":"899","volume":"162","author":"G Arbman","year":"1996","unstructured":"Arbman G, Nilsson E, St\u00f6rgren-Fordell V, Sj\u00f6dahl R. A short diagnostic delay is more important for rectal cancer than for colonic cancer. Eur J Surg. 1996;162(11):899\u2013904.","journal-title":"Eur J Surg"},{"issue":"1","key":"621_CR23","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/S0889-8553(05)70356-3","volume":"27","author":"C Walsh","year":"1998","unstructured":"Walsh C, Fazio VW. Cancer of the colon, rectum, and anus during pregnancy: the surgeon\u2019s perspective. Gastroenterol Clin North Am. 1998;27(1):257\u201367.","journal-title":"Gastroenterol Clin North Am"},{"issue":"1","key":"621_CR24","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/0020-7292(89)90545-6","volume":"28","author":"T Matsuyama","year":"1989","unstructured":"Matsuyama T, Tsukamoto N, Matsukuma K, Kamura T, Kaku T, Saito T. Malignant ovarian tumors associated with pregnancy: report of six cases. Int J Gynaecol Obstet. 1989;28(1):61\u20136.","journal-title":"Int J Gynaecol Obstet"},{"issue":"1","key":"621_CR25","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1002\/jso.2930170106","volume":"17","author":"MH Mason 3rd","year":"1981","unstructured":"Mason 3rd MH, Kovalcik PJ. Ovarian metastases from colon carcinoma. J Surg Oncol. 1981;17(1):33\u20138.","journal-title":"J Surg Oncol"},{"issue":"4","key":"621_CR26","first-page":"335","volume":"157","author":"H Pitluk","year":"1983","unstructured":"Pitluk H, Poticha SM. Carcinoma of the colon and rectum in patients less than 40 years of age. Surg Gynecol Obstet. 1983;157(4):335\u20137.","journal-title":"Surg Gynecol Obstet"},{"issue":"6","key":"621_CR27","first-page":"909","volume":"139","author":"M Recalde","year":"1974","unstructured":"Recalde M, Holyoke ED, Elias EG. Carcinoma of the colon, rectum, and anal canal in young patients. Surg Gynecol Obstet. 1974;139(6):909\u201313.","journal-title":"Surg Gynecol Obstet"},{"issue":"5","key":"621_CR28","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1001\/archsurg.1985.01390290110020","volume":"120","author":"JC Nesbitt","year":"1985","unstructured":"Nesbitt JC, Moise KJ, Sawyers JL. Colorectal carcinoma in pregnancy. Arch Surg. 1985;120(5):636\u201340.","journal-title":"Arch Surg"},{"key":"621_CR29","unstructured":"International Commission on Radiological Protection. The 2007 recommendations of the International Commission on Radiological Protection. Ann ICRP. 103;37(2\u20134)."},{"key":"621_CR30","volume-title":"NCCN clinical practice guidelines in oncology: colon cancer","author":"National Comprehensive Care Network (NCCN)","year":"2012","unstructured":"National Comprehensive Care Network (NCCN). NCCN clinical practice guidelines in oncology: colon cancer. Fort Washington: NCCN; 2012."},{"issue":"5","key":"621_CR31","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1056\/NEJMra040958","volume":"352","author":"JA Meyerhardt","year":"2005","unstructured":"Meyerhardt JA, Mayer RJ. Systemic therapy for colorectal cancer. N Engl J Med. 2005;352(5):476\u201387.","journal-title":"N Engl J Med"},{"key":"621_CR32","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1093\/jncimonographs\/lgi009","volume":"34","author":"K Gwyn","year":"2005","unstructured":"Gwyn K. Children exposed to chemotherapy in utero. J Natl Cancer Inst Monogr. 2005;34:69\u201371.","journal-title":"J Natl Cancer Inst Monogr."},{"issue":"4","key":"621_CR33","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1634\/theoncologist.2002-0279","volume":"7","author":"NA Pavlidis","year":"2002","unstructured":"Pavlidis NA. Coexistence of pregnancy and malignancy. Oncologist. 2002;7(4):279\u201387. A published erratum appears in Oncologist 2002;7(6):585.","journal-title":"Oncologist"},{"issue":"12","key":"621_CR34","first-page":"872","volume":"36","author":"L Le Van","year":"1991","unstructured":"Van Le L, Pizzuti DJ, Greenberg M, Reid R. Accidental use of low-dose 5-fluorouracil in pregnancy. J Reprod Med. 1991;36(12):872\u20134.","journal-title":"J Reprod Med"},{"issue":"6","key":"621_CR35","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1016\/S0002-9378(15)33259-2","volume":"137","author":"JD Stephens","year":"1980","unstructured":"Stephens JD, Golbus MS, Miller TR, Wilber RR, Epstein CJ. Multiple congenital anomalies in a fetus exposed to 5-fluorouracil during the first trimester. Am J Obstet Gynecol. 1980;137(6):747\u20139.","journal-title":"Am J Obstet Gynecol"},{"issue":"5","key":"621_CR36","first-page":"337","volume":"16","author":"DC Doll","year":"1989","unstructured":"Doll DC, Ringenberg QS, Yarbro JW. Antineoplastic agents and pregnancy. Semin Oncol. 1989;16(5):337\u201346.","journal-title":"Semin Oncol"},{"key":"621_CR37","first-page":"457","volume-title":"Chemically induced birth defects","author":"JL Schardein","year":"1993","unstructured":"Schardein JL. Cancer chemotherapeutic agents. In: Chemically induced birth defects. 2nd ed. New York: Marcel Dekker; 1993. p. 457\u2013507.","edition":"2"},{"issue":"10","key":"621_CR38","first-page":"582","volume":"90","author":"R Dreicer","year":"1991","unstructured":"Dreicer R, Love RR. High total dose 5-fluorouracil treatment during pregnancy. Wis Med J. 1991;90(10):582\u20133.","journal-title":"Wis Med J"},{"key":"621_CR39","first-page":"626393","volume":"2013","author":"S Khodaverdi","year":"2013","unstructured":"Khodaverdi S, Kord Valeshabad A, Khodaverdi M. A case of colorectal cancer during pregnancy: a brief review of the literature. Case Rep Obstet Gynecol. 2013;2013:626393.","journal-title":"Case Rep Obstet Gynecol."}],"container-title":["Journal of Medical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s13256-015-0621-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/s13256-015-0621-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s13256-015-0621-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s13256-015-0621-9","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,12]],"date-time":"2022-05-12T20:50:09Z","timestamp":1652388609000},"score":1,"resource":{"primary":{"URL":"https:\/\/jmedicalcasereports.biomedcentral.com\/articles\/10.1186\/s13256-015-0621-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,6,13]]},"references-count":39,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2015,12]]}},"alternative-id":["621"],"URL":"https:\/\/doi.org\/10.1186\/s13256-015-0621-9","relation":{},"ISSN":["1752-1947"],"issn-type":[{"value":"1752-1947","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,6,13]]},"assertion":[{"value":"28 September 2014","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 May 2015","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 June 2015","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}],"article-number":"140"}}