{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T06:54:13Z","timestamp":1780469653292,"version":"3.54.1"},"reference-count":26,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2015,10,31]],"date-time":"2015-10-31T00:00:00Z","timestamp":1446249600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Med Case Reports"],"published-print":{"date-parts":[[2015,12]]},"DOI":"10.1186\/s13256-015-0731-4","type":"journal-article","created":{"date-parts":[[2015,10,27]],"date-time":"2015-10-27T14:31:56Z","timestamp":1445956316000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["\u201cHerbal seizures\u201d \u2013 atypical symptoms after ibogaine intoxication: a case report"],"prefix":"10.1186","volume":"9","author":[{"given":"Lorenz","family":"Breuer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Burkhard S.","family":"Kasper","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernd","family":"Schwarze","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juergen M.","family":"Gschossmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes","family":"Kornhuber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helge H.","family":"M\u00fcller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2015,10,31]]},"reference":[{"key":"731_CR1","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.emc.2013.09.001","volume":"32","author":"ME Nelson","year":"2014","unstructured":"Nelson ME, Bryant SM, Aks SE. Emerging drugs of abuse. Emerg Med Clin North Am. 2014;32:1\u201328.","journal-title":"Emerg Med Clin North Am."},{"key":"731_CR2","doi-asserted-by":"publisher","first-page":"152","DOI":"10.1055\/s-0029-1243252","volume":"43","author":"H Muller","year":"2010","unstructured":"Muller H, Huttner HB, Kohrmann M, Wielopolski JE, Kornhuber J, Sperling W. Panic attack after spice abuse in a patient with ADHD. Pharmacopsychiatry. 2010;43:152\u20133.","journal-title":"Pharmacopsychiatry."},{"key":"731_CR3","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1016\/j.schres.2009.12.001","volume":"118","author":"H Muller","year":"2010","unstructured":"Muller H, Sperling W, Kohrmann M, Huttner HB, Kornhuber J, Maler JM. The synthetic cannabinoid Spice as a trigger for an acute exacerbation of cannabis induced recurrent psychotic episodes. Schizophr Res. 2010;118:309\u201310.","journal-title":"Schizophr Res."},{"key":"731_CR4","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1037\/a0031973","volume":"21","author":"JA Cabriales","year":"2013","unstructured":"Cabriales JA, Cooper TV, Taylor T. Prescription drug misuse, illicit drug use, and their potential risk and protective correlates in a Hispanic college student sample. Exp Clin Psychopharmacol. 2013;21:235\u201344.","journal-title":"Exp Clin Psychopharmacol."},{"key":"731_CR5","doi-asserted-by":"publisher","first-page":"3","DOI":"10.2174\/15672050113109990001","volume":"6","author":"TK Brown","year":"2013","unstructured":"Brown TK. Ibogaine in the treatment of substance dependence. Curr Drug Abuse Rev. 2013;6:3\u201316.","journal-title":"Curr Drug Abuse Rev."},{"key":"731_CR6","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1097\/AIA.0b013e3181ff4da0","volume":"49","author":"C Gevirtz","year":"2011","unstructured":"Gevirtz C. Anesthesia for opiate detoxification and the ibogaine controversy. Int Anesthesiol Clin. 2011;49:31\u201348.","journal-title":"Int Anesthesiol Clin."},{"key":"731_CR7","doi-asserted-by":"publisher","first-page":"1083","DOI":"10.1023\/A:1007665911622","volume":"25","author":"MB Leal","year":"2000","unstructured":"Leal MB, de Souza DO, Elisabetsky E. Long-lasting ibogaine protection against NMDA-induced convulsions in mice. Neurochem Res. 2000;25:1083\u20137.","journal-title":"Neurochem Res."},{"key":"731_CR8","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1016\/0006-8993(96)00734-2","volume":"737","author":"SF Ali","year":"1996","unstructured":"Ali SF, Newport GD, Slikker Jr W, Rothman RB, Baumann MH. Neuroendocrine and neurochemical effects of acute ibogaine administration: a time course evaluation. Brain Res. 1996;737:215\u201320.","journal-title":"Brain Res."},{"key":"731_CR9","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0077262","volume":"8","author":"T Antonio","year":"2013","unstructured":"Antonio T, Childers SR, Rothman RB, Dersch CM, King C, Kuehne M, et al. Effect of Iboga alkaloids on micro-opioid receptor-coupled G protein activation. PLoS One. 2013;8, e77262.","journal-title":"PLoS One."},{"key":"731_CR10","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1016\/S0022-3565(25)12125-3","volume":"275","author":"P Popik","year":"1995","unstructured":"Popik P, Layer RT, Fossom LH, Benveniste M, Geter-Douglass B, Witkin JM, et al. NMDA antagonist properties of the putative antiaddictive drug, ibogaine. J Pharmacol Exp Ther. 1995;275:753\u201360.","journal-title":"J Pharmacol Exp Ther."},{"key":"731_CR11","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1016\/S0099-9598(01)56016-2","volume":"56","author":"P Popik","year":"2001","unstructured":"Popik P, Wrobel M. Anxiogenic action of ibogaine. Alkaloids Chem Biol. 2001;56:227\u201333.","journal-title":"Alkaloids Chem Biol."},{"issue":"Suppl 6","key":"731_CR12","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1111\/epi.12285","volume":"54","author":"CG Wasterlain","year":"2013","unstructured":"Wasterlain CG, Naylor DE, Liu H, Niquet J, Baldwin R. Trafficking of NMDA receptors during status epilepticus: therapeutic implications. Epilepsia. 2013;54 Suppl 6:78\u201380.","journal-title":"Epilepsia."},{"key":"731_CR13","first-page":"91","volume":"43","author":"J Kornhuber","year":"1994","unstructured":"Kornhuber J, Weller M, Schoppmeyer K, Riederer P. Amantadine and memantine are NMDA receptor antagonists with neuroprotective properties. J Neural Transm Suppl. 1994;43:91\u2013104.","journal-title":"J Neural Transm Suppl."},{"key":"731_CR14","doi-asserted-by":"crossref","first-page":"10897","DOI":"10.1523\/JNEUROSCI.23-34-10897.2003","volume":"23","author":"JL Cantero","year":"2003","unstructured":"Cantero JL, Atienza M, Stickgold R, Kahana MJ, Madsen JR, Kocsis B. Sleep-dependent theta oscillations in the human hippocampus and neocortex. J Neurosci. 2003;23:10897\u2013903.","journal-title":"J Neurosci."},{"key":"731_CR15","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1016\/j.psc.2012.04.002","volume":"35","author":"S Ross","year":"2012","unstructured":"Ross S. Serotonergic hallucinogens and emerging targets for addiction pharmacotherapies. Psychiatr Clin North Am. 2012;35:357\u201374.","journal-title":"Psychiatr Clin North Am."},{"key":"731_CR16","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1071\/HC11086","volume":"3","author":"S Galea","year":"2011","unstructured":"Galea S, Lorusso M, Newcombe D, Walters C, Williman J, Wheeler A. Ibogaine \u2013 be informed before you promote or prescribe. J Prim Health Care. 2011;3:86\u20137.","journal-title":"J Prim Health Care."},{"key":"731_CR17","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/S0099-9598(01)56005-8","volume":"56","author":"KR Alper","year":"2001","unstructured":"Alper KR. Ibogaine: a review. Alkaloids Chem Biol. 2001;56:1\u201338.","journal-title":"Alkaloids Chem Biol."},{"key":"731_CR18","doi-asserted-by":"publisher","first-page":"308","DOI":"10.1056\/NEJMc0804248","volume":"360","author":"DW Hoelen","year":"2009","unstructured":"Hoelen DW, Spiering W, Valk GD. Long-QT syndrome induced by the antiaddiction drug ibogaine. N Engl J Med. 2009;360:308\u20139.","journal-title":"N Engl J Med."},{"key":"731_CR19","doi-asserted-by":"publisher","first-page":"398","DOI":"10.1111\/j.1556-4029.2011.02008.x","volume":"57","author":"KR Alper","year":"2012","unstructured":"Alper KR, Stajic M, Gill JR. Fatalities temporally associated with the ingestion of ibogaine. J Forensic Sci. 2012;57:398\u2013412.","journal-title":"J Forensic Sci."},{"issue":"1","key":"731_CR20","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1111\/fcp.12090","volume":"29","author":"A Dhir","year":"2014","unstructured":"Dhir A, Chopra K. Memantine delayed N-Methyl-D-Aspartate (NMDA)-induced convulsions in neonatal rats. Fundam Clin Pharmacol. 2014;29(1):72\u20138.","journal-title":"Fundam Clin Pharmacol"},{"key":"731_CR21","doi-asserted-by":"crossref","first-page":"73","DOI":"10.3892\/etm.2014.1711","volume":"8","author":"H Xu","year":"2014","unstructured":"Xu H, Ou F, Wang P, Naren M, Tu D, Zheng R. High dosage of agmatine alleviates pentylenetetrazole-induced chronic seizures in rats possibly by exerting an anticonvulsive effect. Exp Ther Med. 2014;8:73\u20138.","journal-title":"Exp Ther Med."},{"key":"731_CR22","doi-asserted-by":"publisher","first-page":"1417","DOI":"10.1517\/14656566.2014.915029","volume":"15","author":"S Rheims","year":"2014","unstructured":"Rheims S, Ryvlin P. Pharmacotherapy for tonic-clonic seizures. Expert Opin Pharmacother. 2014;15:1417\u201326.","journal-title":"Expert Opin Pharmacother."},{"key":"731_CR23","doi-asserted-by":"crossref","unstructured":"Chen HY, Albertson TE, Olson KR. Treatment of drug-induced seizures. Br J Clin Pharmacol. 2015. doi:10.1111\/bcp.12720 [Epub ahead of print].","DOI":"10.1111\/bcp.12720"},{"key":"731_CR24","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1016\/S0099-9598(01)56014-9","volume":"56","author":"ZK Binienda","year":"2001","unstructured":"Binienda ZK, Scallet AC, Schmued LC, Ali SF. Ibogaine neurotoxicity assessment: electrophysiological, neurochemical, and neurohistological methods. Alkaloids Chem Biol. 2001;56:193\u2013210.","journal-title":"Alkaloids Chem Biol."},{"key":"731_CR25","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/j.jep.2007.08.034","volume":"115","author":"KR Alper","year":"2008","unstructured":"Alper KR, Lotsof HS, Kaplan CD. The ibogaine medical subculture. J Ethnopharmacol. 2008;115:9\u201324.","journal-title":"J Ethnopharmacol."},{"key":"731_CR26","doi-asserted-by":"publisher","first-page":"1666","DOI":"10.1111\/1556-4029.12250","volume":"58","author":"C Mazoyer","year":"2013","unstructured":"Mazoyer C, Carlier J, Boucher A, Peoc\u2019h M, Lemeur C, Gaillard Y. Fatal case of a 27-year-old male after taking iboga in withdrawal treatment: GC-MS\/MS determination of ibogaine and ibogamine in iboga roots and postmortem biological material. J Forensic Sci. 2013;58:1666\u201372.","journal-title":"J Forensic Sci."}],"container-title":["Journal of Medical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s13256-015-0731-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/s13256-015-0731-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s13256-015-0731-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,31]],"date-time":"2025-05-31T05:03:50Z","timestamp":1748667830000},"score":1,"resource":{"primary":{"URL":"http:\/\/jmedicalcasereports.biomedcentral.com\/articles\/10.1186\/s13256-015-0731-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,10,31]]},"references-count":26,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2015,12]]}},"alternative-id":["731"],"URL":"https:\/\/doi.org\/10.1186\/s13256-015-0731-4","relation":{},"ISSN":["1752-1947"],"issn-type":[{"value":"1752-1947","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,10,31]]},"article-number":"243"}}