{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T16:14:54Z","timestamp":1761581694974},"reference-count":37,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2018,5,22]],"date-time":"2018-05-22T00:00:00Z","timestamp":1526947200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Med Case Reports"],"published-print":{"date-parts":[[2018,12]]},"DOI":"10.1186\/s13256-018-1685-0","type":"journal-article","created":{"date-parts":[[2018,5,9]],"date-time":"2018-05-09T14:45:54Z","timestamp":1525877154000},"update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Delayed presentation of severe rhabdomyolysis leading to acute kidney injury following atorvastatin-gemfibrozil combination therapy: a case report"],"prefix":"10.1186","volume":"12","author":[{"given":"Chamara","family":"Dalugama","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manoji","family":"Pathirage","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. A. M.","family":"Kularatne","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2018,5,22]]},"reference":[{"key":"1685_CR1","doi-asserted-by":"publisher","first-page":"article no. 181","DOI":"10.11604\/pamj.2014.19.181.4872","volume":"19","author":"D Doupa","year":"2014","unstructured":"Doupa D, Seck SM, Dia CA, et al. Dyslipidemia, obesity and other cardiovascular risk factors in the adult population in Senegal. Pan Afr Med J. 2014;19:article no. 181. https:\/\/doi.org\/10.11604\/pamj.2014.19.181.4872 .","journal-title":"Pan Afr Med J"},{"key":"1685_CR2","doi-asserted-by":"publisher","first-page":"937","DOI":"10.1016\/S0140-6736(04)17018-9","volume":"364","author":"S Yusuf","year":"2004","unstructured":"Yusuf S, Hawken S, Ounpuu S, Dans T, Avezum A, Lanas F, et al. Effect of potentially modifiable risk factors associated with MI in 52 countries (the INTERHEART study): case-control study. Lancet. 2004;364:937\u201352.","journal-title":"Lancet"},{"issue":"2","key":"1685_CR3","first-page":"502","volume":"52","author":"RL Line","year":"1995","unstructured":"Line RL, Rust GS. Acute exertional rhabdomyolysis. Am Fam Physician. 1995;52(2):502\u20136.","journal-title":"Am Fam Physician"},{"issue":"3","key":"1685_CR4","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/S0030-5898(20)32006-X","volume":"26","author":"ED Arrington","year":"1995","unstructured":"Arrington ED, Miller MD. Skeletal muscle injuries. Orthop Clin North Am. 1995;26(3):411\u20132.","journal-title":"Orthop Clin North Am"},{"issue":"8A","key":"1685_CR5","doi-asserted-by":"publisher","first-page":"52C","DOI":"10.1016\/j.amjcard.2005.12.010","volume":"97","author":"M Law","year":"2006","unstructured":"Law M, Rudnicka AR. Statin safety: a systematic review. Am J Cardiol. 2006;97(8A):52C\u201360C. Epub 2006 Feb 3","journal-title":"Am J Cardiol"},{"key":"1685_CR6","doi-asserted-by":"publisher","first-page":"1681","DOI":"10.1001\/jama.289.13.1681","volume":"289","author":"PD Thompson","year":"2003","unstructured":"Thompson PD, Clarkson P, Karas RH. Statin-associated myopathy. JAMA. 2003;289:1681\u201390.","journal-title":"JAMA"},{"issue":"8A","key":"1685_CR7","doi-asserted-by":"publisher","first-page":"32C","DOI":"10.1016\/j.amjcard.2005.12.008","volume":"97","author":"MH Davidson","year":"2006","unstructured":"Davidson MH, Clark JA, Glass LM, et al. Statin safety: an appraisal from the adverse event reporting system. Am J Cardiol. 2006;97(8A):32C\u201343C. Epub 2006 Feb 3","journal-title":"Am J Cardiol"},{"issue":"4","key":"1685_CR8","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1254\/jphs.13R06CP","volume":"123","author":"K Sakamoto","year":"2013","unstructured":"Sakamoto K, Kimura J. Mechanism of statin-induced rhabdomyolysis. J Pharmacol Sci. 2013;123(4):289\u201394.","journal-title":"J Pharmacol Sci"},{"key":"1685_CR9","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1007\/s00210-002-0660-9","volume":"367","author":"T Maiguma","year":"2003","unstructured":"Maiguma T, Fujisaki K, Itoh Y, et al. Cell-specific toxicity of fibrates in human embryonal rhabdomyosarcoma cells. Naunyn Schmiedeberg\u2019s Arch Pharmacol. 2003;367:289. https:\/\/doi.org\/10.1007\/s00210-002-0660-9","journal-title":"Naunyn Schmiedeberg\u2019s Arch Pharmacol"},{"key":"1685_CR10","doi-asserted-by":"publisher","first-page":"155","DOI":"10.2165\/00003088-199834020-00003","volume":"34","author":"DB Miller","year":"1998","unstructured":"Miller DB, Spence JD. Clinical pharmacokinetics of fibric acid derivatives (fibrates). Clin Pharmacokinet. 1998;34:155\u201362.","journal-title":"Clin Pharmacokinet"},{"key":"1685_CR11","doi-asserted-by":"publisher","first-page":"497","DOI":"10.1016\/S0002-9149(99)90433-2","volume":"84","author":"JR Guyton","year":"1999","unstructured":"Guyton JR, Dujovne CA, Illingworth DR. Dual hepatic metabolism of cerivastatin\u2014clarifications. Am J Cardiol. 1999;84:497.","journal-title":"Am J Cardiol"},{"key":"1685_CR12","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1001\/jama.1990.03450010075034","volume":"264","author":"LR Pierce","year":"1990","unstructured":"Pierce LR, Wysowski DK, Gross TP. Myopathy and rhabdomyolysis associated with lovastatin-gemfibrozil combination therapy. JAMA. 1990;264:71\u20135.","journal-title":"JAMA"},{"issue":"9601","key":"1685_CR13","doi-asserted-by":"publisher","first-page":"1781","DOI":"10.1016\/S0140-6736(07)60716-8","volume":"370","author":"J Armitage","year":"2007","unstructured":"Armitage J. The safety of statins in clinical practice. Lancet. 2007;370(9601):1781\u201390.","journal-title":"Lancet"},{"key":"1685_CR14","doi-asserted-by":"publisher","first-page":"1658","DOI":"10.1016\/S0140-6736(10)60310-8","volume":"376","author":"J Armitage","year":"2010","unstructured":"Armitage J, Bowman L, Wallendszus K, Bulbulia R, Rahimi K, Haynes R, et al. Intensive lowering of LDL cholesterol with 80 mg versus 20 mg simvastatin daily in 12,064 survivors of myocardial infarction: a double-blind randomised trial. Lancet. 2010;376:1658\u201369.","journal-title":"Lancet"},{"key":"1685_CR15","doi-asserted-by":"publisher","first-page":"858","DOI":"10.7326\/0003-4819-150-12-200906160-00009","volume":"150","author":"TR Joy","year":"2009","unstructured":"Joy TR, Hegele RA. Narrative review: statin-related myopathy. Ann Intern Med. 2009;150:858\u201368. [PubMed]","journal-title":"Ann Intern Med"},{"key":"1685_CR16","first-page":"A10","volume":"21","author":"V Fuhrmans","year":"2002","unstructured":"Fuhrmans V. Bayer discloses higher death toll from Baycol. Wall Street J. 2002;21:A10.","journal-title":"Wall Street J"},{"key":"1685_CR17","doi-asserted-by":"publisher","first-page":"2012","DOI":"10.1345\/aph.1M410","volume":"43","author":"JM Backes","year":"2009","unstructured":"Backes JM, Howard PA, Ruisinger JF, Moriarty PM. Does simvastatin cause more myotoxicity compared with other statins? Ann Pharmacother. 2009;43:2012\u201320.","journal-title":"Ann Pharmacother"},{"issue":"11","key":"1685_CR18","doi-asserted-by":"publisher","first-page":"458","DOI":"10.4103\/0019-5359.48458","volume":"62","author":"R \u00c7etinkaya","year":"2008","unstructured":"\u00c7etinkaya R, Uyanik A, Yildirim R, Bilen Y, Kele\u015f M. Fenofibrate monotherapy-induced rhabdomyolysis in a patient with type-2 diabetes. Indian J Med Sci. 2008;62(11):458\u20139.","journal-title":"Indian J Med Sci"},{"issue":"5","key":"1685_CR19","doi-asserted-by":"publisher","first-page":"1258","DOI":"10.2337\/diacare.28.5.1258","volume":"28","author":"SS Jacob","year":"2005","unstructured":"Jacob SS, Jacob S, Williams C, Deeg MA. Simvastatin, fenofibrate, and rhabdomyolysis. Diabetes Care. 2005;28(5):1258.","journal-title":"Diabetes Care"},{"issue":"4","key":"1685_CR20","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1515\/DMDI.2007.22.4.279","volume":"22","author":"RL Satarasinghe","year":"2007","unstructured":"Satarasinghe RL, Ramesh R, Riyaaz AAA, Gunarathne PAKG, de Silva AP. Hypothyroidism is a predisposing factor for fenofibrate-induced rhabdomyolysis\u2014patient report and literature review. Drug Metabol Drug Interact. 2007;22(4):279\u201383.","journal-title":"Drug Metabol Drug Interact"},{"issue":"3","key":"1685_CR21","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1590\/S0004-27302009000300015","volume":"53","author":"AA de Sousa","year":"2009","unstructured":"de Sousa AA, Kronit HS, Neves FAR, Amato AA. Fenofibrate-induced rhabdomyolysis in a patient with chronic kidney disease: an unusual presenting feature of hypothyroidism. Arq Bras Endocrinol Metabol. 2009;53(3):383\u20136.","journal-title":"Arq Bras Endocrinol Metabol"},{"issue":"4","key":"1685_CR22","doi-asserted-by":"publisher","first-page":"1047","DOI":"10.1093\/ndt\/14.4.1047","volume":"14","author":"Y Clouatre","year":"1999","unstructured":"Clouatre Y, Leblanc M, Ouimet D, Pichette V. Fenofibrate-induced rhabdomyolysis in two dialysis patients with hypothyroidism. Nephrol Dial Transplant. 1999;14(4):1047\u20138.","journal-title":"Nephrol Dial Transplant"},{"key":"1685_CR23","doi-asserted-by":"publisher","first-page":"171","DOI":"10.2165\/11319380-000000000-00000","volume":"33","author":"YS Chatzizisis","year":"2010","unstructured":"Chatzizisis YS, Koskinas KC, Misirli G, Vaklavas C, Hatzitolios A, Giannoglou GD. Risk factors and drug interactions predisposing to statin-induced myopathy: implications for risk assessment, prevention and treatment. Drug Saf. 2010;33:171\u201387.","journal-title":"Drug Saf"},{"key":"1685_CR24","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1097\/CRD.0b013e31817532db","volume":"16","author":"WH Frishman","year":"2008","unstructured":"Frishman WH, Horn J. Statin\u2013drug interactions: not a class effect. Cardiol Rev. 2008;16:205\u201312.","journal-title":"Cardiol Rev"},{"key":"1685_CR25","doi-asserted-by":"publisher","first-page":"1601","DOI":"10.1592\/phco.26.11.1601","volume":"26","author":"CW Holtzman","year":"2006","unstructured":"Holtzman CW, Wiggins BS, Spinler SA. Role of P-glycoprotein in statin drug interactions. Pharmacotherapy. 2006;26:1601\u20137.","journal-title":"Pharmacotherapy"},{"key":"1685_CR26","doi-asserted-by":"publisher","first-page":"703","DOI":"10.1517\/17425250902976854","volume":"5","author":"I Ieiri","year":"2009","unstructured":"Ieiri I, Higuchi S, Sugiyama Y. Genetic polymorphisms of uptake (OATP1B1, 1B3) and efflux (MRP2, BCRP) transporters: implications for inter-individual differences in the pharmacokinetics and pharmacodynamics of statins and other clinically relevant drugs. Expert Opin Drug Metab Toxicol. 2009;5:703\u201329.","journal-title":"Expert Opin Drug Metab Toxicol"},{"issue":"2","key":"1685_CR27","first-page":"142","volume":"28","author":"TK Lau","year":"2001","unstructured":"Lau TK, Leachman DR, Lufschanowski R. Severe Rhabdomyolysis Associated with the Cerivastatin-Gemfibrozil Combination Therapy: Report of a Case. Tex Heart Inst J. 2001;28(2):142\u20135.","journal-title":"Tex Heart Inst J"},{"issue":"1","key":"1685_CR28","first-page":"22","volume":"1","author":"TL Jozi\u0107","year":"2014","unstructured":"Jozi\u0107 TL, Terzi\u0107 BM, Mitrovi\u0107 PM, Kosti\u0107 JD, Milanov MZ, Stojanovi\u0107 MM, A\u0161anin MR. Combined Statin-Fibrate Therapy-Induced Rhabdomyolysis: Case Report. Hosp Pharmacol. 2014;1(1):22\u20136.","journal-title":"Hosp Pharmacol"},{"key":"1685_CR29","doi-asserted-by":"crossref","unstructured":"Prueksaritanont T, Tang C, Qiu Y, Mu L, Subramanian R, Lin JH. Drug Metabolism and Disposition. 2002;30(11):1280-87.","DOI":"10.1124\/dmd.30.11.1280"},{"key":"1685_CR30","doi-asserted-by":"publisher","first-page":"825","DOI":"10.1056\/NEJM199003223221207","volume":"322","author":"OS Better","year":"1990","unstructured":"Better OS, Stein JH. Early management of shock and prophylaxis of acute renal failure in traumatic rhabdomyolysis. N Engl J Med. 1990;322:825\u20139.","journal-title":"N Engl J Med"},{"key":"1685_CR31","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1001\/archinte.1984.00350140077012","volume":"144","author":"D Ron","year":"1984","unstructured":"Ron D, Taitelman U, Michaelson M, Bar-Joseph G, Bursztein S, Better OS. Prevention of acute renal failure in traumatic rhabdomyolysis. Arch Intern Med. 1984;144:277\u201380.","journal-title":"Arch Intern Med"},{"key":"1685_CR32","first-page":"619","volume":"60","author":"RA Zager","year":"1989","unstructured":"Zager RA. Studies of mechanisms and protective maneuvers in myoglobinuric acute renal injury. Lab Investig. 1989;60:619\u201329.","journal-title":"Lab Investig"},{"issue":"Suppl 2","key":"1685_CR33","doi-asserted-by":"publisher","first-page":"1","DOI":"10.4158\/EP171764.APPGL","volume":"23","author":"PS Jellinger","year":"2017","unstructured":"Jellinger PS, Handelsman Y, Rosenblit PD, Bloomgarden ZT, Fonseca VA, Garber AJ, Grunberger G, Guerin CK, Bell DSH, Mechanick JI, Pessah-Pollack R, Wyne K, Smith D, Brinton EA, Fazio S, Davidson M. American Association of Clinical Endocrinologists and American College of Endocrinology guidelines for management of dyslipidemia and prevention of cardiovascular disease. Endocr Pract. 2017;23(Suppl 2):1\u201387.","journal-title":"Endocr Pract"},{"key":"1685_CR34","doi-asserted-by":"crossref","unstructured":"Beall D, Bywaters EGL, Belsey RHR, Miles JAR. Crush Injury with Renal Failure. BMJ. 1941;1(4185):432\u201334.","DOI":"10.1136\/bmj.1.4185.432"},{"key":"1685_CR35","doi-asserted-by":"publisher","first-page":"31731","DOI":"10.1074\/jbc.273.48.31731","volume":"273","author":"KP Moore","year":"1998","unstructured":"Moore KP, Holt SG, Patel RP, et al. A causative role for redox cycling of myoglobin and its inhibition by alkalinization in the pathogenesis and treatment of rhabdomyolysis-induced renal failure. J Biol Chem. 1998;273:31731\u20137.","journal-title":"J Biol Chem"},{"key":"1685_CR36","first-page":"210","volume":"5","author":"SN Heyman","year":"1997","unstructured":"Heyman SN, Greenbaum R, Shina A, Rosen S, Brezis M. Myoglobinuric acute renal failure in the rat: a role for acidosis? Exp Nephrol. 1997;5:210\u20136.","journal-title":"Exp Nephrol"},{"key":"1685_CR37","doi-asserted-by":"publisher","first-page":"417","DOI":"10.1016\/S0140-6736(05)70238-5","volume":"365","author":"N Lameire","year":"2005","unstructured":"Lameire N, Van Biesen W, Vanholder R. Acute renal failure. Lancet. 2005;365:417\u201330.","journal-title":"Lancet"}],"container-title":["Journal of Medical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s13256-018-1685-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/s13256-018-1685-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s13256-018-1685-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,8,22]],"date-time":"2022-08-22T23:43:20Z","timestamp":1661211800000},"score":1,"resource":{"primary":{"URL":"https:\/\/jmedicalcasereports.biomedcentral.com\/articles\/10.1186\/s13256-018-1685-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,5,22]]},"references-count":37,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018,12]]}},"alternative-id":["1685"],"URL":"https:\/\/doi.org\/10.1186\/s13256-018-1685-0","relation":{},"ISSN":["1752-1947"],"issn-type":[{"value":"1752-1947","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,5,22]]},"assertion":[{"value":"23 November 2017","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 April 2018","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 May 2018","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Ethical approval was not obtained for the publication of this case report as this does not involve sharing of the personal details of the patient.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Written informed consent was obtained from the patient for publication of this case report. A copy of the written consent is available for review by the Editor-in-Chief of this journal.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Publisher\u2019s Note"}}],"article-number":"143"}}