{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,17]],"date-time":"2025-09-17T16:10:21Z","timestamp":1758125421926},"reference-count":16,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2018,10,3]],"date-time":"2018-10-03T00:00:00Z","timestamp":1538524800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Med Case Reports"],"published-print":{"date-parts":[[2018,12]]},"DOI":"10.1186\/s13256-018-1815-8","type":"journal-article","created":{"date-parts":[[2018,10,2]],"date-time":"2018-10-02T14:12:50Z","timestamp":1538489570000},"update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Vitamin B12 deficiency-induced pseudothrombotic microangiopathy without macrocytosis presenting with acute renal failure: a case report"],"prefix":"10.1186","volume":"12","author":[{"given":"Jennifer","family":"Vanoli","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Carrer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberto","family":"Martorana","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guido","family":"Grassi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michele","family":"Bombelli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2018,10,3]]},"reference":[{"key":"1815_CR1","doi-asserted-by":"publisher","first-page":"9410727","DOI":"10.1155\/2017\/9410727","volume":"2017","author":"F Yousaf","year":"2017","unstructured":"Yousaf F, Spinowitz B, Charytan C, Galler M. Pernicious Anemia associated cobalamin deficiency and thrombotic Microangiopathy: case report and review of the literature. Case Rep Med. 2017;2017:9410727.","journal-title":"Case Rep Med"},{"issue":"may14 1","key":"1815_CR2","doi-asserted-by":"publisher","first-page":"bcr2015209718","DOI":"10.1136\/bcr-2015-209718","volume":"2015","author":"E. Y. Keskin","year":"2015","unstructured":"Keskin EY, Keskin M. Severe vitamin B12 deficiency in a 15-year-old boy: presentation with haemolysis and pancytopenia. BMJ Case Rep. 2015;2015 \n                    https:\/\/doi.org\/10.1136\/bcr-2015-209718\n                    \n                  .","journal-title":"Case Reports"},{"key":"1815_CR3","first-page":"1087831","volume":"2016","author":"A Malek","year":"2016","unstructured":"Malek A, Nasnas R. An unusual presentation of Pseudothrombotic Microangiopathy in a patient with autoimmune atrophic gastritis. Case Rep Hematol. 2016;2016:1087831.","journal-title":"Case Rep Hematol"},{"key":"1815_CR4","doi-asserted-by":"publisher","unstructured":"Tuten N, Bennett C, Babcock W. Thrombotic thrombocytopenic purpura or cobalamin deficiency? A case report and review. Clin Case Rep Rev. 2015;1 \n                    https:\/\/doi.org\/10.15761\/CCRR.1000152\n                    \n                  .","DOI":"10.15761\/CCRR.1000152"},{"key":"1815_CR5","doi-asserted-by":"publisher","first-page":"e3","DOI":"10.1016\/j.amjmed.2006.02.001","volume":"119","author":"E Andr\u00e8s","year":"2006","unstructured":"Andr\u00e8s E, Affenberger S, Federici L, Korganow AS. Pseudo-thrombotic microangiopathy related to cobalamin deficiency. Am J Med. 2006;119:e3.","journal-title":"Am J Med"},{"key":"1815_CR6","doi-asserted-by":"publisher","first-page":"2041","DOI":"10.1056\/NEJMcp1113996","volume":"368","author":"SP Stabler","year":"2013","unstructured":"Stabler SP. Vitamin B12 deficiency. N Engl J Med. 2013;368:2041\u20132.","journal-title":"N Engl J Med"},{"key":"1815_CR7","doi-asserted-by":"publisher","first-page":"2113","DOI":"10.1001\/jama.281.22.2113","volume":"281","author":"F Nappo","year":"1999","unstructured":"Nappo F, De Rosa N, Marfella R, De Lucia D, Ingrosso D, Perna AF, et al. Impairment of endothelial functions by acute hyperhomocysteinemia and reversal by antioxidant vitamins. JAMA. 1999;281:2113\u20138.","journal-title":"JAMA"},{"key":"1815_CR8","doi-asserted-by":"publisher","first-page":"472","DOI":"10.4297\/najms.2011.3472.","volume":"3","author":"AK Tadakamalla","year":"2011","unstructured":"Tadakamalla AK, Talluri SK, Besur S. Pseudo-thrombotic thrombocytopenic purpura: a rare presentation of pernicious anemia. North Am J Med Sci. 2011;3:472\u20134.","journal-title":"North Am J Med Sci"},{"key":"1815_CR9","doi-asserted-by":"publisher","first-page":"953","DOI":"10.1093\/ajcp\/66.6.953","volume":"66","author":"SK Ballas","year":"1976","unstructured":"Ballas SK, Saidi P, Constantino M. Reduced erythrocytic deformability in megaloblastic anemia. Am J Clin Pathol. 1976;66:953\u20137.","journal-title":"Am J Clin Pathol"},{"key":"1815_CR10","doi-asserted-by":"publisher","first-page":"236","DOI":"10.3121\/cmr.4.3.236","volume":"4","author":"F Aslinia","year":"2006","unstructured":"Aslinia F, Mazza JJ, Yale SH. Megaloblastic anemia and other causes of macrocytosis. Clin Med Res. 2006;4:236\u201341.","journal-title":"Clin Med Res"},{"key":"1815_CR11","doi-asserted-by":"publisher","first-page":"1017","DOI":"10.1093\/qjmed\/hct142","volume":"106","author":"N No\u00ebl","year":"2013","unstructured":"No\u00ebl N, Maign\u00e9 G, Tertian G, Anguel N, Monnet X, Michot J-M, et al. Hemolysis and schistocytosis in the emergency department: consider pseudothrombotic microangiopathy related to vitamin B12 deficiency. QJM Mon J Assoc Physicians. 2013;106:1017\u201322.","journal-title":"QJM Mon J Assoc Physicians"},{"key":"1815_CR12","doi-asserted-by":"crossref","first-page":"2050313X1771314","DOI":"10.1177\/2050313X17713149","volume":"5","author":"S Kandel","year":"2017","unstructured":"Kandel S, Budhathoki N, Pandey S, Bhattarai B, Baqui A, Pandey R, et al. Pseudo-thrombotic thrombocytopenic purpura presenting as multi-organ dysfunction syndrome: a rare complication of pernicious anemia. SAGE Open Med Case Rep. 2017;5:2050313X17713149.","journal-title":"SAGE Open Med Case Rep"},{"key":"1815_CR13","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1186\/s12878-015-0036-2","volume":"15","author":"K Walter","year":"2015","unstructured":"Walter K, Vaughn J, Martin D. Therapeutic dilemma in the management of a patient with the clinical picture of TTP and severe B12 deficiency. BMC Hematol. 2015;15:16.","journal-title":"BMC Hematol"},{"key":"1815_CR14","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1016\/j.amjmed.2007.11.003","volume":"121","author":"CJ Dalsania","year":"2008","unstructured":"Dalsania CJ, Khemka V, Shum M, Devereux L, Lachant NA. A sheep in wolf\u2019s clothing. Am J Med. 2008;121:107\u20139.","journal-title":"Am J Med"},{"key":"1815_CR15","doi-asserted-by":"publisher","first-page":"423","DOI":"10.1016\/S0002-9343(03)00023-8","volume":"114","author":"L Garderet","year":"2003","unstructured":"Garderet L, Maury E, Lagrange M, Najman A, Offenstadt G, Guidet B. Schizocytosis in pernicious anemia mimicking thrombotic thrombocytopenic purpura. Am J Med. 2003;114:423\u20135.","journal-title":"Am J Med"},{"key":"1815_CR16","doi-asserted-by":"publisher","first-page":"2525","DOI":"10.1111\/j.1537-2995.2012.03646.x","volume":"52","author":"S Som","year":"2012","unstructured":"Som S, Deford CC, Kaiser ML, Terrell DR, Kremer Hovinga JA, L\u00e4mmle B, et al. Decreasing frequency of plasma exchange complications in patients treated for thrombotic thrombocytopenic purpura-hemolytic uremic syndrome, 1996 to 2011. Transfusion. 2012;52:2525\u201332. quiz 2524","journal-title":"Transfusion"}],"container-title":["Journal of Medical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s13256-018-1815-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/s13256-018-1815-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s13256-018-1815-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,10,2]],"date-time":"2019-10-02T23:16:52Z","timestamp":1570058212000},"score":1,"resource":{"primary":{"URL":"https:\/\/jmedicalcasereports.biomedcentral.com\/articles\/10.1186\/s13256-018-1815-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,10,3]]},"references-count":16,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018,12]]}},"alternative-id":["1815"],"URL":"https:\/\/doi.org\/10.1186\/s13256-018-1815-8","relation":{},"ISSN":["1752-1947"],"issn-type":[{"value":"1752-1947","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,10,3]]},"assertion":[{"value":"16 May 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 August 2018","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 October 2018","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"JV is internal medicine resident at San Gerardo University Hospital, Monza, Italy and University of Milano-Bicocca, Milano, Italy. Her clinical and research interests are focused on hematology and ultrasound imaging, and she has already published an internal medicine case report (Vanoli <i>et al.<\/i>, Medicine 2017). GG is full professor of Internal Medicine at University of Milano-Bicocca, Milano, Italy, and hypertension world expert. MB is assistant professor of Internal Medicine at University of Milano-Bicocca, Milano, Italy.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Authors\u2019 information"}},{"value":"Approval by ethic committee was not necessary because diagnostic procedures and treatments have been performed according to standard clinical care. The patient signed institutional informed consent for receiving treatments.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Written informed consent was obtained from the patient for publication of this case report and any accompanying images. A copy of the written consent is available for review by the Editor-in-Chief of this journal.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Publisher\u2019s Note"}}],"article-number":"296"}}