{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T22:37:28Z","timestamp":1771713448365,"version":"3.50.1"},"reference-count":13,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2019,1,16]],"date-time":"2019-01-16T00:00:00Z","timestamp":1547596800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Med Case Reports"],"published-print":{"date-parts":[[2019,12]]},"DOI":"10.1186\/s13256-018-1877-7","type":"journal-article","created":{"date-parts":[[2019,1,13]],"date-time":"2019-01-13T22:53:53Z","timestamp":1547420033000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Leukocytoclastic vasculitis with purpura and renal failure induced by the anti-epidermal growth factor receptor antibody panitumumab: a case report"],"prefix":"10.1186","volume":"13","author":[{"given":"Hitomi","family":"Kamo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eiji","family":"Shinozaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takanobu","family":"Sugase","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nobuyuki","family":"Mizunuma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shoji","family":"Taniguchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Gotoh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keisyo","family":"Chin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomoaki","family":"Tanaka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazumi","family":"Koga","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kensei","family":"Yamaguchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2019,1,16]]},"reference":[{"issue":"3","key":"1877_CR1","doi-asserted-by":"publisher","first-page":"214","DOI":"10.1093\/jjco\/hyt196","volume":"44","author":"N Boku","year":"2014","unstructured":"Boku N, Sugihara K, Kitagawa Y, Hatake K, Gemma A, Yamazaki N, Muro K, Hamaguchi T, Yoshino T, Yana I, Ueno H, Ohtsu A. Panitumumab in Japanese patients with unresectable colorectal cancer: a post-marketing surveillance study of 3085 patients. Jpn J Clin Oncol. 2014;44(3):214\u201323.","journal-title":"Jpn J Clin Oncol"},{"key":"1877_CR2","first-page":"3","volume":"23","author":"F Dedeoglu","year":"2015","unstructured":"Dedeoglu F, Kim S. Henoch-Sch\u00f6nlein purpura (immunoglobulin A vasculitis): Clinical manifestations and diagnosis. UpToDate. 2015;23:3.","journal-title":"UpToDate"},{"issue":"1","key":"1877_CR3","first-page":"133","volume":"43","author":"K Kato","year":"2016","unstructured":"Kato K, Michishita Y, Oyama K, Hatano Y, Nozawa T, Ishibashi M, Konda R, Sasaki A. A case of Thrombotic Thrombocytopenic Purpura in a patient undergoing FOLFOX6 plus panitumumab therapy for unresectable recurrent rectal cancer with a rapidly progressive course. Gan To Kagaku Ryoho. 2016;43(1):133\u20136.","journal-title":"Gan To Kagaku Ryoho"},{"issue":"1","key":"1877_CR4","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1002\/hed.21481","volume":"34","author":"K Yang","year":"2012","unstructured":"Yang K, Zhang T, Chen J, Fan L, Yin Z, Hu Y, Mu G. Immune thrombocytopenia as a paraneoplastic syndrome in patients with nasopharyngeal cancer. Head Neck. 2012;34(1):127\u201330.","journal-title":"Head Neck"},{"issue":"7","key":"1877_CR5","first-page":"529","volume":"48","author":"K Nozato","year":"2010","unstructured":"Nozato K, Morishima Y, Furuta J, Fujita J, Miyazaki K, Ogawa R, Kikuchi N, Sakamoto T, Hizawa N. A case of Henoch-Sch\u00f6nlein purpura which was difficult to distinguish from a skin rash associated with gefitinib. Nihon Kokyuki Gakkai Zasshi. 2010;48(7):529\u201334.","journal-title":"Nihon Kokyuki Gakkai Zasshi"},{"issue":"6","key":"1877_CR6","doi-asserted-by":"publisher","first-page":"562","DOI":"10.1111\/j.1346-8138.2010.00896.x","volume":"37","author":"H Uchimiya","year":"2010","unstructured":"Uchimiya H, Higashi Y, Kawai K, Kanekura T. Purpuric drug eruption with leukocytoclastic vasculitis due to gefitinib. J Dermatol. 2010;37(6):562\u20134.","journal-title":"J Dermatol"},{"issue":"8","key":"1877_CR7","doi-asserted-by":"publisher","first-page":"890","DOI":"10.1111\/j.1365-4632.2007.03275.x","volume":"46","author":"M Fern\u00e1ndez-Guarino","year":"2007","unstructured":"Fern\u00e1ndez-Guarino M, Ryan AM, P\u00e9rez-Garc\u00eda B, G\u00f3nzalez-L\u00f3pez C, Olasolo PJ. Necrotizing vasculitis due to gefitinib (Iressa). Int J Dermatol. 2007;46(8):890\u20131.","journal-title":"Int J Dermatol"},{"issue":"9","key":"1877_CR8","doi-asserted-by":"publisher","first-page":"1582","DOI":"10.1093\/annonc\/mdm420","volume":"18","author":"S Boeck","year":"2007","unstructured":"Boeck S, Wollenberg A, Heinemann V. Leukocytoclastic vasculitis during treatment with the oral EGFR tyrosine kinase inhibitor erlotinib. Ann Oncol. 2007;18(9):1582\u20133.","journal-title":"Ann Oncol"},{"issue":"1","key":"1877_CR9","first-page":"81","volume":"48","author":"T Yuba","year":"2010","unstructured":"Yuba T, Nagata K, Shiotsu S, Okano A, Hatsuse M, Murakami S, Morihara K, Shimazaki C. Henoch-Sch\u00f6nlein purpura induced by erlotinib (Tarceva): a case report. Nihon Kokyuki Gakkai Zasshi. 2010;48(1):81\u20135.","journal-title":"Nihon Kokyuki Gakkai Zasshi"},{"issue":"6","key":"1877_CR10","doi-asserted-by":"publisher","first-page":"988","DOI":"10.1053\/j.ajkd.2013.01.008","volume":"61","author":"K Sasaki","year":"2013","unstructured":"Sasaki K, Anderson E, Shankland SJ, Nicosia RF. Diffuse proliferative glomerulonephritis associated with cetuximab, an epidermal growth factor receptor inhibitor. Am J Kidney Dis. 2013;61(6):988\u201391.","journal-title":"Am J Kidney Dis"},{"issue":"3","key":"1877_CR11","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1177\/1078155212459668","volume":"19","author":"C Ito","year":"2013","unstructured":"Ito C, Fujii H, Ogura M, Sato H, Kusano E. Cetuximab-induced nephrotic syndrome in a case of metastatic rectal cancer. J Oncol Pharm Pract. 2013;19(3):265\u20138.","journal-title":"J Oncol Pharm Pract"},{"issue":"12","key":"1877_CR12","doi-asserted-by":"publisher","first-page":"2504","DOI":"10.1200\/JCO.2004.09.064","volume":"22","author":"R Kumasaka","year":"2004","unstructured":"Kumasaka R, Nakamura N, Shirato K, Osawa H, Takanashi S, Hasegawa Y, Yamabe H, Nakamura M, Tamura M, Okumura K. Side effects of therapy: case 1. Nephrotic syndrome associated with gefitinib therapy. J Clin Oncol. 2004;22(12):2504\u20135.","journal-title":"J Clin Oncol"},{"key":"1877_CR13","first-page":"512","volume":"2","author":"N Kurita","year":"2009","unstructured":"Kurita N, Mise N, Fujii A, Ikeda S, Sugimoto T. Crescentic glomerulonephritis in a patient with advanced lung cancer during erlotinib therapy. NDT Plus. 2009;2:512\u20133.","journal-title":"NDT Plus"}],"container-title":["Journal of Medical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s13256-018-1877-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/s13256-018-1877-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s13256-018-1877-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,1,16]],"date-time":"2020-01-16T00:05:13Z","timestamp":1579133113000},"score":1,"resource":{"primary":{"URL":"https:\/\/jmedicalcasereports.biomedcentral.com\/articles\/10.1186\/s13256-018-1877-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1,16]]},"references-count":13,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2019,12]]}},"alternative-id":["1877"],"URL":"https:\/\/doi.org\/10.1186\/s13256-018-1877-7","relation":{},"ISSN":["1752-1947"],"issn-type":[{"value":"1752-1947","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,1,16]]},"assertion":[{"value":"10 June 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 October 2018","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 January 2019","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"This case was approved by the Tumor Board in Koga General Hospital and Cancer Board in Cancer Institute Hospital.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Written informed consent was obtained from the patient\u2019s next-of-kin for publication of this case report and any accompanying images. A copy of the written consent is available for review by the Editor-in-Chief of this journal.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Publisher\u2019s Note"}}],"article-number":"13"}}