{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T14:14:40Z","timestamp":1740147280476,"version":"3.37.3"},"reference-count":20,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2018,12,1]],"date-time":"2018-12-01T00:00:00Z","timestamp":1543622400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81171986","81602024"],"award-info":[{"award-number":["81171986","81602024"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Med Case Reports"],"published-print":{"date-parts":[[2018,12]]},"DOI":"10.1186\/s13256-018-1913-7","type":"journal-article","created":{"date-parts":[[2018,12,21]],"date-time":"2018-12-21T09:05:56Z","timestamp":1545383156000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Episcleritis in a patient with mucosal melanoma treated with interferon alfa-2b and radiotherapy: a case report"],"prefix":"10.1186","volume":"12","author":[{"given":"Li","family":"Yang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shaofei","family":"Ji","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liping","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2018,12,23]]},"reference":[{"key":"1913_CR1","doi-asserted-by":"publisher","first-page":"578","DOI":"10.1097\/DAD.0000000000000035","volume":"36","author":"SV Louren\u00e7o","year":"2014","unstructured":"Louren\u00e7o SV, Fernandes JD, Hsieh R, Coutinho-Camillo CM, Bologna S, Sangueza M, et al. Head and neck mucosal melanoma: a review. Am J Dermatopathol. 2014;36:578\u201387.","journal-title":"Am J Dermatopathol"},{"key":"1913_CR2","doi-asserted-by":"publisher","first-page":"136","DOI":"10.1016\/j.critrevonc.2017.01.019","volume":"112","author":"PA Ascierto","year":"2017","unstructured":"Ascierto PA, Accorona R, Botti G, Farina D, Fossati P, Gatta G, et al. Mucosal melanoma of the head and neck. Crit Rev Oncol Hematol. 2017;112:136\u201352.","journal-title":"Crit Rev Oncol Hematol"},{"key":"1913_CR3","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1053\/j.sult.2005.04.005","volume":"26","author":"MJ Lahaye","year":"2005","unstructured":"Lahaye MJ, Engelen SM, Nelemans PJ, Beets GL, van de Velde CJ, van Engelshoven JM, et al. Imaging for predicting the risk factors--the circumferential resection margin and nodal disease--of local recurrence in rectal cancer: a meta-analysis. Semin Ultrasound CT MR. 2005;26:259\u201368.","journal-title":"Semin Ultrasound CT MR"},{"key":"1913_CR4","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1111\/j.1749-6632.2009.05073.x","volume":"1182","author":"AA Tarhini","year":"2009","unstructured":"Tarhini AA, Kirkwood JM. Clinical and immunologic basis of interferon therapy in melanoma. Ann N Y Acad Sci. 2009;1182:47\u201357.","journal-title":"Ann N Y Acad Sci"},{"key":"1913_CR5","doi-asserted-by":"publisher","first-page":"4843","DOI":"10.1158\/1078-0432.CCR-13-0352","volume":"19","author":"A Sharma","year":"2013","unstructured":"Sharma A, Bode B, Moch H, Moch H, Okoniewski M, Knuth A, et al. Radiotherapy of human sarcoma promotes an intratumoral immune effector signature. Clin Cancer Res. 2013;19:4843\u201353.","journal-title":"Clin Cancer Res"},{"key":"1913_CR6","doi-asserted-by":"publisher","first-page":"696285","DOI":"10.1155\/2011\/696285","volume":"2011","author":"IP Chatziralli","year":"2011","unstructured":"Chatziralli IP, Kanonidou E, Chatzirallis A, Dimitriadis P, Keryttopoulos P. Episcleritis Related to Drug-Induced Lupus Erythematosus following Infliximab Therapy: A Case Report. Case Rep Med. 2011;2011:696285.","journal-title":"Case Rep Med"},{"key":"1913_CR7","doi-asserted-by":"publisher","first-page":"616170","DOI":"10.1155\/2013\/616170","volume":"2013","author":"M Rastrelli","year":"2013","unstructured":"Rastrelli M, Alaibac M, Stramare R, Chiarion Sileni V, Montesco MC, Vecchiato A, et al. Melanoma m (zero): diagnosis and therapy. ISRN Dermatol. 2013;2013:616170.","journal-title":"ISRN Dermatol"},{"key":"1913_CR8","first-page":"1005","volume":"28","author":"M Rastrelli","year":"2014","unstructured":"Rastrelli M, Tropea S, Rossi CR, Alaibac M. Melanoma: epidemiology, risk factors, pathogenesis, diagnosis and classification. In Vivo. 2014;28:1005\u201311.","journal-title":"In Vivo"},{"key":"1913_CR9","first-page":"45","volume":"41","author":"F Sera","year":"2015","unstructured":"Sera F, Gandini S, Cattaruzza MS, Pasquini P, Picconi O, Boyle P, Melchi CF. Meta-analysis of risk factors for cutaneous melanoma: II. Sun exposure Eur J Cancer. 2015;41:45\u201360.","journal-title":"Sun exposure Eur J Cancer"},{"key":"1913_CR10","doi-asserted-by":"publisher","first-page":"626","DOI":"10.1097\/01.coc.0000170805.14058.d3","volume":"28","author":"WM Mendenhall","year":"2005","unstructured":"Mendenhall WM, Amdur RJ, Hinerman RW, Werning JW, Villaret DB, Mendenhall NP. Head and neck mucosal melanoma. Am J Clin Oncol. 2005;28:626\u201330.","journal-title":"Am J Clin Oncol"},{"key":"1913_CR11","doi-asserted-by":"publisher","first-page":"514","DOI":"10.1002\/cncr.31083","volume":"124","author":"M Amit","year":"2018","unstructured":"Amit M, Tam S, Abdelmeguid AS, Roberts DB, Raza SM, Su SY, et al. Approaches to regional lymph node metastasis in patients with head and neck mucosal melanoma. Cancer. 2018;124:514\u201320.","journal-title":"Cancer"},{"key":"1913_CR12","doi-asserted-by":"publisher","first-page":"675","DOI":"10.1002\/hed.23355","volume":"36","author":"CZ Sun","year":"2014","unstructured":"Sun CZ, Li QL, Hu ZD, Jiang YE, Song M, Yang AK. Treatment and prognosis in sinonasal mucosal melanoma: A retrospective analysis of 65 patients from a single cancer center. Head Neck. 2014;36:675\u201381.","journal-title":"Head Neck"},{"key":"1913_CR13","doi-asserted-by":"publisher","first-page":"1592","DOI":"10.1002\/hed.20910","volume":"30","author":"HL Bartell","year":"2008","unstructured":"Bartell HL, Bedikian AY, Papadopoulos NE, Dett TK, Ballo MT, Myers JN, et al. Biochemotherapy in patients with advanced head and neck mucosal melanoma. Head Neck. 2008;30:1592\u20138.","journal-title":"Head Neck."},{"key":"1913_CR14","doi-asserted-by":"publisher","first-page":"797","DOI":"10.1007\/s00347-016-0344-3","volume":"113","author":"C Tappeiner","year":"2016","unstructured":"Tappeiner C, Walscheid K, Heiligenhaus A. Diagnosis and treatment of episcleritis and scleritis. Ophthalmologe. 2016;113:797\u2013810.","journal-title":"Ophthalmologe"},{"key":"1913_CR15","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1016\/S0002-9394(00)00710-8","volume":"130","author":"DA Jabs","year":"2000","unstructured":"Jabs DA, Mudun A, Dunn JP, Marsh MJ. Episcleritis and scleritis: clinical features and treatment results. Am J Ophthalmol. 2000;130:469\u201376.","journal-title":"Am J Ophthalmol"},{"key":"1913_CR16","doi-asserted-by":"publisher","first-page":"A41","DOI":"10.1053\/ejpn.2002.0573","volume":"6 Suppl A","author":"M De Andrea","year":"2002","unstructured":"De Andrea M, Ravera R, Gioia D, Gariglio M, Landolfo S. The interferon system: an overview. Eur J Paediatr Neurol. 2002;6 Suppl A:A41\u20136. discussion A55\u20138","journal-title":"Eur J Paediatr Neurol"},{"key":"1913_CR17","doi-asserted-by":"publisher","first-page":"1219","DOI":"10.1038\/ni1141","volume":"5","author":"M Colonna","year":"2004","unstructured":"Colonna M, Trinchieri G, Liu YJ. Plasmacytoid dendritic cells in immunity. Nat Immunol. 2004;5:1219\u201326.","journal-title":"Nat Immunol"},{"key":"1913_CR18","doi-asserted-by":"publisher","first-page":"505","DOI":"10.2217\/14796694.3.5.505","volume":"3","author":"Anonymous","year":"2007","unstructured":"Anonymous. IFN-alpha found to act on immune-system cells rather than melanoma cells. Future Oncol. 2007;3:505.","journal-title":"Future Oncol"},{"key":"1913_CR19","doi-asserted-by":"publisher","first-page":"e92572","DOI":"10.1371\/journal.pone.0092572","volume":"9","author":"Y Yoshimoto","year":"2014","unstructured":"Yoshimoto Y, Suzuki Y, Mimura K, Ando K, Oike T, Sato H, et al. Radiotherapy-induced anti-tumor immunity contributes to the therapeutic efficacy of irradiation and can be augmented by CTLA-4 blockade in a mouse model. PLoS One. 2014;9:e92572.","journal-title":"PLoS One"},{"key":"1913_CR20","doi-asserted-by":"publisher","first-page":"558","DOI":"10.4049\/jimmunol.1200563","volume":"189","author":"A Gupta","year":"2012","unstructured":"Gupta A, Probst HC, Vuong V, Landshammer A, Muth S, Yagita H, et al. Radiotherapy promotes tumor-specific effector CD8+ T cells via dendritic cell activation. J Immunol. 2012;189:558\u201366.","journal-title":"J Immunol"}],"container-title":["Journal of Medical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s13256-018-1913-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/s13256-018-1913-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s13256-018-1913-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,12,22]],"date-time":"2019-12-22T19:03:42Z","timestamp":1577041422000},"score":1,"resource":{"primary":{"URL":"https:\/\/jmedicalcasereports.biomedcentral.com\/articles\/10.1186\/s13256-018-1913-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,12]]},"references-count":20,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018,12]]}},"alternative-id":["1913"],"URL":"https:\/\/doi.org\/10.1186\/s13256-018-1913-7","relation":{},"ISSN":["1752-1947"],"issn-type":[{"type":"electronic","value":"1752-1947"}],"subject":[],"published":{"date-parts":[[2018,12]]},"assertion":[{"value":"15 August 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 November 2018","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 December 2018","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Not applicable.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Written informed consent was obtained from the patient for publication of this case report and any accompanying images. A copy of the written consent is available for review by the Editor-in Chief of this journal.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Publisher\u2019s Note"}}],"article-number":"388"}}