{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T23:14:58Z","timestamp":1769814898333,"version":"3.49.0"},"reference-count":15,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2019,9,11]],"date-time":"2019-09-11T00:00:00Z","timestamp":1568160000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2019,9,11]],"date-time":"2019-09-11T00:00:00Z","timestamp":1568160000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Med Case Reports"],"published-print":{"date-parts":[[2019,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n              <jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>Generally, ovarian hyperstimulation syndrome develops after superovulation caused by ovulation-inducing drugs in infertile patients. However, ovarian hyperstimulation syndrome associated with natural pregnancy is rare, and most cases of ovarian hyperstimulation syndrome have been associated with a hydatidiform mole.<\/jats:p>\n              <\/jats:sec>\n              <jats:sec>\n                <jats:title>Case presentation<\/jats:title>\n                <jats:p>We describe a case of a 16-year-old Japanese girl with a complete hydatidiform mole. The patient was referred for intensive examination and treatment of the hydatidiform mole and underwent surgical removal of the hydatidiform mole at 9\u2009weeks, 5\u2009days of gestation. Histopathological examination revealed a complete hydatidiform mole. The patient\u2019s blood human chorionic gonadotropin level decreased from 980,823\u2009IU\/L to 44,815\u2009IU\/L on postoperative day 4, and it was below the cutoff level on postoperative day 64. Transvaginal ultrasonography on postoperative day 7 revealed a multilocular cyst measuring 82\u2009\u00d7\u200943\u2009mm in the right ovary and a multilocular cyst measuring 66\u2009\u00d7\u200950\u2009mm in the left ovary. Both ovarian cysts enlarged further. Magnetic resonance imaging on postoperative day 24 revealed that the right multilocular ovarian cyst had enlarged to 10\u2009\u00d7\u200912\u2009cm and that the left multilocular ovarian cyst had enlarged to 25\u2009\u00d7\u200911\u2009cm. Blood examination showed an elevated estradiol level as high as 3482\u2009pg\/ml. We diagnosed the patient with bilateral giant multilocular cysts accompanied by ovarian hyperstimulation syndrome because of the rapid increase in the size of the cysts. The patient complained of mild abdominal bloating; however, symptoms such as nausea, vomiting, dyspnea, and abdominal pain were not observed. Therefore, we chose spontaneous observation in the outpatient clinic. The cysts gradually decreased and disappeared on postoperative day 242.<\/jats:p>\n              <\/jats:sec>\n              <jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>Physicians should be aware that ovarian cysts can occur and can increase rapidly after abortion of a hydatidiform mole. However, the ovarian cyst can return to its original size spontaneously even if it becomes huge.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s13256-019-2181-x","type":"journal-article","created":{"date-parts":[[2019,9,11]],"date-time":"2019-09-11T00:02:32Z","timestamp":1568160152000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Ovarian hyperstimulation syndrome following surgical removal of a complete hydatidiform mole: a case report"],"prefix":"10.1186","volume":"13","author":[{"given":"Hiroaki","family":"Tsubokura","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yohei","family":"Ikoma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takuya","family":"Yokoe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomoo","family":"Yoshimura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katsuhiko","family":"Yasuda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2019,9,11]]},"reference":[{"key":"2181_CR1","doi-asserted-by":"publisher","first-page":"70","DOI":"10.4103\/0974-1208.86080","volume":"4","author":"P Kumar","year":"2011","unstructured":"Kumar P, Sait SF, Sharma A, Kumar M. Ovarian hyperstimulation syndrome. J Hum Reprod Sci. 2011;4:70\u20135.","journal-title":"J Hum Reprod Sci"},{"key":"2181_CR2","doi-asserted-by":"publisher","first-page":"854","DOI":"10.1111\/j.1471-0528.1966.tb06099.x","volume":"73","author":"AA Hooper","year":"1966","unstructured":"Hooper AA, Mascarenhas AM, O\u2019Sullivan JV. Gross ascites complicating hydatidiform mole. J Obstet Gynaecol Br Commonw. 1966;73:854\u20135.","journal-title":"J Obstet Gynaecol Br Commonw"},{"key":"2181_CR3","first-page":"47","volume":"44","author":"E Moneta","year":"1974","unstructured":"Moneta E, Menini E, Scirpa P, Plotti G. Urinary excretion of steroids in a case of hydatidiform mole with ascites. Obstet Gynecol. 1974;44:47\u201352.","journal-title":"Obstet Gynecol"},{"key":"2181_CR4","doi-asserted-by":"publisher","first-page":"2082","DOI":"10.1093\/humrep\/13.8.2082","volume":"13","author":"M Ludwig","year":"1998","unstructured":"Ludwig M, Gembruch U, Bauer O, Diedrich K. 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A copy of the written consent is available for review by the Editor-in-Chief of this journal.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"292"}}