{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T13:49:37Z","timestamp":1785419377869,"version":"3.56.0"},"reference-count":10,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2019,9,10]],"date-time":"2019-09-10T00:00:00Z","timestamp":1568073600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2019,9,10]],"date-time":"2019-09-10T00:00:00Z","timestamp":1568073600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Med Case Reports"],"published-print":{"date-parts":[[2019,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n              <jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>Neuroblastoma is an embryonal malignancy of the autonomic nervous system and is the most common extracranial tumor of early childhood. However, neuroblastoma in adults is rare with an overall incidence of 1 in 10 million adults\/year. Adults with neuroblastoma have a significantly worse prognosis than children with neuroblastoma.<\/jats:p>\n              <\/jats:sec>\n              <jats:sec>\n                <jats:title>Case presentation<\/jats:title>\n                <jats:p>In this case report we describe a 75-year-old Han Chinese woman with bilateral lower extremities weakness, numbness, and fatigue for 1 week. She initially presented as primary hyperaldosteronism with hypertension, persistent hypokalemia, and an elevated aldosterone\/plasma renin activity ratio. An abdominal computed tomography scan with intravenously administered contrast showed a solid mass arising from her left adrenal gland. She underwent retroperitoneal laparoscopic surgery that allowed the resection of the mass. Microscopic and immunohistochemical staining, which were positive for synaptophysin, CD56, and vimentin, confirmed the diagnosis of adrenal neuroblastoma. Surgical resection of the tumor was done and no chemotherapy or radiation therapy was done postoperatively. She died from lung and brain metastases 22\u2009months after surgical resection.<\/jats:p>\n              <\/jats:sec>\n              <jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>Adrenal neuroblastoma in elderly adults is a very rare disease with sparse data available in the literature. Early stage disease could be managed by surgical resection alone. However, the prognosis is significantly worse than that observed in pediatric patients. Further research focusing on tumor biology and therapy for this rare malignancy in adults may help to improve disease outcome.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s13256-019-2204-7","type":"journal-article","created":{"date-parts":[[2019,9,10]],"date-time":"2019-09-10T00:02:46Z","timestamp":1568073766000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Adrenal neuroblastoma in an elderly adult: a case report and review of the literature"],"prefix":"10.1186","volume":"13","author":[{"given":"Haibin","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziwei","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,9,10]]},"reference":[{"issue":"9579","key":"2204_CR1","doi-asserted-by":"publisher","first-page":"2106","DOI":"10.1016\/S0140-6736(07)60983-0","volume":"369","author":"JM Maris","year":"2007","unstructured":"Maris JM, Hogarty MD, Bagatell R, Cohn SL. Neuroblastoma. Lancet. 2007;369(9579):2106\u201320.","journal-title":"Lancet"},{"issue":"23","key":"2204_CR2","doi-asserted-by":"publisher","first-page":"2202","DOI":"10.1056\/NEJMra0804577","volume":"362","author":"JM Maris","year":"2010","unstructured":"Maris JM. Recent advances in neuroblastoma. N Engl J Med. 2010;362(23):2202\u201311.","journal-title":"N Engl J Med"},{"issue":"6","key":"2204_CR3","doi-asserted-by":"publisher","first-page":"508","DOI":"10.1002\/mpo.10273","volume":"41","author":"BH Kushner","year":"2003","unstructured":"Kushner BH, Kramer K, LaQuaglia MP, Modak S, Cheung NK. Neuroblastoma in adolescents and adults: the Memorial Sloan-Kettering experience. Med Pediatr Oncol. 2003;41(6):508\u201315.","journal-title":"Med Pediatr Oncol"},{"issue":"5","key":"2204_CR4","doi-asserted-by":"publisher","first-page":"684","DOI":"10.1177\/030089161009600507","volume":"96","author":"MG Podda","year":"2010","unstructured":"Podda MG, Luksch R, Polastri D, Gandola L, Piva L, Collini P, et al. Neuroblastoma in patients over 12 years old: a 20-year experience at the Istituto Nazionale Tumori of Milan. Tumori. 2010;96(5):684\u20139.","journal-title":"Tumori."},{"key":"2204_CR5","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1186\/2162-3619-3-20","volume":"3","author":"E Rogowitz","year":"2014","unstructured":"Rogowitz E, Babiker HM, Kanaan M, Millius RA, Ringenberg QS, Bishop M. Neuroblastoma of the elderly, an oncologist's nightmare: case presentation, literature review and SEER database analysis. Exp Hematol Oncol. 2014;3:20.","journal-title":"Exp Hematol Oncol"},{"issue":"1","key":"2204_CR6","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1002\/pbc.20859","volume":"49","author":"N Esiashvili","year":"2007","unstructured":"Esiashvili N, Goodman M, Ward K, Marcus RB Jr, Johnstone PA. Neuroblastoma in adults: Incidence and survival analysis based on SEER data. Pediatr Blood Cancer. 2007;49(1):41\u20136.","journal-title":"Pediatr Blood Cancer"},{"key":"2204_CR7","doi-asserted-by":"publisher","first-page":"375151","DOI":"10.1155\/2014\/375151","volume":"2014","author":"HJ Conter","year":"2014","unstructured":"Conter HJ, Gopalakrishnan V, Ravi V, Ater JL, Patel S, Araujo DM. Adult versus Pediatric Neuroblastoma: The M.D. Anderson Cancer Center Experience. Sarcoma. 2014;2014:375151.","journal-title":"Sarcoma."},{"issue":"3","key":"2204_CR8","first-page":"79","volume":"3","author":"K Gulleroglu","year":"2014","unstructured":"Gulleroglu K, et al. Neuroblastoma accompanied by hyperaldosteronism. J Renal Inj Prev. 2014;3(3):79\u201382.","journal-title":"J Renal Inj Prev"},{"issue":"10","key":"2204_CR9","doi-asserted-by":"publisher","first-page":"659","DOI":"10.1097\/01.mph.0000212995.56812.bb","volume":"28","author":"C Madre","year":"2006","unstructured":"Madre C, et al. Hypertension in childhood cancer: a frequent complication of certain tumor sites. J Pediatr Hematol Oncol. 2006;28(10):659\u201364.","journal-title":"J Pediatr Hematol Oncol"},{"issue":"2","key":"2204_CR10","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1200\/JCO.2008.16.6785","volume":"27","author":"SL Cohn","year":"2009","unstructured":"Cohn SL, Pearson AD, London WB, Monclair T, Ambros PF, Brodeur GM, et al. The International Neuroblastoma Risk Group (INRG) classification system: an INRG Task Force report. J Clin Oncol. 2009;27(2):289\u201397.","journal-title":"J Clin Oncol"}],"container-title":["Journal of Medical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s13256-019-2204-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/s13256-019-2204-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s13256-019-2204-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,9,10]],"date-time":"2020-09-10T09:05:58Z","timestamp":1599728758000},"score":1,"resource":{"primary":{"URL":"https:\/\/jmedicalcasereports.biomedcentral.com\/articles\/10.1186\/s13256-019-2204-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,9,10]]},"references-count":10,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2019,12]]}},"alternative-id":["2204"],"URL":"https:\/\/doi.org\/10.1186\/s13256-019-2204-7","relation":{},"ISSN":["1752-1947"],"issn-type":[{"value":"1752-1947","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,9,10]]},"assertion":[{"value":"16 April 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 July 2019","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 September 2019","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Not applicable.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Written informed consent was obtained from the patient\u2019s next-of-kin for publication of this case report and any accompanying images. A copy of the written consent is available for review by the Editor-in-Chief of this journal.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"284"}}