{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T04:57:16Z","timestamp":1768453036143,"version":"3.49.0"},"reference-count":9,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2019,10,26]],"date-time":"2019-10-26T00:00:00Z","timestamp":1572048000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2019,10,26]],"date-time":"2019-10-26T00:00:00Z","timestamp":1572048000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000865","name":"Bill and Melinda Gates Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100000865","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Med Case Reports"],"published-print":{"date-parts":[[2019,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p><jats:italic>Ralstonia mannitolilytica<\/jats:italic>is an emerging opportunistic pathogen that is associated with severe disease, including septic shock, meningitis, and renal transplant infections. Reports on this pathogen are limited, however, especially on the African continent.<\/jats:p><\/jats:sec><jats:sec><jats:title>Case presentation<\/jats:title><jats:p>A 2-year-old Akan child was presented to a hospital in the northeastern part of Ghana with a 1-week history of fever and chills. We identified<jats:italic>Ralstonia mannitolilytica<\/jats:italic>in her blood culture using both conventional and 16S ribosomal deoxyribonucleic acid (rDNA) techniques. The patient\u2019s condition improved clinically upon treatment with cefuroxime.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our report highlights the potential of<jats:italic>Ralstonia mannitolilytica<\/jats:italic>to cause sepsis and thus emphasizes the need for improved laboratory diagnosis and evidence for use of appropriate antibiotics in rural settings of Africa, where presumptive treatment using antimicrobial agents is rife.<\/jats:p><\/jats:sec>","DOI":"10.1186\/s13256-019-2235-0","type":"journal-article","created":{"date-parts":[[2019,10,26]],"date-time":"2019-10-26T00:03:11Z","timestamp":1572048191000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Ralstonia mannitolilytica sepsis: a case report"],"prefix":"10.1186","volume":"13","author":[{"given":"Michael","family":"Owusu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Godfred","family":"Acheampong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Augustina","family":"Annan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kwadwo Sarfo","family":"Marfo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isaac","family":"Osei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Amuasi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nimako","family":"Sarpong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Justin","family":"Im","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ondari D.","family":"Mogeni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hsin-Ying","family":"Chiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chih-Horng","family":"Kuo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyon Jin","family":"Jeon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ursula","family":"Panzner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Se Eun","family":"Park","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Florian","family":"Marks","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ellis","family":"Owusu-Dabo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yaw","family":"Adu-Sarkodie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2019,10,26]]},"reference":[{"key":"2235_CR1","doi-asserted-by":"publisher","first-page":"1061","DOI":"10.1542\/peds.2006-3739","volume":"119","author":"MA Jhung","year":"2007","unstructured":"Jhung MA, Sunenshine RH, Noble-Wang J, Coffin SE, St John K, Lewis FM, Jensen B, Peterson A, LiPuma J, Arduino MJ, et al. A national outbreak of Ralstonia mannitolilytica associated with use of a contaminated oxygen-delivery device among pediatric patients. Pediatrics. 2007;119:1061\u20138.","journal-title":"Pediatrics"},{"key":"2235_CR2","doi-asserted-by":"publisher","first-page":"547","DOI":"10.1099\/00207713-51-2-547","volume":"51","author":"T De Baere","year":"2001","unstructured":"De Baere T, Steyaert S, Wauters G, Des Vos P, Goris J, Coenye T, Suyama T, Verschraegen G, Vaneechoutte M. Classification of Ralstonia pickettii biovar 3\/\u2018thomasii\u2019 strains (Pickett 1994) and of new isolates related to nosocomial recurrent meningitis as Ralstonia mannitolytica sp. nov. Int J Syst Evol Microbiol. 2001;51:547\u201358.","journal-title":"Int J Syst Evol Microbiol"},{"key":"2235_CR3","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1186\/s13756-017-0178-z","volume":"6","author":"C Lucarelli","year":"2017","unstructured":"Lucarelli C, Di Domenico EG, Toma L, Bracco D, Prignano G, Fortunati M, Pelagalli L, Ensoli F, Pezzotti P, Garc\u00eda-Fern\u00e1ndez A, et al. Ralstonia mannitolilytica infections in an oncologic day ward: description of a cluster among high-risk patients. Antimicrob Resist Infect Control. 2017;6:20.","journal-title":"Antimicrob Resist Infect Control"},{"key":"2235_CR4","doi-asserted-by":"publisher","first-page":"e34373","DOI":"10.5812\/jjm.34373","volume":"9","author":"CX Liu","year":"2016","unstructured":"Liu CX, Yan C, Zhang P, Li FQ, Yang JH, Li XY. Ralstonia mannitolilytica-induced septicemia and homology analysis in infected patients: 3 case reports. Jundishapur J Microbiol. 2016;9:e34373.","journal-title":"Jundishapur J Microbiol"},{"key":"2235_CR5","doi-asserted-by":"publisher","first-page":"4588","DOI":"10.1128\/JCM.39.12.4588-4590.2001","volume":"39","author":"M Vaneechoutte","year":"2001","unstructured":"Vaneechoutte M, De Baere T, Wauters G, Steyaert S, Claeys G, Vogelaers D, Verschraegen G. One case each of recurrent meningitis and hemoperitoneum infection with Ralstonia mannitolilytica. J Clin Microbiol. 2001;39:4588\u201390.","journal-title":"J Clin Microbiol"},{"key":"2235_CR6","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1186\/s13256-017-1230-6","volume":"11","author":"M Owusu","year":"2017","unstructured":"Owusu M, Owusu-Dabo E, Acheampong G, Osei I, Amuasi J, Sarpong N, Annan A, Chiang HY, Kuo CH, Park SE, et al. Pseudomonas oryzihabitans sepsis in a 1-year-old child with multiple skin rashes: a case report. J Med Case Rep. 2017;11:77.","journal-title":"J Med Case Rep"},{"key":"2235_CR7","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1016\/S0255-0857(21)03017-6","volume":"21","author":"C Mukhopadhyay","year":"2003","unstructured":"Mukhopadhyay C, Bhargava A, Ayyagari A. Ralstonia Mannitolilytica infection in renal transplant recipient: first report. Indian J Med Microbiol. 2003;21:284\u20136.","journal-title":"Indian J Med Microbiol"},{"key":"2235_CR8","doi-asserted-by":"publisher","first-page":"3463","DOI":"10.1128\/JCM.43.7.3463-3466.2005","volume":"43","author":"T Coenye","year":"2005","unstructured":"Coenye T, Spilker T, Reik R, Vandamme P, Lipuma JJ. Use of PCR analyses to define the distribution of Ralstonia species recovered from patients with cystic fibrosis. J Clin Microbiol. 2005;43:3463\u20136.","journal-title":"J Clin Microbiol"},{"key":"2235_CR9","doi-asserted-by":"publisher","first-page":"4217","DOI":"10.1128\/AAC.48.11.4217-4225.2004","volume":"48","author":"D Girlich","year":"2004","unstructured":"Girlich D, Naas T, Nordmann P. OXA-60, a chromosomal, inducible, and imipenem-hydrolyzing class D \u03b2-lactamase from Ralstonia pickettii. Antimicrob Agents Chemother. 2004;48:4217\u201325.","journal-title":"Antimicrob Agents Chemother"}],"container-title":["Journal of Medical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s13256-019-2235-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/s13256-019-2235-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s13256-019-2235-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,10,2]],"date-time":"2022-10-02T18:26:25Z","timestamp":1664735185000},"score":1,"resource":{"primary":{"URL":"https:\/\/jmedicalcasereports.biomedcentral.com\/articles\/10.1186\/s13256-019-2235-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,10,26]]},"references-count":9,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2019,12]]}},"alternative-id":["2235"],"URL":"https:\/\/doi.org\/10.1186\/s13256-019-2235-0","relation":{},"ISSN":["1752-1947"],"issn-type":[{"value":"1752-1947","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,10,26]]},"assertion":[{"value":"22 April 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 August 2019","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 October 2019","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"This report was generated as part of a study that is investigating the etiological agents of sepsis in Ghana. The study has been approved by the Committee of Human Research, Ethics and Publication of the Kwame Nkrumah University of Science and Technology.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Written informed consent was obtained from the patient\u2019s legal guardians for publication of this case report and any accompanying images. A copy of the written consent is available for review by the Editor-in-Chief of this journal.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"318"}}