{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,21]],"date-time":"2025-09-21T17:42:40Z","timestamp":1758476560593},"reference-count":8,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2019,11,29]],"date-time":"2019-11-29T00:00:00Z","timestamp":1574985600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2019,11,29]],"date-time":"2019-11-29T00:00:00Z","timestamp":1574985600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Med Case Reports"],"published-print":{"date-parts":[[2019,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n<jats:title>Background<\/jats:title>\n<jats:p>We describe for the first time the clinical features and mechanisms of a bilateral dorsomedial pons and left thalamus infarction with seesaw nystagmus and internuclear ophthalmoplegia.<\/jats:p>\n<\/jats:sec><jats:sec>\n<jats:title>Case presentation<\/jats:title>\n<jats:p>A 62-year-old Chinese man was hospitalized for sudden-onset dizziness, diplopia, and gait disturbance. A neurological examination revealed seesaw nystagmus and internuclear ophthalmoplegia. Magnetic resonance imaging disclosed an acute infarction confined to the bilateral dorsomedial pons and left thalamus. Subsequently, 2 weeks of antithrombotic therapy led to an improvement in his symptoms.<\/jats:p>\n<\/jats:sec><jats:sec>\n<jats:title>Conclusions<\/jats:title>\n<jats:p>This case illustrates that the acute onset of seesaw nystagmus and internuclear ophthalmoplegia accompanied by risk factors for cerebrovascular diseases are highly suggestive of brainstem infarction.<\/jats:p>\n<\/jats:sec>","DOI":"10.1186\/s13256-019-2269-3","type":"journal-article","created":{"date-parts":[[2019,11,29]],"date-time":"2019-11-29T01:02:41Z","timestamp":1574989361000},"update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Seesaw nystagmus with internuclear ophthalmoplegia from bilateral dorsomedial pons and left thalamus infarction: a case report"],"prefix":"10.1186","volume":"13","author":[{"given":"Qian","family":"Zhang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2019,11,29]]},"reference":[{"key":"2269_CR1","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1016\/B978-0-444-52903-9.00019-4","volume":"102","author":"MJ Thurtell","year":"2011","unstructured":"Thurtell MJ, Leigh RJ. Nystagmus and saccadic intrusions. Handb Clin Neurol. 2011;102:333\u201378.","journal-title":"Handb Clin Neurol"},{"issue":"24","key":"2269_CR2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMicm1613244","volume":"376","author":"KVS Hari Kumar","year":"2017","unstructured":"Hari Kumar KVS, Singh P. Seesaw Nystagmus. N Engl J Med. 2017;376(24):e51.","journal-title":"N Engl J Med"},{"issue":"17","key":"2269_CR3","doi-asserted-by":"publisher","first-page":"e57","DOI":"10.1212\/01.wnl.0000310640.37810.b3","volume":"70","author":"TC Frohman","year":"2008","unstructured":"Frohman TC, Galetta S, Fox R, et al. Pearls & Oy-sters: The medial longitudinal fasciculus in ocular motor physiology. Neurology. 2008;70(17):e57\u201367.","journal-title":"Neurology."},{"key":"2269_CR4","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1016\/j.jns.2018.05.002","volume":"390","author":"MT Rizvi","year":"2018","unstructured":"Rizvi MT, Cameron L, Kilbane C, Shaikh AG. Paraneoplastic seesaw nystagmus and opsoclonus provides evidence for hyperexcitable reciprocally innervating mesencephalic network. J Neurol Sci. 2018;390:239\u201345.","journal-title":"J Neurol Sci"},{"issue":"2","key":"2269_CR5","doi-asserted-by":"publisher","first-page":"e111","DOI":"10.1111\/aos.13307","volume":"96","author":"K Sanchez","year":"2018","unstructured":"Sanchez K, Rowe FJ. Role of neural integrators in oculomotor systems: a systematic narrative literature review. Acta Ophthalmol. 2018;96(2):e111\u20138.","journal-title":"Acta Ophthalmol"},{"issue":"10","key":"2269_CR6","doi-asserted-by":"publisher","first-page":"1619","DOI":"10.1007\/s10072-014-1808-3","volume":"35","author":"HA Kim","year":"2014","unstructured":"Kim HA, Lee H. Vertical gaze-evoked nystagmus and internuclear ophthalmoplegia as sole manifestations in paramedian pontine infarction. Neurol Sci. 2014;35(10):1619\u201321.","journal-title":"Neurol Sci"},{"issue":"3","key":"2269_CR7","doi-asserted-by":"publisher","first-page":"456","DOI":"10.1016\/j.jocn.2008.03.015","volume":"16","author":"SY Choi","year":"2009","unstructured":"Choi SY, Kim DH, Lee JH, Kim J. Jerky hemi-seesaw nystagmus and head tilt reaction combined with internuclear ophthalmoplegia from a pontine infarction. J Clin Neurosci. 2009;16(3):456\u20138.","journal-title":"J Clin Neurosci"},{"issue":"7","key":"2269_CR8","doi-asserted-by":"publisher","first-page":"1313","DOI":"10.1212\/01.WNL.0000156905.31773.E1","volume":"64","author":"K Oh","year":"2005","unstructured":"Oh K, Chang JH, Park KW, et al. Jerky seesaw nystagmus in isolated internuclear ophthalmoplegia from focal pontine lesion. Neurology. 2005;64(7):1313\u20134.","journal-title":"Neurology."}],"container-title":["Journal of Medical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s13256-019-2269-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/s13256-019-2269-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s13256-019-2269-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,11,28]],"date-time":"2020-11-28T00:10:59Z","timestamp":1606522259000},"score":1,"resource":{"primary":{"URL":"https:\/\/jmedicalcasereports.biomedcentral.com\/articles\/10.1186\/s13256-019-2269-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,11,29]]},"references-count":8,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2019,12]]}},"alternative-id":["2269"],"URL":"https:\/\/doi.org\/10.1186\/s13256-019-2269-3","relation":{},"ISSN":["1752-1947"],"issn-type":[{"value":"1752-1947","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,11,29]]},"assertion":[{"value":"11 February 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 September 2019","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 November 2019","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Not applicable.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Written informed consent was obtained from the patient for publication of this case report and any accompanying images. A copy of the written consent is available for review by the Editor-in-Chief of this journal.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"352"}}