{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T05:26:45Z","timestamp":1767677205321,"version":"3.37.3"},"reference-count":15,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2020,1,26]],"date-time":"2020-01-26T00:00:00Z","timestamp":1579996800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2020,1,26]],"date-time":"2020-01-26T00:00:00Z","timestamp":1579996800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Med Case Reports"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Anticonvulsant hypersensitivity syndrome is a rare adverse drug reaction associated with aromatic anticonvulsant drugs. This syndrome can range from mild cutaneous rash to drug reaction with eosinophilia and systemic symptoms that include fever, rash, lymphadenopathy, pancytopenia, and involvement of multiple internal organs. We aimed to report this case in the literature and make physicians aware of the uncommon symptoms of this syndrome when they prescribe antiepileptic medications in particular.<\/jats:p><\/jats:sec><jats:sec><jats:title>Case presentation<\/jats:title><jats:p>A 14-year-old Middle Eastern female patient from Iran with free past medical and allergic history was admitted to hospital because of fever, rash, lymphadenopathy, and pancytopenia after taking anticonvulsants due to new-onset seizure. High fever and cutaneous rash along with lymphadenopathy following administration of anticonvulsant medications that could not be explained by other causes alerted the physician to the possibility of this syndrome. Our investigation revealed no further diagnosis and 1 week after discontinuation of the drugs, her symptoms were resolved. Anticonvulsant hypersensitivity syndrome is a diagnosis of exclusion and immediate discontinuation of the suspicious drugs is necessary. Hence, early recognition can prevent permanent multiorgan damage.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Chlorpheniramine as a simple treatment was provided for this syndrome.<\/jats:p><\/jats:sec>","DOI":"10.1186\/s13256-019-2286-2","type":"journal-article","created":{"date-parts":[[2020,1,26]],"date-time":"2020-01-26T01:02:36Z","timestamp":1580000556000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["A 14-year-old female with fever, rash, lymphadenopathy, and pancytopenia: a case report"],"prefix":"10.1186","volume":"14","author":[{"given":"Mojtaba","family":"Varshochi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reyhaneh","family":"Ravanbakhsh Gavgani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Behrooz","family":"Naghili","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhinus","family":"Bayatmakoo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Parinaz","family":"Poorshahverdi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4697-4778","authenticated-orcid":false,"given":"Fatemeh","family":"Ravanbakhsh Gavgani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2020,1,26]]},"reference":[{"issue":"11","key":"2286_CR1","doi-asserted-by":"publisher","first-page":"609","DOI":"10.5694\/j.1326-5377.2011.tb03118.x","volume":"194","author":"I Schweitzer","year":"2011","unstructured":"Schweitzer I. Anticonvulsant hypersensitivity syndrome: a rare and serious complication. Med J Aus. 2011;194(11):609\u201310.","journal-title":"Med J Aus"},{"key":"2286_CR2","first-page":"29","volume":"53","author":"Mason ME","year":"2007","unstructured":"Mason ME. Anticonvulsant hypersensitivity syndrome: recognizing the signs and symptoms. Resid Staff Physician. 2007;53:29\u201336.","journal-title":"Resid Staff Physician"},{"issue":"1","key":"2286_CR3","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1186\/s12948-017-0069-0","volume":"15","author":"M Ghannam","year":"2017","unstructured":"Ghannam M, Mansour S, Nabulsi A, Abdoh QJC. Anticonvulsant hypersensitivity syndrome after phenytoin administration in an adolescent patient: a case report and review of literature. Clin Mol Allergy. 2017;15(1):14.","journal-title":"Clin Mol Allergy"},{"issue":"1","key":"2286_CR4","doi-asserted-by":"publisher","first-page":"59","DOI":"10.4103\/0976-500X.124428","volume":"5","author":"M Mehta","year":"2014","unstructured":"Mehta M, Shah J, Khakhkhar T, Shah R, Hemavathi KJ. Anticonvulsant hypersensitivity syndrome associated with carbamazepine administration: case series. J Pharmacol Pharmacother. 2014;5(1):59\u201362.","journal-title":"J Pharmacol Pharmacother"},{"issue":"1","key":"2286_CR5","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1111\/j.1749-6632.1999.tb07628.x","volume":"876","author":"DS JA","year":"1999","unstructured":"JA DS. Sex hormones and glucocorticoids: interactions with the immune system. Ann N Y Acad Sci. 1999;876(1):102\u201318.","journal-title":"Ann N Y Acad Sci"},{"issue":"10","key":"2286_CR6","doi-asserted-by":"publisher","first-page":"1037","DOI":"10.1345\/aph.18422","volume":"33","author":"IC Wong","year":"1999","unstructured":"Wong IC, Mawer GE, JW S. Factors influencing the incidence of lamotrigine-related skin rash. Ann Pharmacother. 1999;33(10):1037\u201342.","journal-title":"Ann Pharmacother"},{"issue":"11","key":"2286_CR7","doi-asserted-by":"publisher","first-page":"1184","DOI":"10.1111\/j.1365-4632.2008.03827.x","volume":"47","author":"AT Mansur","year":"2008","unstructured":"Mansur AT, Pekcan Ya\u015far \u015e, F G. Anticonvulsant hypersensitivity syndrome: clinical and laboratory features. Int J Dermatol. 2008;47(11):1184\u20139.","journal-title":"Int J Dermatol"},{"key":"2286_CR8","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2012\/723062","volume":"2012","author":"Joshua C. Pritchett","year":"2012","unstructured":"Pritchett JC, Nanau RM, MG N. The link between hypersensitivity syndrome reaction development and human herpes virus-6 reactivation. Int J Hepatol. 2012;2012 https:\/\/doi.org\/10.1155\/2012\/723062.","journal-title":"International Journal of Hepatology"},{"issue":"1","key":"2286_CR9","first-page":"111\u20132","volume":"52","author":"\u00d6 \u00d6","year":"2010","unstructured":"\u00d6 \u00d6. Development of antiepileptic hypersensitivity syndrome after phenytoin treatment. Turk J Pediatr. 2010;52(1):111\u20132.","journal-title":"Turk J Pediatr"},{"issue":"4","key":"2286_CR10","doi-asserted-by":"publisher","first-page":"751","DOI":"10.1016\/j.pnpbp.2006.01.021","volume":"30","author":"K Matsuda","year":"2006","unstructured":"Matsuda K, Ohnuma T, Fukuta M, Kawai M, Suzuki T, Ogawa H, et al. Case reports and literature review: the association between reactivation of human herpes virus-6 and peripheral white blood cell count in patients with carbamazepine-induced hypersensitivity syndrome. Prog Neuro-Psychopharmacol Biol Psychiatry. 2006;30(4):751\u20134.","journal-title":"Prog Neuro-Psychopharmacol Biol Psychiatry"},{"issue":"1","key":"2286_CR11","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1016\/j.jbspin.2013.05.002","volume":"81","author":"V Descamps","year":"2014","unstructured":"Descamps V, S R-R. DRESS syndrome. Joint Bone Spine. 2014;81(1):15\u201321.","journal-title":"Joint Bone Spine"},{"issue":"5","key":"2286_CR12","doi-asserted-by":"publisher","first-page":"380","DOI":"10.1177\/08830738060210051301","volume":"21","author":"D Prais","year":"2006","unstructured":"Prais D, Straussberg R, Amir J, Nussinovitch M, L H. Treatment of anticonvulsant hypersensitivity syndrome with intravenous immunoglobulins and corticosteroids. J Child Neurol. 2006;21(5):380\u20134.","journal-title":"J Child Neurol"},{"issue":"26","key":"2286_CR13","doi-asserted-by":"publisher","first-page":"1852","DOI":"10.1056\/NEJM199106273242604","volume":"324","author":"PM Harrison","year":"1991","unstructured":"Harrison PM, Wendon JA, Gimson AE, Alexander GJ, R W. Improvement by acetylcysteine of hemodynamics and oxygen transport in fulminant hepatic failure. N Engl J Med. 1991;324(26):1852\u20137.","journal-title":"N Engl J Med"},{"issue":"3","key":"2286_CR14","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1097\/01.SMJ.0000054501.05278.5F","volume":"97","author":"J Mostella","year":"2004","unstructured":"Mostella J, Pieroni R, Jones R, CK F. Anticonvulsant hypersensitivity syndrome: treatment with corticosteroids and intravenous immunoglobulin. South Med J. 2004;97(3):319\u201321.","journal-title":"South Med J"},{"issue":"3","key":"2286_CR15","doi-asserted-by":"publisher","first-page":"459","DOI":"10.1016\/j.jaad.2012.08.009","volume":"68","author":"Y-C Chen","year":"2013","unstructured":"Chen Y-C, Chang C-Y, Cho Y-T, Chiu H-C, Chu C-Y. Long-term sequelae of drug reaction with eosinophilia and systemic symptoms: a retrospective cohort study from Taiwan. J Am Acad Dermatol. 2013;68(3):459\u201365.","journal-title":"J Am Acad Dermatol"}],"container-title":["Journal of Medical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s13256-019-2286-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/s13256-019-2286-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s13256-019-2286-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,25]],"date-time":"2023-09-25T17:58:12Z","timestamp":1695664692000},"score":1,"resource":{"primary":{"URL":"https:\/\/jmedicalcasereports.biomedcentral.com\/articles\/10.1186\/s13256-019-2286-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1,26]]},"references-count":15,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2020,12]]}},"alternative-id":["2286"],"URL":"https:\/\/doi.org\/10.1186\/s13256-019-2286-2","relation":{},"ISSN":["1752-1947"],"issn-type":[{"type":"electronic","value":"1752-1947"}],"subject":[],"published":{"date-parts":[[2020,1,26]]},"assertion":[{"value":"1 May 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 October 2019","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 January 2020","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"This case report does not involve any active intervention on patients; therefore, ethics approval is not applicable.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Written informed consent has been obtained from the patient next of kin for publication of this case report and any accompanying images.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"20"}}