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Multi-organ dysfunction secondary to scrub typhus is hard to diagnose and has a high mortality rate. Only one case of scrub typhus with multi-organ dysfunction syndrome and immune thrombocytopenia has been reported thus far. In this study, we report a second case of scrub typhus with multi-organ dysfunction syndrome and immune thrombocytopenia, and we summarize its diagnosis and treatment.<\/jats:p>\n<\/jats:sec><jats:sec>\n<jats:title>Case presentation<\/jats:title>\n<jats:p>A 43-year-old Han Chinese woman, a sanitation worker, was admitted to our hospital after 7\u2009days of a skin infection and 5\u2009days of a sore throat with fever and dizziness. A physical examination revealed the presence of an eschar on the right side of her neck. She had a history of insect bites during her sanitation work. A diagnostic evaluation identified scrub typhus as the primary illness, which was associated with multi-organ dysfunction syndrome and immune thrombocytopenia. She recovered completely after 15\u2009days of treatment and extensive symptomatic supportive care.<\/jats:p>\n<\/jats:sec><jats:sec>\n<jats:title>Conclusion<\/jats:title>\n<jats:p>We report a second case of tsutsugamushi disease with multi-organ dysfunction syndrome and immune thrombocytopenia, which resolved after treatment and extensive care.<\/jats:p>\n<\/jats:sec>","DOI":"10.1186\/s13256-019-2299-x","type":"journal-article","created":{"date-parts":[[2019,12,7]],"date-time":"2019-12-07T01:02:43Z","timestamp":1575680563000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Scrub typhus with multi-organ dysfunction syndrome and immune thrombocytopenia: a case report and review of the literature"],"prefix":"10.1186","volume":"13","author":[{"given":"Weijia","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0752-9110","authenticated-orcid":false,"given":"Lei","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weixing","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,12,7]]},"reference":[{"key":"2299_CR1","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1186\/1471-2334-11-79","volume":"11","author":"BJ Lee","year":"2011","unstructured":"Lee BJ, Chen CY, Hu SY, Tsan YT, Lin TC, Wang LM. 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