{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T14:14:04Z","timestamp":1740147244938,"version":"3.37.3"},"reference-count":11,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2021,3,2]],"date-time":"2021-03-02T00:00:00Z","timestamp":1614643200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2021,3,2]],"date-time":"2021-03-02T00:00:00Z","timestamp":1614643200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Med Case Reports"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>Pneumatosis intestinalis (PI) is a rare entity which refers to the presence of gas within the wall of the small bowel or colon which is a radiographic sign. The etiology and clinical presentation are variable. Patients with PI may present either with chronic mild non-specific symptoms or with acute abdominal pain with peritonitis. Some cases of intestinal pneumatosis have been reported as adverse events of new oncological treatments such as targeted therapies that are widely used in multiple tumors.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Case presentation<\/jats:title>\n                <jats:p>A 59-year-old caucasian female with radioactive iodine-refractory metastatic thyroid papillary carcinoma with <jats:italic>BRAF<\/jats:italic><jats:sup>V600E<\/jats:sup> mutation was treated with dabrafenib and trametinib as a compassionate use. After 4 months treatment, positron emission tomography\u2013computed tomography (PET\u2013CT) showed PI. At the time of diagnosis, the patient was asymptomatic without signs of peritonitis. The initial treatment was conservative and no specific treatment for PI was needed. Unfortunately, after dabrafenib\u2013trametinib withdrawal, the patient developed tumor progression with significant clinical worsening.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>This case report is, in our knowledge, the first description of PI in a patient treated with dabrafenib\u2013trametinib. Conservative treatment is feasible if there are no abdominal symptoms.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s13256-020-02581-9","type":"journal-article","created":{"date-parts":[[2021,3,2]],"date-time":"2021-03-02T15:02:43Z","timestamp":1614697363000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Pneumatosis intestinalis in a radioactive iodine-refractory metastasic thyroid papillary carcinoma with BRAFV600E mutation treated with dabrafenib\u2013trametinib: a case report"],"prefix":"10.1186","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3095-9346","authenticated-orcid":false,"given":"M. C.","family":"Mart\u00edn-Sober\u00f3n","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Ruiz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"De Velasco","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Yarza","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Carretero","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Castellano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. M.","family":"Sep\u00falveda-S\u00e1nchez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,3,2]]},"reference":[{"key":"2581_CR1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02590860","author":"CE Yale","year":"1976","unstructured":"Yale CE, Balish E. Pneumatosis cystoides intestinalis. Dis Colon Rectum. 1976. https:\/\/doi.org\/10.1007\/BF02590860.","journal-title":"Dis Colon Rectum"},{"issue":"6","key":"2581_CR2","first-page":"523","volume":"53","author":"LG Koss","year":"1952","unstructured":"Koss LG. Abdominal gas cysts (pneumatosis cystoides intestinorum hominis); an analysis with a report of a case and a critical review of the literature. AMA Arch Pathol. 1952;53(6):523\u201349.","journal-title":"AMA Arch Pathol."},{"issue":"10","key":"2581_CR3","doi-asserted-by":"publisher","first-page":"672","DOI":"10.1016\/j.gastrohep.2015.09.010","volume":"39","author":"A Vargas","year":"2016","unstructured":"Vargas A, Pag\u00e9s M, Bux\u00f3 E. Pneumatosis intestinalis due to 5-fluorouracil chemotherapy. Gastroenterol Hepatol. 2016;39(10):672\u20133. https:\/\/doi.org\/10.1016\/j.gastrohep.2015.09.010.","journal-title":"Gastroenterol Hepatol"},{"issue":"6","key":"2581_CR4","doi-asserted-by":"publisher","first-page":"1259","DOI":"10.2214\/AJR.12.8782","volume":"199","author":"AB Shinagare","year":"2012","unstructured":"Shinagare AB, Howard SA, Krajewski KM, Zukotynski KA, Jagannathan JP, Ramaiya NH. Pneumatosis intestinalis and bowel perforation associated with molecular targeted therapy: an emerging problem and the role of radiologists in its management. AJR Am J Roentgenol. 2012a;199(6):1259\u201365. https:\/\/doi.org\/10.2214\/AJR.12.8782.","journal-title":"AJR Am J Roentgenol."},{"key":"2581_CR5","doi-asserted-by":"publisher","first-page":"214","DOI":"10.1016\/j.ijscr.2018.10.079","volume":"53","author":"S Dhadlie","year":"2018","unstructured":"Dhadlie S, Mehanna D, McCourtney J. Pneumatosis intestinalis a trap for the unwary: case series and literature review. Int J Surg Case Rep. 2018;53:214\u20137. https:\/\/doi.org\/10.1016\/j.ijscr.2018.10.079.","journal-title":"Int J Surg Case Rep."},{"issue":"8","key":"2581_CR6","doi-asserted-by":"publisher","first-page":"2892","DOI":"10.1210\/jc.2005-2838","volume":"91","author":"C Durante","year":"2006","unstructured":"Durante C, Haddy N, Baudin E, Leboulleux S, Hartl D, Travagli JP, Caillou B, Ricard M, Lumbroso JD, De Vathaire F, Schlumberger M. Long- term outcome of 444 patients with distant metastasis from papillary and folicular thyroid carcinoma: benefits and limits of radioiodine therapy. J Clin Endocrinol Metab. 2006;91(8):2892\u20139 (epub 2006 May 9).","journal-title":"J Clin Endocrinol Metab."},{"issue":"5","key":"2581_CR7","doi-asserted-by":"publisher","first-page":"339","DOI":"10.14735\/amko2018339","volume":"31","author":"J Iva","year":"2018","unstructured":"Iva J, Filip G, Martin B, Pavel \u017d, Jan \u010c. The significance of BRAFV600E mutation in thyroid cancer terms of novel targeted therapies\u2014overview of current knowledge and studies. Klin Onkol Fall. 2018;31(5):339\u201344. https:\/\/doi.org\/10.14735\/amko2018339.","journal-title":"Klin Onkol. Fall"},{"issue":"1","key":"2581_CR8","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1056\/NEJMoa1412690","volume":"372","author":"C Robert","year":"2015","unstructured":"Robert C, Karaszewska B, Schachter J, Rutkowski P, Mackiewicz A, et al. Improved overall survival in melanoma with combined dabrafenib and trametinib. N Engl J Med. 2015;372(1):30\u20139. https:\/\/doi.org\/10.1056\/NEJMoa1412690.","journal-title":"N Engl J Med."},{"issue":"4","key":"2581_CR9","doi-asserted-by":"publisher","first-page":"765","DOI":"10.1111\/bcp.12651","volume":"80","author":"R Rissmann","year":"2015","unstructured":"Rissmann R, Hessel MH, Cohen AF. Vemurafenib\/dabrafenib and trametinib. Br J Clin Pharmacol. 2015;80(4):765\u20137. https:\/\/doi.org\/10.1111\/bcp.12651.","journal-title":"Br J Clin Pharmacol."},{"issue":"5","key":"2581_CR10","doi-asserted-by":"publisher","first-page":"1213","DOI":"10.1148\/radiographics.20.5.g00se011213","volume":"20","author":"C Sebasti\u00e0","year":"2000","unstructured":"Sebasti\u00e0 C, Quiroga S, Espin E, Boy\u00e9 R, Alvarez-Castells A, Armengol M. Portomesenteric vein gas: pathologic mechanisms, CT findings, and prognosis. 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The study of a case report is exempt from ethical approval in our institution.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Written informed consent was obtained from the patient\u2019s next of kin for publication of this case report and any accompanying images. A copy of the written consent is available for review by the Editor-in-Chief of this journal.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"This case report corresponds to a real case diagnosed and treated in our clinical center. Clinical and radiological data presented correspond to real data. The datasets supporting this article are stored in Hospital 12 Octubre medical records.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Availability of data and materials"}},{"value":"The authors included in this case report declare that they have no conflict of interest.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"109"}}