{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T02:18:58Z","timestamp":1772936338784,"version":"3.50.1"},"reference-count":32,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2020,2,12]],"date-time":"2020-02-12T00:00:00Z","timestamp":1581465600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2020,2,12]],"date-time":"2020-02-12T00:00:00Z","timestamp":1581465600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Med Case Reports"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>Agenesis of the corpus callosum can occur isolated or as part of a complex congenital syndrome. Patients with isolated agenesis of the corpus callosum may present with severe intellectual disability, although a proportion of affected individuals develop normal intelligence. However, even in patients with no apparent deficits, subtle neuropsychological alterations may occur as the cognitive demand increases with age. Hence, patients with this deffect require a strict follow-up during their postnatal life. Thus, physicians require a better knowledge of the cognitive features of agenesis of the corpus callosum to improve their approach to this cerebral malformation. Here, we report an illustrative case of a school-age child with isolated agenesis of the corpus callosum and normal intelligence. We also provide a literature review about the postnatal screening of neurocognitive deficits in patients with agenesis of the corpus callosum.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Case presentation<\/jats:title>\n                <jats:p>An 8-year-old Hispanic boy with total agenesis of the corpus callosum attended for medical follow-up. The defect was identified during the neonatal period by cranial ultrasonography and brain computed tomography scan. However, he did not present any craniofacial or non-cerebral malformation suggestive of a congenital syndrome. Furthermore, he showed no neuropsychiatric disorder or intellectual disability during his early childhood. At the age of 4, he was subjected to a control brain magnetic resonance imaging that showed total agenesis of the corpus callosum and colpocephaly. At his arrival, a neurological examination was normal with no signs of intracranial hypertension. His intelligence quotient was unaltered and he scored normal in the Mini-Mental State Examination test. The literature reviewed here suggested that patients with agenesis of the corpus callosum require a strict neurocognitive follow-up during postnatal life, as they may present neuropsychological deficits during adolescence, when development of the corpus callosum is completed and there is maximum reliance on this structure. Thus, our patient was scheduled for future annual neurocognitive testing.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>Isolated agenesis of the corpus callosum is not innocuous, and patients with this defect require a strict neurocognitive follow-up. We provide an informative reference tool useful for the postnatal neuropsychological screening of patients with isolated agenesis of the corpus callosum.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s13256-020-2359-2","type":"journal-article","created":{"date-parts":[[2020,2,12]],"date-time":"2020-02-12T00:03:57Z","timestamp":1581465837000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Isolated agenesis of the corpus callosum and normal general intelligence development during postnatal life: a case report and review of the literature"],"prefix":"10.1186","volume":"14","author":[{"given":"Parm\u00e9nides","family":"Guadarrama-Ortiz","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 Alberto","family":"Chore\u00f1o-Parra","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tania","family":"de la Rosa-Arredondo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2020,2,12]]},"reference":[{"issue":"2","key":"2359_CR1","doi-asserted-by":"publisher","first-page":"184","DOI":"10.1002\/ajmg.c.31405","volume":"166","author":"EE Palmer","year":"2014","unstructured":"Palmer EE, Mowat D. Agenesis of the corpus callosum: A clinical approach to diagnosis. Am J Med Genet Part C Semin Med Genet. 2014;166(2):184\u201397.","journal-title":"Am J Med Genet Part C Semin Med Genet"},{"issue":"1","key":"2359_CR2","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1136\/jnnp.64.1.131","volume":"64","author":"M Taylor","year":"1998","unstructured":"Taylor M, David AS. Agenesis of the corpus callosum: A United Kingdom series of 56 cases. J Neurol Neurosurg Psychiatry. 1998;64(1):131\u20134.","journal-title":"J Neurol Neurosurg Psychiatry"},{"issue":"3","key":"2359_CR3","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1002\/pd.3824","volume":"32","author":"ML Moutard","year":"2012","unstructured":"Moutard ML, Kieffer V, Feingold J, Lewin F, Baron JM, Adamsbaum C, et al. Isolated corpus callosum agenesis: A ten-year follow-up after prenatal diagnosis (How are the children without corpus callosum at 10 years of age?). Prenat Diagn. 2012;32(3):277\u201383.","journal-title":"Prenat Diagn"},{"issue":"1","key":"2359_CR4","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1016\/j.ejpn.2017.08.003","volume":"22","author":"V des Portes","year":"2018","unstructured":"des Portes V, Rolland A, Velazquez-Dominguez J, Peyric E, Cordier MP, Gaucherand P, et al. Outcome of isolated agenesis of the corpus callosum: A population-based prospective study. Eur J Paediatr Neurol. 2018;22(1):82\u201392.","journal-title":"Eur J Paediatr Neurol"},{"issue":"3","key":"2359_CR5","doi-asserted-by":"publisher","first-page":"324","DOI":"10.1017\/S135561771800111X","volume":"25","author":"WS Brown","year":"2019","unstructured":"Brown WS, Paul LK. The Neuropsychological Syndrome of Agenesis of the Corpus Callosum. J Int Neuropsychol Soc. 2019;25(3):324\u201330.","journal-title":"J Int Neuropsychol Soc"},{"key":"2359_CR6","doi-asserted-by":"publisher","first-page":"94","DOI":"10.3389\/fpsyg.2017.00094","volume":"8","author":"B L\u00e1badi","year":"2017","unstructured":"L\u00e1badi B, Beke AM. Mental State Understanding in Children with Agenesis of the Corpus Callosum. Front Psychol. 2017;8:94. https:\/\/doi.org\/10.3389\/fpsyg.2017.00094.","journal-title":"Front Psychol"},{"issue":"1","key":"2359_CR7","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1002\/ar.1091190109","volume":"119","author":"J Tomasch","year":"1954","unstructured":"Tomasch J. Size, distribution, and number of fibres in the human Corpus Callosum. Anat Rec. 1954;119(1):119\u201335.","journal-title":"Anat Rec"},{"issue":"2","key":"2359_CR8","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1007\/s11065-005-6252-y","volume":"15","author":"JS Bloom","year":"2005","unstructured":"Bloom JS, Hynd GW. The role of the corpus callosum in interhemispheric transfer of information: Excitation or inhibition? Neuropsychol Rev. 2005;15(2):59\u201371.","journal-title":"Neuropsychol Rev"},{"issue":"3","key":"2359_CR9","doi-asserted-by":"publisher","first-page":"989","DOI":"10.1016\/j.neuroimage.2006.05.044","volume":"32","author":"S Hofer","year":"2006","unstructured":"Hofer S, Frahm J. Topography of the human corpus callosum revisited-Comprehensive fiber tractography using diffusion tensor magnetic resonance imaging. Neuroimage. 2006;32(3):989\u201394.","journal-title":"Neuroimage"},{"issue":"8","key":"2359_CR10","doi-asserted-by":"publisher","first-page":"e39804","DOI":"10.1371\/journal.pone.0039804","volume":"7","author":"LBN Hinkley","year":"2012","unstructured":"Hinkley LBN, Marco EJ, Findlay AM, Honma S, Jeremy RJ, Strominger Z, et al. The role of corpus callosum development in functional connectivity and cognitive processing. PLoS One. 2012;7(8):e39804. https:\/\/doi.org\/10.1371\/journal.pone.0039804.","journal-title":"PLoS One"},{"issue":"5","key":"2359_CR11","doi-asserted-by":"publisher","first-page":"548","DOI":"10.1136\/jnnp.59.5.548","volume":"59","author":"T Nagumo","year":"1995","unstructured":"Nagumo T, Yamadori A. Callosal disconnection syndrome and knowledge of the body: A case of left-hand isolation from the body schema with names. J Neurol Neurosurg Psychiatry. 1995;59(5):548\u201351.","journal-title":"J Neurol Neurosurg Psychiatry"},{"issue":"10","key":"2359_CR12","doi-asserted-by":"publisher","first-page":"2224","DOI":"10.1093\/brain\/awh622","volume":"128","author":"M Catani","year":"2005","unstructured":"Catani M, Ffytche DH. The rises and falls of disconnection syndromes. Brain. 2005;128(10):2224\u201339.","journal-title":"Brain"},{"issue":"1","key":"2359_CR13","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1016\/j.cortex.2011.04.008","volume":"48","author":"G Berlucchi","year":"2012","unstructured":"Berlucchi G. Frontal callosal disconnection syndromes. Cortex. 2012;48(1):36\u201345.","journal-title":"Cortex"},{"issue":"03","key":"2359_CR14","doi-asserted-by":"publisher","first-page":"190","DOI":"10.4236\/wjns.2013.33024","volume":"03","author":"DG Politis","year":"2013","unstructured":"Politis DG, Tirigay RM, G\u00f3mez PG, Tabernero ME. Description of interhemispheric disconnection syndrome in a patient with Marchiafava-Bignami disease. World J Neurosci. 2013;03(03):190\u20137.","journal-title":"World J Neurosci"},{"issue":"2","key":"2359_CR15","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1080\/135468000395781","volume":"5","author":"WS Brown","year":"2000","unstructured":"Brown WS, Paul LK. Cognitive and psychosocial deficits in agenesis of the corpus callosum with normal intelligence. Cogn Neuropsychiatry. 2000;5(2):135\u201357.","journal-title":"Cogn Neuropsychiatry"},{"issue":"2","key":"2359_CR16","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1016\/j.pediatrneurol.2004.09.007","volume":"32","author":"L Sztriha","year":"2005","unstructured":"Sztriha L. Spectrum of corpus callosum agenesis. Pediatr Neurol. 2005;32(2):94\u2013101.","journal-title":"Pediatr Neurol"},{"issue":"19","key":"2359_CR17","doi-asserted-by":"publisher","first-page":"2495","DOI":"10.1002\/ajmg.a.32418","volume":"146","author":"HC Glass","year":"2008","unstructured":"Glass HC, Shaw GM, Ma C, Sherr EH. Agenesis of the corpus callosum in California 1983-2003: A population-based study. Am J Med Genet Part A. 2008;146(19):2495\u2013500.","journal-title":"Am J Med Genet Part A"},{"issue":"1","key":"2359_CR18","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1002\/cne.901320103","volume":"132","author":"P Rakic","year":"1968","unstructured":"Rakic P, Yakovlev PI. Development of the corpus callosum and cavum septi in man. J Comp Neurol. 1968;132(1):45\u201372.","journal-title":"J Comp Neurol"},{"issue":"6","key":"2359_CR19","doi-asserted-by":"publisher","first-page":"447","DOI":"10.1007\/s00234-010-0696-3","volume":"52","author":"C Raybaud","year":"2010","unstructured":"Raybaud C. The corpus callosum, the other great forebrain commissures, and the septum pellucidum: Anatomy, development, and malformation. Neuroradiology. 2010;52(6):447\u201377.","journal-title":"Neuroradiology"},{"issue":"4","key":"2359_CR20","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1038\/nrn2107","volume":"8","author":"LK Paul","year":"2007","unstructured":"Paul LK, Brown WS, Adolphs R, Tyszka JM, Richards LJ, Mukherjee P, et al. Agenesis of the corpus callosum: Genetic, developmental and functional aspects of connectivity. Nat Rev Neurosci. 2007;8(4):287\u201399.","journal-title":"Nat Rev Neurosci"},{"issue":"3","key":"2359_CR21","doi-asserted-by":"publisher","first-page":"186","DOI":"10.1016\/j.pediatrneurol.2005.08.008","volume":"34","author":"MF Bedeschi","year":"2006","unstructured":"Bedeschi MF, Bonaglia MC, Grasso R, Pellegri A, Garghentino RR, Battaglia MA, et al. Agenesis of the corpus callosum: Clinical and genetic study in 63 young patients. Pediatr Neurol. 2006;34(3):186\u201393.","journal-title":"Pediatr Neurol"},{"issue":"2","key":"2359_CR22","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1111\/j.1530-0277.1998.tb03651.x","volume":"22","author":"SN Mattson","year":"1998","unstructured":"Mattson SN, Riley EP. A review of the neurobehavioral deficits in children with fetal alcohol syndrome or prenatal exposure to alcohol. Alcohol Clin Exp Res. 1998;22(2):279\u201394.","journal-title":"Alcohol Clin Exp Res"},{"issue":"19","key":"2359_CR23","doi-asserted-by":"publisher","first-page":"2501","DOI":"10.1002\/ajmg.a.32476","volume":"146","author":"CC Schell-Apacik","year":"2008","unstructured":"Schell-Apacik CC, Wagner K, Bihler M, Ertl-Wagner B, Heinrich U, Klopocki E, et al. Agenesis and dysgenesis of the corpus callosum: Clinical, genetic and neuroimaging findings in a series of 41 patients. Am J Med Genet Part A. 2008;146(19):2501\u201311.","journal-title":"Am J Med Genet Part A"},{"issue":"2","key":"2359_CR24","doi-asserted-by":"publisher","first-page":"257","DOI":"10.3174\/ajnr.A1331","volume":"30","author":"PH Tang","year":"2009","unstructured":"Tang PH, Bartha AI, Norton ME, Barkovich AJ, Sherr EH, Glenn OA. Agenesis of the corpus callosum: An MR imaging analysis of associated abnormalities in the fetus. Am J Neuroradiol. 2009;30(2):257\u201363.","journal-title":"Am J Neuroradiol"},{"issue":"3","key":"2359_CR25","doi-asserted-by":"publisher","first-page":"531","DOI":"10.1093\/cercor\/bhj178","volume":"17","author":"F Tovar-Moll","year":"2007","unstructured":"Tovar-Moll F, Moll J, De Oliveira-Souza R, Bramati I, Andreiuolo PA, Lent R. Neuroplasticity in human callosal dysgenesis: A diffusion tensor imaging study. Cereb Cortex. 2007;17(3):531\u201341.","journal-title":"Cereb Cortex"},{"key":"2359_CR26","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1016\/j.cortex.2014.08.022","volume":"63","author":"A B\u00e9n\u00e9zit","year":"2015","unstructured":"B\u00e9n\u00e9zit A, Hertz-Pannier L, Dehaene-Lambertz G, Monzalvo K, Germanaud D, Duclap D, et al. Organising white matter in a brain without corpus callosum fibres. Cortex. 2015;63:155\u201371.","journal-title":"Cortex"},{"issue":"10","key":"2359_CR27","doi-asserted-by":"publisher","first-page":"935","DOI":"10.1016\/j.biopsych.2009.07.022","volume":"66","author":"TW Frazier","year":"2009","unstructured":"Frazier TW, Hardan AY. A Meta-Analysis of the Corpus Callosum in Autism. Biol Psychiatry. 2009;66(10):935\u201341.","journal-title":"Biol Psychiatry"},{"issue":"5","key":"2359_CR28","doi-asserted-by":"publisher","first-page":"513","DOI":"10.1002\/uog.12315","volume":"40","author":"S Santo","year":"2012","unstructured":"Santo S, D\u2019antonio F, Homfray T, Rich P, Pilu G, Bhide A, et al. Counseling in fetal medicine: Agenesis of the corpus callosum. Ultrasound Obstet Gynecol. 2012;40(5):513\u201321.","journal-title":"Ultrasound Obstet Gynecol"},{"key":"2359_CR29","volume-title":"Regional Development of Brain in Early Life","author":"PI Yakovlev","year":"1967","unstructured":"Yakovlev PI, Lecours A-R. The myelogenetic cycles of regional maturation of the brain. In: Minkowski A, editor. Regional Development of Brain in Early Life. Oxford: Blackwell; 1967. p. 3\u201370."},{"issue":"1","key":"2359_CR30","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1037\/0894-4105.14.1.41","volume":"14","author":"DH Weissman","year":"2000","unstructured":"Weissman DH, Banich MT. The cerebral hemispheres cooperate to perform complex but not simple tasks. Neuropsychology. 2000;14(1):41\u201359.","journal-title":"Neuropsychology"},{"key":"2359_CR31","doi-asserted-by":"publisher","first-page":"2675","DOI":"10.1007\/978-0-387-79948-3_1073","volume-title":"Encyclopedia of Clinical Neuropsychology","author":"Donald H. Saklofske","year":"2011","unstructured":"Saklofske DH, Schoenberg MR. Wechsler Adult Intelligence Scale (All Versions). In: Kreutzer JS, DeLuca J, Caplan B. (eds) Encyclopedia of Clinical Neuropsychology. New York: Springer; 2011."},{"key":"2359_CR32","doi-asserted-by":"publisher","first-page":"2682","DOI":"10.1007\/978-0-387-79948-3_1605","volume-title":"Encyclopedia of Clinical Neuropsychology","author":"Lisa A. Jacobson","year":"2011","unstructured":"Jacobson LA, Mahone EM. Wechsler Intelligence Scale for Children. In: Kreutzer JS, DeLuca J, Caplan B. (eds) Encyclopedia of Clinical Neuropsychology. New York: Springer; 2011."}],"container-title":["Journal of Medical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s13256-020-2359-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/s13256-020-2359-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s13256-020-2359-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,2,11]],"date-time":"2021-02-11T10:01:38Z","timestamp":1613037698000},"score":1,"resource":{"primary":{"URL":"https:\/\/jmedicalcasereports.biomedcentral.com\/articles\/10.1186\/s13256-020-2359-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,2,12]]},"references-count":32,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2020,12]]}},"alternative-id":["2359"],"URL":"https:\/\/doi.org\/10.1186\/s13256-020-2359-2","relation":{},"ISSN":["1752-1947"],"issn-type":[{"value":"1752-1947","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,2,12]]},"assertion":[{"value":"15 July 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 January 2020","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 February 2020","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Not applicable.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Written informed consent was obtained from the patient\u2019s legal guardian(s) for publication of this case report and any accompanying images. A copy of the written consent is available for review by the Editor-in-Chief of this journal.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"28"}}